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Aliases for MIR708 Gene

Subcategory (RNA class) for MIR708 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR708 Gene

  • MicroRNA 708 2 3 5
  • Hsa-Mir-708 3
  • MIRN708 3

External Ids for MIR708 Gene

Previous HGNC Symbols for MIR708 Gene

  • MIRN708

Previous GeneCards Identifiers for MIR708 Gene

  • GC11M078793
  • GC11M079113

Summaries for MIR708 Gene

Entrez Gene Summary for MIR708 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR708 Gene

MIR708 (MicroRNA 708) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

fRNAdb sequence ontologies for MIR708 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR708

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR708 Gene

Genomics for MIR708 Gene

Regulatory Elements for MIR708 Gene

Enhancers for MIR708 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F079371 0.2 ENCODE 10.9 +30.7 30738 0.2 CTCF ZMYM3 MIR708 TENM4 GC11M079348
GH11F079433 0.2 ENCODE 10.8 -32.2 -32152 0.9 MIR708 TENM4 MIR5579
GH11F079375 1.1 Ensembl ENCODE 10.5 +25.8 25841 1.3 ELF3 SOX13 TEAD1 NFIA SIN3A REST RAD21 NR2F2 TEAD3 JUND MIR708 TENM4 GC11M079348
GH11F079266 0.2 ENCODE 9 +135.5 135519 0.2 FEZF1 MIR708 ENSG00000254885 GC11M079348
GH11F079267 0.2 ENCODE 9 +136.0 136019 0.2 ZFP3 REST MIR708 ENSG00000254885 GC11M079348
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR708 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR708 Gene

Chromosome:
11
Start:
79,402,022 bp from pter
End:
79,402,109 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR708 Gene

Genes around MIR708 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR708 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR708 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR708 Gene

ORGUL Member Location for MIR708 Gene

ORGUL Member Location for MIR708 gene

Proteins for MIR708 Gene

Post-translational modifications for MIR708 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR708 Gene

Domains & Families for MIR708 Gene

Gene Families for MIR708 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR708: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR708 Gene

Function for MIR708 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR708 Gene

Localization for MIR708 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR708 Gene

Pathways & Interactions for MIR708 Gene

genes like me logo Genes that share pathways with MIR708: view

Pathways by source for MIR708 Gene

1 BioSystems pathway for MIR708 Gene

Interacting Proteins for MIR708 Gene

Gene Ontology (GO) - Biological Process for MIR708 Gene

None

No data available for SIGNOR curated interactions for MIR708 Gene

Transcripts for MIR708 Gene

fRNAdb Secondary structures for MIR708 Gene

  • hsa-miR-708-3p_MIMAT0004927_Homo_sapiens_miR-708-3p_mature

mRNA/cDNA for MIR708 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR708 Gene

No ASD Table

Relevant External Links for MIR708 Gene

GeneLoc Exon Structure for
MIR708
ECgene alternative splicing isoforms for
MIR708

Expression for MIR708 Gene

mRNA expression in normal human tissues for MIR708 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR708 Gene:

MIR708
genes like me logo Genes that share expression patterns with MIR708: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR708 Gene

Orthologs for MIR708 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR708 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-708 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-708 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-708 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir708 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
OneToOne
Species where no ortholog for MIR708 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR708 Gene

ENSEMBL:
Gene Tree for MIR708 (if available)
TreeFam:
Gene Tree for MIR708 (if available)

Paralogs for MIR708 Gene

No data available for Paralogs for MIR708 Gene

Variants for MIR708 Gene

Sequence variations from dbSNP and Humsavar for MIR708 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111275230 -- 79,401,950(+) GTGGT(C/T)GACGC intron-variant, downstream-variant-500B
rs113353613 -- 79,404,005(+) GTCCC(A/C)AGAAA intron-variant, upstream-variant-2KB
rs138529973 -- 79,403,680(+) TGTCT(-/TCCCTCAAC)TCCCT intron-variant, upstream-variant-2KB
rs138842347 -- 79,402,442(+) TTCAC(C/T)TTTGC intron-variant, upstream-variant-2KB
rs141013435 -- 79,401,953(+) GTTGA(C/T)GCCAT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR708 Gene

Variant ID Type Subtype PubMed ID
nsv832214 CNV gain 17160897
nsv832216 CNV gain 17160897

Relevant External Links for MIR708 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR708

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR708 Gene

Disorders for MIR708 Gene

Relevant External Links for MIR708

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR708

No disorders were found for MIR708 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR708 Gene

Publications for MIR708 Gene

  1. MicroRNA-708-5p acts as a therapeutic agent against metastatic lung cancer. (PMID: 26678031) Wu X. … Luo Z. (Oncotarget 2016) 3 64
  2. MicroRNA Mediated Chemokine Responses in Human Airway Smooth Muscle Cells. (PMID: 26998837) Dileepan M. … Kannan M.S. (PLoS ONE 2016) 3 64
  3. Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B. (PMID: 25569036) Lin K.T. … Wang L.H. (Nat Commun 2015) 3 64
  4. Epigenetic silencing of miR-708 enhances NF-I_B signaling in chronic lymphocytic leukemia. (PMID: 25704289) Baer C. … Plass C. (Int. J. Cancer 2015) 3 64
  5. MicroRNA-708 is downregulated in hepatocellular carcinoma and suppresses tumor invasion and migration. (PMID: 26211597) Li G. … Liu J. (Biomed. Pharmacother. 2015) 3 64

Products for MIR708 Gene

Sources for MIR708 Gene

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