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Aliases for MIR92B Gene

Subcategory (RNA class) for MIR92B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR92B Gene

  • MicroRNA 92b 2 3 5
  • Hsa-Mir-92b 3
  • Mir-92b 3
  • MIRN92B 3

External Ids for MIR92B Gene

Previous HGNC Symbols for MIR92B Gene

  • MIRN92B

Previous GeneCards Identifiers for MIR92B Gene

  • GC01U902188
  • GC01P153433
  • GC01P155164

Summaries for MIR92B Gene

Entrez Gene Summary for MIR92B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR92B Gene

MIR92B (MicroRNA 92b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR92B Gene

Genomics for MIR92B Gene

Regulatory Elements for MIR92B Gene

Enhancers for MIR92B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F154728 1 Ensembl ENCODE 12.6 -464.9 -464940 3.1 JUN ZIC2 ZNF316 POLR2A ZNF366 NFE2 MAFK NFE2L2 ZNF263 RFX1 MIR92B KCNN3 CHRNB2 UBE2Q1 ADAR DCST1-AS1 ADAM15 CRTC2 PIR49202 PIR50309
GH01F155231 1.1 Ensembl ENCODE 12.4 +37.2 37227 1.7 ARID1B PKNOX1 POLR2A GLIS1 SPI1 GBA FAM189B SCAMP3 THBS3 MTX1 MIR92B MUC1 KRTCAP2 TRIM46 FDPS
GH01F155093 1.1 Ensembl ENCODE 11.5 -100.8 -100803 1.2 KLF17 ARID4B ZNF2 RAD21 ZEB1 RFX5 GLIS2 KLF7 EGR2 ZNF654 EFNA1 EFNA4 ENSG00000251246 SLC50A1 KRTCAP2 MUC1 MIR92B MTX1 THBS3 TRIM46
GH01F155091 1.1 Ensembl ENCODE 11 -103.4 -103409 0.9 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 EFNA1 SLC50A1 KRTCAP2 MIR92B MUC1 MTX1 THBS3 DCST1-AS1 ADAM15 EFNA3
GH01F155084 0.2 ENCODE 11 -109.7 -109727 2.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ADAM15 ASH1L PYGO2 EFNA1 SLC50A1 KRTCAP2 MIR92B MUC1 MTX1 THBS3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR92B on UCSC Golden Path with GeneCards custom track

Promoters for MIR92B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166853 -304 3401 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A ZNF2 ZNF207 ZNF143

Genomic Location for MIR92B Gene

Chromosome:
1
Start:
155,195,004 bp from pter
End:
155,205,495 bp from pter
Size:
10,492 bases
Orientation:
Plus strand

Genomic View for MIR92B Gene

Genes around MIR92B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR92B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR92B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR92B Gene

Proteins for MIR92B Gene

Post-translational modifications for MIR92B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR92B Gene

Domains & Families for MIR92B Gene

Gene Families for MIR92B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR92B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR92B Gene

Function for MIR92B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR92B Gene

Localization for MIR92B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR92B Gene

Pathways & Interactions for MIR92B Gene

SuperPathways for MIR92B Gene

No Data Available

Interacting Proteins for MIR92B Gene

Gene Ontology (GO) - Biological Process for MIR92B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR92B Gene

Transcripts for MIR92B Gene

mRNA/cDNA for MIR92B Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR92B Gene

No ASD Table

Relevant External Links for MIR92B Gene

GeneLoc Exon Structure for
MIR92B
ECgene alternative splicing isoforms for
MIR92B

Expression for MIR92B Gene

mRNA expression in normal human tissues for MIR92B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR92B Gene:

MIR92B
genes like me logo Genes that share expression patterns with MIR92B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR92B Gene

Orthologs for MIR92B Gene

Evolution for MIR92B Gene

ENSEMBL:
Gene Tree for MIR92B (if available)
TreeFam:
Gene Tree for MIR92B (if available)

No data available for Orthologs for MIR92B Gene

Paralogs for MIR92B Gene

No data available for Paralogs for MIR92B Gene

Variants for MIR92B Gene

Sequence variations from dbSNP and Humsavar for MIR92B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1058189 -- 155,195,765(-) GAGGT(C/T)TAAGC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1058195 -- 155,195,730(-) CCCTT(C/T)TCTGG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1058197 -- 155,195,685(-) ACCCC(A/C)CCCTT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs112599564 -- 155,194,714(+) GCGGC(C/G)CCCGA upstream-variant-2KB
rs11465201 -- 155,193,390(-) GAGCC(A/C)AAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR92B Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
nsv1010146 CNV gain 25217958
nsv2988 CNV insertion 18451855
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv527682 CNV gain 19592680
nsv547961 CNV loss 21841781

Relevant External Links for MIR92B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR92B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR92B Gene

Disorders for MIR92B Gene

Relevant External Links for MIR92B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR92B

No disorders were found for MIR92B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR92B Gene

Publications for MIR92B Gene

  1. MicroRNA-92b promotes hepatocellular carcinoma progression by targeting Smad7 and is mediated by long non-coding RNA XIST. (PMID: 27100897) Zhuang L.K. … Qu Z.Q. (Cell Death Dis 2016) 3 64
  2. Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma. (PMID: 27453764) Triozzi P.L. … Singh A.D. (Clin Epigenetics 2016) 3 64
  3. Inhibition of miR-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting RECK. (PMID: 24162673) Lei L. … Gong W. (Mol. Cell. Biochem. 2014) 3 64
  4. miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase. (PMID: 23416699) Wang K. … Wang Y. (Neuro-oncology 2013) 3 64
  5. The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas. (PMID: 23892108) Wu Z.B. … Zhou L.F. (Brain Res. 2013) 3 64

Products for MIR92B Gene

Sources for MIR92B Gene

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