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Aliases for MIR7-1 Gene

Subcategory (RNA class) for MIR7-1 Gene

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Quality Score for this RNA gene is

8.2

Aliases for MIR7-1 Gene

  • MicroRNA 7-1 2 3 5
  • Hsa-Mir-7-1 3
  • MiR-7-5p 3
  • Mir-7-1 3
  • MIRN7-1 3

External Ids for MIR7-1 Gene

Previous HGNC Symbols for MIR7-1 Gene

  • MIRN7-1

Previous GeneCards Identifiers for MIR7-1 Gene

  • GC09M085776
  • GC09M086584

Summaries for MIR7-1 Gene

Entrez Gene Summary for MIR7-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7-1 Gene

MIR7-1 (MicroRNA 7-1) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR7-1 include Au-Kline Syndrome. Among its related pathways are Gene Expression and Metabolism of proteins.

fRNAdb sequence ontologies for MIR7-1 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR7-1

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR7-1 Gene

Genomics for MIR7-1 Gene

Regulatory Elements for MIR7-1 Gene

Enhancers for MIR7-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G083965 1 Ensembl ENCODE 0.7 +4.3 4269 1.2 HDAC1 PKNOX1 CEBPG ZNF48 ZNF324 POLR2A ZNF600 PAF1 SMAD5 KLF6 KIF27 LOC105376116 IDNK ENSG00000231616 MIR7-1 C9orf64
GH09G083961 0.9 ENCODE 0.4 +7.4 7375 1.3 TBP PKNOX1 ZSCAN4 INSM2 FEZF1 YY1 KLF7 ZNF362 CEBPB ZEB2 KIF27 LOC105376116 RMI1 C9orf64 MIR7-1
GH09G083959 0.6 ENCODE 0.4 +10.6 10627 0.2 ZNF394 ZNF384 TEAD3 JUND MAFF ZNF629 PRDM10 WT1 MAFK ZXDB C9orf64 MIR7-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR7-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR7-1 Gene

Chromosome:
9
Start:
83,969,748 bp from pter
End:
83,969,857 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR7-1 Gene

Genes around MIR7-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR7-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7-1 Gene

ORGUL Member Location for MIR7-1 Gene

ORGUL Member Location for MIR7-1 gene

Proteins for MIR7-1 Gene

Post-translational modifications for MIR7-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR7-1 Gene

Domains & Families for MIR7-1 Gene

Gene Families for MIR7-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR7-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR7-1 Gene

Function for MIR7-1 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7-1 Gene

Localization for MIR7-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR7-1 Gene

Pathways & Interactions for MIR7-1 Gene

genes like me logo Genes that share pathways with MIR7-1: view

Pathways by source for MIR7-1 Gene

1 KEGG pathway for MIR7-1 Gene

Interacting Proteins for MIR7-1 Gene

Gene Ontology (GO) - Biological Process for MIR7-1 Gene

None

No data available for SIGNOR curated interactions for MIR7-1 Gene

Drugs & Compounds for MIR7-1 Gene

No Compound Related Data Available

Transcripts for MIR7-1 Gene

fRNAdb Secondary structures for MIR7-1 Gene

  • FR244379

mRNA/cDNA for MIR7-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-1 Gene

No ASD Table

Relevant External Links for MIR7-1 Gene

GeneLoc Exon Structure for
MIR7-1
ECgene alternative splicing isoforms for
MIR7-1

Expression for MIR7-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR7-1 Gene

genes like me logo Genes that share expression patterns with MIR7-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR7-1 Gene

Orthologs for MIR7-1 Gene

Evolution for MIR7-1 Gene

ENSEMBL:
Gene Tree for MIR7-1 (if available)
TreeFam:
Gene Tree for MIR7-1 (if available)

No data available for Orthologs for MIR7-1 Gene

Paralogs for MIR7-1 Gene

No data available for Paralogs for MIR7-1 Gene

Variants for MIR7-1 Gene

Sequence variations from dbSNP and Humsavar for MIR7-1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs767454980 Pathogenic 83,970,273(+) CTCCC(A/G/T)ACTCA upstream-variant-2KB, reference, missense, stop-gained
rs1002519950 -- 83,969,629(+) TAAAT(C/T)GGACA intron-variant, downstream-variant-500B
rs1003514753 -- 83,969,638(+) CATTA(A/G)TAGAA intron-variant, downstream-variant-500B
rs1006188137 -- 83,970,973(+) TACTT(A/T)AAAAA intron-variant, upstream-variant-2KB
rs1006460187 -- 83,971,517(+) AATCC(C/T)CCAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR7-1 Gene

Variant ID Type Subtype PubMed ID
esv2759701 CNV gain 17122850
esv3620911 CNV gain 21293372
nsv1043703 CNV gain 25217958
nsv436717 OTHER inversion 17901297
nsv469859 CNV gain 16826518
nsv831644 CNV gain 17160897
nsv8541 CNV gain 18304495
nsv972408 CNV duplication 23825009

Relevant External Links for MIR7-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR7-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR7-1 Gene

Disorders for MIR7-1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR7-1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
au-kline syndrome
  • neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-hip dysplasia syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR7-1

Human Genome Epidemiology (HuGE) Navigator
MIR7-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR7-1
genes like me logo Genes that share disorders with MIR7-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR7-1 Gene

Publications for MIR7-1 Gene

  1. Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma. (PMID: 28314263) Hara K. … Kuwano H. (Anticancer Res. 2017) 3 64
  2. Breviscapine suppresses the growth of non-small cell lung cancer by enhancing microRNA-7 expression. (PMID: 28229971) Zeng J. … Cai S. (J. Biosci. 2017) 3 64
  3. MicroRNA-7 regulates IL-1I^-induced extracellular matrix degeneration by targeting GDF5 in human nucleus pulposus cells. (PMID: 27583982) Liu W. … Yang C. (Biomed. Pharmacother. 2016) 3 64
  4. Inhibition of miR-7 promotes angiogenesis in human umbilical vein endothelial cells by upregulating VEGF via KLF4. (PMID: 27431648) Li Y.Z. … Liu W.C. (Oncol. Rep. 2016) 3 64
  5. MicroRNA-7 downregulates the oncogene VDAC1 to influence hepatocellular carcinoma proliferation and metastasis. (PMID: 26831666) Wang F. … Chen Z. (Tumour Biol. 2016) 3 64

Products for MIR7-1 Gene

Sources for MIR7-1 Gene

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