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Aliases for MIR876 Gene

Subcategory (RNA class) for MIR876 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR876 Gene

  • MicroRNA 876 2 3 5
  • Hsa-Mir-876 3
  • Mir-876 3
  • MIRN876 3

External Ids for MIR876 Gene

Previous HGNC Symbols for MIR876 Gene

  • MIRN876

Summaries for MIR876 Gene

Entrez Gene Summary for MIR876 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR876 Gene

MIR876 (MicroRNA 876) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR876 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR876

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR876 Gene

Genomics for MIR876 Gene

Regulatory Elements for MIR876 Gene

Enhancers for MIR876 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G028820 0.5 ENCODE 0.3 +42.5 42461 1.9 CTCF RAD21 EP300 MIR876 GC09P028634
GH09G028778 0.6 ENCODE 0.2 +84.2 84247 1.2 JUND ATF3 CEBPA JUN CEBPB EP300 TCF7L2 MIR876 GC09P028634
GH09G028810 0.5 ENCODE 0.2 +52.9 52885 0.4 JUND JUN EP300 PRDM1 MIR876 GC09P028634
GH09G028688 0.4 ENCODE 0.1 +175.3 175329 0.0 CHD7 EZH2 GC09P028634 MIR876
GH09G028768 0.3 FANTOM5 0.1 +95.5 95523 0.4 MIR876 GC09P028634
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR876 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR876 Gene

Chromosome:
9
Start:
28,863,626 bp from pter
End:
28,863,706 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR876 Gene

Genes around MIR876 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR876 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR876 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR876 Gene

ORGUL Member Location for MIR876 Gene

ORGUL Member Location for MIR876 gene

Proteins for MIR876 Gene

Post-translational modifications for MIR876 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR876 Gene

Domains & Families for MIR876 Gene

Gene Families for MIR876 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR876: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR876 Gene

Function for MIR876 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR876 Gene

Localization for MIR876 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR876 Gene

Pathways & Interactions for MIR876 Gene

SuperPathways for MIR876 Gene

No Data Available

Interacting Proteins for MIR876 Gene

Gene Ontology (GO) - Biological Process for MIR876 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR876 Gene

Transcripts for MIR876 Gene

fRNAdb Secondary structures for MIR876 Gene

  • hsa-mir-876_MI0005542_Homo_sapiens_miR-876_stem-loop_hairpin

mRNA/cDNA for MIR876 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR876 Gene

No ASD Table

Relevant External Links for MIR876 Gene

GeneLoc Exon Structure for
MIR876
ECgene alternative splicing isoforms for
MIR876

Expression for MIR876 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR876 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR876 Gene:

MIR876
genes like me logo Genes that share expression patterns with MIR876: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR876 Gene

Orthologs for MIR876 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR876 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-876 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-876 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-876 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir876 35
  • 89 (a)
OneToOne
Species where no ortholog for MIR876 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR876 Gene

ENSEMBL:
Gene Tree for MIR876 (if available)
TreeFam:
Gene Tree for MIR876 (if available)

Paralogs for MIR876 Gene

No data available for Paralogs for MIR876 Gene

Variants for MIR876 Gene

Sequence variations from dbSNP and Humsavar for MIR876 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001936281 -- 28,864,220(+) CTTGT(A/G)CCCCT intron-variant, upstream-variant-2KB
rs1002535678 -- 28,865,561(+) GAGGA(A/T)CATGA intron-variant, upstream-variant-2KB
rs1004006574 -- 28,864,527(+) CTATA(A/C)ATCTT intron-variant, upstream-variant-2KB
rs1005681044 -- 28,865,643(+) GCCGG(C/G)CATAG intron-variant, upstream-variant-2KB
rs1010191406 -- 28,864,944(+) AATAG(A/G)TGTTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR876 Gene

Variant ID Type Subtype PubMed ID
dgv12628n54 CNV loss 21841781
dgv7498n100 CNV loss 25217958
nsv1020624 CNV loss 25217958
nsv471296 CNV loss 18288195

Relevant External Links for MIR876 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR876

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR876 Gene

Disorders for MIR876 Gene

Relevant External Links for MIR876

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR876

No disorders were found for MIR876 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR876 Gene

Publications for MIR876 Gene

  1. Elevated expression of circulating miR876-5p is a specific response to severe EV71 infections. (PMID: 27052555) Wang R.Y. … Chen C.J. (Sci Rep 2016) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  5. Identification and classification of conserved RNA secondary structures in the human genome. (PMID: 16628248) Pedersen J.S. … Haussler D. (PLoS Comput. Biol. 2006) 1

Products for MIR876 Gene

Sources for MIR876 Gene

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