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Aliases for MIR639 Gene

Subcategory (RNA class) for MIR639 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR639 Gene

  • MicroRNA 639 2 3
  • Trans-2,3-Enoyl-CoA Reductase 4 5
  • TECR 4 5
  • Synaptic Glycoprotein SC2 4
  • Hsa-Mir-639 3
  • EC 1.3.1.38 61
  • EC 1.3.1.93 4
  • EC 1.3.1 61
  • MIRN639 3
  • GPSN2 4
  • SC2 4
  • TER 4

External Ids for MIR639 Gene

Previous HGNC Symbols for MIR639 Gene

  • MIRN639

Previous GeneCards Identifiers for MIR639 Gene

  • GC19P014503
  • GC19P014640

Summaries for MIR639 Gene

Entrez Gene Summary for MIR639 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR639 Gene

MIR639 (MicroRNA 639) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR639 include Mental Retardation, Autosomal Recessive 14. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. An important paralog of this gene is TECRL.

UniProtKB/Swiss-Prot for MIR639 Gene

  • Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR639 Gene

Genomics for MIR639 Gene

Regulatory Elements for MIR639 Gene

Enhancers for MIR639 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F014000 1.6 FANTOM5 ENCODE 10.7 -513.0 -512986 7.0 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D CCDC130 MIR24-2 RFX1 DCAF15 MRI1 ITGB1P1 LYL1 ZSWIM4 TRMT1 MIR639
GH19F014512 1.5 FANTOM5 ENCODE 11.4 +1.4 1445 12.0 HDGF PKNOX1 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 AKAP8 SYDE1 DNAJB1 ITGB1P1 MIR639 TECR GIPC1 IL27RA ADGRE5 PKN1
GH19F014111 1.5 FANTOM5 ENCODE 10.7 -401.0 -400951 9.3 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS CCDC130 MRI1 TRMT1 ZNF333 RFX1 DCAF15 PRKACA MIR24-2 MIR639 ADGRE5
GH19F014227 1.1 Ensembl ENCODE 10.7 -288.7 -288684 1.2 ZFP64 ZNF493 ZNF138 ZNF354C EGR2 ZNF202 ZNF680 ZNF654 SMAD5 OVOL3 CCDC130 MRI1 ZNF333 RFX1 DCAF15 MIR639 RN7SL231P ENSG00000267406
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR639 on UCSC Golden Path with GeneCards custom track

Promoters for MIR639 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215294 715 2401 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for MIR639 Gene

Chromosome:
19
Start:
14,517,085 bp from pter
End:
14,565,980 bp from pter
Size:
48,896 bases
Orientation:
Plus strand

Genomic View for MIR639 Gene

Genes around MIR639 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR639 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR639 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR639 Gene

Proteins for MIR639 Gene

  • Protein details for MIR639 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZ01-TECR_HUMAN
    Recommended name:
    Very-long-chain enoyl-CoA reductase
    Protein Accession:
    Q9NZ01
    Secondary Accessions:
    • B2RD55
    • O75350
    • Q6IBB2
    • Q9BWK3
    • Q9Y6P0

    Protein attributes for MIR639 Gene

    Size:
    308 amino acids
    Molecular mass:
    36034 Da
    Quaternary structure:
    • Interacts with ELOVL1 and LASS2.
    • Interacts with ELOVL1 and LASS2.

    Three dimensional structures from OCA and Proteopedia for MIR639 Gene

    Alternative splice isoforms for MIR639 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR639 Gene

Selected DME Specific Peptides for MIR639 Gene

Q9NZ01:
  • FVHRFSHGTMP
  • TMPLRNIFKNC
  • LRDLRPAGSK

Post-translational modifications for MIR639 Gene

  • Glycosylated.
  • Ubiquitination at Lys 2, Lys 12, Lys 16, Lys 22, Lys 33, Lys 38, Lys 67, and Lys 291
  • Glycosylation at Asn 164 and Asn 247
  • Modification sites at PhosphoSitePlus

Domains & Families for MIR639 Gene

Gene Families for MIR639 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZ01

UniProtKB/Swiss-Prot:

TECR_HUMAN :
  • Belongs to the steroid 5-alpha reductase family.
Family:
  • Belongs to the steroid 5-alpha reductase family.
genes like me logo Genes that share domains with MIR639: view

No data available for Suggested Antigen Peptide Sequences for MIR639 Gene

Function for MIR639 Gene

Molecular function for MIR639 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A very-long-chain acyl-CoA + NADP(+) = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH.
UniProtKB/Swiss-Prot Function:
Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

Enzyme Numbers (IUBMB) for MIR639 Gene

Gene Ontology (GO) - Molecular Function for MIR639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors IEA --
GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity TAS --
genes like me logo Genes that share ontologies with MIR639: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR639 Gene

Localization for MIR639 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR639 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with MIR639: view

No data available for Subcellular locations from COMPARTMENTS for MIR639 Gene

Pathways & Interactions for MIR639 Gene

genes like me logo Genes that share pathways with MIR639: view

UniProtKB/Swiss-Prot Q9NZ01-TECR_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis.

Gene Ontology (GO) - Biological Process for MIR639 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0030497 fatty acid elongation IDA --
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
genes like me logo Genes that share ontologies with MIR639: view

No data available for SIGNOR curated interactions for MIR639 Gene

Transcripts for MIR639 Gene

mRNA/cDNA for MIR639 Gene

(26) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR639 Gene

No ASD Table

Relevant External Links for MIR639 Gene

GeneLoc Exon Structure for
MIR639
ECgene alternative splicing isoforms for
MIR639

Expression for MIR639 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR639 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR639 Gene:

MIR639

mRNA Expression by UniProt/SwissProt for MIR639 Gene:

Q9NZ01-TECR_HUMAN
Tissue specificity: Expressed in most tissues tested. Highly expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with MIR639: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR639 Gene

Orthologs for MIR639 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR639 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TECR 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TECR 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tecr 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TECR 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TECR 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TECR 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TECR 35
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TECR 35
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tecrb 35
  • 85 (a)
OneToMany
tecra 35
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sc2 35
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea art-1 35
  • 53 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TSC13 35 37
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7956 35
  • 62 (a)
OneToMany
Species where no ortholog for MIR639 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR639 Gene

ENSEMBL:
Gene Tree for MIR639 (if available)
TreeFam:
Gene Tree for MIR639 (if available)

Paralogs for MIR639 Gene

Paralogs for MIR639 Gene

Pseudogenes.org Pseudogenes for MIR639 Gene

genes like me logo Genes that share paralogs with MIR639: view

Variants for MIR639 Gene

Sequence variations from dbSNP and Humsavar for MIR639 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10406346 -- 14,528,132(+) gcctg(C/T)cttgg intron-variant, upstream-variant-2KB
rs112614575 -- 14,528,252(+) TTTTC(-/T)TTTTT intron-variant, upstream-variant-2KB
rs113083115 -- 14,527,814(+) ATCTG(A/C/G)AAACA intron-variant, upstream-variant-2KB, reference, missense
rs113751040 -- 14,529,576(+) GGGCG(C/G)GGCGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs114121047 -- 14,529,566(+) CGGCC(C/T)GGAGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Relevant External Links for MIR639 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR639

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR639 Gene

Disorders for MIR639 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR639 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 14
  • mental retardation non-syndromic autosomal recessive 14
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TECR_HUMAN
  • Mental retardation, autosomal recessive 14 (MRT14) [MIM:614020]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:21212097}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR639

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR639
genes like me logo Genes that share disorders with MIR639: view

No data available for Genatlas for MIR639 Gene

Publications for MIR639 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. miR-639 regulates transforming growth factor beta-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting FOXC1. (PMID: 25130698) Lin Z. … Li J. (Cancer Sci. 2014) 3 64
  3. Exome sequencing reveals a novel mutation for autosomal recessive non-syndromic mental retardation in the TECR gene on chromosome 19p13. (PMID: 21212097) Caliskan M. … Ober C. (Hum. Mol. Genet. 2011) 4 64
  4. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64
  5. ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. (PMID: 20937905) Ohno Y. … Kihara A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 4 64

Products for MIR639 Gene

Sources for MIR639 Gene

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