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Aliases for MIR639 Gene

Subcategory (RNA class) for MIR639 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR639 Gene

  • MicroRNA 639 2 3 5
  • Hsa-Mir-639 3
  • MIRN639 3

External Ids for MIR639 Gene

ORGUL Members for MIR639 Gene

Previous HGNC Symbols for MIR639 Gene

  • MIRN639

Previous GeneCards Identifiers for MIR639 Gene

  • GC19P014503
  • GC19P014640

Summaries for MIR639 Gene

Entrez Gene Summary for MIR639 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR639 Gene

MIR639 (MicroRNA 639) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).

fRNAdb sequence ontologies for MIR639 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR639 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR639 Gene

Genomics for MIR639 Gene

Regulatory Elements for MIR639 Gene


Promoters for MIR639 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107555 157 1801 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Locations for MIR639 Gene

Genomic Locations for MIR639 Gene
chr19:14,529,543-14,529,640
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand
chr19:14,640,355-14,640,452
(GRCh37/hg19)

Genomic View for MIR639 Gene

Genes around MIR639 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR639 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR639 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR639 Gene

ORGUL Member Location for MIR639 Gene

ORGUL Member Location for MIR639 gene

Proteins for MIR639 Gene

Post-translational modifications for MIR639 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR639 Gene

Domains & Families for MIR639 Gene

Gene Families for MIR639 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR639: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR639 Gene

Function for MIR639 Gene

Gene Ontology (GO) - Molecular Function for MIR639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR639: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR639 Gene

Localization for MIR639 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR639 Gene

Pathways & Interactions for MIR639 Gene

genes like me logo Genes that share pathways with MIR639: view

Interacting Proteins for MIR639 Gene

Gene Ontology (GO) - Biological Process for MIR639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 20190813
genes like me logo Genes that share ontologies with MIR639: view

No data available for SIGNOR curated interactions for MIR639 Gene

Drugs & Compounds for MIR639 Gene

No Compound Related Data Available

Transcripts for MIR639 Gene

mRNA/cDNA for MIR639 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR639 Gene

No ASD Table

Relevant External Links for MIR639 Gene

GeneLoc Exon Structure for
MIR639
ECgene alternative splicing isoforms for
MIR639

Expression for MIR639 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR639 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR639 Gene:

MIR639
genes like me logo Genes that share expression patterns with MIR639: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR639 Gene

Orthologs for MIR639 Gene

Evolution for MIR639 Gene

ENSEMBL:
Gene Tree for MIR639 (if available)
TreeFam:
Gene Tree for MIR639 (if available)

No data available for Orthologs for MIR639 Gene

Paralogs for MIR639 Gene

No data available for Paralogs for MIR639 Gene

Variants for MIR639 Gene

Sequence variations from dbSNP and Humsavar for MIR639 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000700558 -- 14,529,351(+) CAAAG(A/G)GACGC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1004286863 -- 14,529,404(+) CTTCT(C/G)TTTAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1006372271 -- 14,527,589(+) TAGCG(C/T)TGGCT intron-variant, upstream-variant-2KB
rs1007060500 -- 14,530,076(+) AAATC(-/T)TGCGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1010812581 -- 14,529,050(+) GGGTT(C/G)CCAAA intron-variant, upstream-variant-2KB

Relevant External Links for MIR639 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR639

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR639 Gene

Disorders for MIR639 Gene

Relevant External Links for MIR639

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR639

No disorders were found for MIR639 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR639 Gene

Publications for MIR639 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 60
  2. MiR-639 promoted cell proliferation and cell cycle in human thyroid cancer by suppressing CDKN1A expression. (PMID: 27829546) Lei ST … Xu B (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 3 60
  3. miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1. (PMID: 25130698) Lin Z … Li J (Cancer science 2014) 3 60
  4. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. (PMID: 20190813) Wu S … He X (Oncogene 2010) 3 60
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR639 Gene

Sources for MIR639 Gene

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