Aliases for MIR718 Gene
Subcategory (RNA class) for MIR718 Gene
miRNA
Quality Score for this RNA gene is
3
External Ids for MIR718 Gene
- HGNC: 37317
- Entrez Gene: 100313781
- Ensembl: ENSG00000284286
- OMIM: 300929
- miRBase: hsa-mir-718
ORGUL Members for MIR718 Gene
Previous GeneCards Identifiers for MIR718 Gene
- GC00U930648
- GC0XM153286
Summaries for MIR718 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR718 Gene
MIR718 (MicroRNA 718) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are IL-1 signaling pathway and Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways.
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR718 Gene
Genomics for MIR718 Gene
Regulatory Elements for MIR718 Gene
Enhancers for MIR718 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH0XG154017 | 0.9 | ENCODE | 0.7 | 0.0 | -21 | 4.2 | HDGF RB1 ZNF2 YY1 GLIS2 ELK1 EGR1 ZNF362 HCFC1 SMAD5 | TMEM187 MIR718 GC0XP154020 |
| GH0XG154001 | 1.2 | Ensembl ENCODE | 0.4 | +17.6 | 17580 | 1.7 | PKNOX1 ATF1 YY1 ZNF121 ZNF766 ELK1 KLF13 CAVIN1 REST ZNF592 | HCFC1 TMEM187 HCFC1-AS1 IRAK1 EMD MIR718 MIR3202-2 |
| GH0XG153980 | 1.5 | FANTOM5 Ensembl ENCODE | 0.3 | +36.2 | 36172 | 7.3 | HDGF PKNOX1 ARNT TCF12 ZNF121 ZNF766 ZNF263 SP3 ZNF592 SREBF1 | TMEM187 ARHGAP4 MECP2 ABCD1 TAZ RENBP DNASE1L1 MIR3202-2 MIR718 |
| GH0XG154009 | 1.1 | Ensembl ENCODE | 0.4 | +8.1 | 8132 | 4.6 | CTCF FOXA2 CEBPG DMAP1 ZNF2 THRB RAD21 RARA POLR2A ZNF143 | TMEM187 F8A1 MIR718 MIR3202-2 |
| GH0XG154007 | 1 | Ensembl ENCODE | 0.4 | +11.8 | 11828 | 1.7 | PKNOX1 AGO1 BACH1 BMI1 EBF1 ZFHX2 ARID3A POLR2A EED ZNF600 | TMEM187 MIR718 MIR3202-2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around MIR718 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for MIR718 Gene
- Chromosome:
- X
- Start:
- 154,019,920 bp from pter
- End:
- 154,019,989 bp from pter
- Size:
- 70 bases
- Orientation:
- Minus strand
Genomic View for MIR718 Gene
Genes around MIR718 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq28 by Ensembl
- Xq28 by Entrez Gene
- Xq28 by HGNC
MIR718 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR718 Gene
Proteins for MIR718 Gene
Post-translational modifications for MIR718 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR718
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR718
- Origene Custom Protein Services for MIR718
- Search GeneTex for Proteins for MIR718
No data available for DME Specific Peptides for MIR718 Gene
Domains & Families for MIR718 Gene
Gene Families for MIR718 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR718 Gene
Function for MIR718 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR718
-
- Search ViGene Biosciences for MIR718
miRNA Products
- Search ViGene Biosciences for MIR718
-
Origene geneexpression products in human, mouse, rat for MIR718
- Browse OriGene miRNA Products For MIR718
Inhibitory RNA Products
- Search ViGene Biosciences for MIR718
Clone Products
- GenScript: Custom all cDNA clones Services for MIR718
- VectorBuilder custom plasmid, inducible vectors for MIR718
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR718
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR718 Gene
Localization for MIR718 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR718 Gene
Pathways & Interactions for MIR718 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated TLR4 signalling | ||
| 2 | Diseases associated with the TLR signaling cascade | ||
| 3 | p75 NTR receptor-mediated signalling | ||
| 4 | IL-1 signaling pathway | ||
| 5 | Cytokine Signaling in Immune system | ||
Pathways by source for MIR718 Gene
12 BioSystems pathways for MIR718 Gene
37 Reactome pathways for MIR718 Gene
Interacting Proteins for MIR718 Gene
No data available for SIGNOR curated interactions for MIR718 Gene
Transcripts for MIR718 Gene
mRNA/cDNA for MIR718 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
miRNA Products
- Search ViGene Biosciences for MIR718
-
Origene geneexpression products in human, mouse, rat for MIR718
- Browse OriGene miRNA Products For MIR718
Inhibitory RNA Products
- Search ViGene Biosciences for MIR718
Clone Products
- GenScript: Custom all cDNA clones Services for MIR718
- VectorBuilder custom plasmid, inducible vectors for MIR718
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR718
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Expression for MIR718 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR718 Gene:
MIR718Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR718 Gene
Orthologs for MIR718 Gene
No data available for Orthologs for MIR718 Gene
Paralogs for MIR718 Gene
No data available for Paralogs for MIR718 Gene
Variants for MIR718 Gene
| SNP ID | Clin | Chr 0X pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs267608360 | Benign | 154,021,864(-) | CCCCC(-/C)ACTGA | upstream-variant-2KB, utr-variant-3-prime | |
| rs267608391 | Benign | 154,021,867(-) | CCCCC(C/G)CCCAC | upstream-variant-2KB, utr-variant-3-prime | |
| rs267608396 | Benign | 154,021,863(-) | AAACA(-/C)CCCCC | upstream-variant-2KB, utr-variant-3-prime | |
| rs1005276589 | -- | 154,020,892(+) | ACTTA(C/T)ACACA | upstream-variant-2KB | |
| rs1005616683 | -- | 154,020,460(+) | CACCC(C/T)GTACC | upstream-variant-2KB |
Relevant External Links for MIR718 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR718
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR718 Gene
Disorders for MIR718 Gene
Relevant External Links for MIR718
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- MIR718
No disorders were found for MIR718 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR718 Gene
Publications for MIR718 Gene
- Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma. (PMID: 26756617) Sun L. … He F. (Cancer Biomark 2016) 3 64
- Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. (PMID: 25584485) Sugimachi K. … Mimori K. (Br. J. Cancer 2015) 3 64
- MiR-718 represses VEGF and inhibits ovarian cancer cell progression. (PMID: 24815691) Leng R. … Tang L. (FEBS Lett. 2014) 3 64
- miRNAminer: a tool for homologous microRNA gene search. (PMID: 18215311) Artzi S. … Shomron N. (BMC Bioinformatics 2008) 3 64
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
Products for MIR718 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
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- Custom Antibody Services
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- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR718
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- Browse CRISPR knockouts for MIR718
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Browse OriGene miRNA Products For MIR718
- GenScript: Custom all cDNA clones Services for MIR718
- GenScript Custom Purified and Recombinant Proteins Services for MIR718
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- Design optimal peptide antigens
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- Browse Sino Biological cDNA Clones
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- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies at Cloud-Clone Corp.
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Search GeneTex for Antibodies for MIR718
- Search GeneTex for Proteins for MIR718
- Search ViGene Biosciences for MIR718
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR718
- VectorBuilder custom plasmid, inducible vectors for MIR718
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR718
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for MIR718 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus Biologicals
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer
- (156) abm
- (157) CrownBio