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Aliases for MIR874 Gene

Subcategory (RNA class) for MIR874 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR874 Gene

  • MicroRNA 874 2 3 5
  • Hsa-Mir-874 3
  • Mir-874 3
  • MIRN874 3

External Ids for MIR874 Gene

Previous HGNC Symbols for MIR874 Gene

  • MIRN874

Previous GeneCards Identifiers for MIR874 Gene

  • GC05M137013
  • GC05M136983

Summaries for MIR874 Gene

Entrez Gene Summary for MIR874 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR874 Gene

MIR874 (MicroRNA 874) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR874 Gene

Genomics for MIR874 Gene

Regulatory Elements for MIR874 Gene

Enhancers for MIR874 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR874 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR874 Gene

Chromosome:
5
Start:
137,647,562 bp from pter
End:
137,647,673 bp from pter
Size:
112 bases
Orientation:
Minus strand

Genomic View for MIR874 Gene

Genes around MIR874 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR874 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR874 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR874 Gene

ORGUL Member Location for MIR874 Gene

ORGUL Member Location for MIR874 gene

Proteins for MIR874 Gene

Post-translational modifications for MIR874 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR874 Gene

Domains & Families for MIR874 Gene

Gene Families for MIR874 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR874: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR874 Gene

Function for MIR874 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR874 Gene

Localization for MIR874 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR874 Gene

Pathways & Interactions for MIR874 Gene

SuperPathways for MIR874 Gene

No Data Available

Interacting Proteins for MIR874 Gene

Gene Ontology (GO) - Biological Process for MIR874 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR874 Gene

Drugs & Compounds for MIR874 Gene

No Compound Related Data Available

Transcripts for MIR874 Gene

mRNA/cDNA for MIR874 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR874 Gene

No ASD Table

Relevant External Links for MIR874 Gene

GeneLoc Exon Structure for
MIR874
ECgene alternative splicing isoforms for
MIR874

Expression for MIR874 Gene

mRNA expression in normal human tissues for MIR874 Gene

genes like me logo Genes that share expression patterns with MIR874: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR874 Gene

Orthologs for MIR874 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR874 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-874 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-874 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir874 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-874 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR874:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR874 Gene

ENSEMBL:
Gene Tree for MIR874 (if available)
TreeFam:
Gene Tree for MIR874 (if available)

Paralogs for MIR874 Gene

No data available for Paralogs for MIR874 Gene

Variants for MIR874 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR874 Gene

Variant ID Type Subtype PubMed ID
nsv830499 CNV Loss 17160897

Relevant External Links for MIR874 Gene

HapMap Linkage Disequilibrium report
MIR874

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR874 Gene

Disorders for MIR874 Gene

Relevant External Links for MIR874

Genetic Association Database (GAD)
MIR874
Human Genome Epidemiology (HuGE) Navigator
MIR874
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR874

No disorders were found for MIR874 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR874 Gene

Publications for MIR874 Gene

  1. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PMID: 19240791) Graubert T.A. … Walter M.J. (PLoS ONE 2009) 3 48 67
  2. miR-874 functions as a tumor suppressor by inhibiting angiogenesis through STAT3/VEGF-A pathway in gastric cancer. (PMID: 25596740) Zhang X. … Xu Z. (Oncotarget 2015) 3
  3. MicroRNA-874 inhibits cell proliferation and induces apoptosis in human breast cancer by targeting CDK9. (PMID: 25281924) Wang L. … Wang F. (FEBS Lett. 2014) 3
  4. miR-874 Inhibits cell proliferation, migration and invasion through targeting aquaporin-3 in gastric cancer. (PMID: 23800944) Jiang B. … Xu Z. (J. Gastroenterol. 2014) 3
  5. Suppression of tumor cell invasiveness and in vivo tumor growth by microRNA-874 in non-small cell lung cancer. (PMID: 23583374) Kesanakurti D. … Chetty C. (Biochem. Biophys. Res. Commun. 2013) 3

Products for MIR874 Gene

Sources for MIR874 Gene

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