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Aliases for MIR874 Gene

Subcategory (RNA class) for MIR874 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR874 Gene

  • MicroRNA 874 2 3 5
  • Hsa-Mir-874 3
  • Mir-874 3
  • MIRN874 3

External Ids for MIR874 Gene

Previous HGNC Symbols for MIR874 Gene

  • MIRN874

Previous GeneCards Identifiers for MIR874 Gene

  • GC05M137013
  • GC05M136983

Summaries for MIR874 Gene

Entrez Gene Summary for MIR874 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR874 Gene

MIR874 (MicroRNA 874) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR874 Gene

Genomics for MIR874 Gene

Regulatory Elements for MIR874 Gene

Enhancers for MIR874 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F137620 0.7 Ensembl ENCODE 11.3 +25.4 25419 2.7 SOX5 USF1 NFYC USF2 CEBPB CEBPG YY1 RAD51 ATF3 NFYB SPOCK1 MIR874 KLHL3 NME5 EGR1 GC05M137619 GC05M137622 PIR48538
GH05F137672 0.2 ENCODE 10.9 -24.5 -24538 0.2 KLHL3 MIR874 GC05P137671 GC05P137691
GH05F137714 0.5 ENCODE 10.4 -67.7 -67664 0.7 CTCF SMC3 RAD21 KLHL3 MIR874 PKD2L2 GC05P137725 GC05P137691
GH05F137660 0.2 ENCODE 0.4 -12.9 -12878 0.2 CTCF PKNOX1 MAX RAD21 TEAD3 ZFHX2 ZBTB48 SCRT2 ZNF143 SMC3 KLHL3 GFRA3 GC05P137671 MIR874
GH05F137665 1 FANTOM5 Ensembl ENCODE 0.3 -19.0 -19020 1.9 PKNOX1 STAT1 HLF HMBOX1 PRDM1 SPI1 KLHL3 MYOT FAM13B GC05P137671 MIR874
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR874 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR874 Gene

Chromosome:
5
Start:
137,647,572 bp from pter
End:
137,647,649 bp from pter
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR874 Gene

Genes around MIR874 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR874 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR874 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR874 Gene

ORGUL Member Location for MIR874 Gene

ORGUL Member Location for MIR874 gene

Proteins for MIR874 Gene

Post-translational modifications for MIR874 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR874 Gene

Domains & Families for MIR874 Gene

Gene Families for MIR874 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR874: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR874 Gene

Function for MIR874 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR874 Gene

Localization for MIR874 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR874 Gene

Pathways & Interactions for MIR874 Gene

genes like me logo Genes that share pathways with MIR874: view

Pathways by source for MIR874 Gene

1 BioSystems pathway for MIR874 Gene

Interacting Proteins for MIR874 Gene

Gene Ontology (GO) - Biological Process for MIR874 Gene

None

No data available for SIGNOR curated interactions for MIR874 Gene

Transcripts for MIR874 Gene

mRNA/cDNA for MIR874 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR874 Gene

No ASD Table

Relevant External Links for MIR874 Gene

GeneLoc Exon Structure for
MIR874
ECgene alternative splicing isoforms for
MIR874

Expression for MIR874 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR874 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR874 Gene:

MIR874
genes like me logo Genes that share expression patterns with MIR874: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR874 Gene

Orthologs for MIR874 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR874 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-874 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-874 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-874 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir874 35
  • 99 (a)
OneToOne
Species where no ortholog for MIR874 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR874 Gene

ENSEMBL:
Gene Tree for MIR874 (if available)
TreeFam:
Gene Tree for MIR874 (if available)

Paralogs for MIR874 Gene

No data available for Paralogs for MIR874 Gene

Variants for MIR874 Gene

Sequence variations from dbSNP and Humsavar for MIR874 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs115189656 -- 137,647,556(+) GGTGA(A/G)CTGGG intron-variant, downstream-variant-500B
rs115968785 -- 137,647,897(+) GTGGC(G/T)ATGAG intron-variant, upstream-variant-2KB
rs13356664 -- 137,648,412(+) TGAAC(C/G/T)GGAAT intron-variant, upstream-variant-2KB
rs140024591 -- 137,648,736(+) GAAAG(A/G)ACTTG intron-variant, upstream-variant-2KB
rs142963534 -- 137,649,509(+) CACCC(C/T)GACCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR874 Gene

Variant ID Type Subtype PubMed ID
nsv830499 CNV loss 17160897

Relevant External Links for MIR874 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR874

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR874 Gene

Disorders for MIR874 Gene

Relevant External Links for MIR874

Genetic Association Database (GAD)
MIR874
Human Genome Epidemiology (HuGE) Navigator
MIR874
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR874

No disorders were found for MIR874 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR874 Gene

Publications for MIR874 Gene

  1. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert T.A. … Walter M.J. (PLoS ONE 2009) 3 46 64
  2. MiR-874 inhibits cell growth and induces apoptosis by targeting STAT3 in human colorectal cancer cells. (PMID: 26875895) Zhao B. … Dong A.S. (Eur Rev Med Pharmacol Sci 2016) 3 64
  3. miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. (PMID: 25596740) Zhang X. … Xu Z. (Oncotarget 2015) 3 64
  4. miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer. (PMID: 23800944) Jiang B. … Xu Z. (J. Gastroenterol. 2014) 3 64
  5. MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9. (PMID: 25281924) Wang L. … Wang F. (FEBS Lett. 2014) 3 64

Products for MIR874 Gene

Sources for MIR874 Gene

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