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Aliases for MIR658 Gene

Subcategory (RNA class) for MIR658 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR658 Gene

  • MicroRNA 658 2 3
  • ANKRD54 4 5
  • Lyn-Interacting Ankyrin Repeat Protein 4
  • Ankyrin Repeat Domain 54 5
  • Hsa-Mir-658 3
  • MIRN658 3
  • LIAR 4

External Ids for MIR658 Gene

Previous HGNC Symbols for MIR658 Gene

  • MIRN658

Previous GeneCards Identifiers for MIR658 Gene

  • GC22M036571
  • GC22M038241
  • GC22M038314
  • GC22M039043
  • GC22M039413
  • GC22M040091
  • GC22M038389
  • GC22M038511
  • GC22M038823
  • GC22M039960

Summaries for MIR658 Gene

Entrez Gene Summary for MIR658 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR658 Gene

MIR658 (MicroRNA 658) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is ANKRD23.

UniProtKB/Swiss-Prot for MIR658 Gene

  • Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR658 Gene

Genomics for MIR658 Gene

Regulatory Elements for MIR658 Gene

Enhancers for MIR658 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F037801 1.4 FANTOM5 ENCODE 12.3 +43.8 43798 7.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GCAT H1F0 GALR3 KDELR3 MIR658 ANKRD54 MIR659 EIF3L CBY1 PRDX3P1
GH22F037809 0.6 ENCODE 12.3 +40.0 40028 0.0 PAF1 TFAP4 SAP130 ARID4B ZIC2 TBX21 POLR2A NR2F6 MIR658 ANKRD54 EIF3L MIR659 GCAT GALR3
GH22F037886 0.2 ENCODE 11.8 -38.4 -38434 2.3 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF48 ZNF121 ELK1 FOS SP5 GALR3 ANKRD54 EIF3L MIR659 MIR658 GCAT H1F0 POLR2F SOX10 GC22P037892
GH22F038824 0.8 ENCODE 11.7 -975.4 -975394 0.2 ZFP64 ARID4B YBX1 SLC30A9 ZNF143 ZNF263 MXD4 MIER2 REST PPARG DNAL4 SUN2 MIR658 GC22M041408
GH22F037463 0.9 ENCODE 11.7 +386.2 386230 0.2 KLF11 TFE3 SAP130 KLF6 MIER1 ZFP64 ARID4B MIER2 REST ZSCAN9 MIR658 GC22M041368 GC22P037457
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR658 on UCSC Golden Path with GeneCards custom track

Promoters for MIR658 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085470 27 2601 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for MIR658 Gene

Chromosome:
22
Start:
37,830,855 bp from pter
End:
37,849,327 bp from pter
Size:
18,473 bases
Orientation:
Minus strand

Genomic View for MIR658 Gene

Genes around MIR658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR658 Gene

Proteins for MIR658 Gene

  • Protein details for MIR658 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXT1-ANR54_HUMAN
    Recommended name:
    Ankyrin repeat domain-containing protein 54
    Protein Accession:
    Q6NXT1
    Secondary Accessions:
    • Q6ZSB1
    • Q9UGV1

    Protein attributes for MIR658 Gene

    Size:
    300 amino acids
    Molecular mass:
    32505 Da
    Quaternary structure:
    • Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.
    • Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.

    Alternative splice isoforms for MIR658 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR658 Gene

Post-translational modifications for MIR658 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR658 Gene

Domains & Families for MIR658 Gene

Gene Families for MIR658 Gene

Protein Domains for MIR658 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NXT1

UniProtKB/Swiss-Prot:

ANR54_HUMAN :
  • Contains 4 ANK repeats.
Similarity:
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with MIR658: view

No data available for Suggested Antigen Peptide Sequences for MIR658 Gene

Function for MIR658 Gene

Molecular function for MIR658 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

Gene Ontology (GO) - Molecular Function for MIR658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019887 protein kinase regulator activity IEA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with MIR658: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR658 Gene

Localization for MIR658 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR658 Gene

Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MIR658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0030496 midbody ISS --
genes like me logo Genes that share ontologies with MIR658: view

No data available for Subcellular locations from COMPARTMENTS for MIR658 Gene

Pathways & Interactions for MIR658 Gene

SuperPathways for MIR658 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0045648 positive regulation of erythrocyte differentiation IEA --
GO:0045859 regulation of protein kinase activity IEA --
GO:1902531 regulation of intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with MIR658: view

No data available for Pathways by source and SIGNOR curated interactions for MIR658 Gene

Transcripts for MIR658 Gene

mRNA/cDNA for MIR658 Gene

(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR658 Gene

No ASD Table

Relevant External Links for MIR658 Gene

GeneLoc Exon Structure for
MIR658
ECgene alternative splicing isoforms for
MIR658

Expression for MIR658 Gene

mRNA expression in normal human tissues for MIR658 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR658 Gene:

MIR658
genes like me logo Genes that share expression patterns with MIR658: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR658 Gene

Orthologs for MIR658 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR658 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANKRD54 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANKRD54 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANKRD54 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ankrd54 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 79 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ANKRD54 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANKRD54 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANKRD54 35
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ankrd54 35
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10809 35
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 35
  • 18 (a)
OneToMany
Species where no ortholog for MIR658 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR658 Gene

ENSEMBL:
Gene Tree for MIR658 (if available)
TreeFam:
Gene Tree for MIR658 (if available)

Paralogs for MIR658 Gene

Paralogs for MIR658 Gene

Pseudogenes.org Pseudogenes for MIR658 Gene

genes like me logo Genes that share paralogs with MIR658: view

Variants for MIR658 Gene

Sequence variations from dbSNP and Humsavar for MIR658 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10600027 -- 37,845,022(+) AACGC(-/A)AAAAA intron-variant, upstream-variant-2KB
rs111364503 -- 37,844,260(+) GGGCC(G/T)GGCCG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs111780229 -- 37,846,344(+) GACAG(G/T)ATCTC intron-variant, upstream-variant-2KB
rs112367253 -- 37,844,610(+) GCGAC(A/G)GAGTC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs113730097 -- 37,843,881(+) CCGCC(C/T)CGGGC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR658 Gene

Variant ID Type Subtype PubMed ID
esv2666189 CNV deletion 23128226
esv2758838 CNV loss 17122850
esv3647720 CNV loss 21293372
esv3893482 CNV gain 25118596

Relevant External Links for MIR658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR658

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR658 Gene

Disorders for MIR658 Gene

Relevant External Links for MIR658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR658

No disorders were found for MIR658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR658 Gene

Publications for MIR658 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64
  4. Large-scale proteomics analysis of the human kinome. (PMID: 19369195) Oppermann F.S. … Daub H. (Mol. Cell. Proteomics 2009) 4 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for MIR658 Gene

Sources for MIR658 Gene

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