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Aliases for MIR718 Gene

Subcategory (RNA class) for MIR718 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR718 Gene

  • MicroRNA 718 2 3 5
  • Hsa-Mir-718 3

External Ids for MIR718 Gene

Previous GeneCards Identifiers for MIR718 Gene

  • GC00U930648
  • GC0XM153286

Summaries for MIR718 Gene

Entrez Gene Summary for MIR718 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR718 Gene

MIR718 (MicroRNA 718) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are IL-1 signaling pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR718 Gene

Genomics for MIR718 Gene

Regulatory Elements for MIR718 Gene

Enhancers for MIR718 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG154017 0.9 ENCODE 0.7 0.0 -21 4.2 HDGF RB1 ZNF2 YY1 GLIS2 ELK1 EGR1 ZNF362 HCFC1 SMAD5 TMEM187 MIR718 GC0XP154020
GH0XG154001 1.2 Ensembl ENCODE 0.4 +17.6 17580 1.7 PKNOX1 ATF1 YY1 ZNF121 ZNF766 ELK1 KLF13 CAVIN1 REST ZNF592 HCFC1 TMEM187 HCFC1-AS1 IRAK1 EMD MIR718 MIR3202-2
GH0XG153980 1.5 FANTOM5 Ensembl ENCODE 0.3 +36.2 36172 7.3 HDGF PKNOX1 ARNT TCF12 ZNF121 ZNF766 ZNF263 SP3 ZNF592 SREBF1 TMEM187 ARHGAP4 MECP2 ABCD1 TAZ RENBP DNASE1L1 MIR3202-2 MIR718
GH0XG154009 1.1 Ensembl ENCODE 0.4 +8.1 8132 4.6 CTCF FOXA2 CEBPG DMAP1 ZNF2 THRB RAD21 RARA POLR2A ZNF143 TMEM187 F8A1 MIR718 MIR3202-2
GH0XG154007 1 Ensembl ENCODE 0.4 +11.8 11828 1.7 PKNOX1 AGO1 BACH1 BMI1 EBF1 ZFHX2 ARID3A POLR2A EED ZNF600 TMEM187 MIR718 MIR3202-2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR718 on UCSC Golden Path with GeneCards custom track

Promoters for MIR718 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249628 389 2001 HDGF RB1 ZNF2 YY1 GLIS2 ELK1 FOS HCFC1 ZBTB11 ZHX2

Genomic Location for MIR718 Gene

Chromosome:
X
Start:
154,019,920 bp from pter
End:
154,019,989 bp from pter
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR718 Gene

Genes around MIR718 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR718 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR718 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR718 Gene

Proteins for MIR718 Gene

Post-translational modifications for MIR718 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR718 Gene

Domains & Families for MIR718 Gene

Gene Families for MIR718 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR718: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR718 Gene

Function for MIR718 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR718 Gene

Localization for MIR718 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR718 Gene

Pathways & Interactions for MIR718 Gene

SuperPathways for MIR718 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Diseases associated with the TLR signaling cascade
3 p75 NTR receptor-mediated signalling
4 IL-1 signaling pathway
5 Cytokine Signaling in Immune system
genes like me logo Genes that share pathways with MIR718: view

Interacting Proteins for MIR718 Gene

Gene Ontology (GO) - Biological Process for MIR718 Gene

None

No data available for SIGNOR curated interactions for MIR718 Gene

Drugs & Compounds for MIR718 Gene

No Compound Related Data Available

Transcripts for MIR718 Gene

mRNA/cDNA for MIR718 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR718 Gene

No ASD Table

Relevant External Links for MIR718 Gene

GeneLoc Exon Structure for
MIR718
ECgene alternative splicing isoforms for
MIR718

Expression for MIR718 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR718 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR718 Gene:

MIR718
genes like me logo Genes that share expression patterns with MIR718: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR718 Gene

Orthologs for MIR718 Gene

Evolution for MIR718 Gene

ENSEMBL:
Gene Tree for MIR718 (if available)
TreeFam:
Gene Tree for MIR718 (if available)

No data available for Orthologs for MIR718 Gene

Paralogs for MIR718 Gene

No data available for Paralogs for MIR718 Gene

Variants for MIR718 Gene

Sequence variations from dbSNP and Humsavar for MIR718 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs267608360 Benign 154,021,864(-) CCCCC(-/C)ACTGA upstream-variant-2KB, utr-variant-3-prime
rs267608391 Benign 154,021,867(-) CCCCC(C/G)CCCAC upstream-variant-2KB, utr-variant-3-prime
rs267608396 Benign 154,021,863(-) AAACA(-/C)CCCCC upstream-variant-2KB, utr-variant-3-prime
rs1005276589 -- 154,020,892(+) ACTTA(C/T)ACACA upstream-variant-2KB
rs1005616683 -- 154,020,460(+) CACCC(C/T)GTACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR718 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv1133775 CNV deletion 24896259

Relevant External Links for MIR718 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR718

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR718 Gene

Disorders for MIR718 Gene

Relevant External Links for MIR718

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR718

No disorders were found for MIR718 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR718 Gene

Publications for MIR718 Gene

  1. Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma. (PMID: 26756617) Sun L. … He F. (Cancer Biomark 2016) 3 64
  2. Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. (PMID: 25584485) Sugimachi K. … Mimori K. (Br. J. Cancer 2015) 3 64
  3. MiR-718 represses VEGF and inhibits ovarian cancer cell progression. (PMID: 24815691) Leng R. … Tang L. (FEBS Lett. 2014) 3 64
  4. miRNAminer: a tool for homologous microRNA gene search. (PMID: 18215311) Artzi S. … Shomron N. (BMC Bioinformatics 2008) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR718 Gene

Sources for MIR718 Gene

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