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Aliases for MIR9-1 Gene

Subcategory (RNA class) for MIR9-1 Gene

miRNA

Quality Score for this RNA gene is

10

Aliases for MIR9-1 Gene

  • MicroRNA 9-1 2 3 5
  • Hsa-Mir-9-1 3
  • MiRNA9-1 3
  • Mir-9-1 3
  • MIRN9-1 3

External Ids for MIR9-1 Gene

Previous HGNC Symbols for MIR9-1 Gene

  • MIRN9-1

Previous GeneCards Identifiers for MIR9-1 Gene

  • GC01M154657
  • GC01M156390

Summaries for MIR9-1 Gene

Entrez Gene Summary for MIR9-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR9-1 Gene

MIR9-1 (MicroRNA 9-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR9-1 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR9-1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR9-1 Gene

Genomics for MIR9-1 Gene

Regulatory Elements for MIR9-1 Gene

Enhancers for MIR9-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156445 0.5 Ensembl ENCODE 12.3 -25.5 -25521 0.3 ELF3 WRNIP1 KLF17 ARID4B SIN3A ZNF48 RAD21 RFX5 ELK1 ZNF143 MIR9-1 CCT3 RHBG TSACC NAXE PAQR6 BCAN C1orf61 ENSG00000236947
GH01F156453 0.5 Ensembl 12 -33.0 -32972 0.4 ZBTB48 CEBPB FOS MIR9-1 HAPLN2 RHBG CCT3 BCAN NAXE TSACC ENSG00000236947 C1orf61
GH01F156450 0.2 ENCODE 12 -31.4 -31422 1.7 ATF1 CREB3L1 SIN3A GLIS2 ZNF548 KDM4B ZNF263 SP3 YY2 NFYC KIAA0907 RRNAD1 MSTO2P LOC246784 MIR9-1 ENSG00000271267 HAPLN2 CCT3 RHBG BCAN
GH01F156456 1.2 FANTOM5 ENCODE 11.6 -36.9 -36948 2.7 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 KIAA0907 RRNAD1 ENSG00000271267 LOC246784 SSR2 ENSG00000229961 DAP3P1 TSACC ARHGEF2 C1orf61
GH01F156460 0.6 Ensembl ENCODE 11.6 -41.3 -41334 1.7 SOX13 ATF1 PKNOX1 CBX3 ESRRA TBL1XR1 ZNF133 CHAMP1 POLR2A ZBTB48 C1orf61 MIR9-1 GPATCH4 NAXE HAPLN2 HDGF MRPL24 GC01M156440 ENSG00000206651 GC01M156484
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR9-1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR9-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001525032 -1271 201 TBP ATF1 ZNF76 KLF17 ZNF2 ZNF121 GLIS2 ZNF366 ZNF391 CREM

Genomic Location for MIR9-1 Gene

Chromosome:
1
Start:
156,420,341 bp from pter
End:
156,420,429 bp from pter
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR9-1 Gene

Genes around MIR9-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR9-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR9-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR9-1 Gene

ORGUL Member Location for MIR9-1 Gene

ORGUL Member Location for MIR9-1 gene

Proteins for MIR9-1 Gene

Post-translational modifications for MIR9-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR9-1 Gene

Domains & Families for MIR9-1 Gene

Gene Families for MIR9-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR9-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR9-1 Gene

Function for MIR9-1 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR9-1 Gene

Localization for MIR9-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR9-1 Gene

Pathways & Interactions for MIR9-1 Gene

genes like me logo Genes that share pathways with MIR9-1: view

Pathways by source for MIR9-1 Gene

1 BioSystems pathway for MIR9-1 Gene
1 KEGG pathway for MIR9-1 Gene

Interacting Proteins for MIR9-1 Gene

Gene Ontology (GO) - Biological Process for MIR9-1 Gene

None

No data available for SIGNOR curated interactions for MIR9-1 Gene

Transcripts for MIR9-1 Gene

fRNAdb Secondary structures for MIR9-1 Gene

  • hsa-mir-9-1_MI0000466_Homo_sapiens_miR-9-1_stem-loop_hairpin

mRNA/cDNA for MIR9-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR9-1 Gene

No ASD Table

Relevant External Links for MIR9-1 Gene

GeneLoc Exon Structure for
MIR9-1
ECgene alternative splicing isoforms for
MIR9-1

Expression for MIR9-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR9-1 Gene

genes like me logo Genes that share expression patterns with MIR9-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR9-1 Gene

Orthologs for MIR9-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR9-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia -- 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-9-1 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm25641 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-9-1 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-9a-3 35
  • 65 (a)
ManyToMany
mdo-mir-9b 35
  • 50 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-9-1 35
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-9-2 35
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-9-1 35
  • 68 (a)
ManyToMany
dre-mir-9-4 35
  • 64 (a)
ManyToMany
Species where no ortholog for MIR9-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR9-1 Gene

ENSEMBL:
Gene Tree for MIR9-1 (if available)
TreeFam:
Gene Tree for MIR9-1 (if available)

Paralogs for MIR9-1 Gene

No data available for Paralogs for MIR9-1 Gene

Variants for MIR9-1 Gene

Sequence variations from dbSNP and Humsavar for MIR9-1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs112276358 -- 156,421,337(+) CGGCT(C/T)TGTTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs112487499 -- 156,420,772(+) GGTCC(C/G/T)AGGTG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs113486968 -- 156,421,966(+) TACTA(A/C/G)GTCTC intron-variant, upstream-variant-2KB
rs116416891 -- 156,420,695(+) ACCCC(C/G)ATCCA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs12123291 -- 156,421,461(+) AGGGT(C/G)GGGGC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Relevant External Links for MIR9-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR9-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR9-1 Gene

Disorders for MIR9-1 Gene

Relevant External Links for MIR9-1

Genetic Association Database (GAD)
MIR9-1
Human Genome Epidemiology (HuGE) Navigator
MIR9-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR9-1

No disorders were found for MIR9-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR9-1 Gene

Publications for MIR9-1 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  3. Down-regulation of microRNA-9 leads to activation of IL-6/Jak/STAT3 pathway through directly targeting IL-6 in HeLa cell. (PMID: 25809226) Zhang J. … Lu F. (Mol. Carcinog. 2016) 3 64
  4. Aberrant expression of miR-9/9* in myeloid progenitors inhibits neutrophil differentiation by post-transcriptional regulation of ERG. (PMID: 26174629) Nowek K. … Jongen-Lavrencic M. (Leukemia 2016) 3 64
  5. Expression and DNA methylation alterations of seven cancer-associated 3p genes and their predicted regulator miRNAs (miR-129-2, miR-9-1) in breast and ovarian cancers. (PMID: 26519551) Pronina I.V. … Braga E.A. (Gene 2016) 3 64

Products for MIR9-1 Gene

Sources for MIR9-1 Gene

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