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Aliases for MIR663B Gene

Subcategory (RNA class) for MIR663B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR663B Gene

  • MicroRNA 663b 2 3 5
  • Hsa-Mir-663b 3
  • Mir-663b 3
  • MIRN663B 3

External Ids for MIR663B Gene

Previous HGNC Symbols for MIR663B Gene

  • MIRN663B

Previous GeneCards Identifiers for MIR663B Gene

  • GC00U923109
  • GC02M132733
  • GC02M133014
  • GC02M132283
  • GC02M132303
  • GC02M132325
  • GC02M132347
  • GC02M132353

Summaries for MIR663B Gene

Entrez Gene Summary for MIR663B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR663B Gene

MIR663B (MicroRNA 663b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR663B Gene

Genomics for MIR663B Gene

Regulatory Elements for MIR663B Gene

Enhancers for MIR663B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G132260 0.9 ENCODE 0.7 -0.6 -603 0.2 TBP CBX3 ATF1 DNMT3B GATA4 ELK1 CBX5 PCBP1 ETV6 KDM4B ENSG00000213222 MIR663B ANKRD30BL
GH02G132259 0.5 ENCODE 0.7 -0.2 -159 0.2 GABPB1 CBX2 EZH2 MIR663B ANKRD30BL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR663B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR663B Gene

Chromosome:
2
Start:
132,256,966 bp from pter
End:
132,257,080 bp from pter
Size:
115 bases
Orientation:
Minus strand

Genomic View for MIR663B Gene

Genes around MIR663B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR663B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR663B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR663B Gene

Proteins for MIR663B Gene

Post-translational modifications for MIR663B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR663B Gene

Domains & Families for MIR663B Gene

Gene Families for MIR663B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR663B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR663B Gene

Function for MIR663B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR663B Gene

Localization for MIR663B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR663B Gene

Pathways & Interactions for MIR663B Gene

SuperPathways for MIR663B Gene

No Data Available

Interacting Proteins for MIR663B Gene

Gene Ontology (GO) - Biological Process for MIR663B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR663B Gene

Drugs & Compounds for MIR663B Gene

No Compound Related Data Available

Transcripts for MIR663B Gene

mRNA/cDNA for MIR663B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR663B Gene

No ASD Table

Relevant External Links for MIR663B Gene

GeneLoc Exon Structure for
MIR663B
ECgene alternative splicing isoforms for
MIR663B

Expression for MIR663B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR663B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR663B Gene:

MIR663B
genes like me logo Genes that share expression patterns with MIR663B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR663B Gene

Orthologs for MIR663B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR663B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-663b 35
  • 96 (a)
OneToOne
Species where no ortholog for MIR663B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR663B Gene

ENSEMBL:
Gene Tree for MIR663B (if available)
TreeFam:
Gene Tree for MIR663B (if available)

Paralogs for MIR663B Gene

No data available for Paralogs for MIR663B Gene

Variants for MIR663B Gene

Sequence variations from dbSNP and Humsavar for MIR663B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1001665003 -- 132,257,429(+) TCTCC(C/T)CTGAC intron-variant, upstream-variant-2KB
rs1001863151 -- 132,256,578(+) CCTCG(C/T)GGCAC intron-variant, downstream-variant-500B
rs1001926148 -- 132,257,621(+) GGGAT(C/T)CGGTA nc-transcript-variant, upstream-variant-2KB
rs1002141650 -- 132,258,070(+) GCGTG(A/G)GAGGG upstream-variant-2KB
rs1003059892 -- 132,258,258(+) AGGCT(C/T)ACGCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR663B Gene

Variant ID Type Subtype PubMed ID
dgv4081n100 CNV gain 25217958
dgv666n67 CNV gain 20364138
esv2583265 CNV gain 19546169
esv25933 CNV gain 19812545
esv2759092 CNV gain+loss 17122850
esv2763165 CNV gain 21179565
esv32851 CNV gain+loss 17666407
esv3893370 CNV gain 25118596
nsv1011421 CNV gain 25217958
nsv10191 CNV gain+loss 18304495
nsv1077376 CNV duplication 25765185
nsv1118649 CNV duplication 24896259
nsv1124818 CNV duplication 24896259
nsv1149928 CNV duplication 26484159
nsv2928 CNV insertion 18451855
nsv526029 CNV gain 19592680
nsv583148 CNV gain 21841781
nsv819534 CNV insertion 19587683
nsv820317 CNV duplication 20802225
nsv821716 CNV gain 20364138
nsv953182 CNV duplication 24416366
nsv963727 CNV duplication 23825009
nsv979281 CNV duplication 23825009

Relevant External Links for MIR663B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR663B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR663B Gene

Disorders for MIR663B Gene

Relevant External Links for MIR663B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR663B

No disorders were found for MIR663B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR663B Gene

Publications for MIR663B Gene

  1. Interleukin 21 Controls mRNA and MicroRNA Expression in CD40-Activated Chronic Lymphocytic Leukemia Cells. (PMID: 26305332) De Cecco L. … Ferrini S. (PLoS ONE 2015) 3 64
  2. Epigenetically silenced microRNAs in gastric cancer: Functional analysis and identification of their target genes. (PMID: 26043902) Bae J.H. … Yi J.M. (Oncol. Rep. 2015) 3 64
  3. Clinical impact of circulating miR-133, miR-1291 and miR-663b in plasma of patients with acute myocardial infarction. (PMID: 24885383) Peng L. … Zhen-wen H. (Diagn Pathol 2014) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. MicroRNA expression profiles of human leukemias. (PMID: 17989710) Takada S. … Mano H. (Leukemia 2008) 3 64

Products for MIR663B Gene

Sources for MIR663B Gene

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