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Aliases for MIR770 Gene

Subcategory (RNA class) for MIR770 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR770 Gene

  • MicroRNA 770 2 3 5
  • Hsa-Mir-770 3
  • MIRN770 3

External Ids for MIR770 Gene

ORGUL Members for MIR770 Gene

Previous HGNC Symbols for MIR770 Gene

  • MIRN770

Previous GeneCards Identifiers for MIR770 Gene

  • GC14P100389
  • GC14P101318
  • GC14P101215
  • GC14P101796
  • GC14P102089
  • GC14P102323
  • GC14P102494
  • GC14P102669
  • GC14P102842

Summaries for MIR770 Gene

Entrez Gene Summary for MIR770 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR770 Gene

MIR770 (MicroRNA 770) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR770 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR770 Gene

Genomics for MIR770 Gene

GeneHancer (GH) Regulatory Elements for MIR770 Gene

Promoters and enhancers for MIR770 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I100851 Enhancer 1.1 Ensembl ENCODE 550.8 -1.1 -1089 0.2 KLF17 SIN3A ZNF76 ZBTB7B ZNF48 RAD21 RFX5 SLC30A9 CBX5 ELK1 GC14M100850 MIR770 GC14P103160 ENSG00000258663 ENSG00000258399 MEG3
GH14I100707 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -142.1 -142081 4.8 CTCF ESRRA CLOCK FOXA2 MAX BACH1 ZNF48 RAD21 POLR2A SCRT2 LOC105370669 MEG3 MIR770 PIR37335 GC14P103258
GH14I101215 Enhancer 0.8 ENCODE 10 +364.3 364334 2.8 FOXA2 ARID4B RAD21 ZNF48 ZSCAN9 RARA CREM RXRA CEBPB NR2F2 LOC100128373 SNORD113-3 SNORD113-4 SNORD113-6 SNORD113-7 SNORD113-8 SNORD113-9 MIR543 ENSG00000222185 ENSG00000222095
GH14I100140 Enhancer 1.4 Ensembl ENCODE dbSUPER 5.1 -708.0 -707975 8.8 HDGF FOXA2 ARID4B SIN3A DMAP1 POLR2B ZNF766 E2F8 ZNF143 SP5 GC14P100143 GC14P100144 DEGS2 EVL SLC25A29 MIR770 GC14M100159
GH14I100121 Enhancer 0.7 ENCODE dbSUPER 5.1 -729.9 -729925 1.8 CTCF POLR2A REST RAD21 DEGS2 YY1 MIR770 GC14M100124 PIR51478 EVL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR770 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR770 Gene

Genomic Locations for MIR770 Gene
chr14:100,852,390-100,852,487
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand
chr14:101,318,727-101,318,824
(GRCh37/hg19)

Genomic View for MIR770 Gene

Genes around MIR770 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR770 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR770 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR770 Gene

Proteins for MIR770 Gene

Post-translational modifications for MIR770 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR770 Gene

Domains & Families for MIR770 Gene

Gene Families for MIR770 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR770: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR770 Gene

Function for MIR770 Gene

Phenotypes From GWAS Catalog for MIR770 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR770 Gene

Localization for MIR770 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR770 Gene

Pathways & Interactions for MIR770 Gene

SuperPathways for MIR770 Gene

No Data Available

Interacting Proteins for MIR770 Gene

Gene Ontology (GO) - Biological Process for MIR770 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR770 Gene

Drugs & Compounds for MIR770 Gene

No Compound Related Data Available

Transcripts for MIR770 Gene

mRNA/cDNA for MIR770 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR770 Gene

No ASD Table

Relevant External Links for MIR770 Gene

GeneLoc Exon Structure for
MIR770
ECgene alternative splicing isoforms for
MIR770

Expression for MIR770 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR770 Gene

mRNA differential expression in normal tissues according to GTEx for MIR770 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Pituitary (x5.7), and Brain - Cerebellar Hemisphere (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of MIR770 Gene:

MIR770
genes like me logo Genes that share expression patterns with MIR770: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR770 Gene

Orthologs for MIR770 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR770 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-770 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir770 34
  • 73 (a)
OneToOne
Species where no ortholog for MIR770 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR770 Gene

ENSEMBL:
Gene Tree for MIR770 (if available)
TreeFam:
Gene Tree for MIR770 (if available)

Paralogs for MIR770 Gene

No data available for Paralogs for MIR770 Gene

Variants for MIR770 Gene

Sequence variations from dbSNP and Humsavar for MIR770 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1004461191 -- 100,852,732(+) G/A downstream_transcript_variant
rs1006727694 -- 100,850,965(+) G/T upstream_transcript_variant
rs1007086532 -- 100,851,241(+) T/C upstream_transcript_variant
rs1007111460 -- 100,851,203(+) A/G upstream_transcript_variant
rs1007167048 -- 100,851,458(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR770 Gene

Variant ID Type Subtype PubMed ID
esv2751158 CNV gain 17911159
esv3635518 CNV gain 21293372
nsv483116 CNV gain 15286789
nsv509549 CNV insertion 20534489
nsv832876 CNV loss 17160897

Additional Variant Information for MIR770 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR770

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR770 Gene

Disorders for MIR770 Gene

Additional Disease Information for MIR770

No disorders were found for MIR770 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR770 Gene

Publications for MIR770 Gene

  1. MiR-770 inhibits tumorigenesis and EMT by targeting JMJD6 and regulating WNT/β-catenin pathway in non-small cell lung cancer. (PMID: 28882645) Zhang Z … Zhang X (Life sciences 2017) 3 58
  2. Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma. (PMID: 28345805) Guo W … Liang J (Molecular carcinogenesis 2017) 3 58
  3. Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase. (PMID: 28333152) Lee HC … Lee JS (Cell death & disease 2017) 3 58
  4. Increased serum microRNAs are closely associated with the presence of microvascular complications in type 2 diabetes mellitus. (PMID: 26831044) Wang C … Wang J (Scientific reports 2016) 3 58
  5. Wnt/β-catenin signaling inhibits FBXW7 expression by upregulation of microRNA-770 in hepatocellular carcinoma. (PMID: 26602384) Wu WJ … Wu ZX (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58

Products for MIR770 Gene

Sources for MIR770 Gene

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