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Aliases for MIR770 Gene

Subcategory (RNA class) for MIR770 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR770 Gene

  • MicroRNA 770 2 3 5
  • Hsa-Mir-770 3
  • MIRN770 3

External Ids for MIR770 Gene

ORGUL Members for MIR770 Gene

Previous HGNC Symbols for MIR770 Gene

  • MIRN770

Previous GeneCards Identifiers for MIR770 Gene

  • GC14P100389
  • GC14P101318
  • GC14P101215
  • GC14P101796
  • GC14P102089
  • GC14P102323
  • GC14P102494
  • GC14P102669

Summaries for MIR770 Gene

Entrez Gene Summary for MIR770 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR770 Gene

MIR770 (MicroRNA 770) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR770 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR770 Gene

Genomics for MIR770 Gene

Regulatory Elements for MIR770 Gene

Enhancers for MIR770 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H100707 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -142.1 -142082 4 CTCF ESRRA MAX RAD21 POLR2A SCRT2 NR2F6 MIXL1 EZH2 SMARCA5 MEG3 MIR770 GC14P103062 LOC105370669 PIR37335
GH14H100140 1.6 Ensembl ENCODE dbSUPER 5.1 -708.0 -707975 8 HDGF ARID4B SIN3A DMAP1 ZNF766 SP5 MXD4 REST ZNF592 KAT8 DEGS2 EVL SLC25A29 MIR770 GC14P100143 GC14P100144 GC14M100159
GH14H101215 0.8 ENCODE 10 +364.3 364335 2 SOX13 TFAP4 FOXA2 SAP130 ARID4B CEBPG RAD21 ZNF644 ZSCAN9 RARA SNORD113-3 SNORD113-8 SNORD113-9 SNORD113-6 SNORD113-7 SNORD113-4 MIR543 ENSG00000222185 ENSG00000222095 SNORD114-31
GH14H100121 0.8 ENCODE dbSUPER 5.1 -729.9 -729926 1 CTCF POLR2A REST RAD21 DEGS2 YY1 MIR770 GC14M100124 PIR51478
GH14H100111 0.5 dbSUPER 4.4 -736.5 -736517 9 ZFHX2 POLR2A GLIS1 EGR2 DEGS2 WARS WDR25 SLC25A29 MIR770 PIR51478 GC14M100124
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR770 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR770 Gene

Chromosome:
14
Start:
100,852,390 bp from pter
End:
100,852,487 bp from pter
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR770 Gene

Genes around MIR770 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR770 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR770 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR770 Gene

Proteins for MIR770 Gene

Post-translational modifications for MIR770 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR770 Gene

Domains & Families for MIR770 Gene

Gene Families for MIR770 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR770: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR770 Gene

Function for MIR770 Gene

Phenotypes From GWAS Catalog for MIR770 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR770
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR770 Gene

Localization for MIR770 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR770 Gene

Pathways & Interactions for MIR770 Gene

SuperPathways for MIR770 Gene

No Data Available

Interacting Proteins for MIR770 Gene

Gene Ontology (GO) - Biological Process for MIR770 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR770 Gene

Drugs & Compounds for MIR770 Gene

No Compound Related Data Available

Transcripts for MIR770 Gene

mRNA/cDNA for MIR770 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR770
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR770 Gene

No ASD Table

Relevant External Links for MIR770 Gene

GeneLoc Exon Structure for
MIR770
ECgene alternative splicing isoforms for
MIR770

Expression for MIR770 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR770 Gene

mRNA differential expression in normal tissues according to GTEx for MIR770 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x6.5), Pituitary (x5.7), and Brain - Cerebellar Hemisphere (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of MIR770 Gene:

MIR770
genes like me logo Genes that share expression patterns with MIR770: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR770 Gene

Orthologs for MIR770 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR770 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-770 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir770 34
  • 73 (a)
OneToOne
Species where no ortholog for MIR770 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR770 Gene

ENSEMBL:
Gene Tree for MIR770 (if available)
TreeFam:
Gene Tree for MIR770 (if available)

Paralogs for MIR770 Gene

No data available for Paralogs for MIR770 Gene

Variants for MIR770 Gene

Sequence variations from dbSNP and Humsavar for MIR770 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1004461191 -- 100,852,732(+) AAGGC(A/G)GGGAA intron-variant, nc-transcript-variant, downstream-variant-500B
rs1005892345 -- 100,850,611(+) AAAAG(-/AA)AAAAA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1006727694 -- 100,850,965(+) AGGGA(G/T)GGTGG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1007086532 -- 100,851,241(+) TTGCA(C/T)GAACG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1007111460 -- 100,851,203(+) TAGGC(A/G)GGAAG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR770 Gene

Variant ID Type Subtype PubMed ID
esv2751158 CNV gain 17911159
esv3635518 CNV gain 21293372
nsv483116 CNV gain 15286789
nsv509549 CNV insertion 20534489
nsv832876 CNV loss 17160897

Relevant External Links for MIR770 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR770

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR770 Gene

Disorders for MIR770 Gene

Relevant External Links for MIR770

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR770

No disorders were found for MIR770 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR770 Gene

Publications for MIR770 Gene

  1. PCGEM1 stimulates proliferation of osteoarthritic synoviocytes by acting as a sponge for miR-770. (PMID: 26340084) Kang Y … Jin EJ (Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2016) 3 60
  2. Wnt/β-catenin signaling inhibits FBXW7 expression by upregulation of microRNA-770 in hepatocellular carcinoma. (PMID: 26602384) Wu WJ … Wu ZX (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  3. Increased serum microRNAs are closely associated with the presence of microvascular complications in type 2 diabetes mellitus. (PMID: 26831044) Wang C … Wang J (Scientific reports 2016) 3 60
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60
  5. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E … Cuppen E (Genome research 2006) 3 60

Products for MIR770 Gene

Sources for MIR770 Gene

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