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Aliases for MIR937 Gene

Subcategory (RNA class) for MIR937 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR937 Gene

  • MicroRNA 937 2 3
  • SCRIB 4 5
  • Scribbled Planar Cell Polarity Protein 5
  • Protein LAP4 4
  • Hsa-Mir-937 3
  • KIAA0147 4
  • Scribble 4
  • Mir-937 3
  • MIRN937 3
  • VARTUL 4
  • HScrib 4
  • CRIB1 4
  • SCRB1 4
  • LAP4 4

External Ids for MIR937 Gene

Previous HGNC Symbols for MIR937 Gene

  • MIRN937

Previous GeneCards Identifiers for MIR937 Gene

  • GC08M144969
  • GC08M144895
  • GC08M140148
  • GC08M143812

Summaries for MIR937 Gene

Entrez Gene Summary for MIR937 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR937 Gene

MIR937 (MicroRNA 937) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR937 include Encephalitis and Craniorachischisis. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and TSH signaling pathway. An important paralog of this gene is LRRC7.

UniProtKB/Swiss-Prot for MIR937 Gene

  • Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR937 Gene

Genomics for MIR937 Gene

Regulatory Elements for MIR937 Gene

Enhancers for MIR937 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F143835 0.9 Ensembl ENCODE 12.3 -21.0 -20983 1.7 CTCF SAP130 ZNF740 ARID4B RAD21 YY1 ZFP3 SMC3 SMAD4 CHD2 MIR937 SCRIB EPPK1 MIR661 PLEC PARP10 SPATC1 PUF60 FAM83H NAPRT
GH08F143905 0.9 ENCODE 11.4 -90.9 -90880 1.5 HDAC1 ELF3 TBP ARID4B DMAP1 ZNF48 RAD21 RARA SLC30A9 CBX5 PLEC EPPK1 PUF60 MIR661 NRBP2 MIR6845 MIR937 SCRIB SPATC1 PARP10
GH08F143903 0.8 Ensembl ENCODE 11.5 -89.2 -89188 1.8 PKNOX1 RFX1 POLR2A KLF9 MNT RAD21 TRIM28 PLEC EPPK1 PUF60 MIR661 MIR6845 NRBP2 MIR937 SCRIB PARP10 SPATC1
GH08F143760 0.7 Ensembl 12.5 +54.4 54361 0.8 CBX3 SAP130 ZNF48 CBX5 POLR2A THAP11 EZH2 PHF8 MAZ SP5 PUF60 FAM83H SCRIB MIR937 FAM83H-AS1 ENSG00000254973 LOC105375800 LOC642574
GH08F143819 1.1 ENCODE 0.8 -4.8 -4770 0.5 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 KLF13 ZNF263 SP3 LRRC14 ZNF517 ADCK5 VPS28 LOC105375803 ZNF696 ZNF251 PUF60 MIR937 SCRIB
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR937 on UCSC Golden Path with GeneCards custom track

Promoters for MIR937 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001906722 1279 201 ZNF362

Genomic Location for MIR937 Gene

Chromosome:
8
Start:
143,790,920 bp from pter
End:
143,815,379 bp from pter
Size:
24,460 bases
Orientation:
Minus strand

Genomic View for MIR937 Gene

Genes around MIR937 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR937 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR937 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR937 Gene

Proteins for MIR937 Gene

  • Protein details for MIR937 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14160-SCRIB_HUMAN
    Recommended name:
    Protein scribble homolog
    Protein Accession:
    Q14160
    Secondary Accessions:
    • Q6P496
    • Q7Z5D1
    • Q8WWV8
    • Q96C69
    • Q96GG1

    Protein attributes for MIR937 Gene

    Size:
    1630 amino acids
    Molecular mass:
    174885 Da
    Quaternary structure:
    • Interacts (via PDZ domains) with VANGL2. Interacts with CTNNB1 and MAPK12 (By similarity). Interacts with UBE3A and HPV E6. Interacts with PAK1 and PAK2. Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7. Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct. Interacts (via PDZ domains) with TJP2. Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells. Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function. Interacts (via PDZ domains 1 and 3) with MCC. Interacts (via fourth PDZ domain) with tick-borne encephalitis virus NS5 protein; this interaction inhibits SCRIB and downstream STAT1 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway.
    • Interacts (via PDZ domains) with VANGL2. Interacts with CTNNB1 and MAPK12 (By similarity). Interacts with UBE3A and HPV E6. Interacts with PAK1 and PAK2. Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7. Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct. Interacts (via PDZ domains) with TJP2. Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells. Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function. Interacts (via PDZ domains 1 and 3) with MCC. Interacts (via fourth PDZ domain) with tick-borne encephalitis virus NS5 protein; this interaction inhibits SCRIB and downstream STAT1 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway.

    Three dimensional structures from OCA and Proteopedia for MIR937 Gene

    Alternative splice isoforms for MIR937 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR937 Gene

Post-translational modifications for MIR937 Gene

  • Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
  • Ubiquitination at Lys 53, Lys 164, Lys 266, and Lys 272
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR937 Gene

No data available for DME Specific Peptides for MIR937 Gene

Domains & Families for MIR937 Gene

Gene Families for MIR937 Gene

Protein Domains for MIR937 Gene

Graphical View of Domain Structure for InterPro Entry

Q14160

UniProtKB/Swiss-Prot:

SCRIB_HUMAN :
  • Contains 4 PDZ (DHR) domains.
  • Belongs to the LAP (LRR and PDZ) protein family.
  • Contains 16 LRR (leucine-rich) repeats.
Domain:
  • Contains 4 PDZ (DHR) domains.
Family:
  • Belongs to the LAP (LRR and PDZ) protein family.
Similarity:
  • Contains 16 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with MIR937: view

No data available for Suggested Antigen Peptide Sequences for MIR937 Gene

Function for MIR937 Gene

Molecular function for MIR937 Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

Gene Ontology (GO) - Molecular Function for MIR937 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0098641 cadherin binding involved in cell-cell adhesion IDA --
genes like me logo Genes that share ontologies with MIR937: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR937 Gene

Localization for MIR937 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR937 Gene

Cell membrane; Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.

Gene Ontology (GO) - Cellular Components for MIR937 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IEA --
GO:0005911 cell-cell junction IDA --
GO:0005912 adherens junction IEA --
genes like me logo Genes that share ontologies with MIR937: view

No data available for Subcellular locations from COMPARTMENTS for MIR937 Gene

Pathways & Interactions for MIR937 Gene

genes like me logo Genes that share pathways with MIR937: view

Pathways by source for MIR937 Gene

Interacting Proteins for MIR937 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349486%0d%0a9606.ENSP00000364893%0d%0a9606.ENSP00000381045%0d%0a9606.ENSP00000257430%0d%0a9606.ENSP00000200457%0d%0a9606.ENSP00000200457%0d%0a
Selected Interacting proteins: Q14160-SCRIB_HUMAN ENSP00000349486 for MIR937 Gene via MINT STRING UniProtKB IID

Symbol External ID(s) Details
ARHGEF7
MCC
APC
PHLPP1
TJP2

Gene Ontology (GO) - Biological Process for MIR937 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IMP --
GO:0002093 auditory receptor cell morphogenesis IEA --
GO:0007275 multicellular organism development IEA --
GO:0008105 asymmetric protein localization IEA --
GO:0008283 cell proliferation IDA --
genes like me logo Genes that share ontologies with MIR937: view

No data available for SIGNOR curated interactions for MIR937 Gene

Transcripts for MIR937 Gene

mRNA/cDNA for MIR937 Gene

(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR937 Gene

No ASD Table

Relevant External Links for MIR937 Gene

GeneLoc Exon Structure for
MIR937
ECgene alternative splicing isoforms for
MIR937

Expression for MIR937 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR937 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR937 Gene:

MIR937

mRNA Expression by UniProt/SwissProt for MIR937 Gene:

Q14160-SCRIB_HUMAN
Tissue specificity: Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
genes like me logo Genes that share expression patterns with MIR937: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR937 Gene

Orthologs for MIR937 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR937 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCRIB 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCRIB 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scrib 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCRIB 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCRIB 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCRIB 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCRIB 35
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii scrib 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta scrib 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-413 35
  • 39 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7054 35
  • 42 (a)
OneToMany
Species where no ortholog for MIR937 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR937 Gene

ENSEMBL:
Gene Tree for MIR937 (if available)
TreeFam:
Gene Tree for MIR937 (if available)

Paralogs for MIR937 Gene

Paralogs for MIR937 Gene

genes like me logo Genes that share paralogs with MIR937: view

Variants for MIR937 Gene

Sequence variations from dbSNP and Humsavar for MIR937 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs112295309 -- 143,813,896(+) GGATA(G/T)CTGTC upstream-variant-2KB, reference, missense
rs113070193 -- 143,814,345(+) GCCTC(C/T)ACTCT intron-variant, upstream-variant-2KB
rs113368976 -- 143,814,834(+) CACCC(C/T)TGCAC intron-variant, upstream-variant-2KB
rs113426047 -- 143,813,891(+) CTCAG(A/G)GATAT upstream-variant-2KB, reference, missense
rs11404566 -- 143,812,532(+) TTGCC(-/T)CCACA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR937 Gene

Variant ID Type Subtype PubMed ID
nsv1161815 CNV deletion 26073780
nsv466009 CNV loss 19166990
nsv612895 CNV loss 21841781
nsv612896 CNV loss 21841781
nsv612897 CNV loss 21841781
nsv6442 CNV deletion 18451855
nsv950014 CNV deletion 24416366

Relevant External Links for MIR937 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR937

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR937 Gene

Disorders for MIR937 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR937 Gene - From: GeneCards

Disorder Aliases PubMed IDs
encephalitis
craniorachischisis
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

SCRIB_HUMAN
  • Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. {ECO:0000269 PubMed:22095531}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR937

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR937
genes like me logo Genes that share disorders with MIR937: view

No data available for Genatlas for MIR937 Gene

Publications for MIR937 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis. (PMID: 22095531) Robinson A. … Stanier P. (Hum. Mutat. 2012) 4 64
  4. The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells. (PMID: 22480440) Pangon L. … Kohonen-Corish M.R. (Biochim. Biophys. Acta 2012) 4 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR937 Gene

Sources for MIR937 Gene

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