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Aliases for MIR744 Gene

Subcategory (RNA class) for MIR744 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR744 Gene

  • MicroRNA 744 2 3 5
  • Hsa-Mir-744 3
  • Mir-744 3
  • MIRN744 3

External Ids for MIR744 Gene

Previous HGNC Symbols for MIR744 Gene

  • MIRN744

Previous GeneCards Identifiers for MIR744 Gene

  • GC17P011927

Summaries for MIR744 Gene

Entrez Gene Summary for MIR744 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR744 Gene

MIR744 (MicroRNA 744) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR744 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR744 Gene

Genomics for MIR744 Gene

Regulatory Elements for MIR744 Gene

Enhancers for MIR744 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H012023 0.9 Ensembl ENCODE 11 -57.3 -57298 2 FOXA2 JUN CEBPB DPF2 EP300 JUND SCRT2 ZSCAN5C STAT3 FOSL2 MIR744 ENSG00000241185 RNU11-2P
GH17H012046 0.4 ENCODE 11.1 -35.1 -35080 1 SOX6 HLF MAP2K4 MIR744 RNU11-2P
GH17H012050 0.2 ENCODE 11.6 -31.1 -31058 1 MIR744 MAP2K4 RNU11-2P
GH17H011999 0.2 ENCODE 10.3 -82.0 -81965 0 RNU11-2P MIR744 ZNF18 RPL21P122
GH17H012078 0.5 ENCODE 0.7 -3.0 -3021 0 ZNF362 JUND ZNF629 ATF2 MIR744 RNU11-2P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR744 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR744 Gene

Chromosome:
17
Start:
12,081,899 bp from pter
End:
12,081,996 bp from pter
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR744 Gene

Genes around MIR744 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR744 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR744 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR744 Gene

Proteins for MIR744 Gene

Post-translational modifications for MIR744 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR744 Gene

Domains & Families for MIR744 Gene

Gene Families for MIR744 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR744: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR744 Gene

Function for MIR744 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR744
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR744 Gene

Localization for MIR744 Gene

Gene Ontology (GO) - Cellular Components for MIR744 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR744: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR744 Gene

Pathways & Interactions for MIR744 Gene

SuperPathways for MIR744 Gene

No Data Available

Interacting Proteins for MIR744 Gene

Gene Ontology (GO) - Biological Process for MIR744 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR744 Gene

Drugs & Compounds for MIR744 Gene

No Compound Related Data Available

Transcripts for MIR744 Gene

mRNA/cDNA for MIR744 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR744
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR744 Gene

No ASD Table

Relevant External Links for MIR744 Gene

GeneLoc Exon Structure for
MIR744
ECgene alternative splicing isoforms for
MIR744

Expression for MIR744 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR744 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR744 Gene:

MIR744
genes like me logo Genes that share expression patterns with MIR744: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR744 Gene

Orthologs for MIR744 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR744 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-744 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir744 34
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-744 34
  • 92 (a)
OneToOne
Species where no ortholog for MIR744 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR744 Gene

ENSEMBL:
Gene Tree for MIR744 (if available)
TreeFam:
Gene Tree for MIR744 (if available)

Paralogs for MIR744 Gene

No data available for Paralogs for MIR744 Gene

Variants for MIR744 Gene

Sequence variations from dbSNP and Humsavar for MIR744 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1002829757 -- 12,079,953(+) TAATA(C/T)GGGTG intron-variant, upstream-variant-2KB
rs1003321895 -- 12,081,655(+) TTTCT(A/C)CAACT intron-variant, upstream-variant-2KB
rs1005543001 -- 12,080,723(+) ACAGT(A/G)TACTA intron-variant, upstream-variant-2KB
rs1005554757 -- 12,080,973(+) GCAAT(A/G)AGGTT intron-variant, upstream-variant-2KB
rs1007003931 -- 12,082,314(+) AAGAT(A/G)TTTCA intron-variant, downstream-variant-500B

Relevant External Links for MIR744 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR744

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR744 Gene

Disorders for MIR744 Gene

Relevant External Links for MIR744

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR744

No disorders were found for MIR744 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR744 Gene

Publications for MIR744 Gene

  1. MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling. (PMID: 28107193) Guan H … Chen M (Oncotarget 2017) 3 60
  2. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60
  3. MicroRNA-744 inhibited cervical cancer growth and progression through apoptosis induction by regulating Bcl-2. (PMID: 27261616) Chen XF … Liu Y (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 3 60
  4. miR-744 enhances type I interferon signaling pathway by targeting PTP1B in primary human renal mesangial cells. (PMID: 26259828) Zhang X … Shen N (Scientific reports 2015) 3 60
  5. Plasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer. (PMID: 26505678) Miyamae M … Otsuji E (British journal of cancer 2015) 3 60

Products for MIR744 Gene

Sources for MIR744 Gene

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