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Aliases for MIR645 Gene

Subcategory (RNA class) for MIR645 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR645 Gene

  • MicroRNA 645 2 3 5
  • Hsa-Mir-645 3
  • MIRN645 3

External Ids for MIR645 Gene

ORGUL Members for MIR645 Gene

Previous HGNC Symbols for MIR645 Gene

  • MIRN645

Previous GeneCards Identifiers for MIR645 Gene

  • GC20P048636
  • GC20P049202

Summaries for MIR645 Gene

Entrez Gene Summary for MIR645 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR645 Gene

MIR645 (MicroRNA 645) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR645 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR645 Gene

Genomics for MIR645 Gene

GeneHancer (GH) Regulatory Elements for MIR645 Gene

Promoters and enhancers for MIR645 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I050587 Enhancer 0.4 ENCODE 550.8 +1.6 1633 0.1 MAZ POLR2A FOS GC20P050586 GC20P050587 MIR645 MIR1302-5 RIPOR3
GH20I050588 Enhancer 0.4 ENCODE 550.8 +1.5 1453 0.2 MAZ POLR2A FOS GC20P050586 GC20P050587 MIR645 MIR1302-5 RIPOR3
GH20I050507 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -70.4 -70435 14.7 MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF143 ZNF548 SP3 PTPN1 GC20P050514 ADNP ENSG00000232043 DPM1 CEBPB PSMD10P1 MOCS3 LINC01273 MIR645
GH20I050721 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 +149.4 149399 27.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PARD6B ADNP ENSG00000232043 DPM1 RIPOR3 PTPN1 MOCS3 BCAS4 PSMD10P1 MIR645
GH20I050557 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 12.2 -27.2 -27161 1.6 HDGF PKNOX1 ATF1 ARNT TCF12 FOS ATF7 NCOA1 ZNF592 ATF4 PTPN1 RN7SL672P ENSG00000232043 ADNP MIR645 DPM1 PSMD10P1 CEBPB GC20P050564
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR645 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR645 Gene

Genomic Locations for MIR645 Gene
chr20:50,585,786-50,585,879
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr20:49,202,323-49,202,416
(GRCh37/hg19)

Genomic View for MIR645 Gene

Genes around MIR645 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR645 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR645 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR645 Gene

Proteins for MIR645 Gene

Post-translational modifications for MIR645 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR645 Gene

Domains & Families for MIR645 Gene

Gene Families for MIR645 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR645: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR645 Gene

Function for MIR645 Gene

Phenotypes From GWAS Catalog for MIR645 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR645 Gene

Localization for MIR645 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR645 Gene

Pathways & Interactions for MIR645 Gene

SuperPathways for MIR645 Gene

No Data Available

Interacting Proteins for MIR645 Gene

Gene Ontology (GO) - Biological Process for MIR645 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR645 Gene

Drugs & Compounds for MIR645 Gene

No Compound Related Data Available

Transcripts for MIR645 Gene

mRNA/cDNA for MIR645 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR645 Gene

No ASD Table

Relevant External Links for MIR645 Gene

GeneLoc Exon Structure for
MIR645
ECgene alternative splicing isoforms for
MIR645

Expression for MIR645 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR645 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR645 Gene:

MIR645
genes like me logo Genes that share expression patterns with MIR645: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR645 Gene

Orthologs for MIR645 Gene

Evolution for MIR645 Gene

ENSEMBL:
Gene Tree for MIR645 (if available)
TreeFam:
Gene Tree for MIR645 (if available)

No data available for Orthologs for MIR645 Gene

Paralogs for MIR645 Gene

No data available for Paralogs for MIR645 Gene

Variants for MIR645 Gene

Sequence variations from dbSNP and Humsavar for MIR645 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000972207 -- 50,584,834(+) A/G/T upstream_transcript_variant
rs1002810713 -- 50,585,053(+) TTGTTTG/TTGTTTGTTTG upstream_transcript_variant
rs1003145119 -- 50,585,368(+) G/A upstream_transcript_variant
rs1005094934 -- 50,583,976(+) C/T upstream_transcript_variant
rs1006594059 -- 50,584,089(+) C/T upstream_transcript_variant

Additional Variant Information for MIR645 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR645

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR645 Gene

Disorders for MIR645 Gene

Additional Disease Information for MIR645

No disorders were found for MIR645 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR645 Gene

Publications for MIR645 Gene

  1. Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis. (PMID: 27609068) Wang Y … Zhang W (Cancer letters 2016) 3 58
  2. MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2. (PMID: 25174799) Feng X … Gao S (BMC cancer 2014) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  4. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 58

Products for MIR645 Gene

Sources for MIR645 Gene

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