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Aliases for MIR659 Gene

Subcategory (RNA class) for MIR659 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR659 Gene

  • MicroRNA 659 2 3 5
  • Hsa-Mir-659 3
  • Mir-659 3
  • MIRN659 3

External Ids for MIR659 Gene

Previous HGNC Symbols for MIR659 Gene

  • MIRN659

Previous GeneCards Identifiers for MIR659 Gene

  • GC22M036574
  • GC22M038243
  • GC22M038390
  • GC22M038512
  • GC22M038824
  • GC22M039961
  • GC22M040652
  • GC22M041101
  • GC22M041504

Summaries for MIR659 Gene

Entrez Gene Summary for MIR659 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR659 Gene

MIR659 (MicroRNA 659) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR659 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR659

Additional gene information for MIR659 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR659 Gene

Genomics for MIR659 Gene

GeneHancer (GH) Regulatory Elements for MIR659 Gene

Promoters and enhancers for MIR659 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I037847 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -1.4 -1365 2.6 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 EIF3L ANKRD54 PIR48437 MIR659 GC22M042607 ENSG00000230912 CSNK1E ENSG00000272582 CBY1 GCAT
GH22I037801 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.7 +42.2 42244 7.3 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GCAT H1F0 GALR3 DDX17 ANKRD54 EIF3L MIR659 CSNK1E PLA2G6 CBY1
GH22I037931 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -85.3 -85349 2.9 HDGF MLX ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF207 ZNF143 GALR3 EIF3L DDX17 ENSG00000230149 ENSG00000273076 ENSG00000272669 TRIOBP ENSG00000225450 RNU6-900P MICALL1
GH22I037886 Enhancer 0.9 ENCODE dbSUPER 11.9 -40.0 -39987 2.3 NCOA3 CTCF ESRRA CLOCK SIN3A FEZF1 RAD21 CTBP1 GATA3 ELK1 GALR3 ANKRD54 EIF3L MIR659 GCAT H1F0 POLR2F SOX10 GC22P037892 ENSG00000279738
GH22I037727 Enhancer 1 Ensembl ENCODE dbSUPER 10.4 +119.4 119418 2 CEBPB CEBPG ATF2 ATF4 ATF3 IKZF1 CEBPA PRDM10 ATF7 PRDM1 ANKRD54 TRIOBP ENSG00000100101 LGALS1 LOC101927051 PDXP GCAT H1F0 GGA1 MIR659
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR659 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR659 Gene

Genomic Locations for MIR659 Gene
chr22:37,847,678-37,847,774
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr22:38,243,685-38,243,781
(GRCh37/hg19)

Genomic View for MIR659 Gene

Genes around MIR659 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR659 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR659 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR659 Gene

ORGUL Member Location for MIR659 Gene

ORGUL Member Location for MIR659 gene

Proteins for MIR659 Gene

Post-translational modifications for MIR659 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR659 Gene

Domains & Families for MIR659 Gene

Gene Families for MIR659 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR659: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR659 Gene

Function for MIR659 Gene

Phenotypes From GWAS Catalog for MIR659 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR659 Gene

Localization for MIR659 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR659 Gene

Pathways & Interactions for MIR659 Gene

SuperPathways for MIR659 Gene

No Data Available

Interacting Proteins for MIR659 Gene

Gene Ontology (GO) - Biological Process for MIR659 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR659 Gene

Drugs & Compounds for MIR659 Gene

No Compound Related Data Available

Transcripts for MIR659 Gene

fRNAdb Secondary structures for MIR659 Gene

  • FR027573
  • hsa-miR-659-5p_MIMAT0022710_Homo_sapiens_miR-659-5p_mature

mRNA/cDNA for MIR659 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR659 Gene

No ASD Table

Relevant External Links for MIR659 Gene

GeneLoc Exon Structure for
MIR659
ECgene alternative splicing isoforms for
MIR659

Expression for MIR659 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR659 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR659 Gene:

MIR659
genes like me logo Genes that share expression patterns with MIR659: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR659 Gene

Orthologs for MIR659 Gene

Evolution for MIR659 Gene

ENSEMBL:
Gene Tree for MIR659 (if available)
TreeFam:
Gene Tree for MIR659 (if available)

No data available for Orthologs for MIR659 Gene

Paralogs for MIR659 Gene

No data available for Paralogs for MIR659 Gene

Variants for MIR659 Gene

Sequence variations from dbSNP and Humsavar for MIR659 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1001382673 -- 37,847,850(-) C/T upstream_transcript_variant
rs1001485336 -- 37,847,541(-) C/T downstream_transcript_variant
rs1003827220 -- 37,848,483(-) C/G upstream_transcript_variant
rs1003988675 -- 37,847,463(-) C/T downstream_transcript_variant
rs1004199519 -- 37,848,241(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR659 Gene

Variant ID Type Subtype PubMed ID
esv2758838 CNV loss 17122850
esv3893482 CNV gain 25118596

Additional Variant Information for MIR659 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR659

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR659 Gene

Disorders for MIR659 Gene

Additional Disease Information for MIR659

No disorders were found for MIR659 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR659 Gene

Publications for MIR659 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients. (PMID: 25980492) Stigliani S … Corrias MV (Oncotarget 2015) 3 58
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  4. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. (PMID: 18723524) Rademakers R … Dickson DW (Human molecular genetics 2008) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR659 Gene

Sources for MIR659 Gene

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