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Aliases for MIR658 Gene

Subcategory (RNA class) for MIR658 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR658 Gene

  • MicroRNA 658 2 3 5
  • Hsa-Mir-658 3
  • MIRN658 3

External Ids for MIR658 Gene

Previous HGNC Symbols for MIR658 Gene

  • MIRN658

Previous GeneCards Identifiers for MIR658 Gene

  • GC22M036571
  • GC22M038241
  • GC22M038314
  • GC22M039043
  • GC22M039413
  • GC22M040091
  • GC22M038389
  • GC22M038511
  • GC22M038823
  • GC22M039960
  • GC22M040651
  • GC22M041099

Summaries for MIR658 Gene

Entrez Gene Summary for MIR658 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR658 Gene

MIR658 (MicroRNA 658) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR658 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR658

Additional gene information for MIR658 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR658 Gene

Genomics for MIR658 Gene

Regulatory Elements for MIR658 Gene

Enhancers for MIR658 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H037841 1.1 ENCODE 0.7 +0.8 802 3 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207 GGA1 ANKRD54 LL22NC01-81G9.3 PLA2G6 MIR658 PIR42346
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR658 on UCSC Golden Path with GeneCards custom track

Promoters for MIR658 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146075 171 2001 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for MIR658 Gene

Chromosome:
22
Start:
37,844,272 bp from pter
End:
37,844,371 bp from pter
Size:
100 bases
Orientation:
Minus strand

Genomic View for MIR658 Gene

Genes around MIR658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR658 Gene

ORGUL Member Location for MIR658 Gene

ORGUL Member Location for MIR658 gene

Proteins for MIR658 Gene

Post-translational modifications for MIR658 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR658 Gene

Domains & Families for MIR658 Gene

Gene Families for MIR658 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR658: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR658 Gene

Function for MIR658 Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR658
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR658 Gene

Localization for MIR658 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR658 Gene

Pathways & Interactions for MIR658 Gene

SuperPathways for MIR658 Gene

No Data Available

Interacting Proteins for MIR658 Gene

Gene Ontology (GO) - Biological Process for MIR658 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR658 Gene

Drugs & Compounds for MIR658 Gene

No Compound Related Data Available

Transcripts for MIR658 Gene

fRNAdb Secondary structures for MIR658 Gene

  • hsa-miR-658_MIMAT0003336_Homo_sapiens_miR-658_mature

mRNA/cDNA for MIR658 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR658
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR658 Gene

No ASD Table

Relevant External Links for MIR658 Gene

GeneLoc Exon Structure for
MIR658
ECgene alternative splicing isoforms for
MIR658

Expression for MIR658 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR658 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR658 Gene:

MIR658
genes like me logo Genes that share expression patterns with MIR658: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR658 Gene

Orthologs for MIR658 Gene

Evolution for MIR658 Gene

ENSEMBL:
Gene Tree for MIR658 (if available)
TreeFam:
Gene Tree for MIR658 (if available)

No data available for Orthologs for MIR658 Gene

Paralogs for MIR658 Gene

No data available for Paralogs for MIR658 Gene

Variants for MIR658 Gene

Sequence variations from dbSNP and Humsavar for MIR658 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000251975 -- 37,844,949(+) GATTT(G/T)CAGGC intron-variant, upstream-variant-2KB
rs1000380440 -- 37,844,546(+) CCTTG(C/G)CTTTC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001823769 -- 37,845,419(+) AGCAC(G/T)TCTAT intron-variant, upstream-variant-2KB
rs1001942977 -- 37,843,803(+) GGGAC(C/G)CCGGC intron-variant, downstream-variant-500B, utr-variant-5-prime
rs1002191169 -- 37,845,059(+) TGCAT(A/G)ATGTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR658 Gene

Variant ID Type Subtype PubMed ID
esv2666189 CNV deletion 23128226
esv2758838 CNV loss 17122850
esv3647720 CNV loss 21293372
esv3893482 CNV gain 25118596

Relevant External Links for MIR658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR658

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR658 Gene

Disorders for MIR658 Gene

Relevant External Links for MIR658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR658

No disorders were found for MIR658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR658 Gene

Publications for MIR658 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 60
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR658 Gene

Sources for MIR658 Gene

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