Subcategory (RNA class) for MIR639 Gene
Quality Score for this RNA gene is
Aliases for MIR639 Gene
External Ids for MIR639 Gene
Previous HGNC Symbols for MIR639 Gene
Previous GeneCards Identifiers for MIR639 Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR639 Gene
MIR639 (MicroRNA 639) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR639 include Mental Retardation, Autosomal Recessive 14. Among its related pathways are Metabolism and Fatty Acyl-CoA Biosynthesis. An important paralog of this gene is TECRL.
UniProtKB/Swiss-Prot for MIR639 Gene
Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.