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Aliases for MIR648 Gene

Subcategory (RNA class) for MIR648 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR648 Gene

  • MicroRNA 648 2 3 5
  • Hsa-Mir-648 3
  • MIRN648 3

External Ids for MIR648 Gene

Previous HGNC Symbols for MIR648 Gene

  • MIRN648

Previous GeneCards Identifiers for MIR648 Gene

  • GC22M016844
  • GC22M018463

Summaries for MIR648 Gene

Entrez Gene Summary for MIR648 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR648 Gene

MIR648 (MicroRNA 648) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR648 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR648

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR648 Gene

Genomics for MIR648 Gene

Regulatory Elements for MIR648 Gene

Enhancers for MIR648 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F017942 1.2 Ensembl ENCODE 12.4 +38.5 38470 1.0 MIR648 MICAL3 ENSG00000093100 PIR41738 GC22M017948 PIR51874
GH22F017979 1.2 Ensembl ENCODE 0.8 +0.4 361 2.4 HDGF ATF1 PKNOX1 ARNT SIN3A CBX5 ELK1 GATA2 KLF13 NCOA1 MICAL3 MIR648 PIR53397
GH22F017974 1.1 Ensembl ENCODE 0.4 +5.9 5861 1.0 PKNOX1 MXI1 TBL1XR1 WRNIP1 IRF3 EBF1 RELA EED CREM MTA2 MICAL3 ENSG00000093100 MIR648 PIR53397
GH22F017969 1.4 FANTOM5 Ensembl ENCODE 0.4 +9.1 9116 5.2 ELF3 ARID4B SIN3A DMAP1 RAD21 RARA RFX5 SCRT2 RCOR1 FOS MICAL3 ENSG00000093100 MIR648 PIR53397
GH22F017965 0.5 Ensembl 0.4 +14.6 14561 1.2 HDGF BCOR KLF1 TAL1 HIC1 ARID1B GLIS2 ZFHX2 GATA2 SCRT2 MICAL3 MIR648 PIR53397
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR648 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR648 Gene

Chromosome:
22
Start:
17,980,868 bp from pter
End:
17,980,961 bp from pter
Size:
94 bases
Orientation:
Minus strand

Genomic View for MIR648 Gene

Genes around MIR648 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR648 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR648 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR648 Gene

ORGUL Member Location for MIR648 Gene

ORGUL Member Location for MIR648 gene

Proteins for MIR648 Gene

Post-translational modifications for MIR648 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR648 Gene

Domains & Families for MIR648 Gene

Gene Families for MIR648 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR648: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR648 Gene

Function for MIR648 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR648 Gene

Localization for MIR648 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR648 Gene

Pathways & Interactions for MIR648 Gene

SuperPathways for MIR648 Gene

No Data Available

Interacting Proteins for MIR648 Gene

Gene Ontology (GO) - Biological Process for MIR648 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR648 Gene

Transcripts for MIR648 Gene

fRNAdb Secondary structures for MIR648 Gene

  • FR110853
  • hsa-miR-648_MIMAT0003318_Homo_sapiens_miR-648_mature

mRNA/cDNA for MIR648 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR648 Gene

No ASD Table

Relevant External Links for MIR648 Gene

GeneLoc Exon Structure for
MIR648
ECgene alternative splicing isoforms for
MIR648

Expression for MIR648 Gene

mRNA expression in normal human tissues for MIR648 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR648 Gene:

MIR648
genes like me logo Genes that share expression patterns with MIR648: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR648 Gene

Orthologs for MIR648 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR648 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR648 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR648 Gene

ENSEMBL:
Gene Tree for MIR648 (if available)
TreeFam:
Gene Tree for MIR648 (if available)

Paralogs for MIR648 Gene

No data available for Paralogs for MIR648 Gene

Variants for MIR648 Gene

Sequence variations from dbSNP and Humsavar for MIR648 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10599443 -- 17,982,757(+) taaaa(-/AAG)taaaa intron-variant, upstream-variant-2KB
rs10684317 -- 17,982,732(+) ACATA(-/AAAAT)AAAAT intron-variant, upstream-variant-2KB
rs111747811 -- 17,982,404(+) AGGCA(A/C/T)GGTGG intron-variant, upstream-variant-2KB
rs11268253 -- 17,982,679(+) AAATT(-/CATAA/CATAACATAA/CATAACATAACATAA)CATAA intron-variant, upstream-variant-2KB
rs113259309 -- 17,982,445(+) AGGTG(A/G)GTGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR648 Gene

Variant ID Type Subtype PubMed ID
esv3575408 CNV gain 25503493
esv3893428 CNV loss 25118596
nsv428385 CNV gain+loss 18775914

Relevant External Links for MIR648 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR648

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR648 Gene

Disorders for MIR648 Gene

Relevant External Links for MIR648

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR648

No disorders were found for MIR648 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR648 Gene

Publications for MIR648 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. MicroRNA 648 Targets ET-1 mRNA and is cotranscriptionally regulated with MICAL3 by PAX5. (PMID: 25403488) Li C. … Kalra V.K. (Mol. Cell. Biol. 2015) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR648 Gene

Sources for MIR648 Gene

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