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Aliases for MIR632 Gene

Subcategory (RNA class) for MIR632 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR632 Gene

  • MicroRNA 632 2 3
  • Zinc Finger Protein 207 4 5
  • ZNF207 4 5
  • Hsa-Mir-632 3
  • MIRN632 3
  • HBuGZ 4
  • BUGZ 4

External Ids for MIR632 Gene

Previous HGNC Symbols for MIR632 Gene

  • MIRN632

Previous GeneCards Identifiers for MIR632 Gene

  • GC17P027702
  • GC17P030677

Summaries for MIR632 Gene

Entrez Gene Summary for MIR632 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR632 Gene

MIR632 (MicroRNA 632) is an RNA Gene, and is affiliated with the miRNA class.

UniProtKB/Swiss-Prot for MIR632 Gene

  • Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR632 Gene

Genomics for MIR632 Gene

Regulatory Elements for MIR632 Gene

Enhancers for MIR632 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR632 on UCSC Golden Path with GeneCards custom track

Promoters for MIR632 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR632 Gene

Chromosome:
17
Start:
32,350,109 bp from pter
End:
32,381,886 bp from pter
Size:
31,778 bases
Orientation:
Plus strand

Genomic View for MIR632 Gene

Genes around MIR632 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR632 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR632 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR632 Gene

Proteins for MIR632 Gene

  • Protein details for MIR632 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43670-ZN207_HUMAN
    Recommended name:
    BUB3-interacting and GLEBS motif-containing protein ZNF207
    Protein Accession:
    O43670
    Secondary Accessions:
    • A8K6Y6
    • E1P660
    • E1P661
    • E1P662
    • Q53XS9
    • Q96HW5
    • Q9BUQ7

    Protein attributes for MIR632 Gene

    Size:
    478 amino acids
    Molecular mass:
    50751 Da
    Quaternary structure:
    • Interacts (via GLEBS region) with BUB3.
    • Interacts (via GLEBS region) with BUB3.

    Alternative splice isoforms for MIR632 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR632 Gene

Post-translational modifications for MIR632 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR632 Gene

Domains & Families for MIR632 Gene

Gene Families for MIR632 Gene

Protein Domains for MIR632 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O43670

UniProtKB/Swiss-Prot:

ZN207_HUMAN :
  • The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).
  • Contains 2 C2H2-type zinc fingers.
Domain:
  • The GLEBS region mediates interaction with BUB3 (PubMed:24462186, PubMed:24462187).
  • The microtubule-binding region is required for efficient loading of BUB3 onto kinetochores and proper mitosis.
  • Mainly composed of disordered low-complexity regions outside of the C2H2-type zinc fingers. Coacervation depends on hydrophobic and aromatic Phe and Tyr in the disordered low-complexity region, that may promote coacervation by forming intermolecular hydrophobic interactions.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
genes like me logo Genes that share domains with MIR632: view

No data available for Suggested Antigen Peptide Sequences for MIR632 Gene

Function for MIR632 Gene

Molecular function for MIR632 Gene

UniProtKB/Swiss-Prot Function:
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).

Gene Ontology (GO) - Molecular Function for MIR632 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS --
GO:0005515 protein binding IPI --
GO:0008017 microtubule binding IDA --
GO:0008201 heparin binding IEA --
genes like me logo Genes that share ontologies with MIR632: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR632 Gene

Localization for MIR632 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR632 Gene

Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. {ECO:0000269 PubMed:24462186, ECO:0000269 PubMed:24462187}.

Gene Ontology (GO) - Cellular Components for MIR632 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IMP --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus NAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MIR632: view

No data available for Subcellular locations from COMPARTMENTS for MIR632 Gene

Pathways & Interactions for MIR632 Gene

SuperPathways for MIR632 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR632 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation ISS --
GO:0006355 regulation of transcription, DNA-templated NAS --
GO:0007094 mitotic spindle assembly checkpoint IMP --
GO:0008608 attachment of spindle microtubules to kinetochore IMP --
GO:0046785 microtubule polymerization ISS --
genes like me logo Genes that share ontologies with MIR632: view

No data available for Pathways by source and SIGNOR curated interactions for MIR632 Gene

Drugs & Compounds for MIR632 Gene

No Compound Related Data Available

Transcripts for MIR632 Gene

mRNA/cDNA for MIR632 Gene

(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR632 Gene

No ASD Table

Relevant External Links for MIR632 Gene

GeneLoc Exon Structure for
MIR632
ECgene alternative splicing isoforms for
MIR632

Expression for MIR632 Gene

mRNA expression in normal human tissues for MIR632 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR632 Gene:

MIR632

mRNA Expression by UniProt/SwissProt for MIR632 Gene:

O43670-ZN207_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MIR632: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR632 Gene

Orthologs for MIR632 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR632 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 93 (a)
OneToMany
-- 35
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ZNF207 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF207 35
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZNF207 35
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF207 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp207 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF207 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF207 35
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf207a 35
  • 70 (a)
OneToMany
znf207b 35
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17912 35
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0035.1 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10678 35
  • 47 (a)
OneToOne
Species where no ortholog for MIR632 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR632 Gene

ENSEMBL:
Gene Tree for MIR632 (if available)
TreeFam:
Gene Tree for MIR632 (if available)

Paralogs for MIR632 Gene

Pseudogenes.org Pseudogenes for MIR632 Gene

genes like me logo Genes that share paralogs with MIR632: view

No data available for Paralogs for MIR632 Gene

Variants for MIR632 Gene

Relevant External Links for MIR632 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR632

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR632 Gene

Disorders for MIR632 Gene

Relevant External Links for MIR632

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR632

No disorders were found for MIR632 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR632 Gene

Publications for MIR632 Gene

  1. Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly. (PMID: 26388440) Jiang H. … Zheng Y. (Cell 2015) 4 65
  2. A microtubule-associated zinc finger protein, BuGZ, regulates mitotic chromosome alignment by ensuring Bub3 stability and kinetochore targeting. (PMID: 24462186) Jiang H. … Zheng Y. (Dev. Cell 2014) 4 65
  3. BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment. (PMID: 24462187) Toledo C.M. … Paddison P.J. (Dev. Cell 2014) 4 65
  4. Micro-RNA-632 downregulates DNAJB6 in breast cancer. (PMID: 22710984) Mitra A. … Samant R.S. (Lab. Invest. 2012) 3 65
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 65

Products for MIR632 Gene

Sources for MIR632 Gene

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