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Aliases for MIR708 Gene

Subcategory (RNA class) for MIR708 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR708 Gene

  • MicroRNA 708 2 3
  • Hsa-Mir-708 3
  • MIRN708 3

External Ids for MIR708 Gene

Previous Symbols for MIR708 Gene

  • MIRN708

Summaries for MIR708 Gene

Entrez Gene Summary for MIR708 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR708 Gene

MIR708 (MicroRNA 708) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR708 include ewing sarcoma.

fRNAdb sequence ontologies for MIR708 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR708

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR708 Gene

Genomics for MIR708 Gene

Genomic Location for MIR708 Gene

Start:
79,402,022 bp from pter
End:
79,402,109 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR708 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR708 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR708 Gene

ORGUL Member Location for MIR708 Gene

ORGUL Member Location for MIR708 gene

No data available for Regulatory Elements for MIR708 Gene

Proteins for MIR708 Gene

Post-translational modifications for MIR708 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR708 Gene

Domains for MIR708 Gene

Gene Families for MIR708 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR708: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR708 Gene

Function for MIR708 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR708 Gene

Localization for MIR708 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR708 Gene

Pathways for MIR708 Gene

SuperPathways for MIR708 Gene

No Data Available

Interacting Proteins for MIR708 Gene

Gene Ontology (GO) - Biological Process for MIR708 Gene

None

No data available for Pathways by source for MIR708 Gene

Transcripts for MIR708 Gene

fRNAdb Secondary structures for MIR708 Gene

  • hsa-miR-708-3p_MIMAT0004927_Homo_sapiens_miR-708-3p_mature

mRNA/cDNA for MIR708 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR708 Gene

No ASD Table

Relevant External Links for MIR708 Gene

GeneLoc Exon Structure for
MIR708
ECgene alternative splicing isoforms for
MIR708

Expression for MIR708 Gene

mRNA expression in normal human tissues for MIR708 Gene

genes like me logo Genes that share expressions with MIR708: view

Orthologs for MIR708 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR708 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-708 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-708 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-708 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir708 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 57 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
-- 37
  • 57 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
-- 37
  • 55 (a)
OneToMany
Species with no ortholog for MIR708:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR708 Gene

ENSEMBL:
Gene Tree for MIR708 (if available)
TreeFam:
Gene Tree for MIR708 (if available)

Paralogs for MIR708 Gene

No data available for Paralogs for MIR708 Gene

Variants for MIR708 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR708 Gene

Variant ID Type Subtype PubMed ID
nsv832214 CNV Gain 17160897
nsv832216 CNV Gain 17160897

Relevant External Links for MIR708 Gene

HapMap Linkage Disequilibrium report
MIR708

No data available for Sequence variations from dbSNP and Humsavar for MIR708 Gene

Disorders for MIR708 Gene

(1) MalaCards Diseases for MIR708 Gene

Search for MIR708 Gene in MalaCards »
genes like me logo Genes that share disorders with MIR708: view

No data available for UniProtKB/Swiss-Prot for MIR708 Gene

Publications for MIR708 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  3. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3
  4. MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells. (PMID: 21852381) Saini S. … Dahiya R. (Cancer Res. 2011) 3
  5. miRNA-708 control of CD44(+) prostate cancer-initiating cells. (PMID: 22552290) Saini S. … Dahiya R. (Cancer Res. 2012) 3

Products for MIR708 Gene

Sources for MIR708 Gene

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