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Aliases for MIR636 Gene

Subcategory (RNA class) for MIR636 Gene

lncRNA

Quality Score for this RNA gene is

3.2

Aliases for MIR636 Gene

  • MicroRNA 636 2 3
  • SRSF2 4 5
  • Serine And Arginine Rich Splicing Factor 2 5
  • Splicing Factor, Arginine/Serine-Rich 2 4
  • Splicing Component, 35 KDa 4
  • Splicing Factor SC35 4
  • Protein PR264 4
  • Hsa-Mir-636 3
  • MIRN636 3
  • SC-35 4
  • SFRS2 4

External Ids for MIR636 Gene

ORGUL Members for MIR636 Gene

Previous HGNC Symbols for MIR636 Gene

  • MIRN636

Previous GeneCards Identifiers for MIR636 Gene

  • GC17M072245
  • GC17M074732
  • GC17M076736
  • GC17M076737

Summaries for MIR636 Gene

Entrez Gene Summary for MIR636 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR636 Gene

MIR636 (MicroRNA 636) is an RNA Gene, and is affiliated with the lncRNA class. Among its related pathways are Transport of Mature Transcript to Cytoplasm and mRNA Splicing - Major Pathway. An important paralog of this gene is SRSF8.

UniProtKB/Swiss-Prot for MIR636 Gene

  • Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5- and 3-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5- and 3-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5-AGSAGAGTA-3 (S=C or G) or 5-GTTCGAGTA-3. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.

fRNAdb sequence ontologies for MIR636 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR636

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR636 Gene

Genomics for MIR636 Gene

Regulatory Elements for MIR636 Gene

Enhancers for MIR636 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F076772 0.9 Ensembl ENCODE 11.7 -35.7 -35675 1.8 CTCF KLF1 KLF17 SIN3A RAD21 YY1 ZKSCAN1 ZNF664 CTBP1 GATA3 SRSF2 MFSD11 MIR636 JMJD6 METTL23 UBALD2 GC17P076792 RNU6-97P
GH17F076734 1.5 ENCODE 0.8 +0.1 116 7.8 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 UNK ENSG00000267342 MXRA7 CDK3 ENSG00000266980 TRIM65 HMGN2P43 MFSD11 H3F3B METTL23
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR636 on UCSC Golden Path with GeneCards custom track

Promoters for MIR636 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353815 174 5201 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3

Genomic Location for MIR636 Gene

Chromosome:
17
Start:
76,734,115 bp from pter
End:
76,737,374 bp from pter
Size:
3,260 bases
Orientation:
Minus strand

Genomic View for MIR636 Gene

Genes around MIR636 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR636 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR636 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR636 Gene

ORGUL Member Location for MIR636 Gene

ORGUL Member Location for MIR636 gene

Proteins for MIR636 Gene

  • Protein details for MIR636 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01130-SRSF2_HUMAN
    Recommended name:
    Serine/arginine-rich splicing factor 2
    Protein Accession:
    Q01130
    Secondary Accessions:
    • B3KWD5
    • B4DN89
    • H0YG49

    Protein attributes for MIR636 Gene

    Size:
    221 amino acids
    Molecular mass:
    25476 Da
    Quaternary structure:
    • Interacts with BRDT (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus).
    • Interacts with BRDT (By similarity). In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SREK1/SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SCAF11. Interacts with ZRSR2/U2AF1-RS2. Interacts with CCDC55 (via C-terminus).

    Three dimensional structures from OCA and Proteopedia for MIR636 Gene

    Alternative splice isoforms for MIR636 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR636 Gene

Post-translational modifications for MIR636 Gene

  • Acetylation on Lys-52 by KAT5/TIP60 promotes its proteasomal degradation. This effect is counterbalanced by HDAC6, which positively controls SRSF2 protein level by deacetylating it and preventing its proteasomal degradation.
  • Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by SRPK2 and this causes its redistribution from the nuclear speckle to nucleoplasm and controls cell fate decision in response to cisplatin treatment. KAT5/TIP60 inhibits its phosphorylation by preventing SRPK2 nuclear translocation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR636 Gene

Domains & Families for MIR636 Gene

Gene Families for MIR636 Gene

Graphical View of Domain Structure for InterPro Entry

Q01130

UniProtKB/Swiss-Prot:

SRSF2_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the splicing factor SR family.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the splicing factor SR family.
genes like me logo Genes that share domains with MIR636: view

No data available for Suggested Antigen Peptide Sequences for MIR636 Gene

Function for MIR636 Gene

Molecular function for MIR636 Gene

UniProtKB/Swiss-Prot Function:
Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5- and 3-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5- and 3-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5-AGSAGAGTA-3 (S=C or G) or 5-GTTCGAGTA-3. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment.
UniProtKB/Swiss-Prot Induction:
Accumulates in a hypoacetylated/phosphorylated form in response to cisplatin treatment.

Gene Ontology (GO) - Molecular Function for MIR636 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003714 transcription corepressor activity NAS --
GO:0003723 RNA binding IEA --
GO:0005080 protein kinase C binding IEA --
GO:0005515 protein binding IPI --
genes like me logo Genes that share ontologies with MIR636: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR636 Gene

Localization for MIR636 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR636 Gene

Nucleus. Nucleus, nucleoplasm. Nucleus speckle. Note=Phosphorylation by SRPK2 provokes its redistribution from the nuclear specke to nucleoplasm.

Gene Ontology (GO) - Cellular Components for MIR636 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0016605 PML body IDA --
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with MIR636: view

No data available for Subcellular locations from COMPARTMENTS for MIR636 Gene

Pathways & Interactions for MIR636 Gene

genes like me logo Genes that share pathways with MIR636: view

Pathways by source for MIR636 Gene

Gene Ontology (GO) - Biological Process for MIR636 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IEA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006369 termination of RNA polymerase II transcription TAS --
GO:0006397 mRNA processing TAS --
GO:0006405 RNA export from nucleus TAS --
genes like me logo Genes that share ontologies with MIR636: view

No data available for SIGNOR curated interactions for MIR636 Gene

Transcripts for MIR636 Gene

fRNAdb Secondary structures for MIR636 Gene

  • FR398778

mRNA/cDNA for MIR636 Gene

(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR636 Gene

No ASD Table

Relevant External Links for MIR636 Gene

GeneLoc Exon Structure for
MIR636
ECgene alternative splicing isoforms for
MIR636

Expression for MIR636 Gene

mRNA expression in normal human tissues for MIR636 Gene

mRNA differential expression in normal tissues according to GTEx for MIR636 Gene

This gene is overexpressed in Testis (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of MIR636 Gene:

MIR636
genes like me logo Genes that share expression patterns with MIR636: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR636 Gene

Orthologs for MIR636 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR636 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SRSF2 35
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Srsf2 35
  • 100 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 100 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia SRSF2 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 49 (a)
OneToMany
chicken
(Gallus gallus)
Aves SRSF2 35
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 99 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii srsf2a 35
  • 83 (a)
ManyToMany
srsf2b 35
  • 80 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta SC35 35
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rsp-4 35
  • 59 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11125 35
  • 70 (a)
OneToMany
Species where no ortholog for MIR636 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR636 Gene

ENSEMBL:
Gene Tree for MIR636 (if available)
TreeFam:
Gene Tree for MIR636 (if available)

Paralogs for MIR636 Gene

Paralogs for MIR636 Gene

Pseudogenes.org Pseudogenes for MIR636 Gene

genes like me logo Genes that share paralogs with MIR636: view

Variants for MIR636 Gene

Sequence variations from dbSNP and Humsavar for MIR636 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs113640504 -- 76,737,384(+) TGGCG(C/T)CCGCG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs114769537 -- 76,736,123(+) AATTA(A/G)GGTTA intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs11550962 -- 76,736,388(-) GCCGC(C/T)CGAAG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs11550963 -- 76,737,022(-) TCCCG(C/G)GGGAT nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs11652034 -- 76,737,476(+) AGCGC(C/T)TGCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR636 Gene

Variant ID Type Subtype PubMed ID
nsv1110921 OTHER inversion 24896259
nsv833550 CNV loss 17160897

Relevant External Links for MIR636 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR636

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR636 Gene

Disorders for MIR636 Gene

Relevant External Links for MIR636

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR636

No disorders were found for MIR636 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR636 Gene

Publications for MIR636 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma. (PMID: 23306701) Jang J.Y. … Kim C.W. (Exp. Mol. Med. 2013) 3 64
  4. Genetic loci for retinal arteriolar microcirculation. (PMID: 23776548) Sim X. … Wong T.Y. (PLoS ONE 2013) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for MIR636 Gene

Sources for MIR636 Gene

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