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Aliases for MIR922 Gene

Subcategory (RNA class) for MIR922 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR922 Gene

  • MicroRNA 922 2 3
  • RUBCN 4 5
  • RUN And Cysteine Rich Domain Containing Beclin 1 Interacting Protein 5
  • Beclin-1 Associated RUN Domain Containing Protein 4
  • Hsa-Mir-922 3
  • KIAA0226 4
  • MIRN922 3
  • Rubicon 4
  • Baron 4

External Ids for MIR922 Gene

Previous HGNC Symbols for MIR922 Gene

  • MIRN922

Previous GeneCards Identifiers for MIR922 Gene

  • GC03M198888
  • GC03M197401

Summaries for MIR922 Gene

Entrez Gene Summary for MIR922 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR922 Gene

MIR922 (MicroRNA 922) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR922 include Spinocerebellar Ataxia, Autosomal Recessive 15. An important paralog of this gene is RUBCNL.

UniProtKB/Swiss-Prot for MIR922 Gene

  • Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745).

  • Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR922 Gene

Genomics for MIR922 Gene

Regulatory Elements for MIR922 Gene

Enhancers for MIR922 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F197701 0.4 ENCODE 11.7 +47.7 47696 1.6 IRF2 KLF1 ZNF2 ZNF335 ZNF366 FOXK2 SCRT2 KLF7 ZNF600 ZSCAN29 LOC220729 MIR922 FYTTD1 RUBCN PIR54031
GH03F197597 0.2 ENCODE 11.6 +152.1 152090 1.2 SOX13 ELF3 DRAP1 SAP130 TAL1 ARID4B CEBPG RAD21 TEAD3 GATA4 LOC220729 BDH1 MIR922 PIR46687 RPL36P7
GH03F197674 0.2 ENCODE 11 +74.6 74599 1.5 SCRT1 SCRT2 ATF2 FYTTD1 LOC220729 RUBCN MIR922 GC03P197672 GC03P197699
GH03F197781 0.6 ENCODE 10.9 -32.6 -32567 1.1 BCOR SMARCA5 ZMYM3 RELA POLR2A EED IKZF1 ADNP STAT3 ETV6 RUBCN MIR922 FYTTD1 GC03P197788
GH03F197728 0.6 Ensembl 10.8 +21.4 21427 0.6 IKZF1 SIN3A ZBTB33 KDM1A PRDM1 MIR922 LOC220729 FYTTD1 PIR54031
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR922 on UCSC Golden Path with GeneCards custom track

Promoters for MIR922 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001487879 -573 3401 ATF1 PKNOX1 CREB3L1 SIN3A YBX1 ZNF2 YY1 GTF3C2 ZNF121 GLIS2

Genomic Location for MIR922 Gene

Chromosome:
3
Start:
197,671,393 bp from pter
End:
197,749,727 bp from pter
Size:
78,335 bases
Orientation:
Minus strand

Genomic View for MIR922 Gene

Genes around MIR922 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR922 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR922 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR922 Gene

Proteins for MIR922 Gene

  • Protein details for MIR922 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92622-RUBIC_HUMAN
    Recommended name:
    Run domain Beclin-1-interacting and cysteine-rich domain-containing protein
    Protein Accession:
    Q92622
    Secondary Accessions:
    • Q96CK5

    Protein attributes for MIR922 Gene

    Size:
    972 amino acids
    Molecular mass:
    108622 Da
    Quaternary structure:
    • Associates with PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex II (PI3KC3-C2) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with UVRAG; in the complex interacts directly with PI3KC3 and UVRAG (PubMed:19270696, PubMed:21062745). Interacts with Rab7 (RAB7A or RAB7B) (GTP-bound form); Rab7 and UVRAG compete for RUBCN binding; can interact simultaneously with Rab7 and the PI3K complex (PubMed:20943950, PubMed:20974968, PubMed:21062745). Interacts with CYBA and CYBB; indicative for the association with the CYBA:CYBB NADPH oxidase heterodimer. Interacts with NOX4 and probably associates with the CYBA:NOX4 complex (PubMed:22423966). Interacts with YWHAB and CARD9 in a competetive and stimulation-dependent manner; RUBCN exchanges interaction from YWHAB to CARD9 upon stimulation with beta-1,3-glucan (PubMed:22423967).
    • Associates with PI3K (PI3KC3/PI3K-III/class III phosphatidylinositol 3-kinase) complex II (PI3KC3-C2) in which the core composed of the catalytic subunit PIK3C3, the regulatory subunit PIK3R4 and BECN1 is associated with UVRAG; in the complex interacts directly with PI3KC3 and UVRAG (PubMed:19270696, PubMed:21062745). Interacts with Rab7 (RAB7A or RAB7B) (GTP-bound form); Rab7 and UVRAG compete for RUBCN binding; can interact simultaneously with Rab7 and the PI3K complex (PubMed:20943950, PubMed:20974968, PubMed:21062745). Interacts with CYBA and CYBB; indicative for the association with the CYBA:CYBB NADPH oxidase heterodimer. Interacts with NOX4 and probably associates with the CYBA:NOX4 complex (PubMed:22423966). Interacts with YWHAB and CARD9 in a competetive and stimulation-dependent manner; RUBCN exchanges interaction from YWHAB to CARD9 upon stimulation with beta-1,3-glucan (PubMed:22423967).
    SequenceCaution:
    • Sequence=BAA13215.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR922 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR922 Gene

Post-translational modifications for MIR922 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR922 Gene

Domains & Families for MIR922 Gene

Gene Families for MIR922 Gene

Protein Domains for MIR922 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q92622

UniProtKB/Swiss-Prot:

RUBIC_HUMAN :
  • Contains 1 RUN domain.
Domain:
  • Contains 1 RUN domain.
genes like me logo Genes that share domains with MIR922: view

No data available for Suggested Antigen Peptide Sequences for MIR922 Gene

Function for MIR922 Gene

Molecular function for MIR922 Gene

UniProtKB/Swiss-Prot Function:
Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (PubMed:20974968, PubMed:21062745).
UniProtKB/Swiss-Prot Function:
Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines (PubMed:22423966). Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or DDX58/RIG-I-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (PubMed:22423967).

Gene Ontology (GO) - Molecular Function for MIR922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with MIR922: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR922 Gene

Localization for MIR922 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR922 Gene

Late endosome. Lysosome. Early endosome. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endososome and not at all in the Golgi apparatus.

Gene Ontology (GO) - Cellular Components for MIR922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005764 lysosome IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
genes like me logo Genes that share ontologies with MIR922: view

No data available for Subcellular locations from COMPARTMENTS for MIR922 Gene

Pathways & Interactions for MIR922 Gene

SuperPathways for MIR922 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR922 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006909 phagocytosis IEA --
GO:0006914 autophagy IEA --
GO:0010507 negative regulation of autophagy IMP --
GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity IDA --
genes like me logo Genes that share ontologies with MIR922: view

No data available for Pathways by source and SIGNOR curated interactions for MIR922 Gene

Transcripts for MIR922 Gene

mRNA/cDNA for MIR922 Gene

(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR922 Gene

No ASD Table

Relevant External Links for MIR922 Gene

GeneLoc Exon Structure for
MIR922
ECgene alternative splicing isoforms for
MIR922

Expression for MIR922 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR922 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR922 Gene:

MIR922
genes like me logo Genes that share expression patterns with MIR922: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR922 Gene

Orthologs for MIR922 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR922 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-922 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA0226 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA0226 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700021K19Rik 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA0226 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA0226 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA0226 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA0226 35
  • 68 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-280h16.1 35
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG12772 35
  • 30 (a)
OneToOne
Species where no ortholog for MIR922 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR922 Gene

ENSEMBL:
Gene Tree for MIR922 (if available)
TreeFam:
Gene Tree for MIR922 (if available)

Paralogs for MIR922 Gene

Paralogs for MIR922 Gene

genes like me logo Genes that share paralogs with MIR922: view

Variants for MIR922 Gene

Sequence variations from dbSNP and Humsavar for MIR922 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs28562770 Likely benign 197,675,081(+) TAGTC(C/T)GACAG upstream-variant-2KB, reference, synonymous-codon
rs113117018 -- 197,676,123(+) CAAAA(C/T)GCTGT intron-variant, upstream-variant-2KB
rs114207349 -- 197,676,289(+) CCTCT(C/T)GATTC intron-variant, upstream-variant-2KB
rs114222731 -- 197,675,063(+) TCCGC(A/G)GGCTC upstream-variant-2KB, reference, synonymous-codon
rs114272728 -- 197,674,631(+) CTCCA(C/G)AACTG upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR922 Gene

Variant ID Type Subtype PubMed ID
dgv5042n100 CNV gain 25217958
esv2759214 CNV gain+loss 17122850
esv3575646 CNV gain 25503493
esv3599313 CNV gain 21293372
esv3599318 CNV gain 21293372
esv3599319 CNV gain 21293372
nsv1011831 CNV gain 25217958
nsv428433 CNV gain+loss 18775914
nsv508983 CNV insertion 20534489
nsv829831 CNV loss 17160897

Relevant External Links for MIR922 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR922

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR922 Gene

Disorders for MIR922 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR922 Gene - From: GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia, autosomal recessive 15
  • autosomal recessive spinocerebellar ataxia 15
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RUBIC_HUMAN
  • Spinocerebellar ataxia, autosomal recessive, 15 (SCAR15) [MIM:615705]: Spinocerebellar ataxia defines a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR15 patients manifest cerebellar ataxia in early childhood and delayed motor development with delayed walking. Additional features include dysarthria, upper limb involvement, abnormal eye movements, and hyporeflexia. {ECO:0000269 PubMed:20826435}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR922

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR922
genes like me logo Genes that share disorders with MIR922: view

No data available for Genatlas for MIR922 Gene

Publications for MIR922 Gene

  1. MicroRNA-922 promotes tau phosphorylation by downregulating ubiquitin carboxy-terminal hydrolase L1 (UCHL1) expression in the pathogenesis of Alzheimer's disease. (PMID: 24950120) Zhao Z.B. … Chen S.D. (Neuroscience 2014) 3 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. Regulated microRNAs in the CSF of patients with multiple sclerosis: a case-control study. (PMID: 23077021) Haghikia A. … Gold R. (Neurology 2012) 3 64
  4. Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. (PMID: 22423966) Yang C.S. … Jung J.U. (Cell Host Microbe 2012) 4 64
  5. The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. (PMID: 22423967) Yang C.S. … Jung J.U. (Cell Host Microbe 2012) 4 64

Products for MIR922 Gene

Sources for MIR922 Gene

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