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Aliases for MIR718 Gene

Subcategory (RNA class) for MIR718 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR718 Gene

  • MicroRNA 718 2 3
  • EC 2.7.11.1 4 61
  • IRAK1 4 5
  • Interleukin 1 Receptor Associated Kinase 1 5
  • Hsa-Mir-718 3
  • EC 2.7.11 61
  • IRAK-1 4
  • IRAK 4

External Ids for MIR718 Gene

Previous GeneCards Identifiers for MIR718 Gene

  • GC00U930648
  • GC0XM153286

Summaries for MIR718 Gene

Entrez Gene Summary for MIR718 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR718 Gene

MIR718 (MicroRNA 718) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Activated TLR4 signalling and Interleukin-1 signaling. An important paralog of this gene is IRAK2.

UniProtKB/Swiss-Prot for MIR718 Gene

  • Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR718 Gene

Genomics for MIR718 Gene

Regulatory Elements for MIR718 Gene

Enhancers for MIR718 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF154049 0.5 ENCODE 13.6 -29.9 -29896 0.2 GATA3 PKNOX1 CTBP1 IRAK1 MIR718 HCFC1 TMEM187 HCFC1-AS1 ATP6AP1 PIR60620
GH0XF154051 0.5 ENCODE 13.6 -31.3 -31305 0.4 ZNF263 CTCF ZNF654 ZNF143 SMC3 TRIM22 ZNF384 RAD21 IRAK1 MIR718 HCFC1 TMEM187 HCFC1-AS1 PIR60620
GH0XF154038 1.2 FANTOM5 Ensembl ENCODE 13.5 -23.3 -23315 9.2 ZNF133 FEZF1 RAD21 ZNF121 GATA2 SCRT2 FOS EGR2 CEBPB NR2F2 TMEM187 HCFC1 MIR718 HCFC1-AS1 PLXNA3 IKBKG ABCD1 DNASE1L1 MECP2 FAM50A
GH0XF154056 0.7 Ensembl ENCODE 13.5 -37.2 -37188 1.8 ELF3 MLX ARID4B DMAP1 THRB ZNF48 ZSCAN9 RAD21 ZNF2 RARA IRAK1 MIR718 TMEM187 HCFC1 HCFC1-AS1 ATP6AP1 PIR60620
GH0XF154090 0.4 ENCODE 13.1 -72.1 -72057 2.4 CTCF HDAC1 ESRRA ETV1 CBX5 NR2F6 CREM ZNF362 RFX1 DPF2 IRAK1 MIR718 PLXNA3 HCFC1 TMEM187 PIR60620 MECP2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR718 on UCSC Golden Path with GeneCards custom track

Promoters for MIR718 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000073928 489 2601 ZNF2 YY1 GLIS2 HCFC1 ZBTB11 ZEB2 POLR2H ZNF341 MYC ZBTB26

Genomic Location for MIR718 Gene

Chromosome:
X
Start:
154,010,500 bp from pter
End:
154,019,989 bp from pter
Size:
9,490 bases
Orientation:
Minus strand

Genomic View for MIR718 Gene

Genes around MIR718 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR718 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR718 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR718 Gene

Proteins for MIR718 Gene

  • Protein details for MIR718 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51617-IRAK1_HUMAN
    Recommended name:
    Interleukin-1 receptor-associated kinase 1
    Protein Accession:
    P51617
    Secondary Accessions:
    • D3DWW3
    • D3DWW4
    • Q7Z5V4
    • Q96C06
    • Q96RL2

    Protein attributes for MIR718 Gene

    Size:
    712 amino acids
    Molecular mass:
    76537 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer (By similarity). Forms a complex with TRAF6, PELI1, IRAK4 and MYD88 (PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:16951688). The TRAF6-PELI1-IRAK4-MYD88 complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation (PubMed:16951688). Interaction with MYD88 recruits IRAK1 to the stimulated receptor complex (PubMed:9430229). Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation (PubMed:10854325). Interacts with IL1RL1 (PubMed:16286016). Interacts with PELI1 and TRAF6 (PubMed:12496252). Interacts (when polyubiquitinated) with IKBKG/NEMO (PubMed:18347055). Interacts with RSAD2/viperin (By similarity). Interacts with IRAK1BP1 (By similarity). Interacts with PELI2 (By similarity). Interacts with ZC3H12A; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity). Interacts with IRAK4 (PubMed:11960013). Interacts with PELI3 (PubMed:12874243).
    • Homodimer (By similarity). Forms a complex with TRAF6, PELI1, IRAK4 and MYD88 (PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:16951688). The TRAF6-PELI1-IRAK4-MYD88 complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation (PubMed:16951688). Interaction with MYD88 recruits IRAK1 to the stimulated receptor complex (PubMed:9430229). Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation (PubMed:10854325). Interacts with IL1RL1 (PubMed:16286016). Interacts with PELI1 and TRAF6 (PubMed:12496252). Interacts (when polyubiquitinated) with IKBKG/NEMO (PubMed:18347055). Interacts with RSAD2/viperin (By similarity). Interacts with IRAK1BP1 (By similarity). Interacts with PELI2 (By similarity). Interacts with ZC3H12A; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity). Interacts with IRAK4 (PubMed:11960013). Interacts with PELI3 (PubMed:12874243).

    Alternative splice isoforms for MIR718 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR718 Gene

Selected DME Specific Peptides for MIR718 Gene

Post-translational modifications for MIR718 Gene

  • Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting in a conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387 phosphorylation in the activation loop is required to achieve full enzymatic activity.
  • Polyubiquitinated by TRAF6 after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with polyubiquitin chains linked through Lys-63. Ubiquitination promotes interaction with NEMO/IKBKG. Also sumoylated; leading to nuclear translocation.
  • Ubiquitination at Lys 134, Lys 180, Lys 342, Lys 355, and Lys 397
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR718 Gene

Gene Families for MIR718 Gene

Graphical View of Domain Structure for InterPro Entry

P51617

UniProtKB/Swiss-Prot:

IRAK1_HUMAN :
  • The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
Domain:
  • The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation.
  • Contains 1 death domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.
genes like me logo Genes that share domains with MIR718: view

No data available for Suggested Antigen Peptide Sequences for MIR718 Gene

Function for MIR718 Gene

Molecular function for MIR718 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.

Enzyme Numbers (IUBMB) for MIR718 Gene

Gene Ontology (GO) - Molecular Function for MIR718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004704 NF-kappaB-inducing kinase activity TAS --
GO:0005515 protein binding IPI --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MIR718: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR718 Gene

Localization for MIR718 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR718 Gene

Cytoplasm. Nucleus. Lipid droplet. Note=Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MIR718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005811 lipid particle ISS --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with MIR718: view

No data available for Subcellular locations from COMPARTMENTS for MIR718 Gene

Pathways & Interactions for MIR718 Gene

SuperPathways for MIR718 Gene

genes like me logo Genes that share pathways with MIR718: view

Gene Ontology (GO) - Biological Process for MIR718 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS --
GO:0001959 regulation of cytokine-mediated signaling pathway IMP --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002376 immune system process IEA --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MIR718: view

No data available for SIGNOR curated interactions for MIR718 Gene

Transcripts for MIR718 Gene

mRNA/cDNA for MIR718 Gene

(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR718 Gene

No ASD Table

Relevant External Links for MIR718 Gene

GeneLoc Exon Structure for
MIR718
ECgene alternative splicing isoforms for
MIR718

Expression for MIR718 Gene

mRNA expression in normal human tissues for MIR718 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR718 Gene:

MIR718

mRNA Expression by UniProt/SwissProt for MIR718 Gene:

P51617-IRAK1_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.
genes like me logo Genes that share expression patterns with MIR718: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR718 Gene

Orthologs for MIR718 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR718 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia IRAK1 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IRAK1 35
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia IRAK1 35
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Irak1 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia IRAK1 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IRAK1 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IRAK1 35
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii irak1 35
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pll 35
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pik-1 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for MIR718 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR718 Gene

ENSEMBL:
Gene Tree for MIR718 (if available)
TreeFam:
Gene Tree for MIR718 (if available)

Paralogs for MIR718 Gene

Paralogs for MIR718 Gene

Pseudogenes.org Pseudogenes for MIR718 Gene

genes like me logo Genes that share paralogs with MIR718: view

Variants for MIR718 Gene

Sequence variations from dbSNP and Humsavar for MIR718 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs267608360 Benign 154,021,864(-) CCCCC(-/C)ACTGA upstream-variant-2KB, utr-variant-3-prime
rs267608391 Benign 154,021,867(-) CCCCC(C/G)CCCAC upstream-variant-2KB, utr-variant-3-prime
rs267608396 Benign 154,021,863(-) CCCCC(-/C)ACTGA upstream-variant-2KB, utr-variant-3-prime
rs113551912 -- 154,019,429(+) CGCTC(A/C/T)CAGGC downstream-variant-500B, splice-donor-variant
rs12848461 -- 154,020,189(+) AGCTC(A/C)TGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR718 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV gain+loss 17666407
esv33784 CNV gain+loss 17666407
nsv1133775 CNV deletion 24896259

Relevant External Links for MIR718 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR718

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR718 Gene

Disorders for MIR718 Gene

Relevant External Links for MIR718

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR718

No disorders were found for MIR718 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR718 Gene

Publications for MIR718 Gene

  1. Predictive value of plasma miRNA-718 for esophageal squamous cell carcinoma. (PMID: 26756617) Sun L. … He F. (Cancer Biomark 2016) 3 64
  2. Identification of a bona fide microRNA biomarker in serum exosomes that predicts hepatocellular carcinoma recurrence after liver transplantation. (PMID: 25584485) Sugimachi K. … Mimori K. (Br. J. Cancer 2015) 3 64
  3. MiR-718 represses VEGF and inhibits ovarian cancer cell progression. (PMID: 24815691) Leng R. … Tang L. (FEBS Lett. 2014) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for MIR718 Gene

Sources for MIR718 Gene

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