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Aliases for MIR671 Gene

Subcategory (RNA class) for MIR671 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR671 Gene

  • MicroRNA 671 2 3
  • Chondroitin Polymerizing Factor 2 4 5
  • CHPF2 4 5
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 4
  • Chondroitin Glucuronyltransferase 4
  • Chondroitin Synthase 3 4
  • EC 2.4.1.226 4
  • Hsa-Mir-671 3
  • CSGLCA-T 4
  • KIAA1402 4
  • CSGlcAT 4
  • Mir-671 3
  • MIRN671 3
  • ChPF-2 4
  • ChSy-3 4
  • CHSY3 4

External Ids for MIR671 Gene

Previous HGNC Symbols for MIR671 Gene

  • MIRN671

Previous GeneCards Identifiers for MIR671 Gene

  • GC07P150567
  • GC07P150935

Summaries for MIR671 Gene

Entrez Gene Summary for MIR671 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR671 Gene

MIR671 (MicroRNA 671) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metabolism and Chondroitin sulfate/dermatan sulfate metabolism. An important paralog of this gene is CHPF.

UniProtKB/Swiss-Prot for MIR671 Gene

  • Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR671 Gene

Genomics for MIR671 Gene

Regulatory Elements for MIR671 Gene

Enhancers for MIR671 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F151206 0.9 ENCODE 12.1 -25.2 -25236 2.1 HDAC1 PKNOX1 CBX3 TBL1XR1 GATA2 SIRT6 FOS CREM ZNF680 USF2 ABCF2 GBX1 CHPF2 MIR671 SMARCD3 LOC105375569 IQCA1L
GH07F151304 1.1 Ensembl ENCODE 11 +72.6 72566 0.5 MCM3 SMARCD3 LOC105375569 ASB10 GBX1 CHPF2 MIR671 ABCF2 NUB1
GH07F151303 0.7 Ensembl ENCODE 11 +71.2 71172 0.9 HDGF ZNF2 RAD21 GLIS2 ZNF143 EGR2 THAP11 REST SMARCA4 MTA1 SMARCD3 LOC105375569 ASB10 GBX1 CHPF2 MIR671 ABCF2 NUB1
GH07F151084 1.2 FANTOM5 ENCODE 10.3 -144.7 -144702 5.9 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ABCB8 ENSG00000243433 SLC4A2 AGAP3 FASTK CDK5 ASIC3 SMARCD3 GBX1 ASB10
GH07F151447 0.6 Ensembl ENCODE 10.2 +216.1 216114 1.6 CTCF CREB3L1 MAX RAD21 ZNF121 CTBP1 ZNF143 SMC3 RCOR1 ZNF654 ENSG00000241456 RHEB SMARCD3 LOC105375569 CHPF2 MIR671 ABCF2 CRYGN GC07M151465
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR671 on UCSC Golden Path with GeneCards custom track

Promoters for MIR671 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000636270 411 1801 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS

Genomic Location for MIR671 Gene

Chromosome:
7
Start:
151,232,489 bp from pter
End:
151,238,827 bp from pter
Size:
6,339 bases
Orientation:
Plus strand

Genomic View for MIR671 Gene

Genes around MIR671 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR671 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR671 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR671 Gene

Proteins for MIR671 Gene

  • Protein details for MIR671 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E5-CHPF2_HUMAN
    Recommended name:
    Chondroitin sulfate glucuronyltransferase
    Protein Accession:
    Q9P2E5
    Secondary Accessions:
    • B2DBD8
    • Q6P2I4
    • Q6UXD2

    Protein attributes for MIR671 Gene

    Size:
    772 amino acids
    Molecular mass:
    85948 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92640.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR671 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR671 Gene

Post-translational modifications for MIR671 Gene

  • Glycosylation at Asn 121 and Asn 342
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR671 Gene

No data available for DME Specific Peptides for MIR671 Gene

Domains & Families for MIR671 Gene

Gene Families for MIR671 Gene

Protein Domains for MIR671 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9P2E5

UniProtKB/Swiss-Prot:

CHPF2_HUMAN :
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with MIR671: view

No data available for Suggested Antigen Peptide Sequences for MIR671 Gene

Function for MIR671 Gene

Molecular function for MIR671 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.
UniProtKB/Swiss-Prot Function:
Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

Enzyme Numbers (IUBMB) for MIR671 Gene

Gene Ontology (GO) - Molecular Function for MIR671 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity TAS --
genes like me logo Genes that share ontologies with MIR671: view

Animal Model Products

miRNA for MIR671 Gene

miRTarBase miRNAs that target MIR671

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR671 Gene

Localization for MIR671 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR671 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Gene Ontology (GO) - Cellular Components for MIR671 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with MIR671: view

No data available for Subcellular locations from COMPARTMENTS for MIR671 Gene

Pathways & Interactions for MIR671 Gene

genes like me logo Genes that share pathways with MIR671: view

Pathways by source for MIR671 Gene

Gene Ontology (GO) - Biological Process for MIR671 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with MIR671: view

No data available for SIGNOR curated interactions for MIR671 Gene

Transcripts for MIR671 Gene

mRNA/cDNA for MIR671 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR671 Gene

No ASD Table

Relevant External Links for MIR671 Gene

GeneLoc Exon Structure for
MIR671
ECgene alternative splicing isoforms for
MIR671

Expression for MIR671 Gene

mRNA expression in normal human tissues for MIR671 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR671 Gene:

MIR671

mRNA Expression by UniProt/SwissProt for MIR671 Gene:

Q9P2E5-CHPF2_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in placenta, small intestine and pancreas.
genes like me logo Genes that share expression patterns with MIR671: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR671 Gene

Orthologs for MIR671 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR671 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-671 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-671 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-671 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chpf2 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHPF2 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHPF2 35
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHPF2 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii chpf2 35
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43313 35
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-22 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5086 35
  • 38 (a)
OneToMany
Species where no ortholog for MIR671 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR671 Gene

ENSEMBL:
Gene Tree for MIR671 (if available)
TreeFam:
Gene Tree for MIR671 (if available)

Paralogs for MIR671 Gene

Paralogs for MIR671 Gene

genes like me logo Genes that share paralogs with MIR671: view

Variants for MIR671 Gene

Sequence variations from dbSNP and Humsavar for MIR671 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs112310377 -- 151,236,865(+) AGCTC(C/T)GCACA intron-variant, upstream-variant-2KB
rs112915285 -- 151,238,832(+) TTTTA(C/G)GTCTA downstream-variant-500B
rs113523875 -- 151,237,535(+) GCTCC(C/T)AAGTG upstream-variant-2KB, reference, synonymous-codon
rs115178275 -- 151,236,463(+) GGAAG(A/G)GAGCT upstream-variant-2KB, reference, missense
rs117700307 -- 151,236,731(+) AGGCC(A/G)ACCAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR671 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv609035 CNV loss 21841781

Relevant External Links for MIR671 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR671

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR671 Gene

Disorders for MIR671 Gene

Relevant External Links for MIR671

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR671

No disorders were found for MIR671 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR671 Gene

Publications for MIR671 Gene

  1. miR-671-5p inhibits epithelial-to-mesenchymal transition by downregulating FOXM1 expression in breast cancer. (PMID: 26588055) Tan X. … Fu S.W. (Oncotarget 2016) 3 64
  2. Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme. (PMID: 26683098) Barbagallo D. … Purrello M. (Oncotarget 2016) 3 64
  3. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. miRNA expression profiles in myelodysplastic syndromes reveal Epstein-Barr virus miR-BART13 dysregulation. (PMID: 21649547) Borze I. … Knuutila S. (Leuk. Lymphoma 2011) 3 64

Products for MIR671 Gene

Sources for MIR671 Gene

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