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Aliases for MIR759 Gene

Subcategory (RNA class) for MIR759 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR759 Gene

  • MicroRNA 759 2 3
  • Hsa-Mir-759 3

External Ids for MIR759 Gene

Previous GeneCards Identifiers for MIR759 Gene

  • GC00U929326
  • GC13P053385
  • GC13P034098

Summaries for MIR759 Gene

Entrez Gene Summary for MIR759 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR759 Gene

MIR759 (MicroRNA 759) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR759 include pulmonary hypertension.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR759 Gene

Genomics for MIR759 Gene

Genomic Location for MIR759 Gene

Start:
52,810,044 bp from pter
End:
52,810,140 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR759 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR759 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR759 Gene

No data available for Regulatory Elements for MIR759 Gene

Proteins for MIR759 Gene

Post-translational modifications for MIR759 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR759 Gene

Domains for MIR759 Gene

Gene Families for MIR759 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR759: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR759 Gene

Function for MIR759 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR759 Gene

Localization for MIR759 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR759 Gene

Pathways for MIR759 Gene

SuperPathways for MIR759 Gene

No Data Available

Interacting Proteins for MIR759 Gene

Gene Ontology (GO) - Biological Process for MIR759 Gene

None

No data available for Pathways by source for MIR759 Gene

Transcripts for MIR759 Gene

mRNA/cDNA for MIR759 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR759 Gene

No ASD Table

Relevant External Links for MIR759 Gene

GeneLoc Exon Structure for
MIR759
ECgene alternative splicing isoforms for
MIR759

Expression for MIR759 Gene

mRNA expression in normal human tissues for MIR759 Gene

genes like me logo Genes that share expressions with MIR759: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR759 Gene

Orthologs for MIR759 Gene

Evolution for MIR759 Gene

ENSEMBL:
Gene Tree for MIR759 (if available)
TreeFam:
Gene Tree for MIR759 (if available)

No data available for Orthologs for MIR759 Gene

Paralogs for MIR759 Gene

No data available for Paralogs for MIR759 Gene

Variants for MIR759 Gene

Sequence variations from dbSNP and Humsavar for MIR759 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1324997 -- 52,810,521(-) CTGGT(A/G)TTTCA downstream-variant-500B
rs7983759 -- 52,809,505(+) CTGGG(A/G)CCAAA upstream-variant-2KB
rs7993918 -- 52,808,056(+) aaaat(A/C)caaaa upstream-variant-2KB
rs34357034 -- 52,808,566(+) CATAG(-/C)ATATT upstream-variant-2KB
rs34775782 -- 52,808,088(+) AAAAA(A/T)TTAGC upstream-variant-2KB

Relevant External Links for MIR759 Gene

HapMap Linkage Disequilibrium report
MIR759

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MIR759 Gene

Disorders for MIR759 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR759 Gene in MalaCards »

(1) Diseases for MIR759 Gene including...

genes like me logo Genes that share disorders with MIR759: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR759 Gene

Publications for MIR759 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PMID: 16954537) Berezikov E. … Cuppen E. (Genome Res. 2006) 3
  3. miRNAminer: a tool for homologous microRNA gene search. (PMID: 18215311) Artzi S. … Shomron N. (BMC Bioinformatics 2008) 3
  4. Susceptibility to chronic thromboembolic pulmonary hypertension may be conferred by miR-759 via its targeted interaction with polymorphic fibrinogen alpha gene. (PMID: 20677013) Chen Z. … Kimura A. (Hum. Genet. 2010) 3

Products for MIR759 Gene

Sources for MIR759 Gene

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