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Aliases for MIR7-2 Gene

Subcategory (RNA class) for MIR7-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR7-2 Gene

  • MicroRNA 7-2 2 3 5
  • Hsa-Mir-7-2 3
  • MiR-7-5p 3
  • Mir-7-2 3
  • MIRN7-2 3

External Ids for MIR7-2 Gene

ORGUL Members for MIR7-2 Gene

Previous HGNC Symbols for MIR7-2 Gene

  • MIRN7-2

Previous GeneCards Identifiers for MIR7-2 Gene

  • GC15P086959
  • GC15P089155

Summaries for MIR7-2 Gene

Entrez Gene Summary for MIR7-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7-2 Gene

MIR7-2 (MicroRNA 7-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR7-2 Gene

Genomics for MIR7-2 Gene

Regulatory Elements for MIR7-2 Gene

Enhancers for MIR7-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G088655 1.4 Ensembl ENCODE dbSUPER 11.3 +44.7 44730 3.0 PKNOX1 ZFP64 BMI1 RAD21 EGR1 CBX5 ZNF143 RELB IKZF2 CREM ISG20 AEN MIR7-2 ENSG00000173867 MRPL46 MRPS11 HAPLN3 PIR50540
GH15G088571 0.8 ENCODE 11.2 -39.8 -39765 1.2 ELF3 SIN3A BMI1 RAD21 FOS ZHX2 USF2 ELF1 ZNF579 MBD2 MIR7-2 AEN ENSG00000173867 MRPL46 MRPS11 LINC01586 ENSG00000259569
GH15G088681 0.8 ENCODE 11.2 +70.0 70033 0.7 ELF3 DRAP1 TFAP4 SAP130 MLX MAX DMAP1 ZNF644 ZNF48 YY1 MIR7-2 AEN PIR50540 ISG20
GH15G088476 0.8 ENCODE 11.2 -135.0 -135011 0.1 CTCF USF1 NFIB MAX RAD21 YY1 E2F1 POLR2A FOXK2 HNF4G MIR7-2 ENSG00000279945 PIR48658
GH15G088664 0.5 ENCODE 10.6 +52.8 52780 0.2 CTCF TRIM22 SMC3 RAD21 AEN MIR7-2 ENSG00000173867 MRPL46 MRPS11 ISG20 PIR50540
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR7-2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR7-2 Gene

Chromosome:
15
Start:
88,611,825 bp from pter
End:
88,611,934 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR7-2 Gene

Genes around MIR7-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR7-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7-2 Gene

Proteins for MIR7-2 Gene

Post-translational modifications for MIR7-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR7-2 Gene

Domains & Families for MIR7-2 Gene

Gene Families for MIR7-2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR7-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR7-2 Gene

Function for MIR7-2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7-2 Gene

Localization for MIR7-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR7-2 Gene

Pathways & Interactions for MIR7-2 Gene

SuperPathways for MIR7-2 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR7-2: view

Pathways by source for MIR7-2 Gene

1 KEGG pathway for MIR7-2 Gene

Interacting Proteins for MIR7-2 Gene

Gene Ontology (GO) - Biological Process for MIR7-2 Gene

None

No data available for SIGNOR curated interactions for MIR7-2 Gene

Transcripts for MIR7-2 Gene

mRNA/cDNA for MIR7-2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-2 Gene

No ASD Table

Relevant External Links for MIR7-2 Gene

GeneLoc Exon Structure for
MIR7-2
ECgene alternative splicing isoforms for
MIR7-2

Expression for MIR7-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR7-2 Gene

genes like me logo Genes that share expression patterns with MIR7-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR7-2 Gene

Orthologs for MIR7-2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR7-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-7-2 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-7-1 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7-3 35
  • 80 (a)
OneToMany
oan-mir-7-2 35
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mir7-2 35
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-7-2 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-7-3 35
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-7a-1 35
  • 65 (a)
OneToMany
dre-mir-7a-2 35
  • 53 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-7 35
  • 51 (a)
OneToMany
Species where no ortholog for MIR7-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR7-2 Gene

ENSEMBL:
Gene Tree for MIR7-2 (if available)
TreeFam:
Gene Tree for MIR7-2 (if available)

Paralogs for MIR7-2 Gene

No data available for Paralogs for MIR7-2 Gene

Variants for MIR7-2 Gene

Sequence variations from dbSNP and Humsavar for MIR7-2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000211939 -- 88,610,249(+) CTAAA(A/T)CAATT intron-variant, upstream-variant-2KB
rs1000709408 -- 88,610,476(+) GGGGA(C/G)GAACA intron-variant, upstream-variant-2KB
rs1001074432 -- 88,610,439(+) TGCGG(A/G)GTAGA intron-variant, upstream-variant-2KB
rs1002218760 -- 88,610,801(+) AGAAA(C/T)ACAAT intron-variant, upstream-variant-2KB
rs1002771635 -- 88,611,989(+) TGTTC(-/T)TTTTT intron-variant, downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR7-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR7-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR7-2 Gene

Disorders for MIR7-2 Gene

Relevant External Links for MIR7-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR7-2

No disorders were found for MIR7-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR7-2 Gene

Publications for MIR7-2 Gene

  1. Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma. (PMID: 28314263) Hara K. … Kuwano H. (Anticancer Res. 2017) 3 64
  2. MicroRNA-7 downregulates the oncogene VDAC1 to influence hepatocellular carcinoma proliferation and metastasis. (PMID: 26831666) Wang F. … Chen Z. (Tumour Biol. 2016) 3 64
  3. Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4. (PMID: 27431648) Li Y.Z. … Liu W.C. (Oncol. Rep. 2016) 3 64
  4. miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGI^. (PMID: 25511742) Shi Y. … Ren G. (Cancer Lett. 2015) 3 64
  5. MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death. (PMID: 25814668) Chaudhuri A.D. … Junn E. (J. Biol. Chem. 2015) 3 64

Products for MIR7-2 Gene

Sources for MIR7-2 Gene

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