Aliases for MIR875 Gene
Subcategory (RNA class) for MIR875 Gene
Quality Score for this RNA gene is
External Ids for MIR875 Gene
- HGNC: 33652
- Entrez Gene: 100126309
- Ensembl: ENSG00000216069
- miRBase: hsa-mir-875
ORGUL Members for MIR875 Gene
Previous HGNC Symbols for MIR875 Gene
- MIRN875
Previous GeneCards Identifiers for MIR875 Gene
- GC08M100622
- GC08M100549
Summaries for MIR875 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR875 Gene
MIR875 (MicroRNA 875) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR875 Gene
- Monarch Initiative
- Search for MIR875 at DataMed
- Search for MIR875 at HumanCyc
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR875 Gene
Genomics for MIR875 Gene
GeneHancer (GH) Regulatory Elements for MIR875 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH08I099636 | Enhancer | 0.6 | ENCODE | 10.1 | -97.5 | -97517 | 0.2 | OVOL3 FEZF1 ZIC2 ZNF843 OSR2 PRDM6 GATA3 TCF7 ZNF24 PRDM4 | MIR599 MIR875 RN7SL350P LETM1P3 VPS13B | |
GH08I099634 | Enhancer | 0.5 | ENCODE | 10.1 | -97.3 | -97297 | 0.2 | OSR2 GATA3 PRDM6 TCF7 ZNF24 ZNF843 ZNF18 | MIR599 MIR875 RN7SL350P LETM1P3 VPS13B | |
GH08I099605 | Enhancer | 0.4 | Ensembl ENCODE | 10.6 | -69.8 | -69785 | 1.7 | MIR875 MIR599 GC08M099603 VPS13B | ||
GH08I099577 | Enhancer | 0.2 | ENCODE | 11 | -41.0 | -41019 | 1.2 | MIR599 MIR875 GC08M099603 VPS13B | ||
GH08I099547 | Enhancer | 0.8 | Ensembl ENCODE | 0.4 | -10.7 | -10664 | 0.9 | TCF12 PRDM6 FOXA2 NCOR1 TAL1 CBFA2T3 CBFA2T2 MAFK FOXA1 | VPS13B MIR875 GC08M099603 |
Regulatory Element Products
Genomic Locations for MIR875 Gene
- chr8:99,536,786-99,536,861
- (GRCh38/hg38)
- Size:
- 76 bases
- Orientation:
- Minus strand
- chr8:100,549,014-100,549,089
- (GRCh37/hg19)
Genomic View for MIR875 Gene
- Cytogenetic band:
-
- 8q22.2 by Ensembl
- 8q22.2 by Entrez Gene
- 8q22.2 by HGNC


RefSeq DNA sequence for MIR875 Gene
Proteins for MIR875 Gene
Post-translational modifications for MIR875 Gene
Antibody Products
- Search GeneTex for Antibodies for MIR875
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR875
- Origene Custom Protein Services for MIR875
- Search GeneTex for Proteins for MIR875
No data available for DME Specific Peptides for MIR875 Gene
Domains & Families for MIR875 Gene
Gene Families for MIR875 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR875 Gene
Function for MIR875 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
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CRISPR Products
- Browse CRISPR knockouts for MIR875
- Applied Biological Materials CRISPR for MIR875
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR875
Clone Products
- GenScript: Custom all cDNA clones Services for MIR875
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR875
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR875 Gene
Localization for MIR875 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR875 Gene
Transcripts for MIR875 Gene
mRNA/cDNA for MIR875 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR875
- Applied Biological Materials CRISPR for MIR875
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR875
Clone Products
- GenScript: Custom all cDNA clones Services for MIR875
- VectorBuilder custom plasmid, inducible vectors for MIR875
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR875
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR875
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR875 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR875 Gene:
MIR875Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR875 Gene
Orthologs for MIR875 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-875 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | cfa-mir-875 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | bta-mir-875 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-875 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-875 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mir875 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | aca-mir-875 34 |
|
OneToOne |
- Species where no ortholog for MIR875 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR875 Gene
No data available for Paralogs for MIR875 Gene
Variants for MIR875 Gene
SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000222810 | -- | 99,538,584(-) | G/A | upstream_transcript_variant | |
rs1000509333 | -- | 99,536,543(-) | G/A | downstream_transcript_variant | |
rs1000558271 | -- | 99,536,812(-) | T/A | non_coding_transcript_variant | |
rs1000972532 | -- | 99,537,253(-) | G/A | upstream_transcript_variant | |
rs1001632963 | -- | 99,537,710(-) | G/A | upstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759633 | CNV | loss | 17122850 |
nsv1020614 | CNV | loss | 25217958 |
nsv524617 | CNV | loss | 19592680 |
nsv831408 | CNV | loss | 17160897 |
Additional Variant Information for MIR875 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR875
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR875 Gene
Disorders for MIR875 Gene
Additional Disease Information for MIR875
No disorders were found for MIR875 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR875 Gene
Publications for MIR875 Gene
- miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis. (PMID: 28274892) El Bezawy R … Gandellini P (Cancer letters 2017) 3 58
- Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes. (PMID: 25913515) Lin L … Li Y (Protein & cell 2015) 3 58
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
- The miR-875-5p inhibits SATB2 to promote the invasion of lung cancer cells. (PMID: 29196257) Wang J … Ma C (Gene 2018) 3
Products for MIR875 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR875
- VectorBuilder custom plasmid, inducible vectors for MIR875
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR875
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR875
- Search GeneTex for Proteins for MIR875
Sources for MIR875 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew