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Aliases for MIR889 Gene

Subcategory (RNA class) for MIR889 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR889 Gene

  • MicroRNA 889 2 3 5
  • Hsa-Mir-889 3
  • Mir-889 3
  • MIRN889 3

External Ids for MIR889 Gene

Previous HGNC Symbols for MIR889 Gene

  • MIRN889

Previous GeneCards Identifiers for MIR889 Gene

  • GC14P100827
  • GC14P100917
  • GC14P101518
  • GC14P101547
  • GC14P101581
  • GC14P101621
  • GC14P101649
  • GC14P101682
  • GC14P101720
  • GC14P101762
  • GC14P101820
  • GC14P101960
  • GC14P102157
  • GC14P101259
  • GC14P101870
  • GC14P102189
  • GC14P102358
  • GC14P102528

Summaries for MIR889 Gene

Entrez Gene Summary for MIR889 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR889 Gene

MIR889 (MicroRNA 889) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR889 Gene

Genomics for MIR889 Gene

Regulatory Elements for MIR889 Gene

Enhancers for MIR889 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G101096 1.1 FANTOM5 ENCODE 10.7 +50.4 50447 3.2 CTCF SUZ12 JUN ZIC2 RAD21 ZNF335 GLIS2 ZNF366 GATA2 POLR2A RTL1 LOC105370670 MEG9 MIR412 MIR410 MIR409 MIR656 MIR541 MIR369 MIR154
GH14G101215 1 ENCODE 9.9 +168.8 168824 2.8 HDGF FOXA2 ARID4B ZNF48 TCF12 GATA2 CAVIN1 ZNF592 SSRP1 ZNF658 DYNC1H1 YY1 SNORD113-3 SNORD113-6 SNORD113-7 SNORD113-4 SNORD113-8 SNORD113-9 MIR543 ENSG00000272444
GH14G101287 1 ENCODE 9.4 +241.0 241020 2.5 FOXA2 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 SP5 ZHX2 NFYC MEG3 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR655 MIR1185-1 MIR300
GH14G101004 0.8 Ensembl ENCODE 10.9 -42.8 -42817 1.9 GATA3 MNT MYC ZIC2 TCF7L2 MIR487A MIR134 MIR323B MIR154 MIR485 MIR496 MIR377 MIR376C MIR654 MIR300
GH14G101330 0.9 ENCODE 8.9 +283.0 282954 0.3 ELF3 FOXA2 MLX ARID4B RAD21 THRB ZNF48 ZSCAN9 RARA CREM MIR1185-1 MIR1185-2 MIR300 MIR381 MIR487B MIR539 MIR544A MIR655 MIR889 MIR376C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR889 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR889 Gene

Chromosome:
14
Start:
101,047,901 bp from pter
End:
101,047,979 bp from pter
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR889 Gene

Genes around MIR889 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR889 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR889 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR889 Gene

Proteins for MIR889 Gene

Post-translational modifications for MIR889 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR889 Gene

Domains & Families for MIR889 Gene

Gene Families for MIR889 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR889: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR889 Gene

Function for MIR889 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR889 Gene

Localization for MIR889 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR889 Gene

Pathways & Interactions for MIR889 Gene

SuperPathways for MIR889 Gene

No Data Available

Interacting Proteins for MIR889 Gene

Gene Ontology (GO) - Biological Process for MIR889 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR889 Gene

Drugs & Compounds for MIR889 Gene

No Compound Related Data Available

Transcripts for MIR889 Gene

mRNA/cDNA for MIR889 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR889 Gene

No ASD Table

Relevant External Links for MIR889 Gene

GeneLoc Exon Structure for
MIR889
ECgene alternative splicing isoforms for
MIR889

Expression for MIR889 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR889 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR889 Gene:

MIR889
genes like me logo Genes that share expression patterns with MIR889: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR889 Gene

Orthologs for MIR889 Gene

Evolution for MIR889 Gene

ENSEMBL:
Gene Tree for MIR889 (if available)
TreeFam:
Gene Tree for MIR889 (if available)

No data available for Orthologs for MIR889 Gene

Paralogs for MIR889 Gene

No data available for Paralogs for MIR889 Gene

Variants for MIR889 Gene

Sequence variations from dbSNP and Humsavar for MIR889 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000942364 -- 101,046,276(+) GTGGC(A/G)CTCGT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001499669 -- 101,048,356(+) GTATG(A/G)AACAC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002444581 -- 101,046,676(+) GTCCA(C/T)TTCTT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1005375970 -- 101,048,031(+) GGGGA(C/T)ATTGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1006688709 -- 101,047,488(+) CCTGG(C/G)TGGGG intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR889 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR889 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR889

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR889 Gene

Disorders for MIR889 Gene

Relevant External Links for MIR889

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR889

No disorders were found for MIR889 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR889 Gene

Publications for MIR889 Gene

  1. miR-889 promotes proliferation of esophageal squamous cell carcinomas through DAB2IP. (PMID: 25841337) Xu Y. … Sun F. (FEBS Lett. 2015) 3 64
  2. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR889 Gene

Sources for MIR889 Gene

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