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Aliases for MIR633 Gene

Subcategory (RNA class) for MIR633 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR633 Gene

  • MicroRNA 633 2 3
  • Hsa-Mir-633 3
  • MIRN633 3

External Ids for MIR633 Gene

ORGUL Members for MIR633 Gene

Previous HGNC Symbols for MIR633 Gene

  • MIRN633

Previous GeneCards Identifiers for MIR633 Gene

  • GC17P058376
  • GC17P061021

Summaries for MIR633 Gene

Entrez Gene Summary for MIR633 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR633 Gene

MIR633 (MicroRNA 633) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR633 Gene

Genomics for MIR633 Gene

Genomic Location for MIR633 Gene

Chromosome:
17
Start:
62,944,215 bp from pter
End:
62,944,312 bp from pter
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR633 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR633 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR633 Gene

No data available for Regulatory Elements for MIR633 Gene

Proteins for MIR633 Gene

Post-translational modifications for MIR633 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR633 Gene

Domains & Families for MIR633 Gene

Gene Families for MIR633 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR633: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR633 Gene

Function for MIR633 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR633 Gene

Localization for MIR633 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR633 Gene

Pathways & Interactions for MIR633 Gene

SuperPathways for MIR633 Gene

No Data Available

Interacting Proteins for MIR633 Gene

Gene Ontology (GO) - Biological Process for MIR633 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR633 Gene

Drugs & Compounds for MIR633 Gene

No Compound Related Data Available

Transcripts for MIR633 Gene

mRNA/cDNA for MIR633 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR633 Gene

No ASD Table

Relevant External Links for MIR633 Gene

GeneLoc Exon Structure for
MIR633
ECgene alternative splicing isoforms for
MIR633

Expression for MIR633 Gene

mRNA expression in normal human tissues for MIR633 Gene

genes like me logo Genes that share expression patterns with MIR633: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR633 Gene

Orthologs for MIR633 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR633 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-633 36
  • 98 (a)
OneToOne
Species with no ortholog for MIR633:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR633 Gene

ENSEMBL:
Gene Tree for MIR633 (if available)
TreeFam:
Gene Tree for MIR633 (if available)

Paralogs for MIR633 Gene

No data available for Paralogs for MIR633 Gene

Variants for MIR633 Gene

Sequence variations from dbSNP and Humsavar for MIR633 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9907997 -- 62,944,789(+) gtggc(A/G)caatc downstream-variant-500B
rs17686634 -- 62,942,684(+) ACCAA(C/G)TTGAG upstream-variant-2KB
rs17686669 -- 62,943,364(+) GTTCT(A/G)TCCTT upstream-variant-2KB
rs17686684 -- 62,943,908(+) TATAA(C/T)GAGAG upstream-variant-2KB
rs17759989 -- 62,944,250(+) GGTAG(A/G)TACTA nc-transcript-variant

Relevant External Links for MIR633 Gene

HapMap Linkage Disequilibrium report
MIR633

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR633 Gene

Disorders for MIR633 Gene

Relevant External Links for MIR633

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR633
genes like me logo Genes that share disorders with MIR633: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR633 Gene

Publications for MIR633 Gene

  1. The overexpression of hypomethylated miR-663 induces chemotherapy resistance in human breast cancer cells by targeting heparin sulfate proteoglycan 2 (HSPG2). (PMID: 23436656) Hu H. … Lin L. (J. Biol. Chem. 2013) 67
  2. Regulated microRNAs in the CSF of patients with multiple sclerosis: a case-control study. (PMID: 23077021) Haghikia A. … Gold R. (Neurology 2012) 67
  3. MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma. (PMID: 22249270) Yi C. … Yun J.P. (Oncogene 2012) 67
  4. [Expression level of miRNA-663 in different leukemic cell lines and its biological function]. (PMID: 21518471) Yang Y. … Yu L. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2011) 67
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 67

Products for MIR633 Gene

Sources for MIR633 Gene

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