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Aliases for MIR7-3 Gene

Subcategory (RNA class) for MIR7-3 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR7-3 Gene

  • MicroRNA 7-3 2 3 5
  • Hsa-Mir-7-3 3
  • MiR-7-5p 3
  • Mir-7-3 3
  • MIRN7-3 3

External Ids for MIR7-3 Gene

ORGUL Members for MIR7-3 Gene

Previous HGNC Symbols for MIR7-3 Gene

  • MIRN7-3

Previous GeneCards Identifiers for MIR7-3 Gene

  • GC19P004726

Summaries for MIR7-3 Gene

Entrez Gene Summary for MIR7-3 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7-3 Gene

MIR7-3 (MicroRNA 7-3) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR7-3 Gene

Genomics for MIR7-3 Gene

Regulatory Elements for MIR7-3 Gene

Enhancers for MIR7-3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G004828 1.3 ENCODE dbSUPER 11.5 +60.5 60497 4.6 HDGF ARNT SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF143 ZNF207 ZNF548 SAFB2 PLIN3 SAFB ARRDC5 FEM1A MIR7-3 MIR7-3HG SNRPEP4 ENSG00000269807 DPP9-AS1
GH19G004744 1.1 Ensembl ENCODE 13.5 -25.6 -25573 1.1 FOXA2 SIN3A INSM2 KLF17 EGR1 ZNF366 ZMIZ1 FOS CREM EGR2 MIR7-3HG MIR7-3 FEM1A DPP9 PLIN3 TRV-CAC3-1 GC19M004737
GH19G004741 0.7 ENCODE 13.5 -28.0 -27956 1.4 MXI1 ZNF473 ZSCAN4 CEBPG ZIC2 ZNF48 RAD21 ZFHX2 ZBTB48 SMC3 MIR7-3HG MIR7-3 FEM1A PLIN3 GC19M004737 TRV-CAC3-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR7-3 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR7-3 Gene

Chromosome:
19
Start:
4,770,670 bp from pter
End:
4,770,779 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR7-3 Gene

Genes around MIR7-3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR7-3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7-3 Gene

Proteins for MIR7-3 Gene

Post-translational modifications for MIR7-3 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR7-3 Gene

Domains & Families for MIR7-3 Gene

Gene Families for MIR7-3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR7-3: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR7-3 Gene

Function for MIR7-3 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7-3 Gene

Localization for MIR7-3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR7-3 Gene

Pathways & Interactions for MIR7-3 Gene

SuperPathways for MIR7-3 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR7-3: view

Pathways by source for MIR7-3 Gene

1 KEGG pathway for MIR7-3 Gene

Interacting Proteins for MIR7-3 Gene

Gene Ontology (GO) - Biological Process for MIR7-3 Gene

None

No data available for SIGNOR curated interactions for MIR7-3 Gene

Drugs & Compounds for MIR7-3 Gene

No Compound Related Data Available

Transcripts for MIR7-3 Gene

mRNA/cDNA for MIR7-3 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-3 Gene

No ASD Table

Relevant External Links for MIR7-3 Gene

GeneLoc Exon Structure for
MIR7-3
ECgene alternative splicing isoforms for
MIR7-3

Expression for MIR7-3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR7-3 Gene

genes like me logo Genes that share expression patterns with MIR7-3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR7-3 Gene

Orthologs for MIR7-3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR7-3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-7-3 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-7-3 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir7b 35
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-7-3 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-7-3 35
  • 76 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CR933818.1 35
  • 63 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-7 35
  • 51 (a)
OneToMany
Species where no ortholog for MIR7-3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR7-3 Gene

ENSEMBL:
Gene Tree for MIR7-3 (if available)
TreeFam:
Gene Tree for MIR7-3 (if available)

Paralogs for MIR7-3 Gene

No data available for Paralogs for MIR7-3 Gene

Variants for MIR7-3 Gene

Sequence variations from dbSNP and Humsavar for MIR7-3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001444042 -- 4,768,952(+) CTAGC(C/T)CAGTT upstream-variant-2KB
rs1001791878 -- 4,769,179(+) GGCAC(A/G)CAGAG nc-transcript-variant, upstream-variant-2KB
rs1003848995 -- 4,770,939(+) CATGC(A/G)CCATG intron-variant, downstream-variant-500B
rs1004263760 -- 4,771,122(+) AAAAA(A/T)ATTAT intron-variant, downstream-variant-500B
rs1005509947 -- 4,769,906(+) TGCAA(G/T)TTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR7-3 Gene

Variant ID Type Subtype PubMed ID
nsv1062709 CNV loss 25217958
nsv578452 CNV loss 21841781

Relevant External Links for MIR7-3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR7-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR7-3 Gene

Disorders for MIR7-3 Gene

Relevant External Links for MIR7-3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR7-3

No disorders were found for MIR7-3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR7-3 Gene

Publications for MIR7-3 Gene

  1. MicroRNA-7 downregulates the oncogene VDAC1 to influence hepatocellular carcinoma proliferation and metastasis. (PMID: 26831666) Wang F. … Chen Z. (Tumour Biol. 2016) 3 64
  2. Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4. (PMID: 27431648) Li Y.Z. … Liu W.C. (Oncol. Rep. 2016) 3 64
  3. miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGI^. (PMID: 25511742) Shi Y. … Ren G. (Cancer Lett. 2015) 3 64
  4. MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death. (PMID: 25814668) Chaudhuri A.D. … Junn E. (J. Biol. Chem. 2015) 3 64
  5. miR-7 modulates chemoresistance of small cell lung cancer by repressing MRP1/ABCC1. (PMID: 26108539) Liu H. … Guo L. (Int J Exp Pathol 2015) 3 64

Products for MIR7-3 Gene

Sources for MIR7-3 Gene

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