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Aliases for MIR759 Gene

Subcategory (RNA class) for MIR759 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR759 Gene

  • MicroRNA 759 2 3 5
  • Hsa-Mir-759 3

External Ids for MIR759 Gene

Previous GeneCards Identifiers for MIR759 Gene

  • GC00U929326
  • GC13P053385
  • GC13P034098

Summaries for MIR759 Gene

Entrez Gene Summary for MIR759 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR759 Gene

MIR759 (MicroRNA 759) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR759 Gene

Genomics for MIR759 Gene

Regulatory Elements for MIR759 Gene

Enhancers for MIR759 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G052879 0.5 ENCODE 10.6 +70.6 70580 1.4 BCL11A SCRT2 POU5F1 CHD7 ATF2 MIR759 CKAP2 PCDH8 GC13M052802
GH13G052762 0.3 FANTOM5 10.7 -47.3 -47270 0.3 MIR759 LOC105370209 CNMD
GH13G052809 0.9 ENCODE 0.7 -0.6 -550 0.2 ATF1 NFIB INSM2 RAD21 RARA GLIS2 GATA2 ZNF366 ZSCAN5C RELB PPIAP26 MIR759 LOC105370209
GH13G052779 0.3 FANTOM5 0.3 -30.9 -30859 0.1 PCDH8 HNRNPA1L2 LOC105370209 MIR759
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR759 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR759 Gene

Chromosome:
13
Start:
52,810,050 bp from pter
End:
52,810,140 bp from pter
Size:
91 bases
Orientation:
Plus strand

Genomic View for MIR759 Gene

Genes around MIR759 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR759 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR759 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR759 Gene

Proteins for MIR759 Gene

Post-translational modifications for MIR759 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR759 Gene

Domains & Families for MIR759 Gene

Gene Families for MIR759 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR759: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR759 Gene

Function for MIR759 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR759 Gene

Localization for MIR759 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR759 Gene

Pathways & Interactions for MIR759 Gene

SuperPathways for MIR759 Gene

No Data Available

Interacting Proteins for MIR759 Gene

Gene Ontology (GO) - Biological Process for MIR759 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR759 Gene

Transcripts for MIR759 Gene

mRNA/cDNA for MIR759 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR759 Gene

No ASD Table

Relevant External Links for MIR759 Gene

GeneLoc Exon Structure for
MIR759
ECgene alternative splicing isoforms for
MIR759

Expression for MIR759 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR759 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR759 Gene:

MIR759
genes like me logo Genes that share expression patterns with MIR759: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR759 Gene

Orthologs for MIR759 Gene

Evolution for MIR759 Gene

ENSEMBL:
Gene Tree for MIR759 (if available)
TreeFam:
Gene Tree for MIR759 (if available)

No data available for Orthologs for MIR759 Gene

Paralogs for MIR759 Gene

No data available for Paralogs for MIR759 Gene

Variants for MIR759 Gene

Sequence variations from dbSNP and Humsavar for MIR759 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000408977 -- 52,808,817(+) TTCAA(C/T)GATTT upstream-variant-2KB
rs1001278638 -- 52,809,582(+) GTGCA(A/G)TCAGC upstream-variant-2KB
rs1001306923 -- 52,809,400(+) CCTGG(A/G)AGACA upstream-variant-2KB
rs1001337958 -- 52,809,087(+) GGTTG(A/G)TGAGT upstream-variant-2KB
rs1005948452 -- 52,808,695(+) TCCTT(-/GAGGTGGCTCTAG)GAGAA upstream-variant-2KB

Relevant External Links for MIR759 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR759

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR759 Gene

Disorders for MIR759 Gene

Relevant External Links for MIR759

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR759

No disorders were found for MIR759 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR759 Gene

Publications for MIR759 Gene

  1. Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene. (PMID: 20677013) Chen Z. … Kimura A. (Hum. Genet. 2010) 3 64
  2. miRNAminer: a tool for homologous microRNA gene search. (PMID: 18215311) Artzi S. … Shomron N. (BMC Bioinformatics 2008) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  4. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E. … Cuppen E. (Genome Res. 2006) 3 64

Products for MIR759 Gene

Sources for MIR759 Gene

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