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Aliases for MIR761 Gene

Subcategory (RNA class) for MIR761 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR761 Gene

  • MicroRNA 761 2 3 5
  • Hsa-Mir-761 3

External Ids for MIR761 Gene

Previous GeneCards Identifiers for MIR761 Gene

  • GC00U923916
  • GC01M052303
  • GC01M050418
  • GC01M051791

Summaries for MIR761 Gene

Entrez Gene Summary for MIR761 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR761 Gene

MIR761 (MicroRNA 761) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR761 Gene

Genomics for MIR761 Gene

Regulatory Elements for MIR761 Gene

Enhancers for MIR761 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G051849 1 ENCODE 0.4 -14.2 -14227 1.6 PKNOX1 ATF1 CREB3L1 ARNT TCF12 ZNF766 GATA2 JUNB NCOA1 SMARCB1 ZCCHC11 NRDC ENSG00000266993 GC01M051858 MIR761
GH01G051851 0.7 ENCODE 0.4 -15.7 -15660 0.6 HDAC1 BRD4 ZNF175 ZBTB40 KMT2B RELA ZNF664 IRF9 CREM ZNF740 GC01M051858 MIR761
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR761 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR761 Gene

Chromosome:
1
Start:
51,836,344 bp from pter
End:
51,836,402 bp from pter
Size:
59 bases
Orientation:
Minus strand

Genomic View for MIR761 Gene

Genes around MIR761 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR761 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR761 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR761 Gene

Proteins for MIR761 Gene

Post-translational modifications for MIR761 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR761 Gene

Domains & Families for MIR761 Gene

Gene Families for MIR761 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR761: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR761 Gene

Function for MIR761 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR761 Gene

Localization for MIR761 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR761 Gene

Pathways & Interactions for MIR761 Gene

SuperPathways for MIR761 Gene

No Data Available

Interacting Proteins for MIR761 Gene

Gene Ontology (GO) - Biological Process for MIR761 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR761 Gene

Drugs & Compounds for MIR761 Gene

No Compound Related Data Available

Transcripts for MIR761 Gene

mRNA/cDNA for MIR761 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR761 Gene

No ASD Table

Relevant External Links for MIR761 Gene

GeneLoc Exon Structure for
MIR761
ECgene alternative splicing isoforms for
MIR761

Expression for MIR761 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR761 Gene

mRNA differential expression in normal tissues according to GTEx for MIR761 Gene

This gene is overexpressed in Muscle - Skeletal (x6.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR761 Gene:

MIR761
genes like me logo Genes that share expression patterns with MIR761: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR761 Gene

Orthologs for MIR761 Gene

Evolution for MIR761 Gene

ENSEMBL:
Gene Tree for MIR761 (if available)
TreeFam:
Gene Tree for MIR761 (if available)

No data available for Orthologs for MIR761 Gene

Paralogs for MIR761 Gene

No data available for Paralogs for MIR761 Gene

Variants for MIR761 Gene

Sequence variations from dbSNP and Humsavar for MIR761 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000597007 -- 51,836,801(+) GAGGC(C/T)TTTTA intron-variant, upstream-variant-2KB
rs1000744412 -- 51,838,066(+) TACGA(C/T)CGTGG intron-variant, upstream-variant-2KB
rs1005533738 -- 51,837,373(+) GATAC(A/T)ATAAA intron-variant, upstream-variant-2KB
rs1006942110 -- 51,836,035(+) TCATA(C/T)TTCTG intron-variant, downstream-variant-500B
rs1007326449 -- 51,837,213(+) TGTCA(A/G)TTTTA intron-variant, upstream-variant-2KB

Relevant External Links for MIR761 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR761

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR761 Gene

Disorders for MIR761 Gene

Relevant External Links for MIR761

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR761

No disorders were found for MIR761 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR761 Gene

Publications for MIR761 Gene

  1. microRNA-761 induces aggressive phenotypes in triple-negative breast cancer cells by repressing TRIM29 expression. (PMID: 28054302) Guo G.C. … Li L. (Cell Oncol (Dordr) 2017) 3 64
  2. miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma. (PMID: 26563371) Shi C. … Zhang Z. (Tumour Biol. 2016) 3 64
  3. MicroRNA-761 is upregulated in hepatocellular carcinoma and regulates tumorigenesis by targeting Mitofusin-2. (PMID: 26845057) Zhou X. … Wang W. (Cancer Sci. 2016) 3 64
  4. miRNAminer: a tool for homologous microRNA gene search. (PMID: 18215311) Artzi S. … Shomron N. (BMC Bioinformatics 2008) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR761 Gene

Sources for MIR761 Gene

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