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Aliases for MIR650 Gene

Subcategory (RNA class) for MIR650 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR650 Gene

  • MicroRNA 650 2 3 5
  • Hsa-Mir-650 3
  • MIRN650 3

External Ids for MIR650 Gene

ORGUL Members for MIR650 Gene

Previous HGNC Symbols for MIR650 Gene

  • MIRN650

Previous GeneCards Identifiers for MIR650 Gene

  • GC22P021498
  • GC22P023165

Summaries for MIR650 Gene

Entrez Gene Summary for MIR650 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR650 Gene

MIR650 (MicroRNA 650) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR650 Gene

Genomics for MIR650 Gene

Genomic Location for MIR650 Gene

Chromosome:
22
Start:
22,822,776 bp from pter
End:
22,822,871 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR650 Gene

Genes around MIR650 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR650 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR650 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR650 Gene

No data available for Regulatory Elements for MIR650 Gene

Proteins for MIR650 Gene

Post-translational modifications for MIR650 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR650 Gene

Domains & Families for MIR650 Gene

Gene Families for MIR650 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR650: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR650 Gene

Function for MIR650 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR650 Gene

Localization for MIR650 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR650 Gene

Pathways & Interactions for MIR650 Gene

SuperPathways for MIR650 Gene

No Data Available

Interacting Proteins for MIR650 Gene

Gene Ontology (GO) - Biological Process for MIR650 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR650 Gene

Drugs & Compounds for MIR650 Gene

No Compound Related Data Available

Transcripts for MIR650 Gene

mRNA/cDNA for MIR650 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR650 Gene

No ASD Table

Relevant External Links for MIR650 Gene

GeneLoc Exon Structure for
MIR650
ECgene alternative splicing isoforms for
MIR650

Expression for MIR650 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR650 Gene:

MIR650
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR650 Gene

Orthologs for MIR650 Gene

Evolution for MIR650 Gene

ENSEMBL:
Gene Tree for MIR650 (if available)
TreeFam:
Gene Tree for MIR650 (if available)

No data available for Orthologs for MIR650 Gene

Paralogs for MIR650 Gene

No data available for Paralogs for MIR650 Gene

Variants for MIR650 Gene

Sequence variations from dbSNP and Humsavar for MIR650 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1001545131 -- 22,822,672(+) CCAGG(A/C)CCAAG intron-variant, upstream-variant-2KB
rs1004696142 -- 22,823,058(+) TCCTG(C/T)ACTGG intron-variant, downstream-variant-500B
rs1005063474 -- 22,822,325(+) TGGGA(C/T)GAGCT intron-variant, upstream-variant-2KB
rs1008191242 -- 22,822,715(+) CAGAT(C/T)TGCAT intron-variant, upstream-variant-2KB
rs1008604484 -- 22,821,543(+) ATTTC(A/G)TCTGC nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR650 Gene

Variant ID Type Subtype PubMed ID
dgv39n64 CNV loss 17921354
dgv40n64 CNV loss 17921354
dgv42n64 CNV gain 17921354
dgv4505n100 CNV loss 25217958
dgv4511n100 CNV gain 25217958
dgv4512n100 CNV loss 25217958
dgv4513n100 CNV gain 25217958
dgv4514n100 CNV loss 25217958
dgv4517n100 CNV gain 25217958
dgv4519n100 CNV gain+loss 25217958
dgv4521n100 CNV loss 25217958
dgv4522n100 CNV gain 25217958
dgv4523n100 CNV gain 25217958
dgv4524n100 CNV loss 25217958
dgv4525n100 CNV loss 25217958
dgv551n27 CNV loss 19166990
dgv557n27 CNV loss 19166990
dgv561n27 CNV gain 19166990
dgv562n27 CNV loss 19166990
dgv568n27 CNV loss 19166990
dgv569n27 CNV loss 19166990
dgv570n27 CNV loss 19166990
dgv571n27 CNV loss 19166990
dgv731n67 CNV loss 20364138
dgv733n67 CNV loss 20364138
dgv8004n54 CNV loss 21841781
dgv8005n54 CNV loss 21841781
dgv8015n54 CNV loss 21841781
dgv8025n54 CNV loss 21841781
dgv8032n54 CNV loss 21841781
dgv8033n54 CNV loss 21841781
dgv8034n54 CNV loss 21841781
dgv822e199 CNV deletion 23128226
dgv826e214 CNV loss 21293372
esv2662193 CNV deletion 23128226
esv33722 CNV gain 17666407
esv3568289 CNV loss 25503493
esv3647375 CNV loss 21293372
esv3647377 CNV loss 21293372
esv3893457 CNV gain 25118596
esv990735 CNV gain 20482838
esv997030 CNV gain 20482838
nsv1055811 CNV gain 25217958
nsv1058733 CNV gain 25217958
nsv1061433 CNV gain+loss 25217958
nsv1062929 CNV loss 25217958
nsv1063128 CNV gain+loss 25217958
nsv1066359 CNV loss 25217958
nsv1066891 CNV gain 25217958
nsv1066925 CNV gain+loss 25217958
nsv1066933 CNV gain+loss 25217958
nsv195 CNV deletion 15895083
nsv433178 CNV loss 18776910
nsv438338 CNV loss 16468122
nsv459553 CNV loss 19166990
nsv459655 CNV loss 19166990
nsv469839 CNV gain+loss 16826518
nsv471597 CNV loss 15918152
nsv498982 CNV loss 21111241
nsv514964 CNV loss 21397061
nsv517485 CNV gain+loss 19592680
nsv521695 CNV loss 19592680
nsv588512 CNV loss 21841781
nsv588515 CNV loss 21841781
nsv588516 CNV gain 21841781
nsv588531 CNV gain+loss 21841781
nsv588576 CNV loss 21841781
nsv588582 CNV loss 21841781
nsv7350 OTHER inversion 18451855
nsv817937 CNV loss 17921354
nsv817966 CNV gain+loss 17921354
nsv817975 CNV gain 17921354
nsv817976 CNV gain+loss 17921354
nsv817977 CNV gain+loss 17921354
nsv819428 CNV gain 19587683
nsv820655 CNV deletion 20802225
nsv821694 CNV loss 15273396
nsv828979 CNV gain+loss 20364138
nsv829012 CNV loss 20364138
nsv829014 CNV loss 20364138
nsv834152 CNV loss 17160897
nsv979653 CNV duplication 23825009

Relevant External Links for MIR650 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR650

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR650 Gene

Disorders for MIR650 Gene

Relevant External Links for MIR650

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR650

No disorders were found for MIR650 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR650 Gene

Publications for MIR650 Gene

  1. A 22q11.2 amplification in the region encoding microRNA-650 correlates with the epithelial to mesenchymal transition in breast cancer primary cultures of Mexican patients. (PMID: 28101578) Lango-ChavarrA-a M. … Fuentes-PananA! E.M. (Int. J. Oncol. 2017) 3 64
  2. MiR-650 inhibits proliferation, migration and invasion of rheumatoid arthritis synovial fibroblasts by targeting AKT2. (PMID: 28129626) Xu X. … Wang M. (Biomed. Pharmacother. 2017) 3 64
  3. Pattern recognition receptor mediated downregulation of microRNA-650 fine-tunes MxA expression in dendritic cells infected with influenza A virus. (PMID: 26460926) Pichulik T. … Simmons A. (Eur. J. Immunol. 2016) 3 64
  4. Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression. (PMID: 25956032) Zuo Z.H. … Luo J.H. (Am. J. Pathol. 2015) 3 64
  5. Upregulation of miR-650 is correlated with down-regulation of ING4 and progression of hepatocellular carcinoma. (PMID: 22767438) Zeng Z.L. … Yao L. (J Surg Oncol 2013) 3 64

Products for MIR650 Gene

Sources for MIR650 Gene

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