Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR645 Gene

Subcategory (RNA class) for MIR645 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR645 Gene

  • MicroRNA 645 2 3 5
  • Hsa-Mir-645 3
  • MIRN645 3

External Ids for MIR645 Gene

ORGUL Members for MIR645 Gene

Previous HGNC Symbols for MIR645 Gene

  • MIRN645

Previous GeneCards Identifiers for MIR645 Gene

  • GC20P048636
  • GC20P049202

Summaries for MIR645 Gene

Entrez Gene Summary for MIR645 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR645 Gene

MIR645 (MicroRNA 645) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR645 Gene

Genomics for MIR645 Gene

Regulatory Elements for MIR645 Gene

Enhancers for MIR645 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F050559 1 Ensembl ENCODE 12.7 -24.3 -24311 3.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 BRCA1 ZNF207 FOS ZNF263 JUNB MIR645 ENSG00000232043 PTPN1 GC20P050564 RN7SL672P
GH20F050563 0.6 ENCODE 12.7 -22.2 -22237 0.9 TBP HDGF PKNOX1 ATF1 ARID4B YY1 RARA ZNF121 SCRT2 CREM ENSG00000232043 MIR645 PTPN1 ENSG00000201501
GH20F050564 0.7 ENCODE 12.7 -21.6 -21628 0.2 HDGF ATF1 RARA ZNF121 SCRT2 CREM MIXL1 PPARG SP1 CEBPA MIR645 PTPN1 ENSG00000201501 ENSG00000232043
GH20F050557 0.8 Ensembl ENCODE 12.2 -27.1 -27149 1.6 YBX3 HDAC1 CBX3 PKNOX1 ATF1 ARNT TBL1XR1 FOS CREM ZNF263 ENSG00000232043 MIR645 PTPN1 CEBPB GC20P050564 RN7SL672P
GH20F050554 0.5 Ensembl 12.2 -31.5 -31486 0.2 ZNF558 ENSG00000232043 MIR645 PTPN1 RN7SL672P GC20P050514
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR645 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR645 Gene

Chromosome:
20
Start:
50,585,786 bp from pter
End:
50,585,879 bp from pter
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR645 Gene

Genes around MIR645 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR645 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR645 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR645 Gene

Proteins for MIR645 Gene

Post-translational modifications for MIR645 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR645 Gene

Domains & Families for MIR645 Gene

Gene Families for MIR645 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR645: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR645 Gene

Function for MIR645 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR645 Gene

Localization for MIR645 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR645 Gene

Pathways & Interactions for MIR645 Gene

SuperPathways for MIR645 Gene

No Data Available

Interacting Proteins for MIR645 Gene

Gene Ontology (GO) - Biological Process for MIR645 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR645 Gene

Transcripts for MIR645 Gene

mRNA/cDNA for MIR645 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR645 Gene

No ASD Table

Relevant External Links for MIR645 Gene

GeneLoc Exon Structure for
MIR645
ECgene alternative splicing isoforms for
MIR645

Expression for MIR645 Gene

mRNA expression in normal human tissues for MIR645 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR645 Gene:

MIR645
genes like me logo Genes that share expression patterns with MIR645: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR645 Gene

Orthologs for MIR645 Gene

Evolution for MIR645 Gene

ENSEMBL:
Gene Tree for MIR645 (if available)
TreeFam:
Gene Tree for MIR645 (if available)

No data available for Orthologs for MIR645 Gene

Paralogs for MIR645 Gene

No data available for Paralogs for MIR645 Gene

Variants for MIR645 Gene

Sequence variations from dbSNP and Humsavar for MIR645 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1057207 -- 50,584,633(+) TGGGT(G/T)GGGGG upstream-variant-2KB, utr-variant-3-prime
rs111428553 -- 50,585,768(+) CACTC(A/G)CCTCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs111787621 -- 50,585,212(+) GTGTA(C/T)AAAAT downstream-variant-500B, upstream-variant-2KB
rs111893316 -- 50,585,814(+) AGTAC(C/T)GGTCT intron-variant, nc-transcript-variant, downstream-variant-500B
rs112736998 -- 50,585,537(+) GAACC(A/G)GTTCC upstream-variant-2KB

Relevant External Links for MIR645 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR645

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR645 Gene

Disorders for MIR645 Gene

Relevant External Links for MIR645

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR645

No disorders were found for MIR645 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR645 Gene

Publications for MIR645 Gene

  1. MicroRNA-645, up-regulated in human adencarcinoma of gastric esophageal junction, inhibits apoptosis by targeting tumor suppressor IFIT2. (PMID: 25174799) Feng X. … Gao S. (BMC Cancer 2014) 3 64
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  3. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 64

Products for MIR645 Gene

Sources for MIR645 Gene

Content
Loading form....