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Aliases for MIR634 Gene

Subcategory (RNA class) for MIR634 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR634 Gene

  • MicroRNA 634 2 3 5
  • Hsa-Mir-634 3
  • MIRN634 3

External Ids for MIR634 Gene

ORGUL Members for MIR634 Gene

Previous HGNC Symbols for MIR634 Gene

  • MIRN634

Previous GeneCards Identifiers for MIR634 Gene

  • GC17P062214
  • GC17P064784

Summaries for MIR634 Gene

Entrez Gene Summary for MIR634 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR634 Gene

MIR634 (MicroRNA 634) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR634 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR634 Gene

Genomics for MIR634 Gene

GeneHancer (GH) Regulatory Elements for MIR634 Gene

Promoters and enhancers for MIR634 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I066943 Enhancer 0.9 ENCODE dbSUPER 10.3 +157.2 157228 1.8 HDGF PKNOX1 NFIB NEUROD1 FOSL1 CTBP1 GATA3 POLR2A ZNF207 FOS CACNG4 CACNG5 MIR634 GC17P066938
GH17I066915 Enhancer 0.7 ENCODE 10.3 +128.2 128227 0.2 GTF2F1 CTCF SIN3A ZBTB40 RAD21 GATA3 ELK1 POLR2A SMC3 SMARCA5 CACNG5 MIR634 RNA5SP446 GC17P066938
GH17I066877 Promoter 0.6 EPDnew 11.1 +90.2 90206 0.1 ZNF24 CACNG5 MIR634 RNA5SP446
GH17I066747 Enhancer 0.4 ENCODE 11.4 -39.4 -39383 1 FOSL1 POLR2A NFE2 MIR634 CACNG5 PIR44901 GC17P066788 PRKCA
GH17I066791 Enhancer 0.4 Ensembl 0.8 +4.4 4429 0.6 POLR2A MAX MYC MIR634 PIR49208 PRKCA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR634 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR634 Gene

Genomic Locations for MIR634 Gene
chr17:66,787,072-66,787,168
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr17:64,783,190-64,783,286
(GRCh37/hg19)

Genomic View for MIR634 Gene

Genes around MIR634 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR634 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR634 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR634 Gene

Proteins for MIR634 Gene

Post-translational modifications for MIR634 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR634 Gene

Domains & Families for MIR634 Gene

Gene Families for MIR634 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR634: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR634 Gene

Function for MIR634 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR634 Gene

Localization for MIR634 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR634 Gene

Pathways & Interactions for MIR634 Gene

SuperPathways for MIR634 Gene

No Data Available

Interacting Proteins for MIR634 Gene

Gene Ontology (GO) - Biological Process for MIR634 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR634 Gene

Drugs & Compounds for MIR634 Gene

No Compound Related Data Available

Transcripts for MIR634 Gene

mRNA/cDNA for MIR634 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR634 Gene

No ASD Table

Relevant External Links for MIR634 Gene

GeneLoc Exon Structure for
MIR634
ECgene alternative splicing isoforms for
MIR634

Expression for MIR634 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR634 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR634 Gene:

MIR634
genes like me logo Genes that share expression patterns with MIR634: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR634 Gene

Orthologs for MIR634 Gene

Evolution for MIR634 Gene

ENSEMBL:
Gene Tree for MIR634 (if available)
TreeFam:
Gene Tree for MIR634 (if available)

No data available for Orthologs for MIR634 Gene

Paralogs for MIR634 Gene

No data available for Paralogs for MIR634 Gene

Variants for MIR634 Gene

Sequence variations from dbSNP and Humsavar for MIR634 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000909063 -- 66,786,251(+) C/T upstream_transcript_variant
rs1001821058 -- 66,787,631(+) C/T downstream_transcript_variant
rs1003026332 -- 66,785,554(+) A/G upstream_transcript_variant
rs1005829822 -- 66,785,208(+) G/A upstream_transcript_variant
rs1007635428 -- 66,785,949(+) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR634 Gene

Variant ID Type Subtype PubMed ID
nsv1120054 OTHER inversion 24896259
nsv575899 CNV loss 21841781

Additional Variant Information for MIR634 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR634

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR634 Gene

Disorders for MIR634 Gene

Additional Disease Information for MIR634

No disorders were found for MIR634 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR634 Gene

Publications for MIR634 Gene

  1. miR-634 is a Pol III-dependent intronic microRNA regulating alternative-polyadenylated isoforms of its host gene PRKCA. (PMID: 28212793) Paraboschi EM … Asselta R (Biochimica et biophysica acta 2017) 3 58
  2. miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33. (PMID: 27693040) Zhang CZ … Zhang MF (Molecular oncology 2016) 3 58
  3. Overexpression of microRNA-634 suppresses survival and matrix synthesis of human osteoarthritis chondrocytes by targeting PIK3R1. (PMID: 26972586) Cui X … Xia C (Scientific reports 2016) 3 58
  4. MiR-634 decreases cell proliferation and induces apoptosis by targeting mTOR signaling pathway in cervical cancer cells. (PMID: 26367112) Cong J … Zhang Y (Artificial cells, nanomedicine, and biotechnology 2016) 3 58
  5. Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis. (PMID: 25788529) Bertram A … Kirsch T (Journal of the American Society of Nephrology : JASN 2015) 3 58

Products for MIR634 Gene

Sources for MIR634 Gene

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