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Aliases for MIR635 Gene

Subcategory (RNA class) for MIR635 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR635 Gene

  • MicroRNA 635 2 3 5
  • Hsa-Mir-635 3
  • MIRN635 3

External Ids for MIR635 Gene

Previous HGNC Symbols for MIR635 Gene

  • MIRN635

Previous GeneCards Identifiers for MIR635 Gene

  • GC17M063933
  • GC17M066420

Summaries for MIR635 Gene

Entrez Gene Summary for MIR635 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR635 Gene

MIR635 (MicroRNA 635) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR635 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR635

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR635 Gene

Genomics for MIR635 Gene

Regulatory Elements for MIR635 Gene

Enhancers for MIR635 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G068377 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +41.7 41705 11.7 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 NOL11 ENSG00000267731 MIR635 LOC100418928 SLC16A6 AMZ2 WIPI1 GC17M068333 PRKAR1A ENSG00000267009
GH17G068459 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.4 -37.3 -37275 5.3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 PRKAR1A MIR635 WIPI1 GC17P068532
GH17G068252 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +167.8 167815 8.7 HDGF PKNOX1 FOXA2 SIN3A TCF12 ZNF121 GATA2 ELK1 ZNF143 ZNF207 AMZ2 ARSG WIPI1 MIR635 BPTF ENSG00000265100
GH17G068311 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +111.0 110979 4.1 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 FOS ZNF263 SP5 ZHX2 MIR635 SLC16A6 ABCA6 PRKAR1A BPTF GC17M068333
GH17G068317 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +105.4 105428 3.4 PKNOX1 FOXA2 ARID4B ZNF48 SLC30A9 ZNF121 FOS DEK SP5 MXD4 MIR635 WIPI1 ABCA6 SLC16A6 BPTF GC17M068333
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR635 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR635 Gene

Chromosome:
17
Start:
68,424,451 bp from pter
End:
68,424,548 bp from pter
Size:
98 bases
Orientation:
Minus strand

Genomic View for MIR635 Gene

Genes around MIR635 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR635 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR635 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR635 Gene

ORGUL Member Location for MIR635 Gene

ORGUL Member Location for MIR635 gene

Proteins for MIR635 Gene

Post-translational modifications for MIR635 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR635 Gene

Domains & Families for MIR635 Gene

Gene Families for MIR635 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR635: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR635 Gene

Function for MIR635 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR635 Gene

Localization for MIR635 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR635 Gene

Pathways & Interactions for MIR635 Gene

SuperPathways for MIR635 Gene

No Data Available

Interacting Proteins for MIR635 Gene

Gene Ontology (GO) - Biological Process for MIR635 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR635 Gene

Drugs & Compounds for MIR635 Gene

No Compound Related Data Available

Transcripts for MIR635 Gene

fRNAdb Secondary structures for MIR635 Gene

  • FR284034
  • hsa-mir-635_MI0003650_Homo_sapiens_miR-635_stem-loop_hairpin

mRNA/cDNA for MIR635 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR635 Gene

No ASD Table

Relevant External Links for MIR635 Gene

GeneLoc Exon Structure for
MIR635
ECgene alternative splicing isoforms for
MIR635

Expression for MIR635 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR635 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR635 Gene:

MIR635
genes like me logo Genes that share expression patterns with MIR635: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR635 Gene

Orthologs for MIR635 Gene

Evolution for MIR635 Gene

ENSEMBL:
Gene Tree for MIR635 (if available)
TreeFam:
Gene Tree for MIR635 (if available)

No data available for Orthologs for MIR635 Gene

Paralogs for MIR635 Gene

No data available for Paralogs for MIR635 Gene

Variants for MIR635 Gene

Sequence variations from dbSNP and Humsavar for MIR635 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000167453 -- 68,425,684(+) AAGGA(A/G)GGCAG intron-variant, upstream-variant-2KB
rs1000650232 -- 68,426,422(+) GAGGT(A/C)GGGTC intron-variant, upstream-variant-2KB
rs1003460952 -- 68,424,970(+) GGTCT(A/G)TATGT intron-variant, upstream-variant-2KB
rs1003876999 -- 68,424,745(+) GGTGG(C/T)GCACA intron-variant, upstream-variant-2KB
rs1005546054 -- 68,426,316(+) GTGCC(C/T)AGGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR635 Gene

Variant ID Type Subtype PubMed ID
nsv833523 CNV gain 17160897

Relevant External Links for MIR635 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR635

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR635 Gene

Disorders for MIR635 Gene

Relevant External Links for MIR635

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR635

No disorders were found for MIR635 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR635 Gene

Publications for MIR635 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins J.M. … Velculescu V.E. (Proc. Natl. Acad. Sci. U.S.A. 2006) 1 3 64
  2. The microRNA-635 suppresses tumorigenesis in non-small cell lung cancer. (PMID: 27810784) Zhang Y. … Lin Y. (Biomed. Pharmacother. 2016) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR635 Gene

Sources for MIR635 Gene

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