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Aliases for MIR7-1 Gene

Subcategory (RNA class) for MIR7-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR7-1 Gene

  • MicroRNA 7-1 2 3
  • HNRNPK 4 5
  • Transformation Up-Regulated Nuclear Protein 4
  • Heterogeneous Nuclear Ribonucleoprotein K 5
  • Hsa-Mir-7-1 3
  • MiR-7-5p 3
  • HnRNP K 4
  • Mir-7-1 3
  • MIRN7-1 3
  • HNRPK 4
  • TUNP 4

External Ids for MIR7-1 Gene

Previous HGNC Symbols for MIR7-1 Gene

  • MIRN7-1

Previous GeneCards Identifiers for MIR7-1 Gene

  • GC09M085776
  • GC09M086584

Summaries for MIR7-1 Gene

Entrez Gene Summary for MIR7-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR7-1 Gene

MIR7-1 (MicroRNA 7-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR7-1 include Au-Kline Syndrome and Intellectual Disability. Among its related pathways are mRNA Splicing - Major Pathway and Metabolism of proteins. An important paralog of this gene is PCBP2.

UniProtKB/Swiss-Prot for MIR7-1 Gene

  • One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR7-1 Gene

Genomics for MIR7-1 Gene

Regulatory Elements for MIR7-1 Gene

Enhancers for MIR7-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F083977 0.6 ENCODE 0.8 +0.6 560 5.5 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 C9orf64 KIF27 LOC105376116 IDNK RMI1 GKAP1 MIR7-1 ENSG00000235298
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR7-1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR7-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001307058 715 5000 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for MIR7-1 Gene

Chromosome:
9
Start:
83,968,083 bp from pter
End:
83,980,616 bp from pter
Size:
12,534 bases
Orientation:
Minus strand

Genomic View for MIR7-1 Gene

Genes around MIR7-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR7-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR7-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR7-1 Gene

Proteins for MIR7-1 Gene

  • Protein details for MIR7-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61978-HNRPK_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein K
    Protein Accession:
    P61978
    Secondary Accessions:
    • Q07244
    • Q15671
    • Q59F98
    • Q5T6W4
    • Q60577
    • Q922Y7
    • Q96J62

    Protein attributes for MIR7-1 Gene

    Size:
    463 amino acids
    Molecular mass:
    50976 Da
    Quaternary structure:
    • Interacts with RBM42 and ZIK1. Interacts with BRDT (By similarity). Identified in the spliceosome C complex. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. Interacts with DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53.
    • Interacts with RBM42 and ZIK1. Interacts with BRDT (By similarity). Identified in the spliceosome C complex. Interacts with ANKRD28. Interacts with HCV core protein. Interacts with ASFV p30 protein. Interacts with DDX1. Interacts with MDM2; this interaction leads to ubiquitination and proteasomal degradation. Interacts with p53/TP53.
    SequenceCaution:
    • Sequence=BAD92799.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MIR7-1 Gene

    Alternative splice isoforms for MIR7-1 Gene

neXtProt entry for MIR7-1 Gene

Post-translational modifications for MIR7-1 Gene

  • Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine.
  • O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
  • Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions.
  • Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination.
  • Ubiquitination at Lys 34, Lys 52, Lys 163, Lys 179, Lys 198, Lys 456, and Lys 461
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIR7-1 Gene

Domains & Families for MIR7-1 Gene

Gene Families for MIR7-1 Gene

Protein Domains for MIR7-1 Gene

Graphical View of Domain Structure for InterPro Entry

P61978

UniProtKB/Swiss-Prot:

HNRPK_HUMAN :
  • Contains 3 KH domains.
Domain:
  • Contains 3 KH domains.
genes like me logo Genes that share domains with MIR7-1: view

No data available for Suggested Antigen Peptide Sequences for MIR7-1 Gene

Function for MIR7-1 Gene

Molecular function for MIR7-1 Gene

UniProtKB/Swiss-Prot Function:
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.
UniProtKB/Swiss-Prot Induction:
By DNA damage, including ionizing radiations and phleomycin treatment or UV irradiation. This induction requires ATM kinase activity (ionizing radiations and phleomycin) or ATR activity (UV irradiation). Up-regulation is due to protein stabilization. Constitutive protein levels are controlled by MDM2-mediated ubiquitination and degradation via the proteasome pathway.

Gene Ontology (GO) - Molecular Function for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IMP --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IMP --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding TAS --
genes like me logo Genes that share ontologies with MIR7-1: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR7-1 Gene

Localization for MIR7-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR7-1 Gene

Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Note=Recruited to p53/TP53-responsive promoters, in the presence of functional p53/TP53 (PubMed:16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed:18775702).

Gene Ontology (GO) - Cellular Components for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA --
GO:0002102 podosome IEA --
GO:0005634 nucleus TAS --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
genes like me logo Genes that share ontologies with MIR7-1: view

No data available for Subcellular locations from COMPARTMENTS for MIR7-1 Gene

Pathways & Interactions for MIR7-1 Gene

genes like me logo Genes that share pathways with MIR7-1: view

Pathways by source for MIR7-1 Gene

1 KEGG pathway for MIR7-1 Gene

Gene Ontology (GO) - Biological Process for MIR7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006396 RNA processing TAS --
genes like me logo Genes that share ontologies with MIR7-1: view

No data available for SIGNOR curated interactions for MIR7-1 Gene

Transcripts for MIR7-1 Gene

mRNA/cDNA for MIR7-1 Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR7-1 Gene

No ASD Table

Relevant External Links for MIR7-1 Gene

GeneLoc Exon Structure for
MIR7-1
ECgene alternative splicing isoforms for
MIR7-1

Expression for MIR7-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR7-1 Gene

genes like me logo Genes that share expression patterns with MIR7-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR7-1 Gene

Orthologs for MIR7-1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR7-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRNPK 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPK 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpk 35
  • 99 (a)
OneToMany
Gm7964 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
OneToMany
-- 35
  • 97 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia HNRNPK 35
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves HNRPK 35
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HNRNPK 35
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hnrpkl 35
  • 84 (a)
OneToMany
hnrnpk 35
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bl 35
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F26B1.2 35
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PBP2 35
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToOne
Species where no ortholog for MIR7-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR7-1 Gene

ENSEMBL:
Gene Tree for MIR7-1 (if available)
TreeFam:
Gene Tree for MIR7-1 (if available)

Paralogs for MIR7-1 Gene

Paralogs for MIR7-1 Gene

genes like me logo Genes that share paralogs with MIR7-1: view

Variants for MIR7-1 Gene

Sequence variations from dbSNP and Humsavar for MIR7-1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs11140312 -- 83,970,861(+) GTATG(A/T)AATTA intron-variant, upstream-variant-2KB
rs11140313 -- 83,971,642(+) TACCC(A/C)ACACA intron-variant, upstream-variant-2KB
rs111450543 -- 83,971,387(+) GAACC(A/C/T)GCATT intron-variant, upstream-variant-2KB
rs112635088 -- 83,970,446(+) ATGAT(C/G)TAACG intron-variant, upstream-variant-2KB
rs114279043 -- 83,971,303(+) TCTGA(A/T)GGGCT upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for MIR7-1 Gene

Variant ID Type Subtype PubMed ID
esv2759701 CNV gain 17122850
esv3620911 CNV gain 21293372
nsv1043703 CNV gain 25217958
nsv436717 OTHER inversion 17901297
nsv469859 CNV gain 16826518
nsv831644 CNV gain 17160897
nsv8541 CNV gain 18304495
nsv972408 CNV duplication 23825009

Relevant External Links for MIR7-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR7-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR7-1 Gene

Disorders for MIR7-1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR7-1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
au-kline syndrome
  • neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-hip dysplasia syndrome
intellectual disability
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

HNRPK_HUMAN
  • Au-Kline syndrome (AUKS) [MIM:616580]: A disorder characterized by intellectual disability, facial dysmorphism, cardiac defects, and connective tissue and skeletal abnormalities. Dysmorphic features include long palpebral fissures, ptosis, a broad prominent nasal bridge, hypoplastic alae nasi, an open downturned mouth, ears with underdeveloped and thick helices, high palate, and a unique tongue with a prominent median crease. Hypotonia, hyporeflexia, and high pain tolerance are additional features. {ECO:0000269 PubMed:26173930}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR7-1

Human Genome Epidemiology (HuGE) Navigator
MIR7-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR7-1
genes like me logo Genes that share disorders with MIR7-1: view

No data available for Genatlas for MIR7-1 Gene

Publications for MIR7-1 Gene

  1. MicroRNA-7 Compromises p53 Protein-dependent Apoptosis by Controlling the Expression of the Chromatin Remodeling Factor SMARCD1. (PMID: 26542803) Hong C.F. … Wu C.W. (J. Biol. Chem. 2016) 3 64
  2. MicroRNA-7 Regulates the Function of Mitochondrial Permeability Transition Pore by Targeting VDAC1 Expression. (PMID: 26801612) Chaudhuri A.D. … Junn E. (J. Biol. Chem. 2016) 3 64
  3. Diagnostic and predictive significance of serum microRNA-7 in esophageal squamous cell carcinoma. (PMID: 26708917) Dong W. … Zhang P. (Oncol. Rep. 2016) 3 64
  4. MicroRNAa897 suppresses human colon cancer invasion and proliferation by targeting the expression of focal adhesion kinase. (PMID: 26648422) Zeng C.Y. … Chen Y.X. (Mol Med Rep 2016) 3 64
  5. MicroRNA-7 Promotes Glycolysis to Protect against 1-Methyl-4-phenylpyridinium-induced Cell Death. (PMID: 25814668) Chaudhuri A.D. … Junn E. (J. Biol. Chem. 2015) 3 64

Products for MIR7-1 Gene

Sources for MIR7-1 Gene

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