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Aliases for MIR92B Gene

Subcategory (RNA class) for MIR92B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR92B Gene

  • MicroRNA 92b 2 3 5
  • Hsa-Mir-92b 3
  • Mir-92b 3
  • MIRN92B 3

External Ids for MIR92B Gene

ORGUL Members for MIR92B Gene

Previous HGNC Symbols for MIR92B Gene

  • MIRN92B

Previous GeneCards Identifiers for MIR92B Gene

  • GC01U902188
  • GC01P153433
  • GC01P155164

Summaries for MIR92B Gene

Entrez Gene Summary for MIR92B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR92B Gene

MIR92B (MicroRNA 92b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR92B Gene

Genomics for MIR92B Gene

Regulatory Elements for MIR92B Gene

Promoters for MIR92B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR92B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR92B Gene

Chromosome:
1
Start:
155,195,167 bp from pter
End:
155,195,275 bp from pter
Size:
109 bases
Orientation:
Plus strand

Genomic View for MIR92B Gene

Genes around MIR92B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR92B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR92B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR92B Gene

Proteins for MIR92B Gene

Post-translational modifications for MIR92B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR92B Gene

Domains & Families for MIR92B Gene

Gene Families for MIR92B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR92B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR92B Gene

Function for MIR92B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR92B Gene

Localization for MIR92B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR92B Gene

Pathways & Interactions for MIR92B Gene

SuperPathways for MIR92B Gene

No Data Available

Interacting Proteins for MIR92B Gene

Gene Ontology (GO) - Biological Process for MIR92B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR92B Gene

Drugs & Compounds for MIR92B Gene

No Compound Related Data Available

Transcripts for MIR92B Gene

mRNA/cDNA for MIR92B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR92B Gene

No ASD Table

Relevant External Links for MIR92B Gene

GeneLoc Exon Structure for
MIR92B
ECgene alternative splicing isoforms for
MIR92B

Expression for MIR92B Gene

mRNA expression in normal human tissues for MIR92B Gene

genes like me logo Genes that share expression patterns with MIR92B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR92B Gene

Orthologs for MIR92B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR92B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-92b 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-92b 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-92b 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir92b 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-92b 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-92 36
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-92a-1 36
  • 40 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-92b 36
  • 70 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToOne
Species with no ortholog for MIR92B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR92B Gene

ENSEMBL:
Gene Tree for MIR92B (if available)
TreeFam:
Gene Tree for MIR92B (if available)

Paralogs for MIR92B Gene

No data available for Paralogs for MIR92B Gene

Variants for MIR92B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR92B Gene

Variant ID Type Subtype PubMed ID
nsv464084 CNV Loss 19166990
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv470741 CNV Loss 18288195
nsv872457 CNV Loss 21882294
nsv872458 CNV Loss 21882294
dgv390n71 CNV Loss 21882294
nsv527682 CNV Gain 19592680
nsv2988 CNV Insertion 18451855
dgv391n71 CNV Loss 21882294

Relevant External Links for MIR92B Gene

HapMap Linkage Disequilibrium report
MIR92B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR92B Gene

Disorders for MIR92B Gene

Relevant External Links for MIR92B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR92B

No disorders were found for MIR92B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR92B Gene

Publications for MIR92B Gene

  1. Inhibition of miR-92b suppresses nonsmall cell lung cancer cells growth and motility by targeting RECK. (PMID: 24162673) Lei L. … Gong W. (Mol. Cell. Biochem. 2014) 3 67
  2. miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase. (PMID: 23416699) Wang K. … Wang Y. (Neuro-oncology 2013) 3
  3. The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas. (PMID: 23892108) Wu Z.B. … Zhou L.F. (Brain Res. 2013) 3
  4. MiR-92b regulates the cell growth, cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN. (PMID: 24099768) Li Y. … Guo Q. (Biochem. Biophys. Res. Commun. 2013) 3
  5. MiR-92b inhibitor promoted glioma cell apoptosis via targeting DKK3 and blocking the Wnt/beta-catenin signaling pathway. (PMID: 24325785) Li Q. … Ma J. (J Transl Med 2013) 3

Products for MIR92B Gene

Sources for MIR92B Gene

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