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Aliases for MIR873 Gene

Subcategory (RNA class) for MIR873 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR873 Gene

  • MicroRNA 873 2 3 5
  • Hsa-Mir-873 3
  • Mir-873 3
  • MIRN873 3

External Ids for MIR873 Gene

Previous HGNC Symbols for MIR873 Gene

  • MIRN873

Summaries for MIR873 Gene

Entrez Gene Summary for MIR873 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR873 Gene

MIR873 (MicroRNA 873) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR873 Gene

Genomics for MIR873 Gene

Regulatory Elements for MIR873 Gene

Enhancers for MIR873 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G028915 0.6 ENCODE 0.3 -26.7 -26684 0.7 JUN CEBPB EP300 BRCA1 RFX5 JUND MAFF FOS MAFK TCF7L2 LINGO2 MIR873 GC09P029173
GH09G028927 0.6 ENCODE 0.3 -38.9 -38943 0.2 JUN CEBPB RAD21 EP300 RFX5 JUND STAT3 FOS TCF7L2 MIR873 GC09P029173
GH09G028925 0.6 ENCODE 0.3 -36.5 -36522 0.3 STAT1 JUN CEBPB EP300 ZKSCAN1 JUND STAT3 RCOR1 CHD2 TCF7L2 ENSG00000260412 LINGO2 MIR873 GC09P029173
GH09G028969 0.9 ENCODE dbSUPER 0.2 -81.7 -81729 2.9 CTCF RBBP5 CHD7 RAD21 POLR2A HDAC2 POU5F1 KDM1A LINGO2 MIR873 GC09P029173
GH09G028923 0.4 ENCODE 0.3 -34.6 -34563 0.2 EZH2 MIR873 GC09P029173
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR873 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR873 Gene

Chromosome:
9
Start:
28,888,879 bp from pter
End:
28,888,955 bp from pter
Size:
77 bases
Orientation:
Minus strand

Genomic View for MIR873 Gene

Genes around MIR873 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR873 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR873 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR873 Gene

ORGUL Member Location for MIR873 Gene

ORGUL Member Location for MIR873 gene

Proteins for MIR873 Gene

Post-translational modifications for MIR873 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR873 Gene

Domains & Families for MIR873 Gene

Gene Families for MIR873 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR873: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR873 Gene

Function for MIR873 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR873 Gene

Localization for MIR873 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR873 Gene

Pathways & Interactions for MIR873 Gene

genes like me logo Genes that share pathways with MIR873: view

Pathways by source for MIR873 Gene

2 BioSystems pathways for MIR873 Gene

Interacting Proteins for MIR873 Gene

Gene Ontology (GO) - Biological Process for MIR873 Gene

None

No data available for SIGNOR curated interactions for MIR873 Gene

Drugs & Compounds for MIR873 Gene

No Compound Related Data Available

Transcripts for MIR873 Gene

mRNA/cDNA for MIR873 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR873 Gene

No ASD Table

Relevant External Links for MIR873 Gene

GeneLoc Exon Structure for
MIR873
ECgene alternative splicing isoforms for
MIR873

Expression for MIR873 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR873 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR873 Gene:

MIR873
genes like me logo Genes that share expression patterns with MIR873: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR873 Gene

Orthologs for MIR873 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR873 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-873 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-873 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir873 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-873 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-873 35
  • 86 (a)
OneToOne
Species where no ortholog for MIR873 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR873 Gene

ENSEMBL:
Gene Tree for MIR873 (if available)
TreeFam:
Gene Tree for MIR873 (if available)

Paralogs for MIR873 Gene

No data available for Paralogs for MIR873 Gene

Variants for MIR873 Gene

Sequence variations from dbSNP and Humsavar for MIR873 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1001175947 -- 28,888,734(+) CTTGC(C/G)TAACT intron-variant, downstream-variant-500B
rs1002444324 -- 28,889,641(+) ACTGG(A/G)ATCTT intron-variant, upstream-variant-2KB
rs1002851211 -- 28,890,060(+) GGTAC(A/G)GAATA intron-variant, upstream-variant-2KB
rs1002904060 -- 28,889,839(+) GTAAA(C/T)ATTTT intron-variant, upstream-variant-2KB
rs1003455795 -- 28,890,722(+) TTGCT(A/G)TTAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR873 Gene

Variant ID Type Subtype PubMed ID
dgv12628n54 CNV loss 21841781
dgv7498n100 CNV loss 25217958
nsv1020624 CNV loss 25217958
nsv471296 CNV loss 18288195

Relevant External Links for MIR873 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR873

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR873 Gene

Disorders for MIR873 Gene

Relevant External Links for MIR873

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR873

No disorders were found for MIR873 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR873 Gene

Publications for MIR873 Gene

  1. MicroRNA-873 mediates multidrug resistance in ovarian cancer cells by targeting ABCB1. (PMID: 26850595) Wu D.D. … Zong Z.H. (Tumour Biol. 2016) 3 64
  2. MiR-873 acts as a novel sensitizer of glioma cells to cisplatin by targeting Bcl-2. (PMID: 26323558) Chen X. … He X. (Int. J. Oncol. 2015) 3 64
  3. MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1. (PMID: 25670861) Wang R.J. … Liang H.Q. (J. Biol. Chem. 2015) 3 64
  4. MiR-873 regulates ERI+ transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells. (PMID: 25531331) Cui J. … Zhang C. (Oncogene 2015) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR873 Gene

Sources for MIR873 Gene

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