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Aliases for MIR646 Gene

Subcategory (RNA class) for MIR646 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR646 Gene

  • MicroRNA 646 2 3 5
  • Hsa-Mir-646 3
  • MIRN646 3

External Ids for MIR646 Gene

ORGUL Members for MIR646 Gene

Previous HGNC Symbols for MIR646 Gene

  • MIRN646

Previous GeneCards Identifiers for MIR646 Gene

  • GC20P058317
  • GC20P058883

Summaries for MIR646 Gene

Entrez Gene Summary for MIR646 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR646 Gene

MIR646 (MicroRNA 646) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR646 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR646 Gene

Genomics for MIR646 Gene

GeneHancer (GH) Regulatory Elements for MIR646 Gene

Promoters and enhancers for MIR646 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I060264 Enhancer 0.5 ENCODE dbSUPER 12.1 -43.2 -43155 1.1 CTCF MIR646 LOC105372698 GC20P060310 MIR646HG
GH20I060340 Enhancer 0.5 dbSUPER 12 +32.4 32389 1.5 CTCF ZNF133 CHD1 NR2C1 FOS MIR646 LOC105372697 MTCO2P1 MIR646HG
GH20I060410 Enhancer 0.4 dbSUPER 11.4 +103.7 103679 3.1 PKNOX1 KLF4 MAFK MIR646 MTCO2P1 LOC105372697 MIR646HG
GH20I060275 Enhancer 0.3 dbSUPER 12.4 -32.5 -32474 1.5 ARID3A MIR646 LOC105372698 GC20P060310 MIR646HG
GH20I060278 Enhancer 0.2 dbSUPER 12.7 -29.0 -28986 1.2 MIR646 LOC105372698 GC20P060310 MIR646HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR646 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR646 Gene

Genomic Locations for MIR646 Gene
chr20:60,308,474-60,308,567
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr20:58,883,532-58,883,625
(GRCh37/hg19)

Genomic View for MIR646 Gene

Genes around MIR646 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR646 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR646 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR646 Gene

Proteins for MIR646 Gene

Post-translational modifications for MIR646 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR646 Gene

Domains & Families for MIR646 Gene

Gene Families for MIR646 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR646: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR646 Gene

Function for MIR646 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR646 Gene

Localization for MIR646 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR646 Gene

Pathways & Interactions for MIR646 Gene

SuperPathways for MIR646 Gene

No Data Available

Interacting Proteins for MIR646 Gene

Gene Ontology (GO) - Biological Process for MIR646 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR646 Gene

Drugs & Compounds for MIR646 Gene

No Compound Related Data Available

Transcripts for MIR646 Gene

mRNA/cDNA for MIR646 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR646 Gene

No ASD Table

Relevant External Links for MIR646 Gene

GeneLoc Exon Structure for
MIR646
ECgene alternative splicing isoforms for
MIR646

Expression for MIR646 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR646 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR646 Gene:

MIR646
genes like me logo Genes that share expression patterns with MIR646: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR646 Gene

Orthologs for MIR646 Gene

Evolution for MIR646 Gene

ENSEMBL:
Gene Tree for MIR646 (if available)
TreeFam:
Gene Tree for MIR646 (if available)

No data available for Orthologs for MIR646 Gene

Paralogs for MIR646 Gene

No data available for Paralogs for MIR646 Gene

Variants for MIR646 Gene

Sequence variations from dbSNP and Humsavar for MIR646 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1001650149 -- 60,308,892(+) G/A downstream_transcript_variant
rs1001700849 -- 60,308,636(+) C/T downstream_transcript_variant
rs1003317353 -- 60,307,711(+) T/G upstream_transcript_variant
rs1005936621 -- 60,308,100(+) AAAA/AAA upstream_transcript_variant
rs1006334521 -- 60,308,336(+) G/A upstream_transcript_variant

Additional Variant Information for MIR646 Gene

Human Gene Mutation Database (HGMD)
MIR646
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR646

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR646 Gene

Disorders for MIR646 Gene

Additional Disease Information for MIR646

No disorders were found for MIR646 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR646 Gene

Publications for MIR646 Gene

  1. MiR-646 inhibited cell proliferation and EMT-induced metastasis by targeting FOXK1 in gastric cancer. (PMID: 28632723) Zhang P … Wang JD (British journal of cancer 2017) 3 58
  2. miR-646 is a key negative regulator of EGFR pathway in lung cancer. (PMID: 27462913) Pan Y … Bai C (Experimental lung research 2016) 3 58
  3. Association between a variant in microRNA-646 and the susceptibility to hepatocellular carcinoma in a large-scale population. (PMID: 25177719) Wang R … Liu J (TheScientificWorldJournal 2014) 3 58
  4. A three-stage genome-wide association study of general cognitive ability: hunting the small effects. (PMID: 20306291) Davis OS … Plomin R (Behavior genetics 2010) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR646 Gene

Sources for MIR646 Gene

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