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Aliases for MIR9-2 Gene

Subcategory (RNA class) for MIR9-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR9-2 Gene

  • MicroRNA 9-2 2 3
  • Long Intergenic Non-Protein Coding RNA 461 5
  • Hsa-Mir-9-2 3
  • LINC00461 5
  • MiRNA9-2 3
  • Mir-9-2 3
  • MIRN9-2 3

External Ids for MIR9-2 Gene

Previous HGNC Symbols for MIR9-2 Gene

  • MIRN9-2

Previous GeneCards Identifiers for MIR9-2 Gene

  • GC05M088001
  • GC05M087962
  • GC05M087805
  • GC05M088666

Summaries for MIR9-2 Gene

Entrez Gene Summary for MIR9-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR9-2 Gene

MIR9-2 (MicroRNA 9-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR9-2 Gene

Genomics for MIR9-2 Gene

Regulatory Elements for MIR9-2 Gene

Enhancers for MIR9-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F088659 1.6 FANTOM5 Ensembl ENCODE 11.7 +26.8 26835 9.9 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF263 SP3 REST MBD2 CBX8 ZNF610 MIR9-2 LINC00461 ENSG00000250555 LOC105379071 MEF2C GC05P088664 ENSG00000250705
GH05F088140 1.2 Ensembl ENCODE 11.2 +549.1 549141 3.0 PKNOX1 ZNF2 GLIS2 KLF7 ZNF548 ZNF263 SP3 NFYC REST ZNF518A TMEM161B LINC00461 MIR9-2 ENSG00000245864 ENSG00000250555 LOC105379071 LOC105379070 GC05P088219
GH05F087787 0.8 VISTA 11.2 +903.0 902976 1.7 ZNF362 PKNOX1 JUND BCL11A CBX2 POU5F1 LINC00461 MIR9-2 ENSG00000245864 GC05P087735 GC05M087850
GH05F087781 0.7 Ensembl 11.2 +909.7 909674 0.5 CTCF MAX ZNF2 RAD21 ZNF101 RFX5 ZNF143 SMC3 ZNF654 L3MBTL2 ENSG00000245864 LINC00461 MIR9-2 ENSG00000250555 LOC105379071 GC05P087735 GC05M087850
GH05F088145 0.6 Ensembl 10.5 +545.0 545005 0.9 E2F1 JUND SMARCA4 SUZ12 RNF2 CBX2 MNT EZH2 MIR9-2 LINC00461 ENSG00000245864 LOC105379070 GC05P088219
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR9-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR9-2 Gene

Chromosome:
5
Start:
88,507,546 bp from pter
End:
88,691,041 bp from pter
Size:
183,496 bases
Orientation:
Minus strand

Genomic View for MIR9-2 Gene

Genes around MIR9-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR9-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR9-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR9-2 Gene

Proteins for MIR9-2 Gene

Post-translational modifications for MIR9-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR9-2 Gene

Domains & Families for MIR9-2 Gene

Gene Families for MIR9-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR9-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR9-2 Gene

Function for MIR9-2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR9-2 Gene

Localization for MIR9-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR9-2 Gene

Pathways & Interactions for MIR9-2 Gene

genes like me logo Genes that share pathways with MIR9-2: view

Pathways by source for MIR9-2 Gene

1 BioSystems pathway for MIR9-2 Gene
1 KEGG pathway for MIR9-2 Gene

Interacting Proteins for MIR9-2 Gene

Gene Ontology (GO) - Biological Process for MIR9-2 Gene

None

No data available for SIGNOR curated interactions for MIR9-2 Gene

Transcripts for MIR9-2 Gene

mRNA/cDNA for MIR9-2 Gene

(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR9-2 Gene

No ASD Table

Relevant External Links for MIR9-2 Gene

GeneLoc Exon Structure for
MIR9-2
ECgene alternative splicing isoforms for
MIR9-2

Expression for MIR9-2 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR9-2 Gene

Orthologs for MIR9-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR9-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-9-2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir9-2 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-9-2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-9-2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-9-2 35
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-9a-2 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-9-2 35
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-9-1 35
  • 58 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-9-5 35
  • 92 (a)
OneToMany
dre-mir-9-2 35
  • 56 (a)
OneToMany
Species where no ortholog for MIR9-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR9-2 Gene

ENSEMBL:
Gene Tree for MIR9-2 (if available)
TreeFam:
Gene Tree for MIR9-2 (if available)

Paralogs for MIR9-2 Gene

No data available for Paralogs for MIR9-2 Gene

Variants for MIR9-2 Gene

Sequence variations from dbSNP and Humsavar for MIR9-2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs111952236 -- 88,666,743(+) TAAGG(-/A)AAAAA intron-variant, nc-transcript-variant, downstream-variant-500B
rs113794889 -- 88,668,258(+) GGACT(G/T)CATCG intron-variant, upstream-variant-2KB
rs116208545 -- 88,668,460(+) AAAAA(A/C)CGTTG intron-variant, upstream-variant-2KB
rs116419961 -- 88,668,558(+) TCTAT(A/C)TAGAG intron-variant, upstream-variant-2KB
rs13162910 -- 88,668,596(+) CCTCA(C/T)TCCTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR9-2 Gene

Variant ID Type Subtype PubMed ID
nsv524630 CNV loss 19592680

Relevant External Links for MIR9-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR9-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR9-2 Gene

Disorders for MIR9-2 Gene

Relevant External Links for MIR9-2

Genetic Association Database (GAD)
MIR9-2
Human Genome Epidemiology (HuGE) Navigator
MIR9-2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR9-2

No disorders were found for MIR9-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR9-2 Gene

Publications for MIR9-2 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell. (PMID: 25809226) Zhang J. … Lu F. (Mol. Carcinog. 2016) 3 64
  3. Association of Decreased Expression of Serum miR-9 with Poor Prognosis of Oral Squamous Cell Carcinoma Patients. (PMID: 26813876) Sun L. … Shi Y. (Med. Sci. Monit. 2016) 3 64
  4. MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1. (PMID: 26898797) Jeyabal P. … Krishnamurthy P. (Biochem. Biophys. Res. Commun. 2016) 3 64
  5. miR-9 enhances the transactivation of nuclear factor of activated T cells by targeting KPNB1 and DYRK1B. (PMID: 25696812) Zeng Y. … Gou D. (Am. J. Physiol., Cell Physiol. 2015) 3 64

Products for MIR9-2 Gene

Sources for MIR9-2 Gene

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