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Aliases for MIR675 Gene

Subcategory (RNA class) for MIR675 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR675 Gene

  • MicroRNA 675 2 3
  • H19, Imprinted Maternally Expressed Transcript (Non-Protein Coding) 5
  • Hsa-Mir-675 3
  • MIRN675 3
  • H19 5

External Ids for MIR675 Gene

Previous HGNC Symbols for MIR675 Gene

  • MIRN675

Previous GeneCards Identifiers for MIR675 Gene

  • GC11M001981
  • GC11M002017

Summaries for MIR675 Gene

Entrez Gene Summary for MIR675 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR675 Gene

MIR675 (MicroRNA 675) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR675 Gene

Genomics for MIR675 Gene

Regulatory Elements for MIR675 Gene

Enhancers for MIR675 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F001810 0.9 Ensembl 11.3 +190.5 190470 0.8 ARID4B KLF17 ZSCAN9 RAD21 ZNF48 ZNF335 GLIS2 ZNF143 THAP11 ZNF654 TNNI2 CTSD ENSG00000229512 ENSG00000250644 ENSG00000235027 IFITM10 MRPL23-AS1 LINC01219 H19 MIR675
GH11F002001 0.9 Ensembl ENCODE 0.8 -0.8 -770 1.7 ZBTB10 CTCF ZNF654 REST ZBTB7A RAD21 SMC3 CREM MYC SETDB1 TNNI2 SYT8 KRTAP5-6 FAM99B LOC100505570 H19 PIR50683 MIR675
GH11F002003 0.7 ENCODE 0.8 -3.1 -3132 1.5 PKNOX1 MAFG ZBTB40 GATA3 ZNF316 SCRT2 POU5F1 NFE2 MAFK EMSY TNNI2 SYT8 KRTAP5-6 FAM99B LOC100505570 MRPL23-AS1 H19 PIR50683 MIR675
GH11F001999 0.6 ENCODE 0.8 +1.5 1505 0.2 ZBTB10 CTCF ZNF654 REST RAD21 NR2F2 SMC3 SETDB1 MRPL23-AS1 GC11P001999 H19 MIR675
GH11F002002 0.6 ENCODE 0.8 +0.7 675 0.1 ZBTB10 CTCF SMC3 ZBTB33 REST RAD21 SETDB1 MRPL23-AS1 GC11P001999 H19 MIR675
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR675 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR675 Gene

Chromosome:
11
Start:
1,995,163 bp from pter
End:
2,001,470 bp from pter
Size:
6,308 bases
Orientation:
Minus strand

Genomic View for MIR675 Gene

Genes around MIR675 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR675 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR675 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR675 Gene

Proteins for MIR675 Gene

Post-translational modifications for MIR675 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR675 Gene

Domains & Families for MIR675 Gene

Gene Families for MIR675 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR675: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR675 Gene

Function for MIR675 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR675 Gene

Localization for MIR675 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR675 Gene

Pathways & Interactions for MIR675 Gene

SuperPathways for MIR675 Gene

No Data Available

Interacting Proteins for MIR675 Gene

Gene Ontology (GO) - Biological Process for MIR675 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR675 Gene

Transcripts for MIR675 Gene

mRNA/cDNA for MIR675 Gene

(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR675 Gene

No ASD Table

Relevant External Links for MIR675 Gene

GeneLoc Exon Structure for
MIR675
ECgene alternative splicing isoforms for
MIR675

Expression for MIR675 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR675 Gene:

MIR675
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR675 Gene

Orthologs for MIR675 Gene

Evolution for MIR675 Gene

ENSEMBL:
Gene Tree for MIR675 (if available)
TreeFam:
Gene Tree for MIR675 (if available)

No data available for Orthologs for MIR675 Gene

Paralogs for MIR675 Gene

No data available for Paralogs for MIR675 Gene

Variants for MIR675 Gene

Sequence variations from dbSNP and Humsavar for MIR675 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs115007717 -- 1,996,903(+) CCGGG(A/C/G)CCCCC intron-variant, nc-transcript-variant, upstream-variant-2KB
rs11542717 -- 1,996,996(-) TGCCG(G/T)AGCCT intron-variant, nc-transcript-variant, upstream-variant-2KB
rs11564733 -- 1,997,144(-) CAGCA(C/T)GTGGG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs115696222 -- 1,996,956(+) CTCCC(C/T)GAGCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs115855861 -- 1,998,336(+) GTGGG(C/T)GCGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR675 Gene

Variant ID Type Subtype PubMed ID
dgv1015n100 CNV gain 25217958
dgv1016n100 CNV gain 25217958
esv29980 CNV loss 17803354
nsv1047474 CNV gain 25217958
nsv467645 CNV gain 19166990
nsv469926 CNV loss 18288195
nsv522320 CNV loss 19592680
nsv553047 CNV gain 21841781
nsv553064 CNV loss 21841781
nsv951283 CNV deletion 24416366

Relevant External Links for MIR675 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR675

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR675 Gene

Disorders for MIR675 Gene

Relevant External Links for MIR675

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR675

No disorders were found for MIR675 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR675 Gene

Publications for MIR675 Gene

  1. Long Noncoding RNA H19-Derived miR-675 Enhances Proliferation and Invasion via RUNX1 in Gastric Cancer Cells. (PMID: 26931432) Liu G. … Wang W.X. (Oncol. Res. 2016) 3 64
  2. H19 Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR. (PMID: 26884465) Zou T. … Wang J.Y. (Mol. Cell. Biol. 2016) 3 64
  3. Down-regulation of miR-675-5p contributes to tumor progression and development by targeting pro-tumorigenic GPR55 in non-small cell lung cancer. (PMID: 25889562) He D. … Duan C. (Mol. Cancer 2015) 3 64
  4. H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b. (PMID: 26353930) Vennin C. … Adriaenssens E. (Oncotarget 2015) 3 64
  5. miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer. (PMID: 26376677) Li H. … Lu D. (Oncotarget 2015) 3 64

Products for MIR675 Gene

Sources for MIR675 Gene

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