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Aliases for MIR649 Gene

Subcategory (RNA class) for MIR649 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR649 Gene

  • MicroRNA 649 2 3 5
  • Hsa-Mir-649 3
  • MIRN649 3

External Ids for MIR649 Gene

Previous HGNC Symbols for MIR649 Gene

  • MIRN649

Previous GeneCards Identifiers for MIR649 Gene

  • GC22M019720
  • GC22M021388

Summaries for MIR649 Gene

Entrez Gene Summary for MIR649 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR649 Gene

MIR649 (MicroRNA 649) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR649 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR649

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR649 Gene

Genomics for MIR649 Gene

Regulatory Elements for MIR649 Gene

Enhancers for MIR649 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F021036 1.2 Ensembl ENCODE 0.8 -3.7 -3673 2.1 ATF1 PKNOX1 CREB3L1 SIN3A GATA2 FOS KDM4B MCM3 REST ZNF592 THAP7-AS1 THAP7 P2RX6P P2RX6 SERPIND1 SLC7A4 MIR649
GH22F021041 1.2 Ensembl ENCODE 0.4 -10.0 -10010 4.6 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A GLIS2 FOS KDM4B CEBPZ SP3 THAP7-AS1 THAP7 LRRC74B P2RX6P LOC100420177 SCARF2 DGCR8 CCDC116 SLC7A4 MIR649
GH22F021039 0.9 ENCODE 0.4 -6.0 -6010 0.9 TBP HDGF ATF1 NFRKB PTRF ZBTB40 KLF13 SMARCA5 ZBTB2 MIER1 THAP7 THAP7-AS1 P2RX6 P2RX6P MIR649
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR649 on UCSC Golden Path with GeneCards custom track

Promoters for MIR649 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001842061 1872 801 HDGF ESRRA MTA2 NR2F1 UBTF ZBTB7A JUND HMBOX1 ZBTB33 EZH2

Genomic Location for MIR649 Gene

Chromosome:
22
Start:
21,034,176 bp from pter
End:
21,034,272 bp from pter
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR649 Gene

Genes around MIR649 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR649 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR649 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR649 Gene

ORGUL Member Location for MIR649 Gene

ORGUL Member Location for MIR649 gene

Proteins for MIR649 Gene

Post-translational modifications for MIR649 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR649 Gene

Domains & Families for MIR649 Gene

Gene Families for MIR649 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR649: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR649 Gene

Function for MIR649 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR649 Gene

Localization for MIR649 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR649 Gene

Pathways & Interactions for MIR649 Gene

SuperPathways for MIR649 Gene

No Data Available

Interacting Proteins for MIR649 Gene

Gene Ontology (GO) - Biological Process for MIR649 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR649 Gene

Transcripts for MIR649 Gene

fRNAdb Secondary structures for MIR649 Gene

  • hsa-miR-649_MIMAT0003319_Homo_sapiens_miR-649_mature

mRNA/cDNA for MIR649 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR649 Gene

No ASD Table

Relevant External Links for MIR649 Gene

GeneLoc Exon Structure for
MIR649
ECgene alternative splicing isoforms for
MIR649

Expression for MIR649 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR649 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR649 Gene:

MIR649
genes like me logo Genes that share expression patterns with MIR649: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR649 Gene

Orthologs for MIR649 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR649 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-649 35
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 46 (a)
OneToMany
Species where no ortholog for MIR649 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR649 Gene

ENSEMBL:
Gene Tree for MIR649 (if available)
TreeFam:
Gene Tree for MIR649 (if available)

Paralogs for MIR649 Gene

No data available for Paralogs for MIR649 Gene

Variants for MIR649 Gene

Sequence variations from dbSNP and Humsavar for MIR649 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs113928239 -- 21,033,941(+) GACTA(A/G)GCAGG downstream-variant-500B, upstream-variant-2KB
rs139275843 -- 21,036,064(+) TGTCT(C/T)AGCCT upstream-variant-2KB
rs140059778 -- 21,034,437(+) TTAAA(A/G)TAAGT upstream-variant-2KB
rs141028605 -- 21,035,092(+) ATAGT(A/C)AAAAT upstream-variant-2KB
rs142247197 -- 21,035,241(+) AGTTA(C/G)ATTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR649 Gene

Variant ID Type Subtype PubMed ID
dgv4483n100 CNV gain 25217958
dgv7993n54 CNV gain 21841781
dgv7994n54 CNV gain 21841781
esv2678175 CNV deletion 23128226
esv2760719 CNV gain 21179565
esv2763693 CNV gain 21179565
esv3647304 CNV loss 21293372
esv3647305 CNV gain 21293372
esv3893441 CNV gain+loss 25118596
nsv1056614 CNV loss 25217958
nsv1065617 CNV gain 25217958
nsv3563 CNV deletion 18451855
nsv436864 CNV insertion 17901297
nsv523162 CNV loss 19592680
nsv588305 CNV loss 21841781
nsv588306 CNV gain 21841781
nsv828960 CNV loss 20364138
nsv834141 CNV loss 17160897
nsv834142 CNV gain 17160897

Relevant External Links for MIR649 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR649

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR649 Gene

Disorders for MIR649 Gene

Relevant External Links for MIR649

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR649

No disorders were found for MIR649 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR649 Gene

Publications for MIR649 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR649 Gene

Sources for MIR649 Gene

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