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Aliases for MIR758 Gene

Subcategory (RNA class) for MIR758 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR758 Gene

  • MicroRNA 758 2 3 5
  • Hsa-Mir-758 3
  • Mir-758 3
  • MIRN758 3

External Ids for MIR758 Gene

ORGUL Members for MIR758 Gene

Previous HGNC Symbols for MIR758 Gene

  • MIRN758

Previous GeneCards Identifiers for MIR758 Gene

  • GC14P100816
  • GC14P100908
  • GC14P101494
  • GC14P101708
  • GC14P101749
  • GC14P101807
  • GC14P101947
  • GC14P102138
  • GC14P101237
  • GC14P101805
  • GC14P102099
  • GC14P102334
  • GC14P102506
  • GC14P102683

Summaries for MIR758 Gene

Entrez Gene Summary for MIR758 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR758 Gene

MIR758 (MicroRNA 758) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR758 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR758 Gene

Genomics for MIR758 Gene

Genomic Location for MIR758 Gene

Chromosome:
14
Start:
101,026,020 bp from pter
End:
101,026,107 bp from pter
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR758 Gene

Genes around MIR758 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR758 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR758 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR758 Gene

No data available for Regulatory Elements for MIR758 Gene

Proteins for MIR758 Gene

Post-translational modifications for MIR758 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR758 Gene

Domains & Families for MIR758 Gene

Gene Families for MIR758 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR758: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR758 Gene

Function for MIR758 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR758
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR758 Gene

Localization for MIR758 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR758 Gene

Pathways & Interactions for MIR758 Gene

SuperPathways for MIR758 Gene

No Data Available

Interacting Proteins for MIR758 Gene

Gene Ontology (GO) - Biological Process for MIR758 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR758 Gene

Drugs & Compounds for MIR758 Gene

No Compound Related Data Available

Transcripts for MIR758 Gene

mRNA/cDNA for MIR758 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR758
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR758 Gene

No ASD Table

Relevant External Links for MIR758 Gene

GeneLoc Exon Structure for
MIR758
ECgene alternative splicing isoforms for
MIR758

Expression for MIR758 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR758 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR758 Gene:

MIR758
genes like me logo Genes that share expression patterns with MIR758: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR758 Gene

Orthologs for MIR758 Gene

Evolution for MIR758 Gene

ENSEMBL:
Gene Tree for MIR758 (if available)
TreeFam:
Gene Tree for MIR758 (if available)

No data available for Orthologs for MIR758 Gene

Paralogs for MIR758 Gene

No data available for Paralogs for MIR758 Gene

Variants for MIR758 Gene

Sequence variations from dbSNP and Humsavar for MIR758 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1002887938 -- 101,026,298(+) GGAGG(C/T)ATCCA downstream-variant-500B, upstream-variant-2KB
rs1002938972 -- 101,026,048(+) CCAGA(G/T)AGCAC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1003059623 -- 101,026,297(+) TGGAG(A/G)CATCC downstream-variant-500B, upstream-variant-2KB
rs1003843722 -- 101,026,369(+) CTGAG(-/TGTA)TGCAC downstream-variant-500B, upstream-variant-2KB
rs1005484560 -- 101,025,456(+) ATGTG(G/T)GTTTG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR758 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
esv3635523 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv1426 CNV insertion 18451855
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR758 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR758

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR758 Gene

Disorders for MIR758 Gene

Relevant External Links for MIR758

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR758

No disorders were found for MIR758 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR758 Gene

Publications for MIR758 Gene

  1. High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. (PMID: 27835701) Navarro-Quiroz E … Aroca G (PloS one 2016) 3 60
  2. MicroRNAs and High-Density Lipoprotein Cholesterol Metabolism. (PMID: 26084456) Ono K … Kimura T (International heart journal 2015) 3 60
  3. Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaques. (PMID: 25445880) Mandolini C … Cipollone F (Nutrition, metabolism, and cardiovascular diseases : NMCD 2015) 3 60
  4. Hepatitis C virus infection decreases the expression of Toll-like receptors 3 and 7 via upregulation of miR-758. (PMID: 25008898) Yang Q … Wang J (Archives of virology 2014) 3 60
  5. Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs. (PMID: 22282338) Voellenkle C … Martelli F (RNA (New York, N.Y.) 2012) 3 60

Products for MIR758 Gene

Sources for MIR758 Gene

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