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Aliases for MIR638 Gene

Subcategory (RNA class) for MIR638 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR638 Gene

  • MicroRNA 638 2 3 5
  • Hsa-Mir-638 3
  • MIRN638 3

External Ids for MIR638 Gene

ORGUL Members for MIR638 Gene

Previous HGNC Symbols for MIR638 Gene

  • MIRN638

Previous GeneCards Identifiers for MIR638 Gene

  • GC19U901002
  • GC19P010829

Summaries for MIR638 Gene

Entrez Gene Summary for MIR638 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR638 Gene

MIR638 (MicroRNA 638) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR638 Gene

Genomics for MIR638 Gene

Regulatory Elements for MIR638 Gene

Enhancers for MIR638 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010746 1.4 FANTOM5 Ensembl ENCODE 12.8 +38.8 38810 20.8 MLX DMAP1 YY1 SLC30A9 ZNF143 ZNF263 MCM3 SP3 NFYC TBX21 FBXL12 HNRNPA1P10 SLC44A2 CDKN2D ZNF627 RAVER1 DNM2 KRI1 MIR638 PRKCSH
GH19F010717 0.8 FANTOM5 ENCODE 0.8 +0.8 752 3.7 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 FBXL12 EIF3G DOCK6 ZNF627 LOC100419831 RAVER1 S1PR2 HNRNPA1P10 KANK2 SLC44A2
GH19F010724 0.9 Ensembl ENCODE 0.4 +6.5 6493 0.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 GLIS2 CBX5 SLC44A2 ILF3-AS1 SMARCA4 PIR47140 MIR638
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR638 on UCSC Golden Path with GeneCards custom track

Promoters for MIR638 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000042974 -4 2801 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1

Genomic Location for MIR638 Gene

Chromosome:
19
Start:
10,718,404 bp from pter
End:
10,718,503 bp from pter
Size:
100 bases
Orientation:
Plus strand

Genomic View for MIR638 Gene

Genes around MIR638 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR638 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR638 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR638 Gene

Proteins for MIR638 Gene

Post-translational modifications for MIR638 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR638 Gene

Domains & Families for MIR638 Gene

Gene Families for MIR638 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR638: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR638 Gene

Function for MIR638 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR638 Gene

Localization for MIR638 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR638 Gene

Pathways & Interactions for MIR638 Gene

SuperPathways for MIR638 Gene

No Data Available

Interacting Proteins for MIR638 Gene

Gene Ontology (GO) - Biological Process for MIR638 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR638 Gene

Transcripts for MIR638 Gene

mRNA/cDNA for MIR638 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR638 Gene

No ASD Table

Relevant External Links for MIR638 Gene

GeneLoc Exon Structure for
MIR638
ECgene alternative splicing isoforms for
MIR638

Expression for MIR638 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR638 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR638 Gene:

MIR638
genes like me logo Genes that share expression patterns with MIR638: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR638 Gene

Orthologs for MIR638 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR638 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR638 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR638 Gene

ENSEMBL:
Gene Tree for MIR638 (if available)
TreeFam:
Gene Tree for MIR638 (if available)

Paralogs for MIR638 Gene

No data available for Paralogs for MIR638 Gene

Variants for MIR638 Gene

Sequence variations from dbSNP and Humsavar for MIR638 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs759919549 Likely benign 10,718,332(+) CTGGA(C/T)CTGCC upstream-variant-2KB, reference, synonymous-codon
rs112568560 -- 10,716,521(+) ACCCC(A/C)ATTTT upstream-variant-2KB
rs113305450 -- 10,718,631(+) CAGGG(C/G)GCCGT intron-variant, downstream-variant-500B
rs113872647 -- 10,718,971(+) GCTGT(C/T)TGGCC intron-variant, downstream-variant-500B
rs116956287 -- 10,718,525(+) GGAAC(A/C)GGACG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR638 Gene

Variant ID Type Subtype PubMed ID
nsv1061882 CNV gain 25217958
nsv1160584 CNV deletion 26073780
nsv1160585 CNV deletion 26073780
nsv833745 CNV loss 17160897
nsv833746 CNV loss 17160897

Relevant External Links for MIR638 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR638

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR638 Gene

Disorders for MIR638 Gene

Relevant External Links for MIR638

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR638

No disorders were found for MIR638 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR638 Gene

Publications for MIR638 Gene

  1. miR-146a and miR-638 in BRCA1-deficient triple negative breast cancer tumors, as potential biomarkers for improved overall survival. (PMID: 26835710) Zavala V. … Carvallo P. (Cancer Biomark 2016) 3 64
  2. Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3. (PMID: 25394686) Kubota S. … Watanabe N. (Oncol. Rep. 2015) 3 64
  3. miR-638 regulates differentiation and proliferation in leukemic cells by targeting cyclin-dependent kinase 2. (PMID: 25451924) Lin Y. … Huang Z. (J. Biol. Chem. 2015) 3 64
  4. miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy. (PMID: 25650662) Bhattacharya A. … Kunz M. (Oncotarget 2015) 3 64
  5. MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma. (PMID: 26250158) Zhang J. … Huang Z. (Protein Cell 2015) 3 64

Products for MIR638 Gene

Sources for MIR638 Gene

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