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Aliases for MIR760 Gene

Subcategory (RNA class) for MIR760 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR760 Gene

  • MicroRNA 760 2 3 5
  • Hsa-Mir-760 3
  • Mir-760 3
  • MIRN760 3

External Ids for MIR760 Gene

Previous HGNC Symbols for MIR760 Gene

  • MIRN760

Previous GeneCards Identifiers for MIR760 Gene

  • GC01P094086
  • GC01P094312

Summaries for MIR760 Gene

Entrez Gene Summary for MIR760 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR760 Gene

MIR760 (MicroRNA 760) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR760 Gene

Genomics for MIR760 Gene

Regulatory Elements for MIR760 Gene

Enhancers for MIR760 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G093811 1.6 Ensembl ENCODE dbSUPER 12.8 -31.7 -31719 8.0 PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZNF143 ZNF207 DEK ENSG00000230439 SNORD21 TRR-TCT1-1 RPL5 SNORA66 CCDC18-AS1 DNTTIP2 MIR760 BCAR3 GCLM
GH01G093757 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 -87.8 -87755 2.4 FOXA2 ATF1 MLX DMAP1 ZNF48 YY1 FOS ZHX2 PPARG KAT8 ENSG00000230439 MIR760 BCAR3 GCLM DNTTIP2 GC01P093728
GH01G093621 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -222.6 -222558 5.8 PKNOX1 SAP130 JUN ZNF140 SIN3A CEBPG FEZF1 BMI1 RAD21 RARA BCAR3 MIR760 LOC100129046 GCLM DR1 GC01M093613 GC01M093588
GH01G093612 1.6 Ensembl ENCODE dbSUPER 11.2 -230.5 -230526 8.3 FOXA2 MLX ZFP64 ARID4B DMAP1 FEZF1 YY1 FOS SP5 ZHX2 BCAR3 LOC100129046 MIR760 GCLM CCDC18-AS1 GC01M093588 GC01M093613
GH01G093749 1.5 Ensembl ENCODE dbSUPER 11.1 -93.5 -93477 7.9 PKNOX1 FOXA2 ATF1 BRCA1 YY1 GATA2 FOS PPARG TBX21 KAT8 ENSG00000230439 BCAR3 MIR760 GCLM TRR-TCT1-1 GC01P093728
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR760 on UCSC Golden Path with GeneCards custom track

Promoters for MIR760 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010020 468 2600 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZNF610 GLIS1 RCOR2

Genomic Location for MIR760 Gene

Chromosome:
1
Start:
93,846,832 bp from pter
End:
93,846,911 bp from pter
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR760 Gene

Genes around MIR760 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR760 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR760 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR760 Gene

Proteins for MIR760 Gene

Post-translational modifications for MIR760 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR760 Gene

Domains & Families for MIR760 Gene

Gene Families for MIR760 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR760: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR760 Gene

Function for MIR760 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR760 Gene

Localization for MIR760 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR760 Gene

Pathways & Interactions for MIR760 Gene

genes like me logo Genes that share pathways with MIR760: view

Pathways by source for MIR760 Gene

1 BioSystems pathway for MIR760 Gene

Interacting Proteins for MIR760 Gene

Gene Ontology (GO) - Biological Process for MIR760 Gene

None

No data available for SIGNOR curated interactions for MIR760 Gene

Drugs & Compounds for MIR760 Gene

No Compound Related Data Available

Transcripts for MIR760 Gene

mRNA/cDNA for MIR760 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR760 Gene

No ASD Table

Relevant External Links for MIR760 Gene

GeneLoc Exon Structure for
MIR760
ECgene alternative splicing isoforms for
MIR760

Expression for MIR760 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR760 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR760 Gene:

MIR760
genes like me logo Genes that share expression patterns with MIR760: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR760 Gene

Orthologs for MIR760 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR760 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-760 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-760 35
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir760 35
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 60 (a)
OneToOne
Species where no ortholog for MIR760 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR760 Gene

ENSEMBL:
Gene Tree for MIR760 (if available)
TreeFam:
Gene Tree for MIR760 (if available)

Paralogs for MIR760 Gene

No data available for Paralogs for MIR760 Gene

Variants for MIR760 Gene

Sequence variations from dbSNP and Humsavar for MIR760 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1002420801 -- 93,847,332(+) CCCTC(A/C)CACCG downstream-variant-500B, upstream-variant-2KB
rs1004432599 -- 93,846,365(+) GAATC(C/T)TCCGT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1005485257 -- 93,845,471(+) ATATA(G/T)ATATA intron-variant, upstream-variant-2KB
rs1005564294 -- 93,846,710(+) TGACA(C/G)CCTCC intron-variant, upstream-variant-2KB
rs1009054971 -- 93,844,936(+) CACAG(A/G)GAAAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR760 Gene

Variant ID Type Subtype PubMed ID
nsv998755 CNV loss 25217958

Relevant External Links for MIR760 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR760

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR760 Gene

Disorders for MIR760 Gene

Relevant External Links for MIR760

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR760

No disorders were found for MIR760 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR760 Gene

Publications for MIR760 Gene

  1. MicroR-760 suppresses cancer stem cell subpopulation and breast cancer cell proliferation and metastasis: By down-regulating NANOG. (PMID: 27133070) Han M.L. … Wang Y.M. (Biomed. Pharmacother. 2016) 3 64
  2. Systematic analysis of gene expression pattern in has-miR-760 overexpressed resistance of the MCF-7 human breast cancer cell to doxorubicin. (PMID: 25661353) Lv J. … Xie H. (Biomed. Pharmacother. 2015) 3 64
  3. Upregulation of miR-760 and miR-186 is associated with replicative senescence in human lung fibroblast cells. (PMID: 25139266) Lee Y.H. … Bae Y.S. (Mol. Cells 2014) 3 64
  4. Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer. (PMID: 24097871) Iwaya T. … Mimori K. (Clin. Cancer Res. 2013) 3 64
  5. Plasma miR-601 and miR-760 are novel biomarkers for the early detection of colorectal cancer. (PMID: 22970209) Wang Q. … Du X. (PLoS ONE 2012) 3 64

Products for MIR760 Gene

Sources for MIR760 Gene

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