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Aliases for MIR634 Gene

Subcategory (RNA class) for MIR634 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR634 Gene

  • MicroRNA 634 2 3 5
  • Hsa-Mir-634 3
  • MIRN634 3

External Ids for MIR634 Gene

ORGUL Members for MIR634 Gene

Previous HGNC Symbols for MIR634 Gene

  • MIRN634

Previous GeneCards Identifiers for MIR634 Gene

  • GC17P062214
  • GC17P064784

Summaries for MIR634 Gene

Entrez Gene Summary for MIR634 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR634 Gene

MIR634 (MicroRNA 634) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR634 Gene

Genomics for MIR634 Gene

Regulatory Elements for MIR634 Gene

Enhancers for MIR634 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G066943 1.1 ENCODE dbSUPER 10.3 +157.2 157228 1.8 HDGF PKNOX1 NFIB BMI1 YBX1 RAD21 ELK1 SCRT2 ZNF207 FOS CACNG4 CACNG5 MIR634 GC17P066938
GH17G066915 0.8 ENCODE 10.3 +128.2 128227 0.2 GTF2F1 CTCF JUN SIN3A ZBTB40 RAD21 GATA3 ELK1 POLR2A SMC3 CACNG5 MIR634 RNA5SP446 GC17P066938
GH17G066747 0.6 ENCODE 11.4 -39.4 -39384 1.0 FOSL1 NONO SMARCA4 POLR2A ZNF366 ZNF512 NFE2 PRDM1 NFE2L2 MIR634 CACNG5 PIR44901 GC17P066788
GH17G066791 0.8 Ensembl 0.7 +4.4 4429 0.6 KLF1 SAP130 ZMYM3 MAX CEBPG THRB TEAD3 THAP11 MIXL1 GATAD2A MIR634 PIR49208
GH17G066800 0.7 FANTOM5 0.4 +13.2 13226 0.3 PKNOX1 ZNF687 NFIB MTA2 TRIM22 MNT ZEB2 ZEB1 HIC1 SP1 CACNG5 PIR49208 MIR634
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR634 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR634 Gene

Chromosome:
17
Start:
66,787,072 bp from pter
End:
66,787,168 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR634 Gene

Genes around MIR634 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR634 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR634 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR634 Gene

Proteins for MIR634 Gene

Post-translational modifications for MIR634 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR634 Gene

Domains & Families for MIR634 Gene

Gene Families for MIR634 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR634: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR634 Gene

Function for MIR634 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR634 Gene

Localization for MIR634 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR634 Gene

Pathways & Interactions for MIR634 Gene

SuperPathways for MIR634 Gene

No Data Available

Interacting Proteins for MIR634 Gene

Gene Ontology (GO) - Biological Process for MIR634 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR634 Gene

Drugs & Compounds for MIR634 Gene

No Compound Related Data Available

Transcripts for MIR634 Gene

mRNA/cDNA for MIR634 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR634 Gene

No ASD Table

Relevant External Links for MIR634 Gene

GeneLoc Exon Structure for
MIR634
ECgene alternative splicing isoforms for
MIR634

Expression for MIR634 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR634 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR634 Gene:

MIR634
genes like me logo Genes that share expression patterns with MIR634: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR634 Gene

Orthologs for MIR634 Gene

Evolution for MIR634 Gene

ENSEMBL:
Gene Tree for MIR634 (if available)
TreeFam:
Gene Tree for MIR634 (if available)

No data available for Orthologs for MIR634 Gene

Paralogs for MIR634 Gene

No data available for Paralogs for MIR634 Gene

Variants for MIR634 Gene

Sequence variations from dbSNP and Humsavar for MIR634 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000909063 -- 66,786,251(+) GCCAC(C/T)GTGCC intron-variant, upstream-variant-2KB
rs1001821058 -- 66,787,631(+) GAATC(C/T)ACCCA intron-variant, downstream-variant-500B
rs1003026332 -- 66,785,554(+) ACGGA(A/G)TTTCC intron-variant, upstream-variant-2KB
rs1005829822 -- 66,785,208(+) GGTCA(A/G)GTCTC intron-variant, upstream-variant-2KB
rs1007352476 -- 66,785,828(+) AACTG(-/TGTTTT)TGTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR634 Gene

Variant ID Type Subtype PubMed ID
nsv1120054 OTHER inversion 24896259
nsv575899 CNV loss 21841781

Relevant External Links for MIR634 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR634

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR634 Gene

Disorders for MIR634 Gene

Relevant External Links for MIR634

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR634

No disorders were found for MIR634 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR634 Gene

Publications for MIR634 Gene

  1. MiR-634 decreases cell proliferation and induces apoptosis by targeting mTOR signaling pathway in cervical cancer cells. (PMID: 26367112) Cong J. … Zhang Y. (Artif Cells Nanomed Biotechnol 2016) 3 64
  2. Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1. (PMID: 26972586) Cui X. … Xia C. (Sci Rep 2016) 3 64
  3. Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis. (PMID: 25788529) Bertram A. … Kirsch T. (J. Am. Soc. Nephrol. 2015) 3 64
  4. miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity. (PMID: 26216549) Fujiwara N. … Inazawa J. (Cancer Res. 2015) 3 64
  5. MiR-634 sensitizes nasopharyngeal carcinoma cells to paclitaxel and inhibits cell growth both in vitro and in vivo. (PMID: 25400759) Peng X. … Cao K. (Int J Clin Exp Pathol 2014) 3 64

Products for MIR634 Gene

Sources for MIR634 Gene

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