Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR653 Gene

Subcategory (RNA class) for MIR653 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR653 Gene

  • MicroRNA 653 2 3 5
  • Hsa-Mir-653 3
  • Mir-653 3
  • MIRN653 3

External Ids for MIR653 Gene

Previous HGNC Symbols for MIR653 Gene

  • MIRN653

Previous GeneCards Identifiers for MIR653 Gene

  • GC07M092952
  • GC07M093112

Summaries for MIR653 Gene

Entrez Gene Summary for MIR653 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR653 Gene

MIR653 (MicroRNA 653) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR653 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR653

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR653 Gene

Genomics for MIR653 Gene

Regulatory Elements for MIR653 Gene

Enhancers for MIR653 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G093558 0.7 Ensembl 9.9 -76.6 -76647 1.4 ATF1 NR2F1 MAFG ATF2 JUND CBX8 ZNF316 ATF3 ZNF692 IRF1 MIR653 MIR489 HEPACAM2 CALCR LOC105375400
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR653 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR653 Gene

Chromosome:
7
Start:
93,482,760 bp from pter
End:
93,482,855 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR653 Gene

Genes around MIR653 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR653 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR653 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR653 Gene

ORGUL Member Location for MIR653 Gene

ORGUL Member Location for MIR653 gene

Proteins for MIR653 Gene

Post-translational modifications for MIR653 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR653 Gene

Domains & Families for MIR653 Gene

Gene Families for MIR653 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR653: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR653 Gene

Function for MIR653 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR653 Gene

Localization for MIR653 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR653 Gene

Pathways & Interactions for MIR653 Gene

SuperPathways for MIR653 Gene

No Data Available

Interacting Proteins for MIR653 Gene

Gene Ontology (GO) - Biological Process for MIR653 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR653 Gene

Drugs & Compounds for MIR653 Gene

No Compound Related Data Available

Transcripts for MIR653 Gene

fRNAdb Secondary structures for MIR653 Gene

  • hsa-mir-653_MI0003674_Homo_sapiens_miR-653_stem-loop_hairpin

mRNA/cDNA for MIR653 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR653 Gene

No ASD Table

Relevant External Links for MIR653 Gene

GeneLoc Exon Structure for
MIR653
ECgene alternative splicing isoforms for
MIR653

Expression for MIR653 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR653 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR653 Gene:

MIR653
genes like me logo Genes that share expression patterns with MIR653: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR653 Gene

Orthologs for MIR653 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR653 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-653 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-653 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-653 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir653 35
  • 85 (a)
OneToOne
Species where no ortholog for MIR653 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR653 Gene

ENSEMBL:
Gene Tree for MIR653 (if available)
TreeFam:
Gene Tree for MIR653 (if available)

Paralogs for MIR653 Gene

No data available for Paralogs for MIR653 Gene

Variants for MIR653 Gene

Sequence variations from dbSNP and Humsavar for MIR653 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1002565194 -- 93,483,686(+) CAGTA(A/G)TGATT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1002612697 -- 93,484,192(+) CTAAT(A/C)ATGGA intron-variant, upstream-variant-2KB
rs1005177731 -- 93,483,432(+) AGATA(A/G)ATAGA intron-variant, upstream-variant-2KB
rs1008236598 -- 93,483,343(+) CCTGA(A/G)TATTT intron-variant, upstream-variant-2KB
rs1009265012 -- 93,483,094(+) TAGGT(A/C)CTTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR653 Gene

Variant ID Type Subtype PubMed ID
nsv607815 CNV loss 21841781

Relevant External Links for MIR653 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR653

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR653 Gene

Disorders for MIR653 Gene

Relevant External Links for MIR653

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR653

No disorders were found for MIR653 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR653 Gene

Publications for MIR653 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J. … Kaessmann H. (Genome Res. 2013) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR653 Gene

Sources for MIR653 Gene

Content
Loading form....