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Aliases for MIR637 Gene

Subcategory (RNA class) for MIR637 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR637 Gene

  • MicroRNA 637 2 3 5
  • Hsa-Mir-637 3
  • MIRN637 3

External Ids for MIR637 Gene

Previous HGNC Symbols for MIR637 Gene

  • MIRN637

Previous GeneCards Identifiers for MIR637 Gene

  • GC19M003913

Summaries for MIR637 Gene

Entrez Gene Summary for MIR637 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR637 Gene

MIR637 (MicroRNA 637) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Dimerization of procaspase-8 and CDK-mediated phosphorylation and removal of Cdc6.

fRNAdb sequence ontologies for MIR637 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR637

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR637 Gene

Genomics for MIR637 Gene

Regulatory Elements for MIR637 Gene

Enhancers for MIR637 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G003849 0.7 ENCODE 11.9 +112.2 112155 0.2 CTCF MAZ PKNOX1 CREB3L1 RB1 BHLHE40 REST RAD21 ZKSCAN1 JUND ATCAY MIR637 DAPK3 EEF2 PIR53050 GC19P003837
GH19G003175 1.5 FANTOM5 ENCODE dbSUPER 5.4 +784.8 784778 2.2 HDGF FOXA2 GLIS2 FOS TBX21 ZNF592 MAFF SMARCA4 GLIS1 NBN GNA15 S1PR4 GNA11 MIR637 AES GC19M003171
GH19G003965 1.6 FANTOM5 ENCODE dbSUPER 0.4 -7.3 -7321 5.9 HDGF FOXA2 PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 FEZF1 DAPK3 PLIN5 MIR637
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR637 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR637 Gene

Chromosome:
19
Start:
3,961,414 bp from pter
End:
3,961,512 bp from pter
Size:
99 bases
Orientation:
Minus strand

Genomic View for MIR637 Gene

Genes around MIR637 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR637 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR637 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR637 Gene

ORGUL Member Location for MIR637 Gene

ORGUL Member Location for MIR637 gene

Proteins for MIR637 Gene

Post-translational modifications for MIR637 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR637 Gene

Domains & Families for MIR637 Gene

Gene Families for MIR637 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR637: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR637 Gene

Function for MIR637 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR637 Gene

Localization for MIR637 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR637 Gene

Pathways & Interactions for MIR637 Gene

genes like me logo Genes that share pathways with MIR637: view

Pathways by source for MIR637 Gene

Interacting Proteins for MIR637 Gene

Gene Ontology (GO) - Biological Process for MIR637 Gene

None

No data available for SIGNOR curated interactions for MIR637 Gene

Drugs & Compounds for MIR637 Gene

No Compound Related Data Available

Transcripts for MIR637 Gene

fRNAdb Secondary structures for MIR637 Gene

  • hsa-mir-637_MI0003652_Homo_sapiens_miR-637_stem-loop_hairpin

mRNA/cDNA for MIR637 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR637 Gene

No ASD Table

Relevant External Links for MIR637 Gene

GeneLoc Exon Structure for
MIR637
ECgene alternative splicing isoforms for
MIR637

Expression for MIR637 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR637 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR637 Gene:

MIR637
genes like me logo Genes that share expression patterns with MIR637: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR637 Gene

Orthologs for MIR637 Gene

Evolution for MIR637 Gene

ENSEMBL:
Gene Tree for MIR637 (if available)
TreeFam:
Gene Tree for MIR637 (if available)

No data available for Orthologs for MIR637 Gene

Paralogs for MIR637 Gene

No data available for Paralogs for MIR637 Gene

Variants for MIR637 Gene

Sequence variations from dbSNP and Humsavar for MIR637 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000932278 -- 3,961,250(+) AGCAC(A/G)GAAGA intron-variant, downstream-variant-500B
rs1001365324 -- 3,961,855(+) GGCAC(-/TTTAAATTT)TTTAA intron-variant, upstream-variant-2KB
rs1001427037 -- 3,961,106(+) TGAGA(C/T)GTTGG downstream-variant-500B, reference, missense
rs1001670860 -- 3,962,058(+) TTCAT(C/T)GTGTT intron-variant, upstream-variant-2KB
rs1002340439 -- 3,962,894(+) TCAGG(A/T)GTTCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR637 Gene

Variant ID Type Subtype PubMed ID
nsv833715 CNV loss 17160897
nsv953949 CNV deletion 24416366

Relevant External Links for MIR637 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR637

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR637 Gene

Disorders for MIR637 Gene

Relevant External Links for MIR637

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR637

No disorders were found for MIR637 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR637 Gene

Publications for MIR637 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. Downregulation of microRNA-637 Increases Risk of Hypoxia-Induced Pulmonary Hypertension by Modulating Expression of Cyclin Dependent Kinase 6 (CDK6) in Pulmonary Smooth Muscle Cells. (PMID: 27794186) Sang H.Y. … Chen L.B. (Med. Sci. Monit. 2016) 3 64
  3. Decreased miRNA-637 is an unfavorable prognosis marker and promotes glioma cell growth, migration and invasion via direct targeting Akt1. (PMID: 25597410) Que T. … Qi S. (Oncogene 2015) 3 64
  4. Posttranscriptional Regulation of the Inflammatory Marker C-Reactive Protein by the RNA-Binding Protein HuR and MicroRNA 637. (PMID: 26438598) Kim Y. … Evans M.K. (Mol. Cell. Biol. 2015) 3 64
  5. Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts. (PMID: 23362149) Lisse T.S. … Hewison M. (J. Bone Miner. Res. 2013) 3 64

Products for MIR637 Gene

Sources for MIR637 Gene

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