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Aliases for MIR765 Gene

Subcategory (RNA class) for MIR765 Gene


Quality Score for this RNA gene is


Aliases for MIR765 Gene

  • MicroRNA 765 2 3 5
  • Hsa-Mir-765 3
  • Mir-765 3
  • MIRN765 3

External Ids for MIR765 Gene

Previous HGNC Symbols for MIR765 Gene

  • MIRN765

Previous GeneCards Identifiers for MIR765 Gene

  • GC01M155173

Summaries for MIR765 Gene

Entrez Gene Summary for MIR765 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR765 Gene

MIR765 (MicroRNA 765) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR765 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR765

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR765 Gene

Genomics for MIR765 Gene

Regulatory Elements for MIR765 Gene

Enhancers for MIR765 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F156959 0.4 ENCODE 11.5 -23.4 -23424 0.2 PKNOX1 SP2 FEZF1 OSR2 PBX2 PRDM1 SP7 TRIM28 SETDB1 ZNF558 MIR765 ARHGEF11 LRRC71 PEAR1 RN7SL612P GC01M156985
GH01F156962 1 Ensembl ENCODE 11.5 -27.2 -27157 2.4 PKNOX1 ZFHX2 ZNF157 POLR2A SCRT2 EGR2 SCRT1 USF2 ELF1 ZBTB7A LRRC71 ARHGEF11 PEAR1 MIR765 GC01M156985 RN7SL612P
GH01F156910 0.9 Ensembl 11.3 +25.7 25722 0.7 CBX3 GLI4 ZNF2 RAD21 ZEB1 GLIS2 KLF7 ZNF391 EGR2 ZBTB2 MIR765 ARHGEF11 ETV3L GC01P156919 PEAR1
GH01F156890 0.2 ENCODE 11.3 +46.0 45961 0.2 ZNF48 ZNF2 GLIS2 ZNF143 ZNF207 KLF7 DEK ZNF263 REST ZNF518A LOC246784 LRRC71 INSRR NTRK1 MIR765 ARHGEF11 KIAA0907 LOC105371454 PEAR1 GC01M156849
GH01F156805 1.1 Ensembl ENCODE 10.4 +129.9 129876 1.0 PKNOX1 ZNF140 FEZF1 ZNF121 ZNF23 SCRT2 ZMIZ1 PRDM10 TSHZ1 ZEB2 RRNAD1 KIAA0907 INSRR PEAR1 LRRC71 ISG20L2 HDGF MRPL24 MIR765 ARHGEF11
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR765 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR765 Gene

156,936,131 bp from pter
156,936,244 bp from pter
114 bases
Minus strand

Genomic View for MIR765 Gene

Genes around MIR765 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR765 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR765 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR765 Gene

ORGUL Member Location for MIR765 Gene

ORGUL Member Location for MIR765 gene

Proteins for MIR765 Gene

Post-translational modifications for MIR765 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR765 Gene

Domains & Families for MIR765 Gene

Gene Families for MIR765 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR765: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR765 Gene

Function for MIR765 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR765 Gene

Localization for MIR765 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR765 Gene

Pathways & Interactions for MIR765 Gene

SuperPathways for MIR765 Gene

No Data Available

Interacting Proteins for MIR765 Gene

Gene Ontology (GO) - Biological Process for MIR765 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR765 Gene

Transcripts for MIR765 Gene

fRNAdb Secondary structures for MIR765 Gene

  • hsa-miR-765_MIMAT0003945_Homo_sapiens_miR-765_mature

mRNA/cDNA for MIR765 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR765 Gene

No ASD Table

Relevant External Links for MIR765 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR765 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR765 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR765 Gene:

genes like me logo Genes that share expression patterns with MIR765: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR765 Gene

Orthologs for MIR765 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR765 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-765 35
  • 99 (a)
Species where no ortholog for MIR765 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR765 Gene

Gene Tree for MIR765 (if available)
Gene Tree for MIR765 (if available)

Paralogs for MIR765 Gene

No data available for Paralogs for MIR765 Gene

Variants for MIR765 Gene

Sequence variations from dbSNP and Humsavar for MIR765 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs113264656 -- 156,935,685(+) CAGGC(A/G)TGCGC intron-variant, downstream-variant-500B, utr-variant-3-prime
rs113534569 -- 156,935,724(+) GACCA(C/T)GGTGA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs115538043 -- 156,937,656(+) AGCCC(C/T)CTAAA intron-variant, upstream-variant-2KB
rs12749171 -- 156,936,499(+) aaaaa(A/T)atata intron-variant, upstream-variant-2KB
rs138454533 -- 156,936,829(+) GGGCA(A/G)GGCCC intron-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR765 Gene

Variant ID Type Subtype PubMed ID
esv3890682 CNV loss 25118596
nsv831659 CNV loss 17160897

Relevant External Links for MIR765 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR765 Gene

Disorders for MIR765 Gene

Relevant External Links for MIR765

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR765 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR765 Gene

Publications for MIR765 Gene

  1. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E. … Cuppen E. (Genome Res. 2006) 1 3 64
  2. Circulating miR-765 and miR-149: potential noninvasive diagnostic biomarkers for geriatric coronary artery disease patients. (PMID: 25664324) Ali Sheikh M.S. … Peng J. (Biomed Res Int 2015) 3 64
  3. Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. (PMID: 26398721) Hong X.C. … Zhong Y.H. (Mol Med Rep 2015) 3 64
  4. MicroRNA-765 influences arterial stiffness through modulating apelin expression. (PMID: 25882991) Liao Y.C. … Juo S.H. (Mol. Cell. Endocrinol. 2015) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR765 Gene

Sources for MIR765 Gene

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