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Aliases for MIR646 Gene

Subcategory (RNA class) for MIR646 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR646 Gene

  • MicroRNA 646 2 3 5
  • Hsa-Mir-646 3
  • MIRN646 3

External Ids for MIR646 Gene

ORGUL Members for MIR646 Gene

Previous HGNC Symbols for MIR646 Gene

  • MIRN646

Previous GeneCards Identifiers for MIR646 Gene

  • GC20P058317
  • GC20P058883

Summaries for MIR646 Gene

Entrez Gene Summary for MIR646 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR646 Gene

MIR646 (MicroRNA 646) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR646 Gene

Genomics for MIR646 Gene

Regulatory Elements for MIR646 Gene

Enhancers for MIR646 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F060264 0.5 Ensembl ENCODE 12 -43.1 -43082 1.2 CTCF SUZ12 SIN3A RAD21 ZNF335 HIC1 ZFHX2 EGR2 EZH2 ZBTB10 MIR646 LOC105372698 GC20P060310
GH20F060310 1.1 FANTOM5 0.8 +2.2 2204 0.1 MIR646 LOC105372697
GH20F060332 0.2 ENCODE 0.3 +24.4 24416 0.9 PKNOX1 FEZF1 YY1 CBX5 KLF7 JUNB TSHZ1 MEF2D ZNF610 SMARCA4 LOC105372697 MIR646
GH20F060329 0.2 ENCODE 0.3 +20.6 20638 0.0 NRF1 LOC105372697 MIR646
GH20F060334 0.9 ENCODE 0.3 +25.8 25844 0.2 ELK1 POLR2A ZKSCAN1 LOC105372697 MIR646
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR646 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR646 Gene

Chromosome:
20
Start:
60,308,474 bp from pter
End:
60,308,567 bp from pter
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR646 Gene

Genes around MIR646 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR646 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR646 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR646 Gene

Proteins for MIR646 Gene

Post-translational modifications for MIR646 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR646 Gene

Domains & Families for MIR646 Gene

Gene Families for MIR646 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR646: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR646 Gene

Function for MIR646 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR646 Gene

Localization for MIR646 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR646 Gene

Pathways & Interactions for MIR646 Gene

SuperPathways for MIR646 Gene

No Data Available

Interacting Proteins for MIR646 Gene

Gene Ontology (GO) - Biological Process for MIR646 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR646 Gene

Transcripts for MIR646 Gene

mRNA/cDNA for MIR646 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR646 Gene

No ASD Table

Relevant External Links for MIR646 Gene

GeneLoc Exon Structure for
MIR646
ECgene alternative splicing isoforms for
MIR646

Expression for MIR646 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR646 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR646 Gene:

MIR646
genes like me logo Genes that share expression patterns with MIR646: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR646 Gene

Orthologs for MIR646 Gene

Evolution for MIR646 Gene

ENSEMBL:
Gene Tree for MIR646 (if available)
TreeFam:
Gene Tree for MIR646 (if available)

No data available for Orthologs for MIR646 Gene

Paralogs for MIR646 Gene

No data available for Paralogs for MIR646 Gene

Variants for MIR646 Gene

Sequence variations from dbSNP and Humsavar for MIR646 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111380880 -- 60,308,279(+) GTCAG(A/G)GTTCA intron-variant, upstream-variant-2KB
rs111645699 -- 60,308,673(+) GTGAT(C/T)TTACC intron-variant, downstream-variant-500B
rs111867069 -- 60,308,341(+) GGGAA(A/T)CAGAT intron-variant, upstream-variant-2KB
rs112615245 -- 60,308,401(+) GGGTT(C/T)TCTCG intron-variant, upstream-variant-2KB
rs112798138 -- 60,308,017(+) TCTAG(C/T)TGGAC intron-variant, upstream-variant-2KB

Relevant External Links for MIR646 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR646

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR646 Gene

Disorders for MIR646 Gene

Relevant External Links for MIR646

Human Genome Epidemiology (HuGE) Navigator
MIR646
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR646

No disorders were found for MIR646 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR646 Gene

Publications for MIR646 Gene

  1. Association between a variant in microRNA-646 and the susceptibility to hepatocellular carcinoma in a large-scale population. (PMID: 25177719) Wang R. … Liu J. (ScientificWorldJournal 2014) 3 64
  2. A three-stage genome-wide association study of general cognitive ability: hunting the small effects. (PMID: 20306291) Davis O.S. … Plomin R. (Behav. Genet. 2010) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  4. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 64

Products for MIR646 Gene

Sources for MIR646 Gene

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