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MIR647 Gene(RNA Gene)

MicroRNA 647

GCID:
GC20M063942
GIFtS:
20
Genes Participants
UDN Logo

Aliases for MIR647 Gene

Subcategory (RNA class) for MIR647 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR647 Gene

  • MicroRNA 647 2 3 5
  • Hsa-Mir-647 3
  • MIRN647 3

External Ids for MIR647 Gene

ORGUL Members for MIR647 Gene

Previous HGNC Symbols for MIR647 Gene

  • MIRN647

Previous GeneCards Identifiers for MIR647 Gene

  • GC20M062045
  • GC20M062573

Summaries for MIR647 Gene

Entrez Gene Summary for MIR647 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR647 Gene

MIR647 (MicroRNA 647) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR647 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR647 Gene

Genomics for MIR647 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR647 Gene

Enhancers for MIR647 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G063845 1.6 Ensembl ENCODE dbSUPER 32.6 +95.4 95400 3.3 HDGF FOXA2 PKNOX1 ARNT AGO1 ARID4B SIN3A YBX1 FEZF1 DMAP1 TNFRSF6B PCMTD2 MIR647 RTEL1 ZNF512B UCKL1 ZBTB46-AS1 DNAJC5 PRPF6 C20orf204
GH20G063657 1.2 ENCODE 32.5 +284.3 284292 2.7 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 RTEL1 MIR647 STMN3 PRPF6 GMEB2 HAR1A UCKL1 LIME1 TNFRSF6B RTEL1-TNFRSF6B
GH20G063971 1.6 Ensembl ENCODE dbSUPER 23.9 -30.9 -30877 3.8 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A YBX1 DMAP1 ZNF2 MIR647 C20orf204 PRPF6 UCKL1 SAMD10 ZNF512B
GH20G063893 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.7 +46.0 46035 5.4 HDGF FOXA2 PKNOX1 ARNT MLX AGO1 WRNIP1 SIN3A ARID4B DMAP1 UCKL1 MIR647 GMEB2 PRPF6 RGS19 RTEL1 OPRL1 ZBTB46 C20orf181 FNDC11
GH20G064062 1.7 Ensembl ENCODE dbSUPER 14.3 -122.1 -122121 5.3 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC RGS19 RTEL1 TNFRSF6B ARFGAP1 MIR647 ZNF512B PRPF6 UCKL1 TCEA2 C20orf204
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR647 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR647 Gene

Chromosome:
20
Start:
63,942,631 bp from pter
End:
63,942,726 bp from pter
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR647 Gene

Genes around MIR647 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR647 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR647 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR647 Gene

ORGUL Member Location for MIR647 Gene

ORGUL Member Location for MIR647 gene

Proteins for MIR647 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR647 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR647 Gene

Domains & Families for MIR647 Gene

Gene Families for MIR647 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR647: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR647 Gene

Function for MIR647 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR647 Gene

Localization for MIR647 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR647 Gene

Pathways & Interactions for MIR647 Gene

SuperPathways for MIR647 Gene

PathCards logo More details on SuperPathways for MIR647
No Data Available

Interacting Proteins for MIR647 Gene

Gene Ontology (GO) - Biological Process for MIR647 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR647 Gene

Drugs & Compounds for MIR647 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR647 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR647 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR647 Gene

No ASD Table

Relevant External Links for MIR647 Gene

GeneLoc Exon Structure for
MIR647
ECgene alternative splicing isoforms for
MIR647

Expression for MIR647 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR647 Gene

mRNA expression in normal human tissues for MIR647 Gene
mRNA expression by GTEx for MIR647 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR647 Gene:

MIR647
genes like me logo Genes that share expression patterns with MIR647: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR647 Gene

Orthologs for MIR647 Gene

Evolution for MIR647 Gene

ENSEMBL:
Gene Tree for MIR647 (if available)
TreeFam:
Gene Tree for MIR647 (if available)

No data available for Orthologs for MIR647 Gene

Paralogs for MIR647 Gene

No data available for Paralogs for MIR647 Gene

Variants for MIR647 Gene

Sequence variations from dbSNP and Humsavar for MIR647 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000147518 -- 63,943,090(+) GACAG(C/T)GGGAT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000157374 -- 63,943,255(+) GGTCC(C/G)TGAGG intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000711236 -- 63,942,903(+) CGGAA(G/T)CTGGA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000771301 -- 63,944,035(+) GAGAG(A/G)AGCCT intron-variant, upstream-variant-2KB
rs1002932942 -- 63,942,438(+) CGGGT(C/G)ACACA intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR647 Gene

Variant ID Type Subtype PubMed ID
nsv428381 CNV gain+loss 18775914
nsv469773 CNV gain 16826518
nsv509784 CNV insertion 20534489
nsv586695 CNV loss 21841781
nsv953309 CNV deletion 24416366

Relevant External Links for MIR647 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR647

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR647 Gene

Disorders for MIR647 Gene

Relevant External Links for MIR647

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR647

No disorders were found for MIR647 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR647 Gene

Publications for MIR647 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Role of miR-647 in human gastric cancer suppression. (PMID: 28098914) Cao W. … Xiao Q. (Oncol. Rep. 2017) 3 64
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR647 Gene

Sources for MIR647 Gene

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