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Aliases for MIR663A Gene

Subcategory (RNA class) for MIR663A Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR663A Gene

  • MicroRNA 663a 2 3 5
  • MicroRNA 663 2 3
  • Hsa-Mir-663a 3
  • Hsa-Mir-663 3
  • Mir-663a 3
  • MIRN663 3
  • MIR663 3

External Ids for MIR663A Gene

Previous HGNC Symbols for MIR663A Gene

  • MIRN663
  • MIR663

Summaries for MIR663A Gene

Entrez Gene Summary for MIR663A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR663A Gene

MIR663A (MicroRNA 663a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR663A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR663A

Additional gene information for MIR663A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR663A Gene

Genomics for MIR663A Gene

GeneHancer (GH) Regulatory Elements for MIR663A Gene

Promoters and enhancers for MIR663A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I026208 Enhancer 1.1 ENCODE 550.8 -0.7 -742 1.9 SMAD1 FOXA2 MLX ZFP64 SIN3A DMAP1 IRF4 YY1 ZNF766 CBX5 GC20P026208 MIR663A ZNF337 NANP FAM182B ZNF337-AS1 GC20P026233 MIR663AHG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR663A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR663A Gene

Genomic Locations for MIR663A Gene
chr20:26,208,186-26,208,278
(GRCh38/hg38)
Size:
93 bases
Orientation:
Minus strand
chr20:26,167,556-26,232,162
(GRCh37/hg19)

Genomic View for MIR663A Gene

Genes around MIR663A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR663A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR663A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR663A Gene

ORGUL Member Location for MIR663A Gene

ORGUL Member Location for MIR663A gene

Proteins for MIR663A Gene

Post-translational modifications for MIR663A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR663A Gene

Domains & Families for MIR663A Gene

Gene Families for MIR663A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR663A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR663A Gene

Function for MIR663A Gene

Gene Ontology (GO) - Molecular Function for MIR663A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22042811
genes like me logo Genes that share ontologies with MIR663A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR663A Gene

Localization for MIR663A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR663A Gene

Pathways & Interactions for MIR663A Gene

SuperPathways for MIR663A Gene

No Data Available

Interacting Proteins for MIR663A Gene

Gene Ontology (GO) - Biological Process for MIR663A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 22042811
genes like me logo Genes that share ontologies with MIR663A: view

No data available for Pathways by source and SIGNOR curated interactions for MIR663A Gene

Drugs & Compounds for MIR663A Gene

No Compound Related Data Available

Transcripts for MIR663A Gene

fRNAdb Secondary structures for MIR663A Gene

  • hsa-mir-663a_MI0003672_Homo_sapiens_miR-663a_stem-loop_hairpin

mRNA/cDNA for MIR663A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR663A Gene

No ASD Table

Relevant External Links for MIR663A Gene

GeneLoc Exon Structure for
MIR663A
ECgene alternative splicing isoforms for
MIR663A

Expression for MIR663A Gene

mRNA differential expression in normal tissues according to GTEx for MIR663A Gene

This gene is overexpressed in Testis (x47.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR663A Gene:

MIR663A

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR663A Gene

Orthologs for MIR663A Gene

Evolution for MIR663A Gene

ENSEMBL:
Gene Tree for MIR663A (if available)
TreeFam:
Gene Tree for MIR663A (if available)

No data available for Orthologs for MIR663A Gene

Paralogs for MIR663A Gene

No data available for Paralogs for MIR663A Gene

Variants for MIR663A Gene

Sequence variations from dbSNP and Humsavar for MIR663A Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000281002 -- 26,209,531(-) G/T upstream_transcript_variant
rs1003475975 -- 26,209,096(-) A/C upstream_transcript_variant
rs1003574301 -- 26,208,354(-) A/G upstream_transcript_variant
rs1005017456 -- 26,207,713(-) C/G/T downstream_transcript_variant
rs1005069593 -- 26,208,043(-) T/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR663A Gene

Variant ID Type Subtype PubMed ID
dgv4292n100 CNV gain 25217958
dgv509n27 CNV gain 19166990
dgv7526n54 CNV gain 21841781
esv2758790 CNV gain+loss 17122850
esv2763226 CNV gain 21179565
esv33036 CNV gain 17666407
esv3645613 CNV gain 21293372
esv3893328 CNV gain 25118596
esv3893329 CNV gain 25118596
nsv1060178 CNV gain 25217958
nsv1062308 CNV gain 25217958
nsv458959 CNV loss 19166990
nsv470545 CNV gain 18288195
nsv585761 CNV gain 21841781
nsv585774 CNV gain 21841781
nsv585776 CNV loss 21841781
nsv9799 CNV gain 18304495

Additional Variant Information for MIR663A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR663A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR663A Gene

Disorders for MIR663A Gene

Additional Disease Information for MIR663A

No disorders were found for MIR663A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR663A Gene

Publications for MIR663A Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. MicroRNA-663 suppresses cell invasion and migration by targeting transforming growth factor beta 1 in papillary thyroid carcinoma. (PMID: 26687649) Wang Z … He L (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
  3. MicroRNA-663 inhibits the proliferation, migration and invasion of glioblastoma cells via targeting TGF-β1. (PMID: 26717894) Li Q … Jiang B (Oncology reports 2016) 3 58
  4. MicroRNA-663a is downregulated in non-small cell lung cancer and inhibits proliferation and invasion by targeting JunD. (PMID: 27184257) Zhang Y … He P (BMC cancer 2016) 3 58
  5. Identification of a microRNA (miR-663a) induced by ER stress and its target gene PLOD3 by a combined microRNome and proteome approach. (PMID: 27233793) Amodio G … Remondelli P (Cell biology and toxicology 2016) 3 58

Products for MIR663A Gene

Sources for MIR663A Gene

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