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Aliases for MIR659 Gene

Subcategory (RNA class) for MIR659 Gene


Quality Score for this RNA gene is


Aliases for MIR659 Gene

  • MicroRNA 659 2 3
  • Hsa-Mir-659 3
  • Mir-659 3
  • MIRN659 3

External Ids for MIR659 Gene

Previous HGNC Symbols for MIR659 Gene

  • MIRN659

Previous GeneCards Identifiers for MIR659 Gene

  • GC22M036574
  • GC22M038243
  • GC22M038390

Summaries for MIR659 Gene

Entrez Gene Summary for MIR659 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR659 Gene

MIR659 (MicroRNA 659) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR659 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR659

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR659 Gene

Genomics for MIR659 Gene

Genomic Location for MIR659 Gene

37,847,678 bp from pter
37,847,774 bp from pter
97 bases
Minus strand

Genomic View for MIR659 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR659 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR659 Gene

ORGUL Member Location for MIR659 Gene

ORGUL Member Location for MIR659 gene

No data available for Regulatory Elements for MIR659 Gene

Proteins for MIR659 Gene

Post-translational modifications for MIR659 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR659 Gene

Domains & Families for MIR659 Gene

Gene Families for MIR659 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR659: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR659 Gene

Function for MIR659 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR659 Gene

Localization for MIR659 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR659 Gene

Pathways & Interactions for MIR659 Gene

SuperPathways for MIR659 Gene

No Data Available

Interacting Proteins for MIR659 Gene

Gene Ontology (GO) - Biological Process for MIR659 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR659 Gene

Drugs & Compounds for MIR659 Gene

No Compound Related Data Available

Transcripts for MIR659 Gene

fRNAdb Secondary structures for MIR659 Gene

  • FR027573
  • hsa-miR-659-5p_MIMAT0022710_Homo_sapiens_miR-659-5p_mature

mRNA/cDNA for MIR659 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR659 Gene

No ASD Table

Relevant External Links for MIR659 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR659 Gene

mRNA expression in normal human tissues for MIR659 Gene

genes like me logo Genes that share expression patterns with MIR659: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR659 Gene

Orthologs for MIR659 Gene

Evolution for MIR659 Gene

Gene Tree for MIR659 (if available)
Gene Tree for MIR659 (if available)

No data available for Orthologs for MIR659 Gene

Paralogs for MIR659 Gene

No data available for Paralogs for MIR659 Gene

Variants for MIR659 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR659 Gene

Variant ID Type Subtype PubMed ID
dgv4965n71 CNV Loss 21882294
nsv915035 CNV Loss 21882294
dgv1406e1 CNV Complex 17122850

Relevant External Links for MIR659 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR659 Gene

Disorders for MIR659 Gene

Relevant External Links for MIR659

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR659: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR659 Gene

Publications for MIR659 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 67
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 67
  3. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. (PMID: 18723524) Rademakers R. … Dickson D.W. (Hum. Mol. Genet. 2008) 67
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 67

Products for MIR659 Gene

Sources for MIR659 Gene

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