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Aliases for MIR876 Gene

Subcategory (RNA class) for MIR876 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR876 Gene

  • MicroRNA 876 2 3 5
  • Hsa-Mir-876 3
  • Mir-876 3
  • MIRN876 3

External Ids for MIR876 Gene

Previous HGNC Symbols for MIR876 Gene

  • MIRN876

Summaries for MIR876 Gene

Entrez Gene Summary for MIR876 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR876 Gene

MIR876 (MicroRNA 876) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR876 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR876

Additional gene information for MIR876 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR876 Gene

Genomics for MIR876 Gene

GeneHancer (GH) Regulatory Elements for MIR876 Gene

Promoters and enhancers for MIR876 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I028778 Enhancer 0.6 ENCODE 0.2 +84.2 84247 1.2 JUND ATF3 JUN CEBPA CEBPB RCOR1 EP300 TCF7L2 MIR876 GC09P028634 LINGO2
GH09I028810 Enhancer 0.5 ENCODE 0.2 +52.9 52885 0.4 JUND JUN EP300 PRDM1 MIR876 GC09P028634 LINGO2
GH09I028820 Enhancer 0.3 ENCODE 0.3 +42.5 42460 1.9 CTCF MIR876 GC09P028634 LINGO2
GH09I028670 Promoter 0.5 EPDnew 0.1 +193.4 193406 0.1 LINGO2 GC09P028634 MIR876
GH09I028768 Enhancer 0.2 FANTOM5 0.2 +95.5 95523 0.4 MIR876 GC09P028634 LINGO2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR876 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR876 Gene

Genomic Locations for MIR876 Gene
chr9:28,863,626-28,863,706
(GRCh38/hg38)
Size:
81 bases
Orientation:
Minus strand
chr9:28,863,624-28,863,704
(GRCh37/hg19)

Genomic View for MIR876 Gene

Genes around MIR876 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR876 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR876 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR876 Gene

ORGUL Member Location for MIR876 Gene

ORGUL Member Location for MIR876 gene

Proteins for MIR876 Gene

Post-translational modifications for MIR876 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR876 Gene

Domains & Families for MIR876 Gene

Gene Families for MIR876 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR876: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR876 Gene

Function for MIR876 Gene

Gene Ontology (GO) - Molecular Function for MIR876 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20829195
genes like me logo Genes that share ontologies with MIR876: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR876 Gene

Localization for MIR876 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR876 Gene

Pathways & Interactions for MIR876 Gene

SuperPathways for MIR876 Gene

No Data Available

Interacting Proteins for MIR876 Gene

Gene Ontology (GO) - Biological Process for MIR876 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20829195
genes like me logo Genes that share ontologies with MIR876: view

No data available for Pathways by source and SIGNOR curated interactions for MIR876 Gene

Drugs & Compounds for MIR876 Gene

No Compound Related Data Available

Transcripts for MIR876 Gene

fRNAdb Secondary structures for MIR876 Gene

  • hsa-mir-876_MI0005542_Homo_sapiens_miR-876_stem-loop_hairpin

mRNA/cDNA for MIR876 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR876 Gene

No ASD Table

Relevant External Links for MIR876 Gene

GeneLoc Exon Structure for
MIR876
ECgene alternative splicing isoforms for
MIR876

Expression for MIR876 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR876 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR876 Gene:

MIR876
genes like me logo Genes that share expression patterns with MIR876: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR876 Gene

Orthologs for MIR876 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR876 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-876 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-876 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-876 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir876 34
  • 89 (a)
OneToOne
Species where no ortholog for MIR876 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR876 Gene

ENSEMBL:
Gene Tree for MIR876 (if available)
TreeFam:
Gene Tree for MIR876 (if available)

Paralogs for MIR876 Gene

No data available for Paralogs for MIR876 Gene

Variants for MIR876 Gene

Sequence variations from dbSNP and Humsavar for MIR876 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001936281 -- 28,864,220(-) A/G upstream_transcript_variant
rs1002535678 -- 28,865,561(-) T/A upstream_transcript_variant
rs1004006574 -- 28,864,527(-) A/C upstream_transcript_variant
rs1005681044 -- 28,865,643(-) G/C upstream_transcript_variant
rs1010191406 -- 28,864,944(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR876 Gene

Variant ID Type Subtype PubMed ID
dgv12628n54 CNV loss 21841781
dgv7498n100 CNV loss 25217958
nsv1020624 CNV loss 25217958
nsv471296 CNV loss 18288195

Additional Variant Information for MIR876 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR876

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR876 Gene

Disorders for MIR876 Gene

Additional Disease Information for MIR876

No disorders were found for MIR876 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR876 Gene

Publications for MIR876 Gene

  1. Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections. (PMID: 27052555) Wang RY … Chen CJ (Scientific reports 2016) 3 58
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  3. A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax). (PMID: 20829195) Lam LT … Semizarov D (Molecular cancer therapeutics 2010) 3 58
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR876 Gene

Sources for MIR876 Gene

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