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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR7-3HG Gene

RNA gene   GIFtS: 32
GCID: GC19P004773

MIR7-3 host gene (non-protein coding)

(Previous names: chromosome 19 open reading frame 30, non-protein coding...)
(Previous symbols: C19orf30, NCRNA00306, LINC00306)
  Search for MIR7-3HG
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
MIR7-3 Host Gene (Non-Protein Coding)1 2     PGSF1b1
C19orf301 2 3     Chromosome 19 Open Reading Frame 301
LINC003061 2 3     Long Intergenic Non-Protein Coding RNA 3061
NCRNA003061 2 3     Non-Protein Coding RNA 3061
PGSF11 2 3     Pituitary Gland-Specific Factor 13
PGSF1a1     

External Ids:    HGNC: 300491   Entrez Gene: 2844242   Ensembl: ENSG000001768407   UniProtKB: Q8N6C73   
ORGUL members:         
NONCODE:n407680    

Export aliases for MIR7-3HG gene to outside databases

Previous GC identifer: GC19P004771


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR7-3HG
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR7-3HG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

MIR7-3HG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR7-3HG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004773:  view genomic region     (about GC identifiers)

Start:
4,769,117 bp from pter      End:
4,772,568 bp from pter
Size:
3,452 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PGSF1_HUMAN, Q8N6C7 (See protein sequence)
Recommended Name: Putative uncharacterized protein encoded by MIR7-3HG  
Size: 128 amino acids; 14321 Da
Caution: Product of a dubious CDS prediction. May be a non-coding RNA
Secondary accessions: D6W630 Q17RJ9 Q8N6C6
Alternative splicing: 2 isoforms:  Q8N6C7-1   Q8N6C7-2   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for MIR7-3HG: NX_Q8N6C7

MIR7-3HG Protein expression data from MOPED and PaxDb: --

ENSEMBL proteins: 
 ENSP00000465983   ENSP00000465856   ENSP00000468311   ENSP00000467440   ENSP00000465836  
 ENSP00000467289   ENSP00000467689   ENSP00000465179  

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N6C7


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for MIR7-3HG:
 Synthetic lethal with c-Myc af 

Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MIR7-3HG 

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR7-3HG

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MIR7-3HG
Search CenterWatch for drugs/clinical trials and news about MIR7-3HG 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for MIR7-3HG gene: 
NM_174947.2  

Unigene Cluster for MIR7-3HG:

MIR7-3 host gene (non-protein coding)
Hs.326728  [show with all ESTs]
Unigene Representative Sequence: BE779752
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000317292(uc002mbd.3 uc002mbe.3 uc010xii.2) ENST00000586721
ENST00000592709 ENST00000588711 ENST00000589639 ENST00000591008 ENST00000592663
ENST00000588758 ENST00000588923 ENST00000589368 ENST00000540211

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Additional cDNA sequence: 

AB058892.2 BC090884.1 BC117294.1 BC117296.1 BC143983.1 NR_027148.1 

5 DOTS entries:

DT.75101919  DT.100779671  DT.99976914  DT.121487798  DT.91736370 

24/44 AceView cDNA sequences (see all 44):

AI281968 AI703043 BE550197 AA977000 AW135146 BE220327 AI733168 AW205881 
AI288709 AA976576 BE503154 AB058893 BX096907 AI700564 AB058892 NM_174947 
BE467100 AA988634 CD106009 BE671262 CD109008 CD251059 AI498273 CD513358 

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-3HG (see all 7)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1:                    -     -                                               -                           
SP2:                    -                 -                       -     -     -                           
SP3:                    -                                                                                 
SP4:                                                              -           -                           
SP5:                    -                 -     -     -     -     -     -     -                           


ECgene alternative splicing isoforms for MIR7-3HG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR7-3HG:none

MIR7-3HG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTGAATCA
MIR7-3HG Expression
About this image
Genevestigator expression for MIR7-3HG

SOURCE GeneReport for Unigene cluster: Hs.326728

UniProtKB/Swiss-Prot: PGSF1_HUMAN, Q8N6C7
Tissue specificity: High expression in pituitary gland and weak in pancreas

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for MIR7-3HG (if available)
TreeFam Gene Tree for MIR7-3HG (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/97 NCBI SNPs in MIR7-3HG are shown (see all 97    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1492017241,2
--4767145(+) CTTACC/TGCAAC 1 -- us2k10--------
rs1433388101,2
--4767171(+) TCAAGA/CGATTC 1 -- us2k10--------
rs1512746701,2
--4767257(+) AGAGAC/TGAGGT 1 -- us2k10--------
rs1404815421,2
--4767289(+) GTCTCA/GAACTC 1 -- us2k10--------
rs1456515211,2
--4767424(+) AGAATA/GTCTGG 1 -- us2k10--------
rs116682231,2
C,F,H--4767780(+) AAATAA/GATGGG 1 -- us2k119Minor allele frequency- G:0.09NS EA NA WA 2344
rs169925491,2
C,F,H--4767833(+) CTTACC/TGTAAA 1 -- us2k114Minor allele frequency- T:0.02NA NS EA WA 1536
rs1382484591,2
--4767847(+) ACATGA/TTTGCT 1 -- us2k10--------
rs1427506781,2
--4767857(+) TAGTGC/TCATGC 1 -- us2k10--------
rs559031481,2
C--4767928(+) TACATG/TTTTGA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MIR7-3HG (4769117 - 4772568 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for MIR7-3HG: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR7-3HG gene integrated from 9 sources:
(articles sorted by number of sources associating them with MIR7-3HG)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression profile of active genes in the human pituitary gland. (PubMed id 11854097)1, 2, 3, 9 Tanaka S....Amino N. (2002)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Maternal zinc deficiency raises plasma prolactin levels in lactating rats. (PubMed id 15173390)9 Chowanadisai W....Lonnerdal B. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 284424 HGNC: 30049 AceView: C19orf30 Ensembl:ENSG00000176840 euGenes: HUgn284424
ECgene: MIR7-3HG H-InvDB: MIR7-3HG

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR7-3HG Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR7-3HG gene:
Search GeneIP for patents involving MIR7-3HG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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VWF
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von Willebrand factor
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