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Aliases for MIR675 Gene

Subcategory (RNA class) for MIR675 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR675 Gene

  • MicroRNA 675 2 3 5
  • Hsa-Mir-675 3
  • MIRN675 3

External Ids for MIR675 Gene

Previous HGNC Symbols for MIR675 Gene

  • MIRN675

Previous GeneCards Identifiers for MIR675 Gene

  • GC11M001981
  • GC11M002017

Summaries for MIR675 Gene

Entrez Gene Summary for MIR675 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR675 Gene

MIR675 (MicroRNA 675) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR675 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR675

Additional gene information for MIR675 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR675 Gene

Genomics for MIR675 Gene

Regulatory Elements for MIR675 Gene


Promoters for MIR675 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035875 230 399 KLF1

Genomic Location for MIR675 Gene

Chromosome:
11
Start:
1,996,759 bp from pter
End:
1,996,831 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR675 Gene

Genes around MIR675 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR675 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR675 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR675 Gene

ORGUL Member Location for MIR675 Gene

ORGUL Member Location for MIR675 gene

Proteins for MIR675 Gene

Post-translational modifications for MIR675 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR675 Gene

Domains & Families for MIR675 Gene

Gene Families for MIR675 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR675: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR675 Gene

Function for MIR675 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR675
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR675 Gene

Localization for MIR675 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR675 Gene

Pathways & Interactions for MIR675 Gene

SuperPathways for MIR675 Gene

No Data Available

Interacting Proteins for MIR675 Gene

Gene Ontology (GO) - Biological Process for MIR675 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR675 Gene

Drugs & Compounds for MIR675 Gene

No Compound Related Data Available

Transcripts for MIR675 Gene

fRNAdb Secondary structures for MIR675 Gene

  • hsa-miR-675-5p_MIMAT0004284_Homo_sapiens_miR-675-5p_mature

mRNA/cDNA for MIR675 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR675
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR675 Gene

No ASD Table

Relevant External Links for MIR675 Gene

GeneLoc Exon Structure for
MIR675
ECgene alternative splicing isoforms for
MIR675

Expression for MIR675 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR675 Gene:

MIR675
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR675 Gene

Orthologs for MIR675 Gene

Evolution for MIR675 Gene

ENSEMBL:
Gene Tree for MIR675 (if available)
TreeFam:
Gene Tree for MIR675 (if available)

No data available for Orthologs for MIR675 Gene

Paralogs for MIR675 Gene

No data available for Paralogs for MIR675 Gene

Variants for MIR675 Gene

Sequence variations from dbSNP and Humsavar for MIR675 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1003384042 -- 1,998,335(+) GGTGG(A/G)CGCGG intron-variant, upstream-variant-2KB
rs1003842877 -- 1,998,515(+) CTCTA(C/T)TGACA intron-variant, upstream-variant-2KB
rs1005395880 -- 1,998,018(+) ATTCT(A/C)CAAAG intron-variant, upstream-variant-2KB
rs1008953570 -- 1,997,498(+) TCGTC(C/T)AACCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1011089349 -- 1,997,473(+) ATCAA(A/T)CCCTG intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR675 Gene

Variant ID Type Subtype PubMed ID
dgv1015n100 CNV gain 25217958
dgv1016n100 CNV gain 25217958
esv29980 CNV loss 17803354
nsv1047474 CNV gain 25217958
nsv467645 CNV gain 19166990
nsv469926 CNV loss 18288195
nsv522320 CNV loss 19592680
nsv553047 CNV gain 21841781
nsv553064 CNV loss 21841781
nsv951283 CNV deletion 24416366

Relevant External Links for MIR675 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR675

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR675 Gene

Disorders for MIR675 Gene

Relevant External Links for MIR675

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR675

No disorders were found for MIR675 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR675 Gene

Publications for MIR675 Gene

  1. The imprinted H19 noncoding RNA is a primary microRNA precursor. (PMID: 17237358) Cai X … Cullen BR (RNA (New York, N.Y.) 2007) 1 3 60
  2. H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation. (PMID: 26198047) Liu C … Wang Z (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  3. H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR. (PMID: 26884465) Zou T … Wang JY (Molecular and cellular biology 2016) 3 60
  4. Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells. (PMID: 26931432) Liu G … Wang WX (Oncology research 2016) 3 60
  5. Overexpression of lncRNA H19/miR-675 promotes tumorigenesis in head and neck squamous cell carcinoma. (PMID: 27994496) Guan GF … Wang K (International journal of medical sciences 2016) 3 60

Products for MIR675 Gene

Sources for MIR675 Gene

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