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Aliases for MIR637 Gene

Subcategory (RNA class) for MIR637 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR637 Gene

  • MicroRNA 637 2 3
  • EC 2.7.11.1 4 61
  • DAPK3 4 5
  • Zipper-Interacting Protein Kinase 4
  • Death Associated Protein Kinase 3 5
  • DAP-Like Kinase 4
  • DAP Kinase 3 4
  • MYPT1 Kinase 4
  • Hsa-Mir-637 3
  • ZIP-Kinase 4
  • EC 2.7.11 61
  • MIRN637 3
  • ZIPK 4
  • DLK 4

External Ids for MIR637 Gene

Previous HGNC Symbols for MIR637 Gene

  • MIRN637

Previous GeneCards Identifiers for MIR637 Gene

  • GC19M003913

Summaries for MIR637 Gene

Entrez Gene Summary for MIR637 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR637 Gene

MIR637 (MicroRNA 637) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Regulation by c-FLIP. An important paralog of this gene is DAPK1.

UniProtKB/Swiss-Prot for MIR637 Gene

  • Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on Ser-77 upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR637 Gene

Genomics for MIR637 Gene

Regulatory Elements for MIR637 Gene

Enhancers for MIR637 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F003849 0.2 ENCODE 11.9 +121.8 121766 0.2 CTCF MAZ PKNOX1 CREB3L1 BHLHE40 REST RAD21 ZKSCAN1 JUND SCRT2 ATCAY MIR637 DAPK3 EEF2 PIR53050 GC19P003837
GH19F003175 1.3 FANTOM5 ENCODE 5.4 +794.4 794389 2.2 HDGF KLF17 ZNF335 GLIS2 SCRT2 RCOR1 FOS CREM SMARCA5 ZBTB2 GNA15 S1PR4 GNA11 MIR637 AES GC19M003171
GH19F003965 1.1 FANTOM5 ENCODE 0.8 +2.3 2291 5.9 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 DAPK3 PLIN5 MIR637 GC19M003963
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR637 on UCSC Golden Path with GeneCards custom track

Promoters for MIR637 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000342168 623 2201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for MIR637 Gene

Chromosome:
19
Start:
3,958,453 bp from pter
End:
3,971,123 bp from pter
Size:
12,671 bases
Orientation:
Minus strand

Genomic View for MIR637 Gene

Genes around MIR637 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR637 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR637 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR637 Gene

Proteins for MIR637 Gene

  • Protein details for MIR637 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43293-DAPK3_HUMAN
    Recommended name:
    Death-associated protein kinase 3
    Protein Accession:
    O43293
    Secondary Accessions:
    • A0AVN4
    • B3KQE2
    • Q05JY4

    Protein attributes for MIR637 Gene

    Size:
    454 amino acids
    Molecular mass:
    52536 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homooligomer in its kinase-active form (homotrimers and homodimers are reported); monomeric in its kinase-inactive form. Homodimerization is required for activation segment autophosphorylation (Probable). Isoform 1 and isoform 2 interact with myosin and PPP1R12A; interaction of isoform 1 with PPP1R12A is inhibited by RhoA dominant negative form. Interacts with NLK, DAXX, STAT3, RHOD (GTP-bound form) and TCP10L. Interacts with PAWR; the interaction is reported conflictingly: according to PubMed:17953487 does not interact with PAWR. Interacts with ULK1; may be a substrate of ULK1.
    • Homooligomer in its kinase-active form (homotrimers and homodimers are reported); monomeric in its kinase-inactive form. Homodimerization is required for activation segment autophosphorylation (Probable). Isoform 1 and isoform 2 interact with myosin and PPP1R12A; interaction of isoform 1 with PPP1R12A is inhibited by RhoA dominant negative form. Interacts with NLK, DAXX, STAT3, RHOD (GTP-bound form) and TCP10L. Interacts with PAWR; the interaction is reported conflictingly: according to PubMed:17953487 does not interact with PAWR. Interacts with ULK1; may be a substrate of ULK1.

    Three dimensional structures from OCA and Proteopedia for MIR637 Gene

    Alternative splice isoforms for MIR637 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR637 Gene

Post-translational modifications for MIR637 Gene

  • The phosphorylation status is critical for kinase activity, oligomerization and intracellular localization. Phosphorylation at Thr-180, Thr-225 and Thr-265 is essential for activity. The phosphorylated form is localized in the cytoplasm promoted by phosphorylation at Thr-299; nuclear translocation or retention is maximal when it is not phosphorylated. Phosphorylation increases the trimeric form, and its dephosphorylation favors a kinase-inactive monomeric form. Both isoform 1 and isoform 2 can undergo autophosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIR637 Gene

Domains & Families for MIR637 Gene

Gene Families for MIR637 Gene

Graphical View of Domain Structure for InterPro Entry

O43293

UniProtKB/Swiss-Prot:

DAPK3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
genes like me logo Genes that share domains with MIR637: view

No data available for Suggested Antigen Peptide Sequences for MIR637 Gene

Function for MIR637 Gene

Molecular function for MIR637 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=12 uM for myosin (isoform 2) {ECO:0000269 PubMed:17126281}; KM=6.2 uM for myosin (isoform 1) {ECO:0000269 PubMed:17126281}; KM=73 uM for MYL12B (isoform 2) {ECO:0000269 PubMed:17126281}; KM=10.4 uM for MYL12B (isoform 1) {ECO:0000269 PubMed:17126281}; Vmax=248 nmol/min/mg enzyme toward myosin (isoform 2) {ECO:0000269 PubMed:17126281}; Vmax=120 nmol/min/mg enzyme toward myosin (isoform 1) {ECO:0000269 PubMed:17126281}; Vmax=1.3 umol/min/mg enzyme toward MYL12B (isoform 2) {ECO:0000269 PubMed:17126281}; Vmax=271 nmol/min/mg enzyme toward MYL12B (isoform 1) {ECO:0000269 PubMed:17126281};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
A sequential activation is proposed: autophosphorylation at consensus sites is leading to dimerization of the catalytic domain stabilized by phosphorylation at Ser-50 and activation segment exchange (producing an active confirmation of both kinase modules in trans) followed by phosphorylation at Thr-180 in the activation segment and at other regulatory sites (Probable). Phosphorylation at Thr-180, Thr-225 and Thr-265 is essential for activity. Oligomerization is required for full enzymatic activity. Inhibited by pyridone 6 (K00225), a potent, ATP-competitive inhibitor.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Involved in the regulation of smooth muscle contraction. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in regulation of starvation-induced autophagy. Regulates myosin phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A; the inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton. Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B. Overexpression leads to condensation of actin stress fibers into thick bundles. Involved in actin filament focal adhesion dynamics. The function in both reorganization of actin cytoskeleton and focal adhesion dissolution is modulated by RhoD. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2. Phosphorylates RPL13A on Ser-77 upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor.

Enzyme Numbers (IUBMB) for MIR637 Gene

Gene Ontology (GO) - Molecular Function for MIR637 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0005515 protein binding IPI --
GO:0005524 ATP binding IEA --
GO:0008022 protein C-terminus binding IEA --
genes like me logo Genes that share ontologies with MIR637: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR637 Gene

Localization for MIR637 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR637 Gene

Nucleus. Cytoplasm. Note=Predominantly localizes to the cytoplasm but can shuttle between the nucleus and cytoplasm; cytoplasmic localization is promoted by phosphorylation at Thr-299 and involves Rho/Rock signaling. {ECO:0000269 PubMed:17953487, ECO:0000269 PubMed:20854903}.
Isoform 1: Nucleus. Cytoplasm.
Isoform 2: Nucleus. Cytoplasm.

Gene Ontology (GO) - Cellular Components for MIR637 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IEA --
GO:0005884 actin filament IEA --
GO:0016605 PML body IEA --
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with MIR637: view

No data available for Subcellular locations from COMPARTMENTS for MIR637 Gene

Pathways & Interactions for MIR637 Gene

genes like me logo Genes that share pathways with MIR637: view

Gene Ontology (GO) - Biological Process for MIR637 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS --
GO:0006417 regulation of translation IEA --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with MIR637: view

No data available for SIGNOR curated interactions for MIR637 Gene

Transcripts for MIR637 Gene

mRNA/cDNA for MIR637 Gene

(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR637 Gene

No ASD Table

Relevant External Links for MIR637 Gene

GeneLoc Exon Structure for
MIR637
ECgene alternative splicing isoforms for
MIR637

Expression for MIR637 Gene

mRNA expression in normal human tissues for MIR637 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR637 Gene:

MIR637

mRNA Expression by UniProt/SwissProt for MIR637 Gene:

O43293-DAPK3_HUMAN
Tissue specificity: Widely expressed. Isoform 1 and isoform 2 are expressed in the bladder smooth muscle.
genes like me logo Genes that share expression patterns with MIR637: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR637 Gene

Orthologs for MIR637 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR637 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAPK3 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAPK3 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAPK3 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAPK3 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAPK3 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dapk3 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAPK3 35
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dapk3 35
  • 81 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dapk-1 35
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for MIR637 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR637 Gene

ENSEMBL:
Gene Tree for MIR637 (if available)
TreeFam:
Gene Tree for MIR637 (if available)

Paralogs for MIR637 Gene

Paralogs for MIR637 Gene

genes like me logo Genes that share paralogs with MIR637: view

Variants for MIR637 Gene

Sequence variations from dbSNP and Humsavar for MIR637 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10420705 -- 3,961,867(+) ttttt(A/T)aattt intron-variant, upstream-variant-2KB
rs10426955 -- 3,962,371(+) CACGC(A/G)CTACA intron-variant, upstream-variant-2KB
rs116965244 -- 3,962,504(+) GGCAC(A/G)GTGGC intron-variant, upstream-variant-2KB
rs12982932 -- 3,960,960(+) GGAGT(A/G)GGCCT intron-variant, downstream-variant-500B
rs137989425 -- 3,961,265(+) CTGAC(A/G)GCAGG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR637 Gene

Variant ID Type Subtype PubMed ID
nsv833715 CNV loss 17160897
nsv953949 CNV deletion 24416366

Relevant External Links for MIR637 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR637

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR637 Gene

Disorders for MIR637 Gene

Relevant External Links for MIR637

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR637

No disorders were found for MIR637 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR637 Gene

Publications for MIR637 Gene

  1. Decreased miRNA-637 is an unfavorable prognosis marker and promotes glioma cell growth, migration and invasion via direct targeting Akt1. (PMID: 25597410) Que T. … Qi S. (Oncogene 2015) 3 64
  2. Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637. (PMID: 26438598) Kim Y. … Evans M.K. (Mol. Cell. Biol. 2015) 3 64
  3. Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts. (PMID: 23362149) Lisse T.S. … Hewison M. (J. Bone Miner. Res. 2013) 3 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. Interaction of RhoD and ZIP kinase modulates actin filament assembly and focal adhesion dynamics. (PMID: 23454120) Nehru V. … AspenstrAPm P. (Biochem. Biophys. Res. Commun. 2013) 4 64

Products for MIR637 Gene

Sources for MIR637 Gene

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