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Aliases for MIR661 Gene

Subcategory (RNA class) for MIR661 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR661 Gene

  • MicroRNA 661 2 3 5
  • Hsa-Mir-661 3
  • MIRN661 3

External Ids for MIR661 Gene

Previous HGNC Symbols for MIR661 Gene

  • MIRN661

Previous GeneCards Identifiers for MIR661 Gene

  • GC08M145092
  • GC08M145019
  • GC08M140273

Summaries for MIR661 Gene

Entrez Gene Summary for MIR661 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR661 Gene

MIR661 (MicroRNA 661) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR661 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR661

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR661 Gene

Genomics for MIR661 Gene

Regulatory Elements for MIR661 Gene

Enhancers for MIR661 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G143968 1.7 Ensembl ENCODE dbSUPER 13 -29.0 -28961 11.0 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D PLEC MAF1 WDR97 MIR661 PARP10 SPATC1 EXOSC4 ENSG00000255224 GPAA1 CYC1
GH08G143903 1.2 Ensembl ENCODE dbSUPER 11.7 +40.7 40713 1.8 CTCF PKNOX1 RFX1 SIN3A MNT BMI1 RAD21 ZNF274 POLR2A HSF1 PLEC EPPK1 PUF60 MIR661 NRBP2 SCRIB PARP10 SPATC1 EXOSC4 ENSG00000255224
GH08G143905 1.2 ENCODE dbSUPER 11.7 +39.0 39021 1.5 FOXA2 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B SLC30A9 CBX5 ZNF143 SP5 PLEC EPPK1 PUF60 MIR661 NRBP2 SCRIB SPATC1 PARP10 EXOSC4 ENSG00000255224
GH08G144002 1.1 Ensembl ENCODE 11.6 -59.2 -59225 3.5 HDAC1 PKNOX1 FOXA2 THRB RAD21 YY1 SCRT2 RCOR1 USF2 CEBPB PLEC WDR97 EXOSC4 ENSG00000255224 MIR661 GPAA1 CYC1 MAF1 SHARPIN NRBP2
GH08G143836 0.7 ENCODE 11.3 +108.6 108632 1.0 CTCF RB1 SAP130 ARID4B SIN3A MAX RAD21 YY1 EGR1 SMC3 SCRIB EPPK1 MIR661 PLEC SPATC1 PARP10 FAM83H PUF60 ENSG00000255343 GC08P143837
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR661 on UCSC Golden Path with GeneCards custom track

Promoters for MIR661 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000333977 1379 601 ATF1 ARID4B SIN3A DMAP1 GLI4 ZNF48 ZBTB7B GLIS2 CBX5 KLF7

Genomic Location for MIR661 Gene

Chromosome:
8
Start:
143,945,191 bp from pter
End:
143,945,279 bp from pter
Size:
89 bases
Orientation:
Minus strand

Genomic View for MIR661 Gene

Genes around MIR661 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR661 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR661 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR661 Gene

ORGUL Member Location for MIR661 Gene

ORGUL Member Location for MIR661 gene

Proteins for MIR661 Gene

Post-translational modifications for MIR661 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR661 Gene

Domains & Families for MIR661 Gene

Gene Families for MIR661 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR661: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR661 Gene

Function for MIR661 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR661 Gene

Localization for MIR661 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR661 Gene

Pathways & Interactions for MIR661 Gene

SuperPathways for MIR661 Gene

No Data Available

Interacting Proteins for MIR661 Gene

Gene Ontology (GO) - Biological Process for MIR661 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR661 Gene

Drugs & Compounds for MIR661 Gene

No Compound Related Data Available

Transcripts for MIR661 Gene

fRNAdb Secondary structures for MIR661 Gene

  • FR311315

mRNA/cDNA for MIR661 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR661 Gene

No ASD Table

Relevant External Links for MIR661 Gene

GeneLoc Exon Structure for
MIR661
ECgene alternative splicing isoforms for
MIR661

Expression for MIR661 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR661 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR661 Gene:

MIR661
genes like me logo Genes that share expression patterns with MIR661: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR661 Gene

Orthologs for MIR661 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR661 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-661 35
  • 91 (a)
OneToOne
Species where no ortholog for MIR661 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR661 Gene

ENSEMBL:
Gene Tree for MIR661 (if available)
TreeFam:
Gene Tree for MIR661 (if available)

Paralogs for MIR661 Gene

No data available for Paralogs for MIR661 Gene

Variants for MIR661 Gene

Sequence variations from dbSNP and Humsavar for MIR661 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000424957 -- 143,945,514(+) TGGGC(A/G)CACCC intron-variant, upstream-variant-2KB
rs1001335214 -- 143,944,732(+) CCCCT(C/T)GGAGG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1001696194 -- 143,946,487(+) CCACT(C/T)ATGCC intron-variant, upstream-variant-2KB
rs1003967658 -- 143,945,020(+) GGAGG(C/T)GCGGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1004275869 -- 143,945,186(+) TGGCC(A/G)GGACA intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR661 Gene

Variant ID Type Subtype PubMed ID
dgv12431n54 CNV loss 21841781
dgv12432n54 CNV loss 21841781
dgv12433n54 CNV gain 21841781
dgv906n27 CNV loss 19166990
nsv1161815 CNV deletion 26073780
nsv470249 CNV loss 18288195
nsv470250 CNV gain 18288195
nsv515809 CNV gain+loss 19592680
nsv612906 CNV loss 21841781
nsv612907 CNV gain+loss 21841781
nsv612912 CNV loss 21841781
nsv824794 CNV gain 20364138
nsv950015 CNV deletion 24416366

Relevant External Links for MIR661 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR661

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR661 Gene

Disorders for MIR661 Gene

Relevant External Links for MIR661

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR661

No disorders were found for MIR661 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR661 Gene

Publications for MIR661 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Increased serum microRNAs are closely associated with the presence of microvascular complications in type 2 diabetes mellitus. (PMID: 26831044) Wang C. … Wang J. (Sci Rep 2016) 3 64
  3. MiR-661 contributed to cell proliferation of human ovarian cancer cells by repressing INPP5J expression. (PMID: 26282217) Zhu T. … Li H. (Biomed. Pharmacother. 2015) 3 64
  4. MiR-661 inhibits glioma cell proliferation, migration and invasion by targeting hTERT. (PMID: 26585488) Li Z. … Yao Y.L. (Biochem. Biophys. Res. Commun. 2015) 3 64
  5. miR-661 downregulates both Mdm2 and Mdm4 to activate p53. (PMID: 24141721) Hoffman Y. … Oren M. (Cell Death Differ. 2014) 3 64

Products for MIR661 Gene

Sources for MIR661 Gene

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