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Aliases for MIR939 Gene

Subcategory (RNA class) for MIR939 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR939 Gene

  • MicroRNA 939 2 3
  • Cleavage And Polyadenylation Specificity Factor 160 KDa Subunit 4
  • Cleavage And Polyadenylation Specific Factor 1 5
  • CPSF 160 KDa Subunit 4
  • Hsa-Mir-939 3
  • CPSF160 4
  • Mir-939 3
  • MIRN939 3
  • CPSF1 5

External Ids for MIR939 Gene

Previous HGNC Symbols for MIR939 Gene

  • MIRN939

Previous GeneCards Identifiers for MIR939 Gene

  • GC08M145592
  • GC08M145621
  • GC08M145626
  • GC08M145627
  • GC08M140732
  • GC08M145630
  • GC08M145631
  • GC08M145632
  • GC08M145633

Summaries for MIR939 Gene

Entrez Gene Summary for MIR939 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR939 Gene

MIR939 (MicroRNA 939) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are mRNA Splicing - Major Pathway.

UniProtKB/Swiss-Prot for MIR939 Gene

  • Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR939 Gene

Genomics for MIR939 Gene

Regulatory Elements for MIR939 Gene

Enhancers for MIR939 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR939 on UCSC Golden Path with GeneCards custom track

Promoters for MIR939 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR939 Gene

Chromosome:
8
Start:
144,393,229 bp from pter
End:
144,409,349 bp from pter
Size:
16,121 bases
Orientation:
Minus strand

Genomic View for MIR939 Gene

Genes around MIR939 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR939 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR939 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR939 Gene

ORGUL Member Location for MIR939 Gene

ORGUL Member Location for MIR939 gene

Proteins for MIR939 Gene

  • Protein details for MIR939 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10570-CPSF1_HUMAN
    Recommended name:
    Cleavage and polyadenylation specificity factor subunit 1
    Protein Accession:
    Q10570
    Secondary Accessions:
    • Q96AF0

    Protein attributes for MIR939 Gene

    Size:
    1443 amino acids
    Molecular mass:
    160884 Da
    Quaternary structure:
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.
    • Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Found in a complex with CPSF1, FIP1L1 and PAPOLA. Interacts with FIP1L1, PAPD4/GLD2 and SRRM1. Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3UTR of selected pre-mRNAs.

neXtProt entry for MIR939 Gene

Post-translational modifications for MIR939 Gene

  • The N-terminus is blocked.
  • Ubiquitination at Lys 6, Lys 52, Lys 116, Lys 364, Lys 395, Lys 809, Lys 847, Lys 1104, Lys 1118, Lys 1241, and Lys 1421
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR939 Gene

No data available for DME Specific Peptides for MIR939 Gene

Domains & Families for MIR939 Gene

Gene Families for MIR939 Gene

Protein Domains for MIR939 Gene

Graphical View of Domain Structure for InterPro Entry

Q10570

UniProtKB/Swiss-Prot:

CPSF1_HUMAN :
  • Belongs to the CPSF1 family.
Family:
  • Belongs to the CPSF1 family.
genes like me logo Genes that share domains with MIR939: view

No data available for Suggested Antigen Peptide Sequences for MIR939 Gene

Function for MIR939 Gene

Molecular function for MIR939 Gene

UniProtKB/Swiss-Prot Function:
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.

Gene Ontology (GO) - Molecular Function for MIR939 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0019899 enzyme binding IPI --
GO:0035925 mRNA 3-UTR AU-rich region binding IDA --
genes like me logo Genes that share ontologies with MIR939: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR939 Gene

Localization for MIR939 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR939 Gene

Gene Ontology (GO) - Cellular Components for MIR939 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA --
genes like me logo Genes that share ontologies with MIR939: view

No data available for Subcellular locations from COMPARTMENTS for MIR939 Gene

Pathways & Interactions for MIR939 Gene

SuperPathways for MIR939 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with MIR939: view

Pathways by source for MIR939 Gene

1 BioSystems pathway for MIR939 Gene

Gene Ontology (GO) - Biological Process for MIR939 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006378 mRNA polyadenylation IMP --
GO:0006379 mRNA cleavage IBA --
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation TAS --
GO:0006406 mRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with MIR939: view

No data available for SIGNOR curated interactions for MIR939 Gene

Drugs & Compounds for MIR939 Gene

No Compound Related Data Available

Transcripts for MIR939 Gene

mRNA/cDNA for MIR939 Gene

(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR939 Gene

No ASD Table

Relevant External Links for MIR939 Gene

GeneLoc Exon Structure for
MIR939
ECgene alternative splicing isoforms for
MIR939

Expression for MIR939 Gene

mRNA expression in normal human tissues for MIR939 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR939 Gene:

MIR939
genes like me logo Genes that share expression patterns with MIR939: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR939 Gene

Orthologs for MIR939 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR939 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPSF1 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPSF1 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CPSF1 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpsf1 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPSF1 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPSF1 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cpsf1 35
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cpsf160 35
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cpsf-1 35
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CFT1 35
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToOne
Species where no ortholog for MIR939 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR939 Gene

ENSEMBL:
Gene Tree for MIR939 (if available)
TreeFam:
Gene Tree for MIR939 (if available)

Paralogs for MIR939 Gene

Pseudogenes.org Pseudogenes for MIR939 Gene

genes like me logo Genes that share paralogs with MIR939: view

No data available for Paralogs for MIR939 Gene

Variants for MIR939 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR939 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12437n54 CNV loss 21841781
esv2759652 CNV gain+loss 17122850
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612934 CNV loss 21841781
nsv824805 CNV gain 20364138
nsv831489 CNV loss 17160897

Relevant External Links for MIR939 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR939

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR939 Gene

Disorders for MIR939 Gene

Relevant External Links for MIR939

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR939

No disorders were found for MIR939 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR939 Gene

Publications for MIR939 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 65
  2. MiR-939 promotes the proliferation of human ovarian cancer cells by repressing APC2 expression. (PMID: 25960217) Ying X. … Ji-hong L. (Biomed. Pharmacother. 2015) 3 65
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  4. miRNA-939 regulates human inducible nitric oxide synthase posttranscriptional gene expression in human hepatocytes. (PMID: 22451906) Guo Z. … Geller D.A. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 65
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 65

Products for MIR939 Gene

Sources for MIR939 Gene

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