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Aliases for MIR93 Gene

Subcategory (RNA class) for MIR93 Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR93 Gene

  • MicroRNA 93 2 3
  • MIRN9 3 6
  • Hsa-Mir-93 3
  • MiR-93 3
  • MIRN93 3

External Ids for MIR93 Gene

Previous Symbols for MIR93 Gene

  • MIRN93

Summaries for MIR93 Gene

Entrez Gene Summary for MIR93 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR93 Gene

MIR93 (MicroRNA 93) is an RNA Gene, and belongs to the miRNA class. Among its related pathways are miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR93 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR93 Gene

Genomics for MIR93 Gene

Genomic Location for MIR93 Gene

Start:
100,093,768 bp from pter
End:
100,093,847 bp from pter
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR93 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR93 Gene

ORGUL Member Location for MIR93 Gene

ORGUL Member Location for MIR93 gene

No data available for Regulatory Elements for MIR93 Gene

Proteins for MIR93 Gene

Post-translational modifications for MIR93 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR93 Gene

Domains for MIR93 Gene

Gene Families for MIR93 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR93: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR93 Gene

Function for MIR93 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR93 Gene

Localization for MIR93 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR93 Gene

Pathways for MIR93 Gene

SuperPathways for MIR93 Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR93: view

Pathways by source for MIR93 Gene

1 BioSystems pathway for MIR93 Gene

Interacting Proteins for MIR93 Gene

Gene Ontology (GO) - Biological Process for MIR93 Gene

None

Transcripts for MIR93 Gene

mRNA/cDNA for MIR93 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR93 Gene

No ASD Table

Relevant External Links for MIR93 Gene

GeneLoc Exon Structure for
MIR93
ECgene alternative splicing isoforms for
MIR93

Expression for MIR93 Gene

mRNA expression in normal human tissues for MIR93 Gene

genes like me logo Genes that share expressions with MIR93: view

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR93 Gene

Orthologs for MIR93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-93 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-93 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-93 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir93 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-93 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-20a-2 36
  • 44 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-20a 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-20a 36
  • 47 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-93 36
  • 69 (a)
OneToOne
Species with no ortholog for MIR93:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR93 Gene

ENSEMBL:
Gene Tree for MIR93 (if available)
TreeFam:
Gene Tree for MIR93 (if available)

Paralogs for MIR93 Gene

No data available for Paralogs for MIR93 Gene

Variants for MIR93 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR93 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv510966 CNV Complex 20534489

Relevant External Links for MIR93 Gene

HapMap Linkage Disequilibrium report
MIR93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR93 Gene

Disorders for MIR93 Gene

Relevant External Links for MIR93

Genetic Association Database (GAD)
MIR93
Human Genome Epidemiology (HuGE) Navigator
MIR93
genes like me logo Genes that share disorders with MIR93: view

No data available for UniProtKB/Swiss-Prot for MIR93 Gene

Publications for MIR93 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48
  2. microRNA-dependent modulation of histone acetylation in Waldenstrom macroglobulinemia. (PMID: 20519629) Roccaro A.M. … Ghobrial I.M. (Blood 2010) 3
  3. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  4. MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-I^8. (PMID: 20956944) Fang L. … Yang B.B. (Oncogene 2011) 3
  5. Loss of p21(Sdi1) expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21(Sdi1) gene promoter. (PMID: 21402054) Choi O.R. … Lim I.K. (Biochem. Biophys. Res. Commun. 2011) 3

Products for MIR93 Gene

Sources for MIR93 Gene

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