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Aliases for MIR658 Gene

Subcategory (RNA class) for MIR658 Gene


Quality Score for this RNA gene is


Aliases for MIR658 Gene

  • MicroRNA 658 2 3
  • ANKRD54 4 5
  • Lyn-Interacting Ankyrin Repeat Protein 4
  • Ankyrin Repeat Domain 54 5
  • Hsa-Mir-658 3
  • MIRN658 3
  • LIAR 4

External Ids for MIR658 Gene

Previous HGNC Symbols for MIR658 Gene

  • MIRN658

Previous GeneCards Identifiers for MIR658 Gene

  • GC22M036571
  • GC22M038241
  • GC22M038314
  • GC22M039043
  • GC22M039413
  • GC22M040091
  • GC22M038389
  • GC22M038511
  • GC22M038823
  • GC22M039960

Summaries for MIR658 Gene

Entrez Gene Summary for MIR658 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR658 Gene

MIR658 (MicroRNA 658) is an RNA Gene, and is affiliated with the miRNA class. An important paralog of this gene is ANKRD23.

UniProtKB/Swiss-Prot for MIR658 Gene

  • Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR658 Gene

Genomics for MIR658 Gene

Regulatory Elements for MIR658 Gene

Enhancers for MIR658 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F037801 1.5 FANTOM5 ENCODE 12.3 +43.8 43798 7.3 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC GCAT H1F0 GALR3 KDELR3 ANKRD54 MIR658 MIR659 EIF3L CBY1 PRDX3P1
GH22F037931 1.6 FANTOM5 Ensembl ENCODE 11.3 -83.8 -83796 2.9 HDGF MLX ZFP64 ARID4B SIN3A FEZF1 ZNF48 ZNF2 GLIS2 ZNF207 GALR3 EIF3L ENSG00000230149 ENSG00000273076 ENSG00000272669 ENSG00000225450 RNU6-900P MICALL1 SOX10 PRDX3P1
GH22F038174 1.6 FANTOM5 ENCODE 10.7 -329.5 -329482 8.7 MLX YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 NFYC MAFF PRDX3P1 ENSG00000230149 TMEM184B ENSG00000273076 CBY1 ENSG00000225450 ENSG00000272669 APOBEC3C PLA2G6
GH22F037781 1.4 Ensembl ENCODE 10.8 +65.7 65663 4.6 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF2 CBY1 PRDX3P1 TRIOBP ENSG00000230149 ENSG00000273076 ENSG00000228274 CSNK1E ENSG00000230912 MIR658 ENSG00000225450
GH22F037014 1.3 Ensembl ENCODE 10.6 +828.7 828654 12.5 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 PAF1 ZNF263 ENSG00000229971 MPST LL22NC01-81G9.3 KCTD17 ENSG00000231467 TMPRSS6 TEX33 NCF4 NCF4-AS1 MIR658
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR658 on UCSC Golden Path with GeneCards custom track

Promoters for MIR658 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000085470 27 2601 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for MIR658 Gene

37,830,855 bp from pter
37,849,327 bp from pter
18,473 bases
Minus strand

Genomic View for MIR658 Gene

Genes around MIR658 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR658 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR658 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR658 Gene

Proteins for MIR658 Gene

  • Protein details for MIR658 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ankyrin repeat domain-containing protein 54
    Protein Accession:
    Secondary Accessions:
    • Q6ZSB1
    • Q9UGV1

    Protein attributes for MIR658 Gene

    300 amino acids
    Molecular mass:
    32505 Da
    Quaternary structure:
    • Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.
    • Interacts (via ankyrin repeat region) with LYN (via SH3-domain) in an activation-independent status of LYN. Forms a multiprotein complex with LYN and HCLS1. Interacts with TSN2, VAV1, DBNL AND LASP1.

    Alternative splice isoforms for MIR658 Gene


neXtProt entry for MIR658 Gene

Post-translational modifications for MIR658 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR658 Gene

Domains & Families for MIR658 Gene

Gene Families for MIR658 Gene

Protein Domains for MIR658 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 ANK repeats.
  • Contains 4 ANK repeats.
genes like me logo Genes that share domains with MIR658: view

No data available for Suggested Antigen Peptide Sequences for MIR658 Gene

Function for MIR658 Gene

Molecular function for MIR658 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation.

Gene Ontology (GO) - Molecular Function for MIR658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019887 protein kinase regulator activity IEA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with MIR658: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR658 Gene

Localization for MIR658 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR658 Gene

Nucleus. Cytoplasm. Midbody. Note=Shuttles between nucleus and cytoplasm during the cell cycle. EPO stimulation induces nuclear accumulation (By similarity). {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MIR658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0030496 midbody ISS --
genes like me logo Genes that share ontologies with MIR658: view

No data available for Subcellular locations from COMPARTMENTS for MIR658 Gene

Pathways & Interactions for MIR658 Gene

SuperPathways for MIR658 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR658 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006913 nucleocytoplasmic transport IEA --
GO:0045648 positive regulation of erythrocyte differentiation IEA --
GO:0045859 regulation of protein kinase activity IEA --
GO:1902531 regulation of intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with MIR658: view

No data available for Pathways by source and SIGNOR curated interactions for MIR658 Gene

Transcripts for MIR658 Gene

mRNA/cDNA for MIR658 Gene

(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR658 Gene

No ASD Table

Relevant External Links for MIR658 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR658 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR658 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR658 Gene:

genes like me logo Genes that share expression patterns with MIR658: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR658 Gene

Orthologs for MIR658 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR658 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANKRD54 35
  • 99 (a)
(Bos Taurus)
Mammalia ANKRD54 35
  • 95 (a)
(Canis familiaris)
Mammalia ANKRD54 35
  • 92 (a)
(Mus musculus)
Mammalia Ankrd54 35
  • 92 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 79 (a)
-- 35
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia ANKRD54 35
  • 73 (a)
(Gallus gallus)
Aves ANKRD54 35
  • 80 (a)
(Anolis carolinensis)
Reptilia ANKRD54 35
  • 73 (a)
(Danio rerio)
Actinopterygii ankrd54 35
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10809 35
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NAS6 35
  • 18 (a)
Species where no ortholog for MIR658 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR658 Gene

Gene Tree for MIR658 (if available)
Gene Tree for MIR658 (if available)

Paralogs for MIR658 Gene

Paralogs for MIR658 Gene Pseudogenes for MIR658 Gene

genes like me logo Genes that share paralogs with MIR658: view

Variants for MIR658 Gene

Sequence variations from dbSNP and Humsavar for MIR658 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10600027 -- 37,845,022(+) AACGC(-/A)AAAAA intron-variant, upstream-variant-2KB
rs111364503 -- 37,844,260(+) GGGCC(G/T)GGCCG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs111780229 -- 37,846,344(+) GACAG(G/T)ATCTC intron-variant, upstream-variant-2KB
rs112367253 -- 37,844,610(+) GCGAC(A/G)GAGTC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs113730097 -- 37,843,881(+) CCGCC(C/T)CGGGC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR658 Gene

Variant ID Type Subtype PubMed ID
esv3893482 CNV gain 25118596
esv3647720 CNV loss 21293372
esv2758838 CNV loss 17122850
esv2666189 CNV deletion 23128226

Relevant External Links for MIR658 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR658 Gene

Disorders for MIR658 Gene

Relevant External Links for MIR658

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR658 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR658 Gene

Publications for MIR658 Gene

  1. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
  3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen J.V. … Mann M. (Sci. Signal. 2010) 4 64
  4. Large-scale proteomics analysis of the human kinome. (PMID: 19369195) Oppermann F.S. … Daub H. (Mol. Cell. Proteomics 2009) 4 64
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 4 64

Products for MIR658 Gene

Sources for MIR658 Gene

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