Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR663A Gene

Subcategory (RNA class) for MIR663A Gene


Quality Score for this RNA gene is


Aliases for MIR663A Gene

  • MicroRNA 663a 2 3 5
  • MicroRNA 663 2 3
  • Hsa-Mir-663a 3
  • Hsa-Mir-663 3
  • Mir-663a 3
  • MIRN663 3
  • MIR663 3

External Ids for MIR663A Gene

Previous HGNC Symbols for MIR663A Gene

  • MIRN663
  • MIR663

Summaries for MIR663A Gene

Entrez Gene Summary for MIR663A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR663A Gene

MIR663A (MicroRNA 663a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR663A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR663A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR663A Gene

Genomics for MIR663A Gene

Regulatory Elements for MIR663A Gene

Enhancers for MIR663A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR663A on UCSC Golden Path with GeneCards custom track

Promoters for MIR663A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR663A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR663A Gene

26,208,186 bp from pter
26,208,278 bp from pter
93 bases
Minus strand

Genomic View for MIR663A Gene

Genes around MIR663A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR663A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR663A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR663A Gene

ORGUL Member Location for MIR663A Gene

ORGUL Member Location for MIR663A gene

Proteins for MIR663A Gene

Post-translational modifications for MIR663A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR663A Gene

Domains & Families for MIR663A Gene

Gene Families for MIR663A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR663A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR663A Gene

Function for MIR663A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR663A Gene

Localization for MIR663A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR663A Gene

Pathways & Interactions for MIR663A Gene

SuperPathways for MIR663A Gene

No Data Available

Interacting Proteins for MIR663A Gene

Gene Ontology (GO) - Biological Process for MIR663A Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR663A Gene

Drugs & Compounds for MIR663A Gene

No Compound Related Data Available

Transcripts for MIR663A Gene

fRNAdb Secondary structures for MIR663A Gene

  • hsa-mir-663a_MI0003672_Homo_sapiens_miR-663a_stem-loop_hairpin

mRNA/cDNA for MIR663A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR663A Gene

No ASD Table

Relevant External Links for MIR663A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR663A Gene

mRNA differential expression in normal tissues according to GTEx for MIR663A Gene

This gene is overexpressed in Testis (x47.2).

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR663A Gene

Orthologs for MIR663A Gene

Evolution for MIR663A Gene

Gene Tree for MIR663A (if available)
Gene Tree for MIR663A (if available)

No data available for Orthologs for MIR663A Gene

Paralogs for MIR663A Gene

No data available for Paralogs for MIR663A Gene

Variants for MIR663A Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MIR663A Gene

Disorders for MIR663A Gene

Relevant External Links for MIR663A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR663A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR663A Gene

Publications for MIR663A Gene

  1. MicroRNA-663 activates the canonical Wnt signaling through the adenomatous polyposis coli suppression. (PMID: 26028359) Miao C.G. … Li J. (Immunol. Lett. 2015) 3 67
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3
  3. Waltonitone induces apoptosis through mir-663-induced Bcl-2 downregulation in non-small cell lung cancer. (PMID: 25301444) Zhang Y. … He P. (Tumour Biol. 2015) 3
  4. APP intracellular domain acts as a transcriptional regulator of miR-663 suppressing neuronal differentiation. (PMID: 25695604) Shu R. … Xiao Z.C. (Cell Death Dis 2015) 3
  5. miR-663 attenuates tumor growth and invasiveness by targeting eEF1A2 in pancreatic cancer. (PMID: 25744894) Zang W. … Zhao G. (Mol. Cancer 2015) 3

Products for MIR663A Gene

Sources for MIR663A Gene