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MIR718 Gene(RNA Gene)

MicroRNA 718

GCID:
GC0XM154019
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR718 Gene

Subcategory (RNA class) for MIR718 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR718 Gene

  • MicroRNA 718 2 3 5
  • Hsa-Mir-718 3

External Ids for MIR718 Gene

ORGUL Members for MIR718 Gene

Previous GeneCards Identifiers for MIR718 Gene

  • GC00U930648
  • GC0XM153286

Summaries for MIR718 Gene

Entrez Gene Summary for MIR718 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR718 Gene

MIR718 (MicroRNA 718) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Apoptosis Modulation and Signaling and IL-1 signaling pathway.

Additional gene information for MIR718 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR718 Gene

Genomics for MIR718 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR718 Gene

Promoters and enhancers for MIR718 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH0XI154017 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 0.0 -21 4.2 HDGF RB1 ZNF2 YY1 ZNF335 GLIS2 EGR1 ZNF143 ATF7 RUNX3 IRAK1 MIR718 GC0XP154020 TMEM187 MECP2
GH0XI154001 Enhancer 1.1 Ensembl ENCODE 0.4 +17.6 17579 1.7 PKNOX1 ATF1 YY1 ZNF121 ZNF766 RUNX3 CAVIN1 REST ZNF592 MEF2D HCFC1 SNORA70 HCFC1-AS1 TMEM187 IRAK1 SNORA56 PLXNA3 DKC1 MIR718 MIR3202-2
GH0XI154009 Enhancer 1 Ensembl ENCODE 0.4 +8.1 8132 4.6 CTCF FOXA2 CEBPG DMAP1 ZNF2 THRB RAD21 RARA POLR2A SMC3 TMEM187 F8A1 MIR718 IRAK1 MIR3202-2
GH0XI153980 Enhancer 1.3 FANTOM5 Ensembl ENCODE 0.3 +36.2 36172 7.3 HDGF PKNOX1 TAF9B RB1 NFRKB TCF12 ZNF121 ZNF766 RUNX3 RXRA TMEM187 ARHGAP4 MECP2 ABCD1 TAZ RENBP DNASE1L1 MIR3202-1 MIR3202-2 MIR718
GH0XI154007 Enhancer 0.9 Ensembl ENCODE 0.4 +11.8 11827 1.7 PKNOX1 SMAD1 RB1 BACH1 EBF1 BMI1 IRF4 ZFHX2 POLR2A ATF7 TMEM187 MIR718 MIR3202-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR718 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR718 Gene

Genomic Locations for MIR718 Gene
chrX:154,019,920-154,019,989
(GRCh38/hg38)
Size:
70 bases
Orientation:
Minus strand
chrX:153,285,371-153,285,440
(GRCh37/hg19)

Genomic View for MIR718 Gene

Genes around MIR718 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR718 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR718 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR718 Gene

Proteins for MIR718 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR718 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR718 Gene

Domains & Families for MIR718 Gene

Gene Families for MIR718 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR718: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR718 Gene

Function for MIR718 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR718 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR718 Gene

Localization for MIR718 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR718 Gene

Pathways & Interactions for MIR718 Gene

SuperPathways for MIR718 Gene

PathCards logo More details on SuperPathways for MIR718
SuperPathway Contained pathways
1 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
activated TAK1 mediates p38 MAPK activation
.01
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
.01
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
.01
2 Diseases associated with the TLR signaling cascade
Toll-like Receptor Signaling
.44
TLR4 Signaling and Tolerance
.38
Simplified Depiction of MYD88 Distinct Input-Output Pathway
.34
Interleukin-1 Induced Activation of NF-kappa-B
.32
IRAK1 recruits IKK complex
.31
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
.01
3 p75 NTR receptor-mediated signalling
p75 NTR receptor-mediated signalling
.78
NF-kB is activated and signals survival
.01
p75NTR recruits signalling complexes
.01
p75NTR signals via NF-kB
.01
4 IL-1 signaling pathway
IL-1 signaling pathway
.51
Structural Pathway of Interleukin 1 (IL-1)
.51
Interleukin-1 signaling
.41
5 Cytokine Signaling in Immune system
Cytokine Signaling in Immune system
.70
Signaling by Interleukins
.70
genes like me logo Genes that share pathways with MIR718: view

Interacting Proteins for MIR718 Gene

Gene Ontology (GO) - Biological Process for MIR718 Gene

None

No data available for SIGNOR curated interactions for MIR718 Gene

Drugs & Compounds for MIR718 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR718 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR718 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR718 Gene

No ASD Table

Relevant External Links for MIR718 Gene

GeneLoc Exon Structure for
MIR718
ECgene alternative splicing isoforms for
MIR718

Expression for MIR718 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR718 Gene

mRNA expression in normal human tissues for MIR718 Gene
mRNA expression by GTEx for MIR718 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR718 Gene:

MIR718
genes like me logo Genes that share expression patterns with MIR718: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR718 Gene

Orthologs for MIR718 Gene

Evolution for MIR718 Gene

ENSEMBL:
Gene Tree for MIR718 (if available)
TreeFam:
Gene Tree for MIR718 (if available)

No data available for Orthologs for MIR718 Gene

Paralogs for MIR718 Gene

No data available for Paralogs for MIR718 Gene

Variants for MIR718 Gene

Sequence variations from dbSNP and Humsavar for MIR718 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs267608360 benign, not specified 154,021,864(-) GGGGGGGGGG/GGGGGGGG/GGGGGGGGG/GGGGGGGGGGG upstream_transcript_variant
rs267608391 benign, not specified 154,021,867(-) G/C upstream_transcript_variant
rs1005276589 -- 154,020,892(-) C/T upstream_transcript_variant
rs1005616683 -- 154,020,460(-) C/T upstream_transcript_variant
rs1012794698 -- 154,021,608(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR718 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv1133775 CNV deletion 24896259

Additional Variant Information for MIR718 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR718

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR718 Gene

Disorders for MIR718 Gene

Additional Disease Information for MIR718

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR718 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR718 Gene

Publications for MIR718 Gene

  1. Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells. (PMID: 28070994) Wang ZD … Zhang HD (Journal of Zhejiang University. Science. B 2017) 3 58
  2. Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma. (PMID: 26756617) Sun L … He F (Cancer biomarkers : section A of Disease markers 2016) 3 58
  3. Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. (PMID: 25584485) Sugimachi K … Mimori K (British journal of cancer 2015) 3 58
  4. MiR-718 represses VEGF and inhibits ovarian cancer cell progression. (PMID: 24815691) Leng R … Tang L (FEBS letters 2014) 3 58
  5. miRNAminer: a tool for homologous microRNA gene search. (PMID: 18215311) Artzi S … Shomron N (BMC bioinformatics 2008) 3 58

Products for MIR718 Gene

Sources for MIR718 Gene

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