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Aliases for MIR659 Gene

Subcategory (RNA class) for MIR659 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR659 Gene

  • MicroRNA 659 2 3 5
  • Hsa-Mir-659 3
  • Mir-659 3
  • MIRN659 3

External Ids for MIR659 Gene

Previous HGNC Symbols for MIR659 Gene

  • MIRN659

Previous GeneCards Identifiers for MIR659 Gene

  • GC22M036574
  • GC22M038243
  • GC22M038390
  • GC22M038512
  • GC22M038824
  • GC22M039961

Summaries for MIR659 Gene

Entrez Gene Summary for MIR659 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR659 Gene

MIR659 (MicroRNA 659) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR659 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR659

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR659 Gene

Genomics for MIR659 Gene

Regulatory Elements for MIR659 Gene

Enhancers for MIR659 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F037886 0.2 ENCODE 11.9 -40.0 -39987 2.3 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF48 ZNF121 ELK1 FOS SP5 GALR3 ANKRD54 EIF3L MIR659 MIR658 GCAT H1F0 POLR2F SOX10 GC22P037892
GH22F037880 0.6 ENCODE 11.9 -33.2 -33190 1.1 ZNF121 JUND JUN IKZF1 MLLT1 FOS SP7 EIF3L MIR659 ANKRD54 MIR658 GCAT H1F0 ENSG00000279738 GC22P037892
GH22F037809 0.6 ENCODE 11.7 +38.5 38475 0.0 PAF1 TFAP4 SAP130 ARID4B ZIC2 TBX21 POLR2A NR2F6 ANKRD54 MIR658 EIF3L MIR659 GCAT GALR3
GH22F037801 1.4 FANTOM5 ENCODE 11.7 +42.2 42245 7.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GCAT H1F0 GALR3 KDELR3 ANKRD54 MIR658 MIR659 EIF3L CBY1 PRDX3P1
GH22F037931 1.2 FANTOM5 Ensembl ENCODE 11.4 -85.3 -85349 2.9 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 ZNF48 ZNF2 GLIS2 ZNF207 GALR3 EIF3L ENSG00000230149 ENSG00000273076 ENSG00000272669 ENSG00000225450 RNU6-900P MICALL1 SOX10 PRDX3P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR659 on UCSC Golden Path with GeneCards custom track

Promoters for MIR659 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085470 -1526 2601 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for MIR659 Gene

Chromosome:
22
Start:
37,847,678 bp from pter
End:
37,847,774 bp from pter
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR659 Gene

Genes around MIR659 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR659 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR659 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR659 Gene

ORGUL Member Location for MIR659 Gene

ORGUL Member Location for MIR659 gene

Proteins for MIR659 Gene

Post-translational modifications for MIR659 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR659 Gene

Domains & Families for MIR659 Gene

Gene Families for MIR659 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR659: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR659 Gene

Function for MIR659 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR659 Gene

Localization for MIR659 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR659 Gene

Pathways & Interactions for MIR659 Gene

SuperPathways for MIR659 Gene

No Data Available

Interacting Proteins for MIR659 Gene

Gene Ontology (GO) - Biological Process for MIR659 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR659 Gene

Transcripts for MIR659 Gene

fRNAdb Secondary structures for MIR659 Gene

  • FR027573
  • hsa-miR-659-5p_MIMAT0022710_Homo_sapiens_miR-659-5p_mature

mRNA/cDNA for MIR659 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR659 Gene

No ASD Table

Relevant External Links for MIR659 Gene

GeneLoc Exon Structure for
MIR659
ECgene alternative splicing isoforms for
MIR659

Expression for MIR659 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR659 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR659 Gene:

MIR659
genes like me logo Genes that share expression patterns with MIR659: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR659 Gene

Orthologs for MIR659 Gene

Evolution for MIR659 Gene

ENSEMBL:
Gene Tree for MIR659 (if available)
TreeFam:
Gene Tree for MIR659 (if available)

No data available for Orthologs for MIR659 Gene

Paralogs for MIR659 Gene

No data available for Paralogs for MIR659 Gene

Variants for MIR659 Gene

Sequence variations from dbSNP and Humsavar for MIR659 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111819484 -- 37,847,784(+) TTAAG(C/T)TCCAT intron-variant, upstream-variant-2KB
rs11551389 -- 37,849,469(+) TGATG(A/G)TTATG upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs116342821 -- 37,847,938(+) ATGCA(A/G)ATACC intron-variant, upstream-variant-2KB
rs139887367 -- 37,847,868(+) TGGGG(C/T)TGGGC intron-variant, upstream-variant-2KB
rs140032270 -- 37,848,741(+) GTCCG(A/G)ACGTT upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR659 Gene

Variant ID Type Subtype PubMed ID
esv2758838 CNV loss 17122850
esv3893482 CNV gain 25118596

Relevant External Links for MIR659 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR659

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR659 Gene

Disorders for MIR659 Gene

Relevant External Links for MIR659

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR659

No disorders were found for MIR659 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR659 Gene

Publications for MIR659 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Deregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients. (PMID: 25980492) Stigliani S. … Corrias M.V. (Oncotarget 2015) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. (PMID: 18723524) Rademakers R. … Dickson D.W. (Hum. Mol. Genet. 2008) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR659 Gene

Sources for MIR659 Gene

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