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Aliases for MIR765 Gene

Subcategory (RNA class) for MIR765 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR765 Gene

  • MicroRNA 765 2 3 5
  • Hsa-Mir-765 3
  • Mir-765 3
  • MIRN765 3

External Ids for MIR765 Gene

Previous HGNC Symbols for MIR765 Gene

  • MIRN765

Previous GeneCards Identifiers for MIR765 Gene

  • GC01M155173

Summaries for MIR765 Gene

Entrez Gene Summary for MIR765 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR765 Gene

MIR765 (MicroRNA 765) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR765 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR765

Additional gene information for MIR765 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR765 Gene

Genomics for MIR765 Gene

GeneHancer (GH) Regulatory Elements for MIR765 Gene

Promoters and enhancers for MIR765 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I156804 Enhancer 1.1 FANTOM5 Ensembl dbSUPER 10.4 +131.5 131543 0.6 ZNF316 ZBTB48 VEZF1 NFE2 MAFK IKZF2 CHD2 MAZ ZBTB11 CEBPB MRPL24 INSRR PEAR1 LRRC71 RRNAD1 ISG20L2 HDGF MIR765 ARHGEF11 C1orf61
GH01I156805 Enhancer 1 Ensembl ENCODE dbSUPER 10.4 +129.9 129876 1 MEIS2 PKNOX1 FEZF1 TSHZ1 NR2F2 OSR2 ZNF23 ZNF692 GLIS1 FOXP2 INSRR PEAR1 LRRC71 ISG20L2 RRNAD1 HDGF MRPL24 MIR765 ARHGEF11 GC01P156814
GH01I156890 Enhancer 0.9 ENCODE 11.3 +46.0 45960 0.2 ARNT SIN3A ZNF2 ZNF48 ARID2 ZNF143 KLF7 ATF7 DEK NCOA1 KHDC4 RRNAD1 ISG20L2 LRRC71 INSRR NTRK1 PRCC MIR765 CCT3 LOC246784
GH01I156962 Enhancer 0.8 Ensembl ENCODE 11.5 -27.0 -26957 2 SCRT1 HDAC1 PKNOX1 USF2 ELF1 GABPA MITF MYNN SCRT2 KDM1A LRRC71 ARHGEF11 PEAR1 MIR765 GC01M156985 RN7SL612P GC01P156919
GH01I156910 Enhancer 0.8 Ensembl 11.3 +25.7 25721 0.7 RB1 ZSCAN4 GLI4 ZNF2 RAD21 ZEB1 GLIS2 EGR1 ZNF143 KLF7 MIR765 ARHGEF11 ETV3L GC01P156919 PEAR1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR765 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR765 Gene

Genomic Locations for MIR765 Gene
chr1:156,936,131-156,936,244
(GRCh38/hg38)
Size:
114 bases
Orientation:
Minus strand
chr1:156,905,923-156,906,036
(GRCh37/hg19)

Genomic View for MIR765 Gene

Genes around MIR765 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR765 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR765 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR765 Gene

ORGUL Member Location for MIR765 Gene

ORGUL Member Location for MIR765 gene

Proteins for MIR765 Gene

Post-translational modifications for MIR765 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR765 Gene

Domains & Families for MIR765 Gene

Gene Families for MIR765 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR765: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR765 Gene

Function for MIR765 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR765 Gene

Localization for MIR765 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR765 Gene

Pathways & Interactions for MIR765 Gene

SuperPathways for MIR765 Gene

No Data Available

Interacting Proteins for MIR765 Gene

Gene Ontology (GO) - Biological Process for MIR765 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR765 Gene

Drugs & Compounds for MIR765 Gene

No Compound Related Data Available

Transcripts for MIR765 Gene

fRNAdb Secondary structures for MIR765 Gene

  • hsa-miR-765_MIMAT0003945_Homo_sapiens_miR-765_mature

mRNA/cDNA for MIR765 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR765 Gene

No ASD Table

Relevant External Links for MIR765 Gene

GeneLoc Exon Structure for
MIR765
ECgene alternative splicing isoforms for
MIR765

Expression for MIR765 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR765 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR765 Gene:

MIR765
genes like me logo Genes that share expression patterns with MIR765: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR765 Gene

Orthologs for MIR765 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR765 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-765 34
  • 99 (a)
OneToOne
Species where no ortholog for MIR765 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR765 Gene

ENSEMBL:
Gene Tree for MIR765 (if available)
TreeFam:
Gene Tree for MIR765 (if available)

Paralogs for MIR765 Gene

No data available for Paralogs for MIR765 Gene

Variants for MIR765 Gene

Sequence variations from dbSNP and Humsavar for MIR765 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001943261 -- 156,935,861(-) G/A/C downstream_transcript_variant
rs1004302632 -- 156,935,631(-) A/AA downstream_transcript_variant
rs1004836662 -- 156,937,400(-) G/A upstream_transcript_variant
rs1005189575 -- 156,937,568(-) G/A upstream_transcript_variant
rs1006325602 -- 156,938,044(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR765 Gene

Variant ID Type Subtype PubMed ID
esv3890682 CNV loss 25118596
nsv831659 CNV loss 17160897

Additional Variant Information for MIR765 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR765

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR765 Gene

Disorders for MIR765 Gene

Additional Disease Information for MIR765

No disorders were found for MIR765 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR765 Gene

Publications for MIR765 Gene

  1. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E … Cuppen E (Genome research 2006) 1 3 58
  2. Mir-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma. (PMID: 27062697) Xie BH … Li HP (Cancer biomarkers : section A of Disease markers 2016) 3 58
  3. Epigenetic regulation of SMARCB1 By miR-206, -381 and -671-5p is evident in a variety of SMARCB1 immunonegative soft tissue sarcomas, while miR-765 appears specific for epithelioid sarcoma. A miRNA study of 223 soft tissue sarcomas. (PMID: 27223121) Sápi Z … Fletcher CD (Genes, chromosomes & cancer 2016) 3 58
  4. Circulating miR-765 and miR-149: potential noninvasive diagnostic biomarkers for geriatric coronary artery disease patients. (PMID: 25664324) Ali Sheikh MS … Peng J (BioMed research international 2015) 3 58
  5. MicroRNA-765 influences arterial stiffness through modulating apelin expression. (PMID: 25882991) Liao YC … Juo SH (Molecular and cellular endocrinology 2015) 3 58

Products for MIR765 Gene

Sources for MIR765 Gene

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