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Aliases for MIR935 Gene

Subcategory (RNA class) for MIR935 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR935 Gene

  • MicroRNA 935 2 3
  • CACNG8 4 5
  • Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 8 5
  • Neuronal Voltage-Gated Calcium Channel Gamma-8 Subunit 4
  • Transmembrane AMPAR Regulatory Protein Gamma-8 4
  • TARP Gamma-8 4
  • Hsa-Mir-935 3
  • Mir-935 3
  • MIRN935 3
  • CACNG6 4

External Ids for MIR935 Gene

Previous HGNC Symbols for MIR935 Gene

  • MIRN935

Previous GeneCards Identifiers for MIR935 Gene

  • GC19P059179
  • GC19P054485

Summaries for MIR935 Gene

Entrez Gene Summary for MIR935 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR935 Gene

MIR935 (MicroRNA 935) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Transmission across Chemical Synapses and Cardiac conduction. An important paralog of this gene is CACNG4.

UniProtKB/Swiss-Prot for MIR935 Gene

  • Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR935 Gene

Genomics for MIR935 Gene

Regulatory Elements for MIR935 Gene

Enhancers for MIR935 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F053851 1.5 FANTOM5 Ensembl ENCODE 11.2 -110.4 -110440 3.2 CTCF PKNOX1 MAX ZNF48 ZNF2 RAD21 TEAD3 SCRT2 ZNF143 SMC3 ENSG00000232220 PRKCG MIR935 CACNG6 MYADM VSTM1 LILRA5 OSCAR NLRP12 LILRB2
GH19F053840 1.2 Ensembl ENCODE 11.2 -120.4 -120440 4.0 PKNOX1 ARID4B SIN3A YBX1 ZNF121 FOS SP3 JUNB REST TBX21 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR515-2 MIR519C MIR1283-1 MIR520A MIR515-1
GH19F053847 1.2 FANTOM5 Ensembl ENCODE 11.2 -114.0 -114039 2.4 ZNF146 ZNF384 MEF2D SMARCA4 POLR2A RCOR2 IKZF1 SMAD4 CREM LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MYADM VSTM1 OSCAR NLRP12 LILRA5
GH19F054034 1.1 FANTOM5 Ensembl ENCODE 12.1 +72.7 72663 2.3 JUND JUN STAT3 MAX FOS MYC CACNG6 MIR935 ENSG00000232220 PRKCG LOC105372457 ENSG00000276206 VSTM1
GH19F053941 1 Ensembl ENCODE 12.4 -20.4 -20358 1.9 CTCF SP3 NRF1 REST ZBTB7A NR2F2 RARA SP1 POLR2A IKZF1 CACNG8 MIR935 LOC105372457 PRKCG ENSG00000232220 PIR36356
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR935 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR935 Gene

Chromosome:
19
Start:
53,963,040 bp from pter
End:
53,990,215 bp from pter
Size:
27,176 bases
Orientation:
Plus strand

Genomic View for MIR935 Gene

Genes around MIR935 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR935 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR935 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR935 Gene

Proteins for MIR935 Gene

  • Protein details for MIR935 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXS5-CCG8_HUMAN
    Recommended name:
    Voltage-dependent calcium channel gamma-8 subunit
    Protein Accession:
    Q8WXS5
    Secondary Accessions:
    • Q9BXT0
    • Q9BY23

    Protein attributes for MIR935 Gene

    Size:
    425 amino acids
    Molecular mass:
    43313 Da
    Quaternary structure:
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity).
    • The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5 and CACNG7. Interacts with CNIH2 (By similarity).
    SequenceCaution:
    • Sequence=AAK15019.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAL50049.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MIR935 Gene

Post-translational modifications for MIR935 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR935 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIR935 Gene

Domains & Families for MIR935 Gene

Gene Families for MIR935 Gene

Protein Domains for MIR935 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXS5

UniProtKB/Swiss-Prot:

CCG8_HUMAN :
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
Family:
  • Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
genes like me logo Genes that share domains with MIR935: view

No data available for Suggested Antigen Peptide Sequences for MIR935 Gene

Function for MIR935 Gene

Molecular function for MIR935 Gene

UniProtKB/Swiss-Prot Function:
Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state.

Gene Ontology (GO) - Molecular Function for MIR935 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity NAS --
GO:0005262 calcium channel activity IEA --
GO:0016247 channel regulator activity IBA --
genes like me logo Genes that share ontologies with MIR935: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR935 Gene

Localization for MIR935 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR935 Gene

Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Gene Ontology (GO) - Cellular Components for MIR935 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005891 voltage-gated calcium channel complex NAS --
GO:0014069 postsynaptic density ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MIR935: view

No data available for Subcellular locations from COMPARTMENTS for MIR935 Gene

Pathways & Interactions for MIR935 Gene

genes like me logo Genes that share pathways with MIR935: view

Gene Ontology (GO) - Biological Process for MIR935 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006816 calcium ion transport NAS --
GO:0019226 transmission of nerve impulse IBA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with MIR935: view

No data available for SIGNOR curated interactions for MIR935 Gene

Transcripts for MIR935 Gene

mRNA/cDNA for MIR935 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR935 Gene

No ASD Table

Relevant External Links for MIR935 Gene

GeneLoc Exon Structure for
MIR935
ECgene alternative splicing isoforms for
MIR935

Expression for MIR935 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR935 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR935 Gene:

MIR935
genes like me logo Genes that share expression patterns with MIR935: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR935 Gene

Orthologs for MIR935 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR935 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-935 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-935 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CACNG8 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cacng8 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CACNG8 35
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CACNG8 35
  • 79 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cacng8a 35
  • 58 (a)
OneToMany
cacng8b 35
  • 58 (a)
OneToMany
Species where no ortholog for MIR935 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR935 Gene

ENSEMBL:
Gene Tree for MIR935 (if available)
TreeFam:
Gene Tree for MIR935 (if available)

Paralogs for MIR935 Gene

Paralogs for MIR935 Gene

genes like me logo Genes that share paralogs with MIR935: view

Variants for MIR935 Gene

Sequence variations from dbSNP and Humsavar for MIR935 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111502701 -- 53,980,914(+) AGGGT(C/G)TGCTT intron-variant, upstream-variant-2KB
rs112431113 -- 53,980,579(+) CCCGT(G/T)GCCAT intron-variant, upstream-variant-2KB
rs112823679 -- 53,980,748(+) GCCTA(A/G)ACGAG intron-variant, upstream-variant-2KB
rs113471857 -- 53,980,406(+) GGGCG(A/G)GCCCA intron-variant, upstream-variant-2KB
rs11880805 -- 53,981,113(+) TTTGA(A/C)CAGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR935 Gene

Variant ID Type Subtype PubMed ID
nsv953612 CNV deletion 24416366
nsv833877 CNV loss 17160897
nsv833876 CNV loss 17160897
nsv580111 CNV loss 21841781
nsv580110 CNV gain 21841781
nsv458782 CNV gain 19166990
nsv1063127 CNV gain 25217958
esv2718812 CNV deletion 23290073
dgv1815n106 CNV deletion 24896259

Relevant External Links for MIR935 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR935

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR935 Gene

Disorders for MIR935 Gene

Relevant External Links for MIR935

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR935

No disorders were found for MIR935 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR935 Gene

Publications for MIR935 Gene

  1. miR-935 suppresses gastric signet ring cell carcinoma tumorigenesis by targeting Notch1 expression. (PMID: 26742429) Yan C. … Zhou L. (Biochem. Biophys. Res. Commun. 2016) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. (PMID: 20805473) Shi Y. … Nicoll R.A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 4 64
  4. Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. (PMID: 21172611) Kato A.S. … Bredt D.S. (Neuron 2010) 4 64
  5. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3 64

Products for MIR935 Gene

Sources for MIR935 Gene

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