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Aliases for MIR7-1 Gene

Subcategory (RNA class) for MIR7-1 Gene

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Quality Score for this RNA gene is

8.2

Aliases for MIR7-1 Gene

  • MicroRNA 7-1 2 3 5
  • Hsa-Mir-7-1 3
  • MiR-7-5p 3
  • Mir-7-1 3
  • MIRN7-1 3

External Ids for MIR7-1 Gene

Previous HGNC Symbols for MIR7-1 Gene

  • MIRN7-1

Previous GeneCards Identifiers for MIR7-1 Gene

  • GC09M085776
  • GC09M086584

Summaries for MIR7-1 Gene

Entrez Gene Summary for MIR7-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7-1 Gene

MIR7-1 (MicroRNA 7-1) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer and B Cell Receptor Signaling Pathway (WikiPathways).

fRNAdb sequence ontologies for MIR7-1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR7-1

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR7-1 Gene

Genomics for MIR7-1 Gene

Genomic Location for MIR7-1 Gene

Chromosome:
9
Start:
83,969,748 bp from pter
End:
83,969,857 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR7-1 Gene

Genes around MIR7-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR7-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7-1 Gene

ORGUL Member Location for MIR7-1 Gene

ORGUL Member Location for MIR7-1 gene

No data available for Regulatory Elements for MIR7-1 Gene

Proteins for MIR7-1 Gene

Post-translational modifications for MIR7-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR7-1 Gene

Domains & Families for MIR7-1 Gene

Gene Families for MIR7-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR7-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR7-1 Gene

Function for MIR7-1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7-1 Gene

Localization for MIR7-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR7-1 Gene

Pathways & Interactions for MIR7-1 Gene

genes like me logo Genes that share pathways with MIR7-1: view

Pathways by source for MIR7-1 Gene

2 BioSystems pathways for MIR7-1 Gene
1 KEGG pathway for MIR7-1 Gene

Interacting Proteins for MIR7-1 Gene

Gene Ontology (GO) - Biological Process for MIR7-1 Gene

None

No data available for SIGNOR curated interactions for MIR7-1 Gene

Drugs & Compounds for MIR7-1 Gene

No Compound Related Data Available

Transcripts for MIR7-1 Gene

fRNAdb Secondary structures for MIR7-1 Gene

  • FR244379

mRNA/cDNA for MIR7-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-1 Gene

No ASD Table

Relevant External Links for MIR7-1 Gene

GeneLoc Exon Structure for
MIR7-1
ECgene alternative splicing isoforms for
MIR7-1

Expression for MIR7-1 Gene

mRNA expression in normal human tissues for MIR7-1 Gene

genes like me logo Genes that share expression patterns with MIR7-1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR7-1 Gene

Orthologs for MIR7-1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR7-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-7-2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-7-1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-7 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir7-1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-7-1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-7-1 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-7-1 36
  • 95 (a)
OneToMany
gga-mir-7b 36
  • 93 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-7-2 36
  • 70 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-7b 36
  • 73 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-7 36
  • 53 (a)
OneToMany
Species with no ortholog for MIR7-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR7-1 Gene

ENSEMBL:
Gene Tree for MIR7-1 (if available)
TreeFam:
Gene Tree for MIR7-1 (if available)

Paralogs for MIR7-1 Gene

No data available for Paralogs for MIR7-1 Gene

Variants for MIR7-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR7-1 Gene

Variant ID Type Subtype PubMed ID
nsv469859 CNV Complex 16826518
dgv2394e1 CNV Complex 17122850
nsv8541 CNV Gain 18304495
nsv436717 OTHER Inversion 17901297
nsv831644 CNV Gain 17160897
nsv893514 CNV Gain 21882294

Relevant External Links for MIR7-1 Gene

HapMap Linkage Disequilibrium report
MIR7-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR7-1 Gene

Disorders for MIR7-1 Gene

Relevant External Links for MIR7-1

Human Genome Epidemiology (HuGE) Navigator
MIR7-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR7-1

No disorders were found for MIR7-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR7-1 Gene

Publications for MIR7-1 Gene

  1. MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death. (PMID: 25814668) Chaudhuri A.D. … Junn E. (J. Biol. Chem. 2015) 3 67
  2. miR-7-5p suppresses cell proliferation and induces apoptosis of breast cancer cells mainly by targeting REGI^. (PMID: 25511742) Shi Y. … Ren G. (Cancer Lett. 2015) 3
  3. miR-7 expression in serous ovarian carcinomas. (PMID: 25862909) Swiercz A. … Siwicki J.K. (Anticancer Res. 2015) 3
  4. MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts. (PMID: 24134702) Midgley A.C. … Steadman R. (Aging Cell 2014) 3
  5. PAX6, a novel target of microRNA-7, promotes cellular proliferation and invasion in human colorectal cancer cells. (PMID: 24185687) Li Y. … Li G. (Dig. Dis. Sci. 2014) 3

Products for MIR7-1 Gene

Sources for MIR7-1 Gene

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