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Aliases for MIR633 Gene

Subcategory (RNA class) for MIR633 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR633 Gene

  • MicroRNA 633 2 3 5
  • Hsa-Mir-633 3
  • MIRN633 3

External Ids for MIR633 Gene

ORGUL Members for MIR633 Gene

Previous HGNC Symbols for MIR633 Gene

  • MIRN633

Previous GeneCards Identifiers for MIR633 Gene

  • GC17P058376
  • GC17P061021

Summaries for MIR633 Gene

Entrez Gene Summary for MIR633 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR633 Gene

MIR633 (MicroRNA 633) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR633 Gene

Genomics for MIR633 Gene

Regulatory Elements for MIR633 Gene

Enhancers for MIR633 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G062789 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -152.1 -152058 5.9 HDGF PKNOX1 FOXA2 SIN3A YBX1 FEZF1 ZBTB7B ZNF207 FOS SP3 DDX42 INTS2 MED13 MIR633 STRADA MARCH10 GC17M062789 GC17M062752
GH17G062891 1.5 FANTOM5 Ensembl ENCODE 11.3 -51.4 -51355 2.7 TBP HDGF PKNOX1 NFRKB ZSCAN4 SIN3A YBX1 RAD21 ZBTB40 GATA2 MIR633 CYB561 GC17P062917 GC17P062863
GH17G062723 1.5 Ensembl ENCODE dbSUPER 10.3 -219.1 -219064 2.7 PKNOX1 WRNIP1 SIN3A FEZF1 ZBTB7B CBX5 ZNF143 FOS ZNF263 ZHX2 MIR633 MARCH10 LOC105371855 MRC2 GC17M062741
GH17G062897 1.3 FANTOM5 Ensembl ENCODE 11.4 -45.5 -45518 2.2 PKNOX1 JUN ZBTB11 DPF2 ZNF217 JUND RAD51 SMARCA4 FOSL2 FOS MIR633 CYB561 GC17P062917 GC17P062863
GH17G062702 1.3 ENCODE dbSUPER 10.9 -239.4 -239403 4.0 ARNT SIN3A ZNF2 ZBTB7B ZNF143 FOS SP3 ZHX2 REST SMARCB1 MRC2 RNU6-446P MIR633 LOC105371855 MARCH10 GC17M062741
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR633 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR633 Gene

Chromosome:
17
Start:
62,944,215 bp from pter
End:
62,944,312 bp from pter
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR633 Gene

Genes around MIR633 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR633 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR633 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR633 Gene

Proteins for MIR633 Gene

Post-translational modifications for MIR633 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR633 Gene

Domains & Families for MIR633 Gene

Gene Families for MIR633 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR633: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR633 Gene

Function for MIR633 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR633 Gene

Localization for MIR633 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR633 Gene

Pathways & Interactions for MIR633 Gene

SuperPathways for MIR633 Gene

No Data Available

Interacting Proteins for MIR633 Gene

Gene Ontology (GO) - Biological Process for MIR633 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR633 Gene

Drugs & Compounds for MIR633 Gene

No Compound Related Data Available

Transcripts for MIR633 Gene

mRNA/cDNA for MIR633 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR633 Gene

No ASD Table

Relevant External Links for MIR633 Gene

GeneLoc Exon Structure for
MIR633
ECgene alternative splicing isoforms for
MIR633

Expression for MIR633 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR633 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR633 Gene:

MIR633
genes like me logo Genes that share expression patterns with MIR633: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR633 Gene

Orthologs for MIR633 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR633 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-633 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR633 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR633 Gene

ENSEMBL:
Gene Tree for MIR633 (if available)
TreeFam:
Gene Tree for MIR633 (if available)

Paralogs for MIR633 Gene

No data available for Paralogs for MIR633 Gene

Variants for MIR633 Gene

Sequence variations from dbSNP and Humsavar for MIR633 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000041420 -- 62,943,137(+) ATGAC(A/G)ATCGC upstream-variant-2KB
rs1001931296 -- 62,944,383(+) TTATG(C/T)AAGTC downstream-variant-500B
rs1002773416 -- 62,944,735(+) TTAAT(G/T)TTTTT downstream-variant-500B
rs1004197025 -- 62,943,799(+) GGAAT(G/T)GGTTT upstream-variant-2KB
rs1004674867 -- 62,943,571(+) TGCTC(A/G)GCTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR633 Gene

Variant ID Type Subtype PubMed ID
dgv5741n54 CNV loss 21841781
esv3640980 CNV loss 21293372
nsv457865 CNV loss 19166990
nsv575846 CNV loss 21841781

Relevant External Links for MIR633 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR633

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR633 Gene

Disorders for MIR633 Gene

Relevant External Links for MIR633

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR633

No disorders were found for MIR633 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR633 Gene

Publications for MIR633 Gene

  1. The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2). (PMID: 23436656) Hu H. … Lin L. (J. Biol. Chem. 2013) 3 64
  2. MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma. (PMID: 22249270) Yi C. … Yun J.P. (Oncogene 2012) 3 64
  3. Regulated microRNAs in the CSF of patients with multiple sclerosis: a case-control study. (PMID: 23077021) Haghikia A. … Gold R. (Neurology 2012) 3 64
  4. [Expression level of miRNA-663 in different leukemic cell lines and its biological function]. (PMID: 21518471) Yang Y. … Yu L. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR633 Gene

Sources for MIR633 Gene

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