Subcategory (RNA class) for MIR937 Gene
Quality Score for this RNA gene is
Aliases for MIR937 Gene
External Ids for MIR937 Gene
Previous HGNC Symbols for MIR937 Gene
Previous GeneCards Identifiers for MIR937 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR937 Gene
MIR937 (MicroRNA 937) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR937 include Encephalitis and Craniorachischisis. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and TSH signaling pathway. An important paralog of this gene is LRRC7.
UniProtKB/Swiss-Prot for MIR937 Gene
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.