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Aliases for MIR877 Gene

Subcategory (RNA class) for MIR877 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR877 Gene

  • MicroRNA 877 2 3 5
  • Hsa-Mir-877 3
  • MiRNA877 3
  • Mir-877 3
  • MIRN877 3

External Ids for MIR877 Gene

Previous HGNC Symbols for MIR877 Gene

  • MIRN877

Previous GeneCards Identifiers for MIR877 Gene

  • GC06P030662
  • GC06P030663
  • GC06P030552
  • GC06P030354

Summaries for MIR877 Gene

Entrez Gene Summary for MIR877 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR877 Gene

MIR877 (MicroRNA 877) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR877 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR877 Gene

Genomics for MIR877 Gene

GeneHancer (GH) Regulatory Elements for MIR877 Gene

Promoters and enhancers for MIR877 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I030611 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12.8 +31.2 31220 8.7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP1R10 MRPS18B DDX39B MDC1 TRIM39 ABCF1 NRM DHX16 ZNRD1 TRIM26
GH06I030541 Enhancer 1.4 Ensembl ENCODE dbSUPER 12 -41.4 -41431 3.7 PKNOX1 ATF1 ARID4B SIN3A ZNF2 IRF4 ZNF48 YY1 TCF12 ZNF213 ABCF1 PPP1R10 TRIM39 DHX16 MDC1 ZNRD1 DDX39B PAIP1P1 TRIM26 LINC02569
GH06I030496 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.7 -87.5 -87485 1.7 HDGF ATF1 PKNOX1 SMAD1 ARNT YBX1 ZNF280A TCF12 GATA2 ARID2 ABCF1 DHX16 PRR3 GNL1 MIR877 CCHCR1 VARS2 HLA-E LINC02569
GH06I030493 Enhancer 0.9 ENCODE dbSUPER 11.7 -90.2 -90187 1.5 CTCF BACH1 BMI1 POLR2A NFATC1 ZNF143 NFE2 BCLAF1 IKZF2 RUNX3 ABCF1 PRR3 GNL1 MIR877 DHX16 HLA-E LINC02569
GH06I030500 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.7 -83.5 -83531 0.8 MITF ELF3 ZFP36 PRDM1 TEAD3 GNL1 PRR3 ABCF1 MIR877 RPP21 HLA-E LINC02569
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR877 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR877 Gene

Genomic Locations for MIR877 Gene
chr6:30,584,332-30,584,417
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr6:30,552,109-30,552,194
(GRCh37/hg19)

Genomic View for MIR877 Gene

Genes around MIR877 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR877 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR877 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MIR877 Gene

Post-translational modifications for MIR877 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR877 Gene

Domains & Families for MIR877 Gene

Gene Families for MIR877 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR877: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR877 Gene

Function for MIR877 Gene

Phenotypes From GWAS Catalog for MIR877 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR877 Gene

Localization for MIR877 Gene

Gene Ontology (GO) - Cellular Components for MIR877 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR877: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR877 Gene

Pathways & Interactions for MIR877 Gene

SuperPathways for MIR877 Gene

No Data Available

Interacting Proteins for MIR877 Gene

Gene Ontology (GO) - Biological Process for MIR877 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR877 Gene

Drugs & Compounds for MIR877 Gene

No Compound Related Data Available

Transcripts for MIR877 Gene

mRNA/cDNA for MIR877 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR877 Gene

No ASD Table

Relevant External Links for MIR877 Gene

GeneLoc Exon Structure for
MIR877
ECgene alternative splicing isoforms for
MIR877

Expression for MIR877 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR877 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR877 Gene:

MIR877
genes like me logo Genes that share expression patterns with MIR877: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR877 Gene

Orthologs for MIR877 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR877 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir877 34
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-877 34
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
OneToOne
Species where no ortholog for MIR877 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR877 Gene

ENSEMBL:
Gene Tree for MIR877 (if available)
TreeFam:
Gene Tree for MIR877 (if available)

Paralogs for MIR877 Gene

No data available for Paralogs for MIR877 Gene

Variants for MIR877 Gene

Sequence variations from dbSNP and Humsavar for MIR877 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001537737 -- 30,584,785(+) C/T downstream_transcript_variant
rs1001902395 -- 30,583,498(+) C/T upstream_transcript_variant
rs1002552192 -- 30,583,579(+) C/T upstream_transcript_variant
rs1004867243 -- 30,584,404(+) C/T non_coding_transcript_variant
rs1005108154 -- 30,584,751(+) A/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR877 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5244 CNV deletion 18451855
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781

Additional Variant Information for MIR877 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR877

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR877 Gene

Disorders for MIR877 Gene

Additional Disease Information for MIR877

No disorders were found for MIR877 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR877 Gene

Publications for MIR877 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  2. MiR-100-3p and miR-877-3p regulate overproduction of IL-8 and IL-1β in mesangial cells activated by secretory IgA from IgA nephropathy patients. (PMID: 27542871) Liang Y … Liu Z (Experimental cell research 2016) 3 58
  3. Up-regulation of miR-877 induced by paclitaxel inhibits hepatocellular carcinoma cell proliferation though targeting FOXM1. (PMID: 25973036) Huang X … Lu S (International journal of clinical and experimental pathology 2015) 3 58
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58

Products for MIR877 Gene

Sources for MIR877 Gene

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