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Aliases for MIR650 Gene

Subcategory (RNA class) for MIR650 Gene


Quality Score for this RNA gene is


Aliases for MIR650 Gene

  • MicroRNA 650 2 3
  • Hsa-Mir-650 3
  • MIRN650 3

External Ids for MIR650 Gene

ORGUL Members for MIR650 Gene

Previous HGNC Symbols for MIR650 Gene

  • MIRN650

Previous GeneCards Identifiers for MIR650 Gene

  • GC22P021498
  • GC22P023165

Summaries for MIR650 Gene

Entrez Gene Summary for MIR650 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR650 Gene

MIR650 (MicroRNA 650) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR650 Gene

Genomics for MIR650 Gene

Genomic Location for MIR650 Gene

22,822,776 bp from pter
22,822,871 bp from pter
96 bases
Plus strand

Genomic View for MIR650 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR650 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR650 Gene

No data available for Regulatory Elements for MIR650 Gene

Proteins for MIR650 Gene

Post-translational modifications for MIR650 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR650 Gene

Domains for MIR650 Gene

Gene Families for MIR650 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR650: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR650 Gene

Function for MIR650 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR650 Gene

Localization for MIR650 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR650 Gene

Pathways for MIR650 Gene

SuperPathways for MIR650 Gene

No Data Available

Interacting Proteins for MIR650 Gene

Gene Ontology (GO) - Biological Process for MIR650 Gene


No data available for Pathways by source for MIR650 Gene

Transcripts for MIR650 Gene

mRNA/cDNA for MIR650 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR650 Gene

No ASD Table

Relevant External Links for MIR650 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR650 Gene

No Expression Related Data Available

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR650 Gene

Orthologs for MIR650 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR650 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-650 36
  • 98 (a)
Species with no ortholog for MIR650:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR650 Gene

Gene Tree for MIR650 (if available)
Gene Tree for MIR650 (if available)

Paralogs for MIR650 Gene

No data available for Paralogs for MIR650 Gene

Variants for MIR650 Gene

Sequence variations from dbSNP and Humsavar for MIR650 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs2236734 -- 22,822,553(+) TTTCT(C/G)TCCTG upstream-variant-2KB
rs4521149 -- 22,822,938(+) TCACC(A/G/T)GGGCC downstream-variant-500B
rs5996395 -- 22,822,348(+) GACCA(A/G)GGACC upstream-variant-2KB
rs5996396 -- 22,822,440(+) AAAGA(A/G)GTTAC upstream-variant-2KB
rs5996397 -- 22,822,846(+) CCTCA(C/G)CCTCC nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR650 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv817937 CNV Loss 17921354
nsv828979 CNV Gain+Loss 20364138
dgv731n67 CNV Loss 20364138
dgv551n27 CNV Loss 19166990
nsv438338 CNV Loss 16468122
dgv39n64 CNV Loss 17921354
dgv557n27 CNV Loss 19166990
nsv819428 CNV Gain 19587683
nsv821694 CNV Loss 15273396
nsv459553 CNV Loss 19166990
dgv4900n71 CNV Gain 21882294
esv2662193 CNV Deletion 23128226
esv990735 CNV Gain 20482838
nsv521695 CNV Loss 19592680
dgv561n27 CNV Gain 19166990
dgv562n27 CNV Loss 19166990
dgv40n64 CNV Loss 17921354
nsv517485 CNV Gain+Loss 19592680
nsv433178 CNV Loss 18776910
dgv822e199 CNV Deletion 23128226
nsv514964 CNV Loss 21397061
dgv568n27 CNV Loss 19166990
nsv817966 CNV Gain+Loss 17921354
dgv569n27 CNV Loss 19166990
dgv42n64 CNV Gain 17921354
nsv469839 CNV Complex 16826518
nsv471597 CNV Loss 15918152
nsv834152 CNV Loss 17160897
esv2724033 CNV Deletion 23290073
nsv817975 CNV Gain 17921354
nsv817976 CNV Gain+Loss 17921354
dgv570n27 CNV Loss 19166990
esv2724035 CNV Deletion 23290073
nsv817977 CNV Gain+Loss 17921354
dgv571n27 CNV Loss 19166990
nsv195 CNV Loss 15895083
nsv459655 CNV Loss 19166990
esv997030 CNV Gain 20482838
dgv733n67 CNV Loss 20364138
nsv820655 CNV Deletion 20802225
nsv498982 CNV Loss 21111241
esv33722 CNV Gain 17666407
nsv829012 CNV Loss 20364138
nsv829014 CNV Loss 20364138

Relevant External Links for MIR650 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR650 Gene

Disorders for MIR650 Gene

No disorders were found for MIR650 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR650 Gene

Publications for MIR650 Gene

  1. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  2. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3
  3. MicroRNA-650 targets ING4 to promote gastric cancer tumorigenicity. (PMID: 20381459) Zhang X. … Zhang M. (Biochem. Biophys. Res. Commun. 2010) 3
  4. Down-regulation of NDRG2 gene expression in human colorectal cancer involves promoter methylation and microRNA-650. (PMID: 21352815) Feng L. … Wu Y. (Biochem. Biophys. Res. Commun. 2011) 3
  5. MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic leukemia. (PMID: 22234685) Mraz M. … Pospisilova S. (Blood 2012) 3

Products for MIR650 Gene

Sources for MIR650 Gene

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