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MIR875 Gene(RNA Gene)

MicroRNA 875

GCID:
GC08M099538
GIFtS:
14
Genes Participants
UDN Logo

Aliases for MIR875 Gene

Subcategory (RNA class) for MIR875 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR875 Gene

  • MicroRNA 875 2 3 5
  • Hsa-Mir-875 3
  • MIRN875 3

External Ids for MIR875 Gene

ORGUL Members for MIR875 Gene

Previous HGNC Symbols for MIR875 Gene

  • MIRN875

Previous GeneCards Identifiers for MIR875 Gene

  • GC08M100622
  • GC08M100549

Summaries for MIR875 Gene

Entrez Gene Summary for MIR875 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR875 Gene

MIR875 (MicroRNA 875) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR875 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR875 Gene

Genomics for MIR875 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR875 Gene

Promoters and enhancers for MIR875 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08I099636 Enhancer 0.6 ENCODE 10.1 -97.5 -97517 0.2 OVOL3 FEZF1 ZIC2 ZNF843 OSR2 PRDM6 GATA3 TCF7 ZNF24 PRDM4 MIR599 MIR875 RN7SL350P LETM1P3 VPS13B
GH08I099634 Enhancer 0.5 ENCODE 10.1 -97.3 -97297 0.2 OSR2 GATA3 PRDM6 TCF7 ZNF24 ZNF843 ZNF18 MIR599 MIR875 RN7SL350P LETM1P3 VPS13B
GH08I099605 Enhancer 0.4 Ensembl ENCODE 10.6 -69.8 -69785 1.7 MIR875 MIR599 GC08M099603 VPS13B
GH08I099577 Enhancer 0.2 ENCODE 11 -41.0 -41019 1.2 MIR599 MIR875 GC08M099603 VPS13B
GH08I099547 Enhancer 0.8 Ensembl ENCODE 0.4 -10.7 -10664 0.9 TCF12 PRDM6 FOXA2 NCOR1 TAL1 CBFA2T3 CBFA2T2 MAFK FOXA1 VPS13B MIR875 GC08M099603
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR875 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR875 Gene

Genomic Locations for MIR875 Gene
chr8:99,536,786-99,536,861
(GRCh38/hg38)
Size:
76 bases
Orientation:
Minus strand
chr8:100,549,014-100,549,089
(GRCh37/hg19)

Genomic View for MIR875 Gene

Genes around MIR875 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR875 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR875 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR875 Gene

Proteins for MIR875 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR875 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR875 Gene

Domains & Families for MIR875 Gene

Gene Families for MIR875 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR875: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR875 Gene

Function for MIR875 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR875 Gene

Localization for MIR875 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR875 Gene

Pathways & Interactions for MIR875 Gene

SuperPathways for MIR875 Gene

PathCards logo More details on SuperPathways for MIR875
No Data Available

Interacting Proteins for MIR875 Gene

Gene Ontology (GO) - Biological Process for MIR875 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR875 Gene

Drugs & Compounds for MIR875 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR875 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR875 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR875 Gene

No ASD Table

Relevant External Links for MIR875 Gene

GeneLoc Exon Structure for
MIR875
ECgene alternative splicing isoforms for
MIR875

Expression for MIR875 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR875 Gene

mRNA expression in normal human tissues for MIR875 Gene
mRNA expression by GTEx for MIR875 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR875 Gene:

MIR875
genes like me logo Genes that share expression patterns with MIR875: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR875 Gene

Orthologs for MIR875 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR875 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-875 34
  • 99 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-875 34
  • 96 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-875 34
  • 94 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-875 34
  • 89 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-875 34
  • 87 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir875 34
  • 87 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia aca-mir-875 34
  • 82 (a)
 OneToOne
Species where no ortholog for MIR875 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR875 Gene

ENSEMBL:
Gene Tree for MIR875 (if available)
TreeFam:
Gene Tree for MIR875 (if available)

Paralogs for MIR875 Gene

No data available for Paralogs for MIR875 Gene

Variants for MIR875 Gene

Sequence variations from dbSNP and Humsavar for MIR875 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000222810 -- 99,538,584(-) G/A upstream_transcript_variant
rs1000509333 -- 99,536,543(-) G/A downstream_transcript_variant
rs1000558271 -- 99,536,812(-) T/A non_coding_transcript_variant
rs1000972532 -- 99,537,253(-) G/A upstream_transcript_variant
rs1001632963 -- 99,537,710(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR875 Gene

Variant ID Type Subtype PubMed ID
esv2759633 CNV loss 17122850
nsv1020614 CNV loss 25217958
nsv524617 CNV loss 19592680
nsv831408 CNV loss 17160897

Additional Variant Information for MIR875 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR875

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR875 Gene

Disorders for MIR875 Gene

Additional Disease Information for MIR875

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR875 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR875 Gene

Publications for MIR875 Gene

  1. miR-875-5p counteracts epithelial-to-mesenchymal transition and enhances radiation response in prostate cancer through repression of the EGFR-ZEB1 axis. (PMID: 28274892) El Bezawy R … Gandellini P (Cancer letters 2017) 3 58
  2. Two less common human microRNAs miR-875 and miR-3144 target a conserved site of E6 oncogene in most high-risk human papillomavirus subtypes. (PMID: 25913515) Lin L … Li Y (Protein & cell 2015) 3 58
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  5. The miR-875-5p inhibits SATB2 to promote the invasion of lung cancer cells. (PMID: 29196257) Wang J … Ma C (Gene 2018) 3

Products for MIR875 Gene

Sources for MIR875 Gene

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